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Molecular and cellular insights into T cell exhaustion
Open accessAbstract
In chronic infections and cancer, T cells are exposed to persistent antigen and/or inflammatory signals. This scenario is often associated with the deterioration of T cell function: a state called 'exhaustion'. Exhausted T cells lose robust effector functions, express multiple inhibitory receptors and are defined by an altered transcriptional programme. T cell exhaustion is often associated with inefficient control of persisting infections and tumours, but revitalization of exhausted T cells can reinvigorate immunity. Here, we review recent advances that provide a clearer molecular understanding of T cell exhaustion and reveal new therapeutic targets for persisting infections and cancer.
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“Other situations of chronic antigen stimulation, such as cancer or chronic viral infections, result in T cell exhaustion, characterized by the progressive loss of cytokine expression, proliferative potential, and upregulation of inhibitory receptors (immune checkpoints).”
From Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases (2024) · cites this paper as [32]
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“Exhaustion can be partially reversed by immune checkpoint inhibitors, providing the basis for successful therapies against cancer. 32,33”
From Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases (2024) · cites this paper as [32]
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“In TME, prolonged antigen exposure leads to T cell exhaustion, marked by losing effector functions.”
From Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer (2025) · cites this paper as [24]
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“cells with an exhaustion signature (denoted exhausted, fig. S3B) overexpressing the Lag3, Tbc1d4, Sostdc1, and Tnfsf8 genes (22, 31)”
From Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes (2019) · cites this paper as [31]
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Cites
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989
Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,320
The blockade of immune checkpoints in cancer immunotherapy
Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838
Nivolumab plus Ipilimumab in Advanced Melanoma
Wolchok, J. D., Kluger, H., Callahan, M. K., Postow, M. A., Rizvi, N. A., Lesokhin, A. M., Segal, N. H., Ariyan, C. E., Gordon, R.-A., Reed, K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302369 · Cited by 4,230
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Self-citationRestoring function in exhausted CD8 T cells during chronic viral infection
Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 4,057
Self-citationRegulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Day, C. L., Kaufmann, D. E., Kiepiela, P., Brown, J. A., Moodley, E. S., Reddy, S., Mackey, E. W., Miller, J. D., Leslie, A. J., DePierres, C., et al. (2006) · Nature · doi:10.1038/nature05115 · Cited by 2,680
Self-citationControl of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes
Schmitz, J. E., Kuroda, M. J., Santra, S., Sasseville, V. G., Simon, M. A., Lifton, M. A., Rácz, P., Tenner‐Racz, K., Dalesandro, M. R., Scallon, B. J., et al. (1999) · Science · doi:10.1126/science.283.5403.857 · Cited by 2,167
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103
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Dejima, H., Hu, X. Y., Chen, R., Zhang, J., Fujimoto, J., Parra, E. R., Haymaker, C., Hubert, S. M., Duose, D. Y., Solis, L. M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22890-x · Cited by 144
Khanam, A., Chua, J. V., & Kottilil, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115497 · Cited by 148
Biochemical Underpinnings of Immune Cell Metabolic Phenotypes
Olenchock, B. A., Rathmell, J. C., & Heiden, M. G. V. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.013 · Cited by 141
Wang, X., Shen, H., Zhangyuan, G., Huang, R., Zhang, W., He, Q., Jin, K., Zhuo, H., Zhang, Z., Wang, J., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0180-7 · Cited by 141
Targeting mitochondria in cancer: current concepts and immunotherapy approaches
Pustylnikov, S., Costabile, F., Beghi, S., & Facciabene, A. (2018) · Translational research · doi:10.1016/j.trsl.2018.07.013 · Cited by 142
Iyer, S., Zhang, S., Yucel, S., Horn, H., Smith, S. G., Reinhardt, F., Hoefsmit, E., Assatova, B., Casado, J., Meinsohn, M.-C., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0818 · Cited by 136
PD-1 hi CD8 + resident memory T cells balance immunity and fibrotic sequelae
Wang, Z., Wang, S., Goplen, N. P., Li, C., Cheon, I. S., Dai, Q., Huang, S., Shan, J., Ma, C., Ye, Z., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aaw1217 · Cited by 134
Comprehensive in vitro characterization of PD-L1 small molecule inhibitors
Ganesan, A., Ahmed, M., Okoye, I., Arutyunova, E. I., Babu, D., Turnbull, W. L., Kundu, J. K., Shields, J. A., Agopsowicz, K. C., Xu, L., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-48826-6 · Cited by 136
Unleashing Natural Killer Cells in the Tumor Microenvironment–The Next Generation of Immunotherapy?
Ben‐Shmuel, A., Biber, G., & Barda‐Saad, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00275 · Cited by 138
Joller, N., & Kuchroo, V. K. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_62 · Cited by 145
Zhang, Z., Chen, L., Chen, H., Zhao, J., Li, K., Sun, J., & Zhou, M. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104207 · Cited by 135
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity
Yang, J., Yamashita-Kanemaru, Y., Morris, B. I., Contursi, A., Trajkovski, D., Xu, J., Patrascan, I., Benson, J., Evans, A. C., Conti, A. G., et al. (2025) · Nature · doi:10.1038/s41586-025-08626-7 · Cited by 153
Creatine uptake regulates CD8 T cell antitumor immunity
Di Biase, S., Ma, X., Wang, X., Yu, J., Wang, Y.-C., Smith, D. J., Zhou, Y., Li, Z., Kim, Y. J., Clarke, N., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20182044 · Cited by 132
“In particular, the PD-1hiTim3hiLAG-3hi tumor-infiltrating CD8 T cells, which are considered to be the most “exhausted,” expressed the highest levels of CrT, suggesting that these cells may also benefit the most from creatine supplementation treatment (Fig. S1 K; Nguyen and Ohashi, 2015; Wherry and Kurachi, 2015).”
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Mirzaei, R., Sarkar, S., & Yong, V. W. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.11.005 · Cited by 136
Oncolytic viruses and checkpoint inhibitors: combination therapy in clinical trials
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Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications
Buqué, A., Bloy, N., Aranda, F., Castoldi, F., Eggermont, A. M. M., Cremer, I., Fridman, W. H., Fucikova, J. P., Galon, J., Marabelle, A., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1008814 · Cited by 132
The Unsolved Jigsaw Puzzle of the Immune Response in Chagas Disease
Acevedo, G. R., Girard, M. C., & Gómez, K. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01929 · Cited by 130
N-Acetylcysteine: A potential therapeutic agent for SARS-CoV-2
Poe, F. L., & Corn, J. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109862 · Cited by 130
Simula, L., Pacella, I., Colamatteo, A., Procaccini, C., Cancila, V., Bordi, M., Tregnago, C., Corrado, M., Pigazzi, M., Barnaba, V., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.018 · Cited by 128
Tolerance in the Age of Immunotherapy
Bluestone, J. A., & Anderson, M. S. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1911109 · Cited by 137
Saleh, R., Taha, R. Z., Toor, S. M., Nair, V. S., Murshed, K., Khawar, M., Al‐Dhaheri, M., Petkar, M. A., Nada, M. A., & Elkord, E. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02593-w · Cited by 128
Meng, Y., Ye, F., Nie, P., Zhao, Q., An, L., Wang, W., Qu, S., Shen, Z., Cao, Z., Zhang, X., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.08.024 · Cited by 127
Marisa, L., Svrcek, M., Collura, A., Becht, É., Cervera, P., Wanherdrick, K., Buhard, O., Goloudina, A. R., Jonchère, V., Sèlves, J., et al. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djx136 · Cited by 136
Papavassiliou, A. G., & Musti, A. M. (2020) · Cells · doi:10.3390/cells9112470 · Cited by 124
Short telomere syndromes cause a primary T cell immunodeficiency
Wagner, C. L., Hanumanthu, V. S., Talbot, C. C., Abraham, R. S., Hamm, D. E., Gable, D. L., Kanakry, C. G., Applegate, C. D., Siliciano, J. D., Jackson, J. B., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120216 · Cited by 127
Current advancements and future perspectives of immunotherapy in colorectal cancer research
Kishore, C., & Bhadra, P. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173819 · Cited by 126
Tsai, H.-F., & Hsu, P. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0341-0 · Cited by 134
Zappasodi, R., Budhu, S., Hellmann, M. D., Postow, M. A., Şenbabaoğlu, Y., Manne, S., Gasmi, B., Liu, C., Zhong, H., Li, Y., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.09.007 · Cited by 124
Self-citationMechanisms of resistance to immune checkpoint inhibitors
Nagasaki, J., Ishino, T., & Togashi, Y. (2022) · Cancer Science · doi:10.1111/cas.15497 · Cited by 130
Kilian, M., Sheinin, R., Tan, C. L., Friedrich, M., Krämer, C., Kaminitz, A., Sanghvi, K., Lindner, K. A. M., Chih, Y., Cichon, F., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2022.12.007 · Cited by 124
Selective inhibition of low-affinity memory CD8(+) T cells by corticosteroids
Tokunaga, A., Sugiyama, D., Maeda, Y., Warner, A. B., Panageas, K. S., Ito, S., Togashi, Y., Sakai, C., Wolchok, J. D., & Nishikawa, H. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20190738 · Cited by 124
Lercher, A., Bhattacharya, A., Popa, A., Caldera, M., Schlapansky, M. F., Baazim, H., Agerer, B., Gürtl, B., Kosack, L., Májek, P., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.10.014 · Cited by 124
Nguyen, S., Deléage, C., Darko, S. W., Ransier, A., Truong, D. P., Agarwal, D., Japp, A. S., Wu, V. H., Kuri-Cervantes, L., Abdel‐Mohsen, M., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aax4077 · Cited by 116
T-cells in chronic lymphocytic leukemia: Guardians or drivers of disease?
Roessner, P. M., & Seiffert, M. (2020) · Leukemia · doi:10.1038/s41375-020-0873-2 · Cited by 131
McLane, L. M., Ngiow, S. F., Chen, Z., Attanasio, J., Manne, S., Ruthel, G. T., Wu, J. E., Staupe, R. P., Xu, W., Amaravadi, R. K., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109120 · Cited by 127
Self-citationHigh endothelial venules in cancer: Regulation, function, and therapeutic implication
Vella, G., Hua, Y., & Bergers, G. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.002 · Cited by 132
Si, X., Shao, M., Teng, X., Huang, Y., Ye, M., Wu, L., Wei, J., Liu, L., Gu, T., Song, J., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.010 · Cited by 127
Anti-PD-1/PD-L1 therapy for infectious diseases: learning from the cancer paradigm
Rao, M., Valentini, D., Dodoo, E., Zumla, A. I., & Maeurer, M. J. (2017) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2017.01.028 · Cited by 125
Principles of Immunotherapy: Implications for Treatment Strategies in Cancer and Infectious Diseases
Naran, K., Nundalall, T., Chetty, S., & Barth, S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03158 · Cited by 128
Immune Checkpoints: Novel Therapeutic Targets to Attenuate Sepsis-Induced Immunosuppression
McBride, M. A., Patil, T. K., Bohannon, J. K., Hernandez, A., Sherwood, E. R., & Patil, N. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.624272 · Cited by 127
Colucci, M., Sarill, M., Maddalena, M., Valdata, A., Troiani, M., Massarotti, M., Bolis, M., Bressan, S., Kohl, A., Robesti, D., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.05.015 · Cited by 143
Snell, L. M., MacLeod, B. L., Law, J. C., Osokine, I., Elsaesser, H. J., Hezaveh, K., Dickson, R. J., Gavin, M. A., Guidos, C. J., McGaha, T. L., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.08.002 · Cited by 122
Biomarkers in Triple-Negative Breast Cancer: State-of-the-Art and Future Perspectives
Cocco, S., Piezzo, M., Calabrese, A., Cianniello, D., Caputo, R., Lauro, V. D., Fusco, G., Gioia, G. D., Licenziato, M., & Laurentiis, M. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134579 · Cited by 127
PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes
Nagasaki, J., Inozume, T., Sax, N., Ariyasu, R., Ishikawa, M., Yamashita, K., Kawazu, M., Ueno, T., Irie, T., Tanji, E., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110331 · Cited by 126
Immune checkpoint dysfunction in large and medium vessel vasculitis
Watanabe, R., Zhang, H., Berry, G. J., Goronzy, J. J., & Weyand, C. M. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00024.2017 · Cited by 121
Immune checkpoint inhibitors in advanced non–small cell lung cancer
Assi, H. I., Kamphorst, A. O., Moukalled, N. M., & Ramalingam, S. S. (2017) · Cancer · doi:10.1002/cncr.31105 · Cited by 123
Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies
Muhammad, S., Fan, T. T., Hai, Y., Gao, Y., & He, J. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01826-7 · Cited by 130
Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56
Zou, F., Lu, L., Liu, J., Xia, B., Zhang, W., Hu, Q., Liu, W., Zhang, Y., Lin, Y., Jing, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11893-4 · Cited by 120
A unified atlas of CD8 T cell dysfunctional states in cancer and infection
Pritykin, Y., van der Veeken, J., Pine, A. R., Zhong, Y., Şahin, M., Mažutis, L., Pe’er, D., Rudensky, A. Y., & Leslie, C. S. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.045 · Cited by 117
Tonnerre, P., Wolski, D., Subudhi, S., Aljabban, J., Hoogeveen, R. C., Damasio, M. P. S., Drescher, H. K., Bartsch, L. M., Tully, D. C., Sen, D. R., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00982-6 · Cited by 118
Tieu, V., Sotillo, E., Bjelajac, J. R., Chen, C., Malipatlolla, M. B., Guerrero, J. A., Xu, P., Quinn, P. J., Fisher, C., Klysz, D. D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.01.035 · Cited by 122
Elevation and persistence of CD8 T‐cells in HIV infection: the Achilles heel in the ART era
Cao, W., Mehraj, V., Kaufmann, D., Li, T., & Routy, J. (2016) · Journal of the International AIDS Society · doi:10.7448/ias.19.1.20697 · Cited by 119
Muenchhoff, M., Adland, E., Karimanzira, O., Crowther, C. E., Pace, M. J., Csala, A., Leitman, E. M., Moonsamy, A., McGregor, C., Hurst, J. M., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aag1048 · Cited by 119
Pichler, A., Carrié, N., Cuisinier, M., Ghazali, S., Voisin, A., Axisa, P., Tosolini, M., Mazzotti, C., Golec, D. P., Mahéo, S., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.007 · Cited by 124
Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy
Zhang, Q., Zhu, B., & Li, Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00071 · Cited by 121
Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion
Seo, W., Jerin, C., & Nishikawa, H. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00568-0 · Cited by 125
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Pietrobon, V., Todd, L. A., Goswami, A., Stefanson, O., Yang, Z., & Marincola, F. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910828 · Cited by 124
Wang, Y., Zhong, X., He, X., Hu, Z., Huang, H., Chen, J., Chen, K., Zhao, S., Wei, P., & Li, D. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02729-7 · Cited by 131
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment
Pauken, K. E., Shahid, O., Lagattuta, K. A., Mahuron, K. M., Luber, J. M., Lowe, M. M., Huang, L., Delaney, C., Long, J. M., Fung, M. E., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200920 · Cited by 116
Nishimoto, K. P., Barca, T., Azameera, A., Makkouk, A., Romero, J. M., Bai, L., Brodey, M. M., Kennedy‐Wilde, J., Shao, H., Papaioannou, S., et al. (2022) · Clinical & Translational Immunology · doi:10.1002/cti2.1373 · Cited by 124
Intratumoral regulatory T cells: markers, subsets and their impact on anti-tumor immunity
Yano, H., Andrews, L. P., Workman, C. J., & Vignali, D. A. A. (2019) · Immunology · doi:10.1111/imm.13067 · Cited by 116
Fehlings, M., Simoni, Y., Penny, H. L., Becht, É., Loh, C. Y., Gubin, M. M., Ward, J. P., Wong, S. C., Schreiber, R. D., & Newell, E. W. (2017) · Nature Communications · doi:10.1038/s41467-017-00627-z · Cited by 118
Dysfunctional Immune Response in Acute-on-Chronic Liver Failure: It Takes Two to Tango
Martin-Mateos, R., Alvarez-Mon, M., & Albillos, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00973 · Cited by 116
Gangaplara, A., Martens, C., Dahlstrom, E. W., Metidji, A., Gokhale, A. S., Glass, D. D., Lopez-Ocasio, M. D., Baur, R., Kanakabandi, K., Porcella, S. F., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006985 · Cited by 114
Thwaites, R. S., Coates, M. S., Ito, K., Ghazaly, M., Feather, C., Abdulla, F., Tunstall, T., Jain, P., Cass, L., Rapeport, G., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201712-2567oc · Cited by 115
Liu, X., Hoft, D. F., & Peng, G. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133679 · Cited by 116
Liu, C., Chen, Z., Chen, K., Liao, F.-T., Chung, C.-E., Liu, X., Lin, Y., Keohavong, P., Leikauf, G. D., & Di, Y. P. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-1994 · Cited by 114
NK‐cell exhaustion, B‐cell exhaustion and T‐cell exhaustion—the differences and similarities
Roe, K. (2022) · Immunology · doi:10.1111/imm.13464 · Cited by 115
Buchan, S. L., Fallatah, M., Thirdborough, S. M., Taraban, V. Y., Rogel, A., Thomas, L. J., Penfold, C. A., He, L.-Z., Curran, M. A., Keler, T., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3057 · Cited by 114
Josefsson, S. E., Beiske, K., Blaker, Y. N., Førsund, M. S., Holte, H., Østenstad, B., Kimby, E. K., Köksal, H., Wälchli, S., Bai, B., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0351 · Cited by 118
Xiang, J., Zhang, N., Sun, H., Su, L., Zhang, C., Xu, H., Feng, J., Wang, M., Chen, J., Liu, L., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.10.025 · Cited by 113
Seliger, B. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122168 · Cited by 111
Pu, J., Xu, Z., Nian, J., Fang, Q., Yang, M., Huang, Y., Li, W., Ge, B., Wang, J., & Wei, H. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00556-3 · Cited by 114
Noncoding RNA s and immune checkpoints—clinical implications as cancer therapeutics
Smolle, M. A., Calin, H. N., Pichler, M., & Călin, G. A. (2017) · FEBS Journal · doi:10.1111/febs.14030 · Cited by 114
Pignon, J., Jegede, O. A., Shukla, S. A., Braun, D. A., Horak, C. E., Wind‐Rotolo, M., Ishii, Y., Catalano, P. J., Grosha, J., Flaifel, A., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3206 · Cited by 117
Saleh, R., Toor, S. M., Khalaf, S., & Elkord, E. (2019) · Vaccines · doi:10.3390/vaccines7040149 · Cited by 116
Bispecific Immunomodulatory Antibodies for Cancer Immunotherapy
Blanco, B., Domínguez-Alonso, C., & Álvarez‐Vallina, L. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3770 · Cited by 117
Meermeier, E. W., Welsh, S. J., Sharik, M. E., Du, M. T., Garbitt, V. M., Riggs, D. L., Shi, C., Stein, C. K., Bergsagel, M., Chau, B. H., et al. (2021) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0038 · Cited by 116
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Pansy, K., Uhl, B., Krstić, J., Szmyra, M., Fechter, K., Santiso, A., Thüminger, L., Greinix, H., Kargl, J., Prochazka, K. T., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413311 · Cited by 113
Ngiow, S. F., Manne, S., Huang, Y., Azar, T., Chen, Z., Mathew, D., Chen, Q., Khan, O., Wu, J. E., Alcalde, V., et al. (2024) · Cell · doi:10.1016/j.cell.2024.07.018 · Cited by 116
Self-citationThe role of biomarkers in personalized immunotherapy
Sankar, K., Ye, J. C., Li, Z., Zheng, L., Song, W., & Hu-Lieskovan, S. (2022) · Biomarker Research · doi:10.1186/s40364-022-00378-0 · Cited by 111
The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok
Ciucci, T., Vacchio, M. S., Gao, Y., Tomassoni‐Ardori, F., Candia, J., Mehta, M., Zhao, Y., Tran, B. Q., Pepper, M., Tessarollo, L., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.019 · Cited by 111
Hellmann, M. D., Bivi, N., Calderón, B., Shimizu, T., Delafontaine, B., Liu, Z. T., Szpurka, A. M., Copeland, V., Hodi, F. S., Rottey, S., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3716 · Cited by 112
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Gao, Z., Feng, Y., Xu, J., & Liang, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.977394 · Cited by 118
Wang, Y., Sun, Q., Zhang, Y., Li, X., Liang, Q., Guo, R., Zhang, L., Han, X., Wang, J., Shao, L., et al. (2023) · Journal of Infection · doi:10.1016/j.jinf.2023.03.020 · Cited by 117
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Lin, C., Lin, C.-M., Lee, K.-Y., Chen, K.-Y., Feng, P., Chen, C., Chuang, H., Chen, C.-L., Wang, Y., Tseng, P., et al. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0317-0 · Cited by 112
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McKinney, E. F., & Smith, K. G. C. (2018) · Nature Immunology · doi:10.1038/s41590-018-0045-y · Cited by 112
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Ratnam, N. M., Gilbert, M. R., & Giles, A. J. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy084 · Cited by 110
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Brummelman, J., Pilipow, K., & Lugli, E. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.007 · Cited by 113
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Odagiu, L., May, J., Boulet, S., Baldwin, T. A., & Labrecque, N. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.624122 · Cited by 110
Ford, B. R., Vignali, P., Rittenhouse, N., Scharping, N. E., Peralta, R. M., Lontos, K., Frisch, A. T., Delgoffe, G. M., & Poholek, A. C. (2022) · Science Immunology · doi:10.1126/sciimmunol.abj9123 · Cited by 112
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia
Khawanky, N. E., Hughes, A., Yu, W., Myburgh, R., Matschulla, T., Taromi, S., Aumann, K., Clarson, J., Vinnakota, J. M., Shoumariyeh, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26683-0 · Cited by 108
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Chandele, A., Sewatanon, J., Gunisetty, S., Singla, M., Onlamoon, N., Akondy, R. S., Kissick, H. T., Nayak, K., Reddy, E. S., Kalam, H., et al. (2016) · Journal of Virology · doi:10.1128/jvi.01424-16 · Cited by 104
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Hude, I., Sasse, S., Engert, A., & Bröckelmann, P. J. (2016) · Haematologica · doi:10.3324/haematol.2016.150656 · Cited by 109
Immunosenescence is both functional/adaptive and dysfunctional/maladaptive
Fülöp, T., Larbi, A., Hirokawa, K., Cohen, A. A., & Witkowski, J. M. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00818-9 · Cited by 106
Nutrient-driven histone code determines exhausted CD8 + T cell fates
Ma, S., Dahabieh, M. S., Mann, T. H., Zhao, S., McDonald, B., Song, W., Chung, H., Farsakoglu, Y., Garcia-Rivera, L., Hoffmann, F. A., et al. (2024) · Science · doi:10.1126/science.adj3020 · Cited by 118
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FCRL5+ Memory B Cells Exhibit Robust Recall Responses
Kim, C. C., Baccarella, A., Bayat, A., Pepper, M., & Fontana, M. F. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.019 · Cited by 102
Liu, X., Li, M., Wang, X., Dang, Z., Jiang, Y., Wang, X., Kong, Y., & Yang, Z. (2019) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-019-02426-5 · Cited by 106
Zhou, X., Ni, Y., Liang, X., Lin, Y., An, B., He, X., & Zhao, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.915094 · Cited by 111
Metadata
- Authors
- Wherry, E. J., & Kurachi, M.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Wherry, E. John
- Kurachi, Makoto
- Venue
- Nature Reviews Immunology
- Published
- 2015-07-24
- Volume
- 15
- Issue
- 8
- Pages
- 486-499
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4889009
- OpenAlex
- W1910012553
- Cited by
- 4,652
- References
- 156
- Citations by year
- 2026: 563 · 2025: 494 · 2024: 518 · 2023: 508 · 2022: 517 · 2021: 551 · 2020: 441 · 2019: 381 · 2018: 306 · 2017: 227 · 2016: 129 · 2015: 12
- FWCI
- 21.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (HHSN266200500030C)
- National Institute of Allergy and Infectious Diseases (HHSN266200500030C, AI 082630, R01AI105343, AI095608, AI105343, AI112521, P01AI112521, U01AI095608, U19AI082630)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Keywords
- T cell exhaustion, chronic viral infection, cancer immunotherapy, inhibitory receptors, persistent antigen, inflammatory signals, transcriptional programs, therapeutic target
- MeSH terms
- Bacterial Infections, Gene Expression Regulation, Humans, Immunologic Memory, Lymphocyte Activation, Neoplasms, T-Lymphocytes, Cytotoxic, Transcription, Genetic, Virus Diseases, Signal Transduction, Cytokines, Clonal Anergy, CD57 Antigens, T-Lymphocytes, Regulatory
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