The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain

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Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II

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Born to run: control of transcription elongation by RNA polymerase II

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Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG

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Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly

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Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

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METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

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Nucleated transcriptional condensates amplify gene expression

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Structure and mechanism of the RNA polymerase II transcription machineryPreprint

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Hidden codes in mRNA: Control of gene expression by m6A

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Liquid–liquid phase separation in tumor biology

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Causes and consequences of RNA polymerase II stalling during transcript elongation

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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

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Alternative Splicing and Protein Diversity: Plants Versus Animals

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RNA polymerase II speed: a key player in controlling and adapting transcriptome composition

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The Mediator Complex: At the Nexus of RNA Polymerase II Transcription

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Ion homeostasis for salinity tolerance in plants: a molecular approach

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The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II

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Targeting transcription cycles in cancer

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Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications

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RNA-modifying proteins as anticancer drug targets

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CDK9: A Comprehensive Review of Its Biology, and Its Role as a Potential Target for Anti-Cancer Agents

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Phase separation of RNA-binding protein promotes polymerase binding and transcription

Shao, W., Bi, X., Pan, Y., Gao, B., Wu, J., Yin, Y., Liu, Z., Peng, M., Zhang, W., Jiang, X., et al. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00904-5 · Cited by 150

RNA polymerase II activity revealed by GRO-seq and pNET-seq in Arabidopsis

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Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space

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Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and Long Noncoding RNAs

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Genome-wide analyses of chromatin interactions after the loss of Pol I, Pol II, and Pol III

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The essential and multifunctional TFIIH complex

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Stress-induced nuclear condensation of NELF drives transcriptional downregulation

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CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes

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PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency

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RNA and liquid-liquid phase separation

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Transcription rate strongly affects splicing fidelity and cotranscriptionality in budding yeast

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Tracking chromatin state changes using nanoscale photo-proximity labelling

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R-Loops Enhance Polycomb Repression at a Subset of Developmental Regulator Genes

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Therapeutic targeting of transcriptional cyclin-dependent kinases

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Anticancer mechanism of coumarin-based derivatives

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Non-canonical DNA/RNA structures during Transcription-Coupled Double-Strand Break Repair: Roadblocks or Bona fide repair intermediates?

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Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks

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Genomic regulation of transcription and RNA processing by the multitasking Integrator complex

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BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genomePreprint

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Transcription Factor DynamicsPreprint

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Cryo-ET reveals the macromolecular reorganization of S. pombe mitotic chromosomes in vivo

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ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation

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The logic of protein post‐translational modifications (PTMs): Chemistry, mechanisms and evolution of protein regulation through covalent attachments

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CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stabilityPreprint

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Live-cell single particle imaging reveals the role of RNA polymerase II in histone H2A.Z eviction

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Nascent RNA and the Coordination of Splicing with TranscriptionPreprint

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Chromatin dependencies in cancer and inflammation

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RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control

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Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting

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Discovery of 3-Benzyl-1-( trans -4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors

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The cryoelectron microscopy structure of the human CDK-activating kinase

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Mechanisms of Transcription Elongation Factor DSIF (Spt4–Spt5)

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Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis

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Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes

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Depicting HIV-1 Transcriptional Mechanisms: A Summary of What We Know

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WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin

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G 1 cyclin–Cdk promotes cell cycle entry through localized phosphorylation of RNA polymerase II

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Widespread and precise reprogramming of yeast protein–genome interactions in response to heat shockPreprint

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Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy?

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Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription

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Influenza virus infection causes global RNAPII termination defects

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Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer

Beato, M., & Sharma, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041351 · Cited by 61

Live imaging of transcription sites using an elongating RNA polymerase II–specific probe

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The Integrator complex at the crossroad of coding and noncoding RNA

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The Promise and Current Status of CDK12/13 Inhibition for the Treatment of Cancer

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Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 Is a Direct Regulator of Basal Transcription Machineries

Enserink, J. M., & Chymkowitch, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031293 · Cited by 60

RNA Pol II Length and Disorder Enable Cooperative Scaling of Transcriptional Bursting

Quintero-Cadena, P., Lenstra, T. L., & Sternberg, P. W. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.030 · Cited by 57

The C-Terminal Domain of RNA Polymerase II Is a Multivalent Targeting Sequence that Supports Drosophila Development with Only Consensus Heptads

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Distinct patterns of histone acetyltransferase and Mediator deployment at yeast protein-coding genesPreprint

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Protein kinase CK2 – diverse roles in cancer cell biology and therapeutic promise

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Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene

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The Integrator Complex in Transcription and Development

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Angel or Devil ? - CDK8 as the new drug target

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BRD4: a general regulator of transcription elongation

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PHF3 Regulates Neuronal Gene Expression Through the New Pol II CTD Reader Domain SPOC

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Enhancer-Promoter Interaction of SELF PRUNING 5G Shapes Photoperiod Adaptation

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CDK11 is required for transcription of replication-dependent histone genes

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Coordinated Control of rRNA Processing by RNA Polymerase I

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Dual inhibition of CDK12 and CDK13 uncovers actionable vulnerabilities in patient-derived ovarian cancer organoids

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