Cited by 2,130Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationNeuroscience and Neuropharmacology Research

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The cell biology of neurogenesis

Götz, Magdalena, Huttner, Wieland B.·2005·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm1739

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Abstract

During the development of the mammalian central nervous system, neural stem cells and their derivative progenitor cells generate neurons by asymmetric and symmetric divisions. The proliferation versus differentiation of these cells and the type of division are closely linked to their epithelial characteristics, notably, their apical-basal polarity and cell-cycle length. Here, we discuss how these features change during development from neuroepithelial to radial glial cells, and how this transition affects cell fate and neurogenesis.

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Authors: Götz, M., & Huttner, W. B.
Affiliations: Helmholtz Munich (DE)
ORCID: Götz, Magdalena
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2005-10
Volume: 6
Issue: 10
Pages: 777-788
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm1739
OpenAlex: W1988976106
Cited by: 2,130
References: 145
Citations by year: 2026: 60 · 2025: 84 · 2024: 87 · 2023: 87 · 2022: 80 · 2021: 113 · 2020: 104 · 2019: 107 · 2018: 117 · 2017: 108 · 2016: 123 · 2015: 113 · 2014: 131 · 2013: 137 · 2012: 138
FWCI: 6.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Site cant be reached (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neurogenesis, neural stem cells, progenitor cells, asymmetric cell division, symmetric cell division, apical-basal polarity, cell cycle duration, neuroepithelial cells, radial glia, cell fate, central nervous system development, neuronal differentiation
MeSH terms: Animals, Cell Cycle, Cell Differentiation, Central Nervous System, Humans, Mammals, Neuroglia, Neurons, Stem Cells, Cell Polarity

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