Cited by 2,130Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationNeuroscience and Neuropharmacology Research

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The cell biology of neurogenesis

Götz, Magdalena, Huttner, Wieland B.·2005·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm1739

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Abstract

During the development of the mammalian central nervous system, neural stem cells and their derivative progenitor cells generate neurons by asymmetric and symmetric divisions. The proliferation versus differentiation of these cells and the type of division are closely linked to their epithelial characteristics, notably, their apical-basal polarity and cell-cycle length. Here, we discuss how these features change during development from neuroepithelial to radial glial cells, and how this transition affects cell fate and neurogenesis.

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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799
Mechanisms of intracellular protein transport
Rothman, J. E. (1994) · Nature · doi:10.1038/372055a0 · Cited by 2,267
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
Neurons derived from radial glial cells establish radial units in neocortex
Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R. (2001) · Nature · doi:10.1038/35055553 · Cited by 2,016
Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
Johansson, C. B., Momma, S., Clarke, D. L., Risling, M., Lendahl, U., & Frisén, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80956-3 · Cited by 1,875
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
Chenn, A., & Walsh, C. A. (2002) · Science · doi:10.1126/science.1074192 · Cited by 1,431
A common progenitor for neurons and glia persists in rat retina late in development
Turner, D. L., & Cepko, C. L. (1987) · Nature · doi:10.1038/328131a0 · Cited by 1,430
Clonal and Population Analyses Demonstrate That an EGF-Responsive Mammalian Embryonic CNS Precursor Is a Stem Cell
Reynolds, B. A., & Weiss, S. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0090 · Cited by 1,368

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Pathipati, P., Gorba, T., Scheepens, A., Goffin, V., Sun, Y., & Fraser, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.029 · Cited by 93
SAG/RBX2/ROC2 E3 Ubiquitin Ligase Is Essential for Vascular and Neural Development by Targeting NF1 for Degradation
Tan, M., Zhao, Y., Kim, S.-J., Liu, M., Jia, L., Saunders, T. L., Zhu, Y., & Sun, Y. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.014 · Cited by 94
Control of Activating Transcription Factor 4 (ATF4) Persistence by Multisite Phosphorylation Impacts Cell Cycle Progression and Neurogenesis*
Frank, C. L., Ge, X., Xie, Z., Zhou, Y., & Tsai, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.140699 · Cited by 93
Stem cells of ependymoma
Poppleton, H., & Gilbertson, R. J. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603519 · Cited by 95
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Yao, B., & Jin, P. (2014) · Genes & Development · doi:10.1101/gad.241547.114 · Cited by 97
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Authors: Götz, M., & Huttner, W. B.
Affiliations: Helmholtz Munich (DE)
ORCID: Götz, Magdalena
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2005-10
Volume: 6
Issue: 10
Pages: 777-788
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm1739
OpenAlex: W1988976106
Cited by: 2,130
References: 145
Citations by year: 2026: 60 · 2025: 84 · 2024: 87 · 2023: 87 · 2022: 80 · 2021: 113 · 2020: 104 · 2019: 107 · 2018: 117 · 2017: 108 · 2016: 123 · 2015: 113 · 2014: 131 · 2013: 137 · 2012: 138
FWCI: 6.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Site cant be reached (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neurogenesis, neural stem cells, progenitor cells, asymmetric cell division, symmetric cell division, apical-basal polarity, cell cycle duration, neuroepithelial cells, radial glia, cell fate, central nervous system development, neuronal differentiation
MeSH terms: Animals, Cell Cycle, Cell Differentiation, Central Nervous System, Humans, Mammals, Neuroglia, Neurons, Stem Cells, Cell Polarity

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