Cited by 2,130Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationNeuroscience and Neuropharmacology Research

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The cell biology of neurogenesis

Götz, Magdalena, Huttner, Wieland B.·2005·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm1739

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Abstract

During the development of the mammalian central nervous system, neural stem cells and their derivative progenitor cells generate neurons by asymmetric and symmetric divisions. The proliferation versus differentiation of these cells and the type of division are closely linked to their epithelial characteristics, notably, their apical-basal polarity and cell-cycle length. Here, we discuss how these features change during development from neuroepithelial to radial glial cells, and how this transition affects cell fate and neurogenesis.

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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799
Mechanisms of intracellular protein transport
Rothman, J. E. (1994) · Nature · doi:10.1038/372055a0 · Cited by 2,267
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
Neurons derived from radial glial cells establish radial units in neocortex
Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R. (2001) · Nature · doi:10.1038/35055553 · Cited by 2,016
Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
Johansson, C. B., Momma, S., Clarke, D. L., Risling, M., Lendahl, U., & Frisén, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80956-3 · Cited by 1,875
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
Chenn, A., & Walsh, C. A. (2002) · Science · doi:10.1126/science.1074192 · Cited by 1,431
A common progenitor for neurons and glia persists in rat retina late in development
Turner, D. L., & Cepko, C. L. (1987) · Nature · doi:10.1038/328131a0 · Cited by 1,430
Clonal and Population Analyses Demonstrate That an EGF-Responsive Mammalian Embryonic CNS Precursor Is a Stem Cell
Reynolds, B. A., & Weiss, S. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0090 · Cited by 1,368
Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
Sanai, N., Tramontin, A. D., Quiñones‐Hinojosa, A., Barbaro, N. M., Gupta, N. M., Kunwar, S., Lawton, M. T., McDermott, M. W., Parsa, A. T., García‐Verdugo, J. M., et al. (2004) · Nature · doi:10.1038/nature02301 · Cited by 1,350
Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
Englund, C., Fink, A., Lau, C., Pham, D., Daza, R. A. M., Bulfone, A., Kowalczyk, T., & Hevner, R. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2899-04.2005 · Cited by 1,261
Membrane fusion and exocytosis.
Jahn, R., & Südhof, T. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.863 · Cited by 1,253
Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
Malatesta, P., Hartfuss, E., & Götz, M. (2000) · Development · doi:10.1242/dev.127.24.5253 · Cited by 1,157
Self-citation
EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells
Doetsch, F. K., Petreanu, L., Caillé, I., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2002) · Neuron · doi:10.1016/s0896-6273(02)01133-9 · Cited by 1,048
A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution
Rakic, P. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93934-p · Cited by 1,047
GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain
Garcia, A. D. R., Doan, N., Imura, T., Bush, T. G., & Sofroniew, M. V. (2004) · Nature Neuroscience · doi:10.1038/nn1340 · Cited by 1,019
A unified hypothesis on the lineage of neural stem cells
Álvarez-Buylla, A., García‐Verdugo, J. M., & Tramontin, A. D. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067582 · Cited by 1,018
Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: A major site of neurogenesis
Haubensak, W. E., Attardo, A., Denk, W. T., & Huttner, W. Β. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308600100 · Cited by 1,004
Self-citation
Asymmetric Inheritance of Radial Glial Fibers by Cortical Neurons
Miyata, T., Kawaguchi, A., Okano, H., & Ogawa, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00420-2 · Cited by 892
Timing of CNS Cell Generation
Qian, X., Shen, Q., Goderie, S. K., He, W., Capela, A., Davis, A. A., & Temple, S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00086-6 · Cited by 860
Radial Glia Serve as Neuronal Progenitors in All Regions of the Central Nervous System
Anthony, T. E., Klein, C., Fishell, G., & Heintz, N. (2004) · Neuron · doi:10.1016/s0896-6273(04)00140-0 · Cited by 852
Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells
Miyata, T., Kawaguchi, A., Saito, K., Kawano, M., Muto, T., & Ogawa, M. (2004) · Development · doi:10.1242/dev.01173 · Cited by 791
Glial cells generate neurons: the role of the transcription factor Pax6
Heins, N., Malatesta, P., Cecconi, F., Nakafuku, M., Tucker, K. L., Hack, M. A., Chapouton, P., Barde, Y.-A., & Götz, M. (2002) · Nature Neuroscience · doi:10.1038/nn828 · Cited by 775
Self-citation
Neuronal or Glial Progeny
Malatesta, P., Hack, M. A., Hartfuss, E., Kettenmann, H., Klinkert, W. E. F., Kirchhoff, F., & Götz, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00116-8 · Cited by 771
Self-citation
Cleavage orientation and the asymmetric inheritance of notchl immunoreactivity in mammalian neurogenesis
Chenn, A., & McConnell, S. K. (1995) · Cell · doi:10.1016/0092-8674(95)90035-7 · Cited by 766
Characterization of CNS Precursor Subtypes and Radial Glia
Hartfuss, E., Galli, R., Heins, N., & Götz, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9962 · Cited by 755
Self-citation
Mechanism of action of cytochalasin B on actin
MacLean-Fletcher, S. (1980) · Cell · doi:10.1016/0092-8674(80)90619-4 · Cited by 755
A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
Lin, D., Edwards, A. S., Fawcett, J. P., Mbamalu, G., Scott, J. D., & Pawson, T. (2000) · Nature Cell Biology · doi:10.1038/35019582 · Cited by 743
Mitosis in the neural tube
Sauer, F. C. (1935) · The Journal of Comparative Neurology · doi:10.1002/cne.900620207 · Cited by 713
Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches
Machold, R. P., Hayashi, S., Rutlin, M. L., Muzumdar, M. D., Nery, S. V., Corbin, J. G., Gritli-Linde, A., Dellovade, T., Porter, J. A., Rubin, L. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00561-0 · Cited by 710
Unique Morphological Features of the Proliferative Zones and Postmitotic Compartments of the Neural Epithelium Giving Rise to Striate and Extrastriate Cortex in the Monkey
Smart, I. H. M. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.1.37 · Cited by 687
The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall
Takahashi, T., Nowakowski, R. S., & Caviness, V. S. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06046.1995 · Cited by 673
LeX/ssea-1 Is Expressed by Adult Mouse CNS Stem Cells, Identifying Them as Nonependymal
Capela, A., & Temple, S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00835-8 · Cited by 671
Pax6 Controls Radial Glia Differentiation in the Cerebral Cortex
Götz, M., Stoykova, A., & Gruß, P. (1998) · Neuron · doi:10.1016/s0896-6273(00)80621-2 · Cited by 665
Self-citation
Regeneration of a germinal layer in the adult mammalian brain
Doetsch, F. K., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11619 · Cited by 662
Lineage-independent determination of cell type in the embryonic mouse retina
Turner, D. L., Snyder, E. Y., & Cepko, C. L. (1990) · Neuron · doi:10.1016/0896-6273(90)90136-4 · Cited by 662
Dividing Precursor Cells of the Embryonic Cortical Ventricular Zone Have Morphological and Molecular Characteristics of Radial Glia
Noctor, S. C., Flint, A. C., Weissman, T. A., Wong, W. S., Clinton, B. K., & Kriegstein, A. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03161.2002 · Cited by 647
Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells
Weigmann, A., Corbeil, D., Hellwig, A., & Huttner, W. Β. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12425 · Cited by 601
Self-citation
ASPM is a major determinant of cerebral cortical size
Bond, J., Roberts, E., Mochida, G. H., Hampshire, D. J., Scott, S., Askham, J. M., Springell, K., Mahadevan, M., Crow, Y. J., Markham, A. F., et al. (2002) · Nature Genetics · doi:10.1038/ng995 · Cited by 581
Cell lineage in the cerebral cortex of the mouse studied in vivo and in vitro with a Recombinant Retrovirus
Luskin, M. B. (1988) · Neuron · doi:10.1016/0896-6273(88)90163-8 · Cited by 577
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation
Hatakeyama, J., Bessho, Y., Katoh, K., Ookawara, S., Fujioka, M., Guillemot, F., & Kageyama, R. (2004) · Development · doi:10.1242/dev.01436 · Cited by 575
β1-Class Integrins Regulate the Development of Laminae and Folia in the Cerebral and Cerebellar Cortex
Graus-Porta, D., Blaess, S., Senften, M., Littlewood-Evans, A., Damsky, C. H., Huang, Z., Orban, P. C., Klein, R., Schittny, J. C., & Müller, U. (2001) · Neuron · doi:10.1016/s0896-6273(01)00374-9 · Cited by 569
Expression of Cux‐1 and Cux‐2 in the subventricular zone and upper layers II–IV of the cerebral cortex
Nieto, M., Monuki, E. S., Tang, H., Imitola, J., Haubst, N., Khoury, S. J., Cunningham, J., Götz, M., & Walsh, C. A. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20322 · Cited by 569
Self-citation
Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane
Röper, K., Corbeil, D., & Huttner, W. Β. (2000) · Nature Cell Biology · doi:10.1038/35023524 · Cited by 555
Self-citation
Adult Rodent Neurogenic Regions: The Ventricular Subependyma Contains Neural Stem Cells, But the Dentate Gyrus Contains Restricted Progenitors
Seaberg, R. M., & van der Kooy, D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01784.2002 · Cited by 523
β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
Zechner, D., Fujita, Y., Hülsken, J., Müller, T. H., Walther, I., Taketo, M. M., Crenshaw, E. B., Birchmeier, W., & Birchmeier, C. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00123-4 · Cited by 484
Regulation of Notch Signaling Activity
Schweisguth, F. (2004) · Current Biology · doi:10.1016/j.cub.2004.01.023 · Cited by 467
Lipoprotein receptors in the nervous system
Herz, J., & Bock, H. H. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135342 · Cited by 457
A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function
Faulkner, N. E., Dujardin, D., Tai, C., Vaughan, K. T., O’Connell, C. B., Wang, Y., & Vallee, R. B. (2000) · Nature Cell Biology · doi:10.1038/35041020 · Cited by 438
Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells
Kosodo, Y., Röper, K., Haubensak, W. E., Marzesco, A., Corbeil, D., & Huttner, W. Β. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600223 · Cited by 435
Self-citation
Cell lineage in the rat cerebral cortex: a study using retroviral-mediated gene transfer
Price, J., & Thurlow, L. (1988) · Development · doi:10.1242/dev.104.3.473 · Cited by 424
Intercellular junctions and cellular polarity: the PAR–aPKC complex, a conserved core cassette playing fundamental roles in cell polarity
Ohno, S. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00264-7 · Cited by 418
Constructing the cerebral cortex: Neurogenesis and fate determination
McConnell, S. K. (1995) · Neuron · doi:10.1016/0896-6273(95)90168-x · Cited by 416
Selective Lengthening of the Cell Cycle in the Neurogenic Subpopulation of Neural Progenitor Cells during Mouse Brain Development
Calegari, F., Haubensak, W., Haffner, C., & Huttner, W. B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0778-05.2005 · Cited by 396
Self-citation
Radial glia: multi-purpose cells for vertebrate brain development
Campbell, K., & Götz, M. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02156-2 · Cited by 389
Self-citation
Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex
Sheen, V. L., Ganesh, V. S., Topçu, M., Sébire, G., Bodell, A., Hill, R. S., Grant, P. E., Shugart, Y. Y., Imitola, J., Khoury, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1276 · Cited by 389
Membrane traffic in polarized epithelial cells
Mostov, K. E., Vergés, M., & Altschuler, Y. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00120-4 · Cited by 381
Radial glia diversity: A matter of cell fate
Kriegstein, A., & Götz, M. (2003) · Glia · doi:10.1002/glia.10250 · Cited by 376
Self-citation
An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis
Calegari, F., & Huttner, W. Β. (2003) · Journal of Cell Science · doi:10.1242/jcs.00825 · Cited by 367
Self-citation
Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts
Shen, Q., Zhong, W., Jan, Y. N., & Temple, S. (2002) · Development · doi:10.1242/dev.129.20.4843 · Cited by 361
Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout micePreprint
Klezovitch, O., Fernandez, T. E., Tapscott, S. J., & Vasioukhin, V. I. (2004) · Genes & Development · doi:10.1101/gad.1178004 · Cited by 344
Animal Cell Cytokinesis
Glotzer, M. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.351 · Cited by 342
Cell cycle parameters and patterns of nuclear movement in the neocortical proliferative zone of the fetal mouse
Takahashi, T., Nowakowski, R. S., & Caviness, V. S. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00820.1993 · Cited by 339
Cortical upper layer neurons derive from the subventricular zone as indicated bySvet1gene expression
Tarabykin, V. S., Stoykova, A., Usman, N. Y., & Gruß, P. (2001) · Development · doi:10.1242/dev.128.11.1983 · Cited by 336
The Leaving or Q Fraction of the Murine Cerebral Proliferative Epithelium: A General Model of Neocortical Neuronogenesis
Takahashi, T., Nowakowski, R. S., & Caviness, V. S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06183.1996 · Cited by 332
Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro.
Gabay, L., Lowell, S., Lee, R.-B. L., & Anderson, D. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00637-8 · Cited by 326
Mechanisms of nuclear positioning
Reinsch, S. S., & Gönczy, P. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.16.2283 · Cited by 321
Prominin: A Story of Cholesterol, Plasma Membrane Protrusions and Human Pathology
Corbeil, D., Röper, K., Fargeas, C. A., Joester, A., & Huttner, W. Β. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.020202.x · Cited by 316
Self-citation
Asymmetric cell division during animal development
Knoblich, J. A. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35048085 · Cited by 311
Evidence of newly generated neurons in the human olfactory bulb
Bédard, A., & Parent, A. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.03.021 · Cited by 308
Reduction of microtubule catastrophe events by LIS1, platelet‐activating factor acetylhydrolase subunit
Sapir, T., Elbaum, M., & Reiner, O. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.6977 · Cited by 304
Loss of Occludin and Functional Tight Junctions, but Not ZO-1, during Neural Tube Closure—Remodeling of the Neuroepithelium Prior to Neurogenesis
Aaku‐Saraste, E., Hellwig, A., & Huttner, W. Β. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0336 · Cited by 295
Self-citation
A Critical Function of the Pial Basement Membrane in Cortical Histogenesis
Halfter, W. M., Dong, S., Yip, Y.-P., Willem, M., & Mayer, U. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06029.2002 · Cited by 295
Regionalization and fate specification in neurospheres: the role of Olig2 and Pax6.
Hack, M., Sugimori, M., Lundberg, C., Nakafuku, M., & Götz, M. (2004) · Molecular and cellular neurosciences · doi:10.1016/j.mcn.2003.12.012 · Cited by 294
Self-citation
Neurogenesis and the Cell Cycle
Ohnuma, S., & Harris, W. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00632-9 · Cited by 270
Increased neuronal production, enlarged forebrains and cytoarchitectural distortions in beta-catenin overexpressing transgenic mice
Chenn, A. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.6.599 · Cited by 253
Pax6is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors
Estivill‐Torrús, G., Pearson, H., van Heyningen, V., Price, D. J., & Rashbass, P. (2002) · Development · doi:10.1242/dev.129.2.455 · Cited by 251
Dynamics of Cux2 Expression Suggests that an Early Pool of SVZ Precursors is Fated to Become Upper Cortical Layer Neurons
Zimmer, C. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh102 · Cited by 250
Intrinsic programs of patterned cell lineages in isolated vertebrate CNS ventricular zone cells
Qian, X., Goderie, S. K., Shen, Q., Stern, J. H., & Temple, S. (1998) · Development · doi:10.1242/dev.125.16.3143 · Cited by 245
A cell-intrinsic timer that operates during oligodendrocyte development
Durand, B., & RAFF, M. C. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200001)22:1 · Cited by 245
In search of a function for the TIS21/PC3/BTG1/TOB family
Matsuda, S., Rouault, J.-P., Magaud, J., & Berthet, C. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02436-x · Cited by 245
Mitotic spindle rotation and mode of cell division in the developing telencephalon
Haydar, T. F., Ang, E. S. B. C., & RAKIC, P. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437969100 · Cited by 242
Systematic widespread clonal organization in cerebral cortex
Reid, C. B., Llang, I., & Walsh, C. (1995) · Neuron · doi:10.1016/0896-6273(95)90035-7 · Cited by 232
Radial glial cells as neuronal precursors: a new perspective on the correlation of morphology and lineage restriction in the developing cerebral cortex of mice
Götz, M., Hartfuss, E., & Malatesta, P. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00777-8 · Cited by 229
Self-citation
Intrinsic polarity of mammalian neuroepithelial cells.
Chenn, A., Zhang, Y. A., Chang, B., & McConnell, S. (1998) · Molecular and cellular neurosciences · doi:10.1006/mcne.1998.0680 · Cited by 228
Neurons from radial glia: the consequences of asymmetric inheritance
Fishell, G., & Kriegstein, A. R. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00013-8 · Cited by 224
Asymmetric cell division
Roegiers, F., & Jan, Y. N. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.02.010 · Cited by 223
Radial and horizontal deployment of clonally related cells in the primate neocortex: Relationship to distinct mitotic lineages
Kornack, D. R., & RAKIC, P. T. (1995) · Neuron · doi:10.1016/0896-6273(95)90036-5 · Cited by 221
Role of β-catenin in the developing cortical and hippocampal neuroepithelium
Machoň, O., van den Bout, C. J., Backman, M., Kemler, R., & Krauss, S. J. K. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00519-0 · Cited by 221
Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells.
Reinsch, S. S., & Karsenti, E. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.6.1509 · Cited by 215
The gene PC3 TIS21/BTG2 , prototype member of the PC3/BTG/TOB family: Regulator in control of cell growth, differentiation, and DNA repair?
Tirone, F. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1062 · Cited by 214
Absence of the tight junctional protein AF-6 disrupts epithelial cell–cell junctions and cell polarity during mouse development
Zhadanov, A. B., Provance, D. W., Speer, C. A., Coffin, J. D., Goss, D., Blixt, J. A., Reichert, C. M., & Mercer, J. A. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80392-3 · Cited by 208
Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division
Iacopetti, P., Michelini, M., Stuckmann, I., Oback, B. J., Aaku‐Saraste, E., & Huttner, W. Β. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4639 · Cited by 207
Self-citation
Asymmetric cell division during neurogenesis in Drosophila and vertebrates
Wodarz, A., & Huttner, W. Β. (2003) · Mechanisms of Development · doi:10.1016/j.mod.2003.06.003 · Cited by 206
Self-citation
Designer skin: lineage commitment in postnatal epidermis
Niemann, C., & Watt, F. M. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02263-8 · Cited by 201
Proliferative characteristics of the ependymal layer during the early development of the mouse neocortex: a pilot study based on recording the number, location and plane of cleavage of mitotic figures.
Smart, I. H. (1973) · PubMed · Cited by 201
Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion
Kouprina, N., Pavlíček, A., Mochida, G. H., Solomon, G. G., Gersch, W., Yoon, Y.-H., Collura, R. V., Ruvolo, M., Barrett, J. C., Woods, C. G., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020126 · Cited by 195
Multiple Dose-Dependent Effects of Lis1 on Cerebral Cortical Development
Gambello, M. J., Darling, D. L., Yingling, J., Tanaka, T., Gleeson, J. G., & Wynshaw-Boris, A. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01719.2003 · Cited by 190
Evidence for multiple precursor cell types in the embryonic rat cerebral cortex
Williams, B. P., & Price, J. (1995) · Neuron · doi:10.1016/0896-6273(95)90265-1 · Cited by 187
Syntaxin 2 and Endobrevin Are Required for the Terminal Step of Cytokinesis in Mammalian Cells
Low, S. H., Li, X., Miura, M., Kudo, N., Quiñones, B., & Weimbs, T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00122-9 · Cited by 184
Protein-Truncating Mutations in ASPM Cause Variable Reduction in Brain Size
Bond, J., Scott, S., Hampshire, D. J., Springell, K., Corry, P. C., Abramowicz, M. J., Mochida, G. H., Hennekam, R. C. M., Maher, E. R., Fryns, J., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/379085 · Cited by 183
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Williams, B. P., Park, J. K., Alberta, J. A., Muhlebach, S. G., Hwang, G. Y., Roberts, T. M., & Stiles, C. D. (1997) · Neuron · doi:10.1016/s0896-6273(00)80297-4 · Cited by 181
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Takekuni, K., Ikeda, W., Fujito, T., Morimoto, K., Takeuchi, M., Monden, M., & Takai, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200707200 · Cited by 178
LRP2/megalin is required for patterning of the ventral telencephalon
Spoelgen, R., Hammes, A., Anzenberger, U., Zechner, D., Andersen, O. M., Jerchow, B., & Willnow, T. E. (2004) · Development · doi:10.1242/dev.01580 · Cited by 177
Microdomains of distinctive glycoprotein composition in the kidney proximal tubule brush border.
Kerjaschki, D., Noronha‐Blob, L., Sacktor, B., & Farquhar, M. G. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.98.4.1505 · Cited by 177
Asymmetric division and polarity of neuroepithelial cells
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Self-citation
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Chae, T. H., Kim, S., Marz, K. E., Hanson, P. I., & Walsh, C. A. (2004) · Nature Genetics · doi:10.1038/ng1302 · Cited by 174
Multiple restricted lineages in the embryonic rat cerebral cortex
Grove, E. A., Williams, B. P., Li, D.-Q., Hajihosseini, M. K., Friedrich, A., & Price, J. (1993) · Development · doi:10.1242/dev.117.2.553 · Cited by 169
Migratory paths of neurons and glia in the embryonic chick spinal cord
Leber, S., & Sanes, J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-02-01236.1995 · Cited by 166
Radial arrangement of clonally related cells in the chicken optic tectum: lineage analysis with a recombinant retrovirus.
Gray, G. E., Glover, J. C., Majors, J. E., & Sanes, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7356 · Cited by 152
The activity of microtubules and microfilaments in neurulation in the chick
Karfunkel, P. (1972) · Journal of Experimental Zoology · doi:10.1002/jez.1401810302 · Cited by 149
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Lukaszewicz, A. I., Savatier, P., Cortay, V., Kennedy, H., & Dehay, C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06610.2002 · Cited by 148
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Burgess, R. W., Deitcher, D. L., & Schwarz, T. L. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.4.861 · Cited by 144
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Jan, Y. N., & Jan, L. Y. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097516 · Cited by 134
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Murciano, A., Zamora, J., LOPEZSANCHEZ, J., & Frade, J. M. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1174 · Cited by 134
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McCarthy, M., Turnbull, D. H., Walsh, C. A., & Fishell, G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06772.2001 · Cited by 133
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Ohnuma, S., Philpott, A., & Harris, W. A. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00175-6 · Cited by 127
Emx2 Promotes Symmetric Cell Divisions and a Multipotential Fate in Precursors from the Cerebral Cortex
Heins, N., Cremisi, F., Malatesta, P., Gangemi, R. M. R., Corte, G., Price, J., Goudreau, G., Gruß, P., & Götz, M. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1046 · Cited by 120
Self-citation
Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II‐B heavy chain
Tullio, A. N., Bridgman, P. C., Tresser, N. J., Chan, C., Conti, M. A., Adelstein, R. S., & Hara, Y. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1125 · Cited by 118
Cell cycle and cell fate interactions in neural development
Cremisi, F., Philpott, A., & Ohnuma, S. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00005-9 · Cited by 118
Association of ASIP/mPAR‐3 with adherens junctions of mouse neuroepithelial cells
Manabe, N., Hirai, S., Imai, F., Nakanishi, H., Takai, Y., & Ohno, S. (2002) · Developmental Dynamics · doi:10.1002/dvdy.10139 · Cited by 116
AC133 Antigen, CD133, Prominin-1, Prominin-2, Etc.: Prominin Family Gene Products in Need of a Rational Nomenclature
Fargeas, C. A., Corbeil, D., & Huttner, W. Β. (2003) · Stem Cells · doi:10.1634/stemcells.21-4-506 · Cited by 113
Self-citation
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Bally‐Cuif, L., & Hammerschmidt, M. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00015-1 · Cited by 102
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Morris, N. R. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00004-2 · Cited by 92
Clonal dispersion and evidence for asymmetric cell division in ferret cortex
Reid, C. B., Tavazoie, S. F., & Walsh, C. A. (1997) · Development · doi:10.1242/dev.124.12.2441 · Cited by 90
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May, P., & Herz, J. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00086_4_5.x · Cited by 60
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Authors: Götz, M., & Huttner, W. B.
Affiliations: Helmholtz Munich (DE)
ORCID: Götz, Magdalena
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2005-10
Volume: 6
Issue: 10
Pages: 777-788
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm1739
OpenAlex: W1988976106
Cited by: 2,130
References: 145
Citations by year: 2026: 60 · 2025: 84 · 2024: 87 · 2023: 87 · 2022: 80 · 2021: 113 · 2020: 104 · 2019: 107 · 2018: 117 · 2017: 108 · 2016: 123 · 2015: 113 · 2014: 131 · 2013: 137 · 2012: 138
FWCI: 6.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Site cant be reached (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neurogenesis, neural stem cells, progenitor cells, asymmetric cell division, symmetric cell division, apical-basal polarity, cell cycle duration, neuroepithelial cells, radial glia, cell fate, central nervous system development, neuronal differentiation
MeSH terms: Animals, Cell Cycle, Cell Differentiation, Central Nervous System, Humans, Mammals, Neuroglia, Neurons, Stem Cells, Cell Polarity

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