Lipid rafts: contentious only from simplistic standpoints

Functional rafts in cell membranes

Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

Brown, D. A., & Rose, J. K. (1992) · Cell · doi:10.1016/0092-8674(92)90189-j · Cited by 2,921

Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells

Zacharias, D. A., Violin, J. D., Newton, A. C., & Tsien, R. Y. (2002) · Science · doi:10.1126/science.1068539 · Cited by 2,235

Model Systems, Lipid Rafts, and Cell Membranes

Simons, K., & Vaz, W. L. C. (2004) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.32.110601.141803 · Cited by 1,670

Lipid Rafts

Munro, S. (2003) · Cell · doi:10.1016/s0092-8674(03)00882-1 · Cited by 1,514

Lipid Rafts Reconstituted in Model Membranes

Dietrich, C., Bagatolli, L. A., Volovyk, Z. N., Thompson, N. L., Levi, M., Jacobson, K., & Gratton, E. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76114-0 · Cited by 1,376

The State of Lipid Rafts: From Model Membranes to Cells

Edidin, M. (2003) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.32.110601.142439 · Cited by 1,341

A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains

Anderson, R. G. W., & Jacobson, K. (2002) · Science · doi:10.1126/science.1068886 · Cited by 1,125

Phospholipids undergo hop diffusion in compartmentalized cell membrane

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Nanoscale Organization of Multiple GPI-Anchored Proteins in Living Cell Membranes

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Sphingomyelin/Phosphatidylcholine/Cholesterol Phase Diagram: Boundaries and Composition of Lipid Rafts

de Almeida, R. F. M., Fedorov, A., & Prieto, M. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74664-5 · Cited by 859

Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors

Foster, L. J., de Hoog, C. L., & Mann, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0631608100 · Cited by 834

Seeing spots: Complex phase behavior in simple membranes

Veatch, S. L., & Keller, S. L. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.06.010 · Cited by 765

Single-Molecule Microscopy Reveals Plasma Membrane Microdomains Created by Protein-Protein Networks that Exclude or Trap Signaling Molecules in T Cells

Douglass, A. D., & Vale, R. D. (2005) · Cell · doi:10.1016/j.cell.2005.04.009 · Cited by 743

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

Prior, I. A., Muncke, C., Parton, R. G., & Hancock, J. F. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200209091 · Cited by 735

Insolubility of lipids in Triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts)

London, E., & Brown, D. A. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0304-4157(00)00007-1 · Cited by 688

Membrane-Protein Interactions in Cell Signaling and Membrane Trafficking

Cho, W., & Stahelin, R. V. (2005) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.33.110502.133337 · Cited by 619

A Microscopic Interaction Model of Maximum Solubility of Cholesterol in Lipid Bilayers

Huang, J., & Feigenson, G. W. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77369-8 · Cited by 594

Acute cholesterol depletion inhibits clathrin-coated pit budding

Subtil, A., Gaidarov, I., Kobylarz, K., Lampson, M. A., Keen, J. H., & McGraw, T. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6775 · Cited by 578

Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy

Schütz, G. J., Kada, G., Pastushenko, V. P., & Schindler, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.892 · Cited by 577

Triton Promotes Domain Formation in Lipid Raft Mixtures

Heerklotz, H. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75278-8 · Cited by 558

Structure of Detergent-Resistant Membrane Domains: Does Phase Separation Occur in Biological Membranes?

Brown, D. A., & London, E. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7575 · Cited by 517

Lipid Rafts Are Enriched in Arachidonic Acid and Plasmenylethanolamine and Their Composition Is Independent of Caveolin-1 Expression: A Quantitative Electrospray Ionization/Mass Spectrometric Analysis

Pike, L. J., Han, X., Chung, K.-N., & Gross, R. W. (2002) · Biochemistry · doi:10.1021/bi0156557 · Cited by 512

Role of curvature and phase transition in lipid sorting and fission of membrane tubules

Roux, A., Cuvelier, D., Nassoy, P., Prost, J., Bassereau, P., & Goud, B. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600631 · Cited by 491

Detergent-resistant membranes should not be identified with membrane rafts

Lichtenberg, D., Goñi, F. M., & Heerklotz, H. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.06.004 · Cited by 490

Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin

Kwik, J., Boyle, S., Fooksman, D., Margolis, L., Sheetz, M. P., & Edidin, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336102100 · Cited by 485

H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

Plowman, S. J., Muncke, C., Parton, R. G., & Hancock, J. F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504114102 · Cited by 468

Liquid Domains in Vesicles Investigated by NMR and Fluorescence Microscopy

Veatch, S. L., Polozov, I. V., Gawrisch, K., & Keller, S. L. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74342-8 · Cited by 459

Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol

Mitra, K., Ubarretxena-Belandia, I., Taguchi, T., Warren, G., & Engelman, D. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307332101 · Cited by 456

Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles

Kirkham, M., Fujita, A., Chadda, R., Nixon, S. J., Kurzchalia, T. V., Sharma, D. K., Pagano, R. E., Hancock, J. F., Mayor, S., & Parton, R. G. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407078 · Cited by 439

Ultrafine Membrane Compartments for Molecular Diffusion as Revealed by Single Molecule Techniques

Murase, K., Fujiwara, T., Umemura, Y., Suzuki, K., Iino, R., Yamashita, H., Saito, M., Murakoshi, H., Ritchie, K., & Kusumi, A. (2004) · Biophysical Journal · doi:10.1529/biophysj.103.035717 · Cited by 431

High-Resolution FRET Microscopy of Cholera Toxin B-Subunit and GPI-anchored Proteins in Cell Plasma Membranes

Kenworthy, A. K., Petranova, N., & Edidin, M. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.5.1645 · Cited by 428

Ternary Phase Diagram of Dipalmitoyl-PC/Dilauroyl-PC/Cholesterol: Nanoscopic Domain Formation Driven by Cholesterol

Feigenson, G. W., & Buboltz, J. T. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76245-5 · Cited by 428

Lipids do influence protein function—the hydrophobic matching hypothesis revisited

Jensen, M. Ø., & Mouritsen, O. G. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.06.009 · Cited by 411

Condensed complexes of cholesterol and phospholipids

McConnell, H. M., & Radhakrishnan, A. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00015-4 · Cited by 384

Rafts: Scale‐Dependent, Active Lipid Organization at the Cell Surface

Mayor, S., & Rao, M. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00172.x · Cited by 379

Molecular Dynamics and Interactions for Creation of Stimulation‐Induced Stabilized Rafts from Small Unstable Steady‐State Rafts

Kusumi, A., Koyama‐Honda, I., & Suzuki, K. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.0178.x · Cited by 371

Single-molecule imaging analysis of Ras activation in living cells

Murakoshi, H., Iino, R., Kobayashi, T., Fujiwara, T., Ohshima, C., Yoshimura, A., & Kusumi, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401354101 · Cited by 369

Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers

Dietrich, C., Volovyk, Z. N., Levi, M., Thompson, N. L., & Jacobson, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191168698 · Cited by 329

The Size of Lipid Rafts: An Atomic Force Microscopy Study of Ganglioside GM1 Domains in Sphingomyelin/DOPC/Cholesterol Membranes

Yuan, C., Furlong, J., Burgos, P., & Johnston, L. J. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75596-3 · Cited by 313

Lipid Rafts have Different Sizes Depending on Membrane Composition: A Time-resolved Fluorescence Resonance Energy Transfer Study

de Almeida, R. F. M., Loura, L. M. S., Fedorov, A., & Prieto, M. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.12.026 · Cited by 298

Liquid-Liquid Immiscibility in Membranes

McConnell, H. M., & Vrljic, M. (2003) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.32.110601.141704 · Cited by 262

Condensation of the plasma membrane at the site of T lymphocyte activation

Gaus, K., Chklovskaia, E., Fazekas de St. Groth, B., Jessup, W., & Harder, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505047 · Cited by 251

Characterization of Rapid Membrane Internalization and Recycling

Hao, M., & Maxfield, F. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15279 · Cited by 236

Ras plasma membrane signalling platforms

Hancock, J. F., & Parton, R. G. (2005) · Biochemical Journal · doi:10.1042/bj20050231 · Cited by 233

Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells

Niv, H., Gutman, O., Kloog, Y., & Henis, Y. I. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202009 · Cited by 216

Individual Palmitoyl Residues Serve Distinct Roles in H-Ras Trafficking, Microlocalization, and Signaling

Roy, S., Plowman, S. J., Rotblat, B., Prior, I. A., Muncke, C., Grainger, S., Parton, R. G., Henis, Y. I., Kloog, Y., & Hancock, J. F. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6722-6733.2005 · Cited by 216

Identifying Optimal Lipid Raft Characteristics Required To Promote Nanoscale Protein-Protein Interactions on the Plasma Membrane

Nicolau, D. V., Burrage, K., Parton, R. G., & Hancock, J. F. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.313-323.2006 · Cited by 188

Sphingomyelin-Cholesterol Domains in Phospholipid Membranes: Atomistic Simulation

Pandit, S. A., Vasudevan, S., Chiu, S. W., Jay Mashl, R., Jakobsson, E., & Scott, H. L. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.041939 · Cited by 171

Raft Partitioning and Dynamic Behavior of Human Placental Alkaline Phosphatase in Giant Unilamellar Vesicles

Kahya, N., Brown, D. A., & Schwille, P. (2005) · Biochemistry · doi:10.1021/bi047429d · Cited by 170

Simulation of the Early Stages of Nano-Domain Formation in Mixed Bilayers of Sphingomyelin, Cholesterol, and Dioleylphosphatidylcholine

Pandit, S. A., Jakobsson, E., & Scott, H. L. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.046078 · Cited by 166

The Sensitivity of Lipid Domains to Small Perturbations Demonstrated by the Effect of Triton

Heerklotz, H., Szadkowska, H., Anderson, T., & Seelig, J. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00504-7 · Cited by 162

Three Separable Domains Regulate GTP-Dependent Association of H-ras with the Plasma Membrane

Rotblat, B., Prior, I. A., Muncke, C., Parton, R. G., Kloog, Y., Henis, Y. I., & Hancock, J. F. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6799-6810.2004 · Cited by 150

Fluorescence Energy Transfer Reveals Microdomain Formation at Physiological Temperatures in Lipid Mixtures Modeling the Outer Leaflet of the Plasma Membrane

Silvius, J. R. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74542-1 · Cited by 147

The Effect of Ergosterol on Dipalmitoylphosphatidylcholine Bilayers: A Deuterium NMR and Calorimetric Study

Hsueh, Y.-W., Gilbert, K. M., Trandum, C., Zuckermann, M. J., & Thewalt, J. L. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.051375 · Cited by 141

Nonequilibrium Raftlike Membrane Domains under Continuous Recycling

Turner, M. S., Sens, P., & Socci, N. D. (2005) · Physical Review Letters · doi:10.1103/physrevlett.95.168301 · Cited by 133

Ras Diffusion Is Sensitive to Plasma Membrane Viscosity

Goodwin, J. S., Drake, K. R., Remmert, C. L., & Kenworthy, A. K. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.055640 · Cited by 132

Use of Forster's resonance energy transfer microscopy to study lipid rafts

Rao, M., & Mayor, S. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.08.002 · Cited by 130

Visualizing Association of N-Ras in Lipid Microdomains: Influence of Domain Structure and Interfacial Adsorption

Nicolini, C., Baranski, J., Schlummer, S., Palomo, J. M., Lumbierres-Burgues, M., Kahms, M., Kuhlmann, J., Sánchez, S. A., Gratton, E., Waldmann, H., et al. (2005) · Journal of the American Chemical Society · doi:10.1021/ja055779x · Cited by 123

Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells

Larson, D. R., Gosse, J. A., Holowka, D. A., Baird, B. A., & Webb, W. W. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200503110 · Cited by 116

Effects of Cholesterol Depletion and Increased Lipid Unsaturation on the Properties of Endocytic Membranes

Hao, M., Mukherjee, S., Sun, Y., & Maxfield, F. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309793200 · Cited by 110

Pulse EPR Detection of Lipid Exchange between Protein-Rich Raft and Bulk Domains in the Membrane: Methodology Development and Its Application to Studies of Influenza Viral Membrane

Kawasaki, K., Yin, J., Subczynski, W. K., Hyde, J. S., & Kusumi, A. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76053-5 · Cited by 101

Where sterols are required for endocytosis

Pichler, H., & Riezman, H. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.05.011 · Cited by 99

Membrane Insertion of a Lipidated Ras Peptide Studied by FTIR, Solid-State NMR, and Neutron Diffraction Spectroscopy

Huster, D., Vogel, A., Katzka, C., Scheidt, H. A., Binder, H., Dante, S., Gutberlet, T., Zschörnig, O., Waldmann, H., & Arnold, K. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0289245 · Cited by 77

Membrane Localization and Flexibility of a Lipidated Ras Peptide Studied by Molecular Dynamics Simulations

Gorfe, A. A., Pellarin, R., & Caflisch, A. (2004) · Journal of the American Chemical Society · doi:10.1021/ja046607n · Cited by 75

Effects of farnesol on the physical properties of DMPC membranes

Rowat, A. C., Keller, D., & Ipsen, J. H. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.04.014 · Cited by 37

Structural Analysis of Sterol Distributions in the Plasma Membrane of Living Cells

Zhang, W., McIntosh, A. L., Xu, H., Wu, D., Gruninger, T. R., Atshaves, B. P., Liu, J. C. S., & Schroeder, F. (2005) · Biochemistry · doi:10.1021/bi048172m · Cited by 29

Membrane lipids: where they are and how they behave

van Meer, G., Voelker, D. R., & Feigenson, G. W. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2330 · Cited by 7,157

Lipid rafts as a membrane-organizing principle

Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417

Mechanisms of endocytosis

Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075

The multiple faces of caveolae

Parton, R. G., & Simons, K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2122 · Cited by 1,454

Order of lipid phases in model and plasma membranes

Kaiser, H.-J., Lingwood, D., Levental, I., Sampaio, J. L., Kalvodova, L., Rajendran, L., & Simons, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908987106 · Cited by 482