Cited by 2,607Adipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

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Adipocyte differentiation from the inside out

Rosen, Evan D., MacDougald, Ormond A.·2006·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm2066

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Abstract

Improved knowledge of all aspects of adipose biology will be required to counter the burgeoning epidemic of obesity. Interest in adipogenesis has increased markedly over the past few years with emphasis on the intersection between extracellular signals and the transcriptional cascade that regulates adipocyte differentiation. Many different events contribute to the commitment of a mesenchymal stem cell to the adipocyte lineage including the coordination of a complex network of transcription factors, cofactors and signalling intermediates from numerous pathways.

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Retracted
N-Acetylfarnesylcysteine Is a Novel Class of Peroxisome Proliferator-activated Receptor γ Ligand with Partial and Full Agonist Activity in Vitro and in Vivo
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Authors: Rosen, E. D., & MacDougald, O. A.
Affiliations: Beth Israel Deaconess Medical Center (US)
University of Michigan (US)
Corresponding author: Rosen, Evan D.
ORCID: Rosen, Evan D.
MacDougald, Ormond A.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2006-12-01
Volume: 7
Issue: 12
Pages: 885-896
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2066
OpenAlex: W2059992589
Cited by: 2,607
References: 154
Citations by year: 2026: 60 · 2025: 86 · 2024: 118 · 2023: 129 · 2022: 115 · 2021: 146 · 2020: 145 · 2019: 149 · 2018: 159 · 2017: 156 · 2016: 155 · 2015: 174 · 2014: 190 · 2013: 175 · 2012: 146
FWCI: 9.41
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: adipogenesis, transcription factors, signaling pathways, mesenchymal stem cells, metabolic disorders, obesity, adipose tissue biology
MeSH terms: Animals, Humans, Obesity, Transcription Factors, Transcription, Genetic, Signal Transduction, Adipocytes, Adipogenesis, Mesenchymal Stem Cells

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Adipocyte differentiation from the inside out

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