Cited by 2,607Adipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

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Adipocyte differentiation from the inside out

Rosen, Evan D., MacDougald, Ormond A.·2006·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm2066

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Abstract

Improved knowledge of all aspects of adipose biology will be required to counter the burgeoning epidemic of obesity. Interest in adipogenesis has increased markedly over the past few years with emphasis on the intersection between extracellular signals and the transcriptional cascade that regulates adipocyte differentiation. Many different events contribute to the commitment of a mesenchymal stem cell to the adipocyte lineage including the coordination of a complex network of transcription factors, cofactors and signalling intermediates from numerous pathways.

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Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720
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Prevalence of Overweight and Obesity in the United States
Crespo, C. J., & Smit, E. (2003) · Human Kinetics eBooks · doi:10.5040/9781718206601.ch-001 · Cited by 4,382
Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment
McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K., & Chen, C. S. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00075-9 · Cited by 4,182
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564
Smad transcription factorsPreprint
Massagué, J., Seoane, J., & Wotton, D. (2005) · Genes & Development · doi:10.1101/gad.1350705 · Cited by 2,519
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Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943
Transcriptional regulation of adipogenesisPreprint
Rosen, E. D., Walkey, C. J., Puigserver, P., & Spiegelman, B. M. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 1,908
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Inhibition of Adipogenesis by Wnt Signaling
Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., & MacDougald, O. A. (2000) · Science · doi:10.1126/science.289.5481.950 · Cited by 1,876
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Psychological stress and psoriasis: experimental and prospective correlational studies.
Gaston, L., Crombez, J.-C., Lassonde, M., Bernier-Buzzanga, J., & Hodgins, S. (1991) · PubMed · Cited by 70
Triphenyl phosphate enhances adipogenic differentiation, glucose uptake and lipolysis via endocrine and noradrenergic mechanisms
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Stellavato, A., Noce, M. L., Corsuto, L., Pirozzi, A. V. A., ROSA, M. D., Papaccio, G., Schiraldi, C., & Tirino, V. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485414 · Cited by 70
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Loo, L.-H., Lin, H.-J., Steininger, R. J., Wang, Y., Wu, L. F., & Altschuler, S. J. (2009) · Nature Methods · doi:10.1038/nmeth.1375 · Cited by 69
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Nakatsu, Y., Sakoda, H., Kushiyama, A., Zhang, J., Ono, H., Fujishiro, M., Kikuchi, T., Fukushima, T., Yoneda, M., Ohno, H., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.206904 · Cited by 69
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Du, B., Cawthorn, W. P., Su, A., Doucette, C. R., Yao, Y., Hemati, N., Kampert, S. E., McCoin, C. S., Broome, D. T., Rosen, C. J., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.440370 · Cited by 72
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Gaya, M., Repetto, M. V., Toneatto, J., Anesini, C. A., Piwien‐Pilipuk, G., & Moreno, S. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.03.021 · Cited by 69
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Goldman, S. J., Zhang, Y., & Jin, S. V. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3777 · Cited by 68
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“Wnt Expression Is Induced by Recombinant Irisin Treatment During Adipocyte Differentiation Previous studies have shown that Wnt signaling influences the fate of many cell types and cell differentiation (Logan and Nusse, 2004; Rosen and MacDougald, 2006).”
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Gene expression profiles in Atlantic salmon adipose-derived stromo-vascular fraction during differentiation into adipocytes
Todorčević, M., Škugor, S., Krasnov, A., & Ruyter, B. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-39 · Cited by 67
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Gerin, I., Bommer, G. T., Lidell, M. E., Cederberg, A., Enerbäck, S., & MacDougald, O. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809115200 · Cited by 66
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Younce, C. W., Azfer, A., & Kolattukudy, P. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.025320 · Cited by 64
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Feng, B., Zhang, T., & Xu, H. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12009 · Cited by 66
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“We selected PPARγ as a key regulator of adipogenesis (20), and included GR because glucocorticoids are important regulators of lipid metabolism (21).”
Background
Effects of fermented rooibos (Aspalathus linearis) on adipocyte differentiation
Sanderson, M., Mazibuko, S. E., Joubert, E., de Beer, D., Johnson, R., Pheiffer, C., Louw, J., & Muller, C. J. F. (2013) · Phytomedicine · doi:10.1016/j.phymed.2013.08.011 · Cited by 64
12- and 15-lipoxygenases in adipose tissue inflammation
Cole, B. K., Lieb, D. C., Dobrian, A. D., & Nadler, J. L. (2012) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2012.07.004 · Cited by 66
Allied Industry Approaches to Alter Intramuscular Fat Content and Composition in Beef Animals
Dodson, M. V., Jiang, Z., Chen, J., Hausman, G. J., Guan, L. L., NOVAKOFSKI, J. E., Thompson, D. P., Lorenzen, C. L., Fernyhough, M. E., Mir, P. S., et al. (2009) · Journal of Food Science · doi:10.1111/j.1750-3841.2009.01396.x · Cited by 64
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Cousin, W., Fontaine, C., Dani, C., & Peraldi, P. (2007) · Biochimie · doi:10.1016/j.biochi.2007.08.012 · Cited by 64
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HA, J.-H., Jang, J., Chung, S., & Yoon, Y. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2484 · Cited by 64
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Chen, D., Wang, Y., Wu, K., & Wang, X. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061547 · Cited by 66
“While the pro-adipogenic C/EBPβ gene is induced early and transiently upregulated during adipocyte differentiation, C/EBPα and PPARγ promote terminal differentiation by transactivating downstream adipogenic genes [16,29].”
BackgroundInfluential
Long noncoding RNA Plnc1 controls adipocyte differentiation by regulating peroxisome proliferator‐activated receptor γ
Zhu, E., Zhang, J., Li, Y., Yuan, H., Zhou, J., & Wang, B. (2018) · The FASEB Journal · doi:10.1096/fj.201800739rrr · Cited by 65
m6A methylation modulates adipogenesis through JAK2-STAT3-C/EBPβ signaling.
Wu, R., Guo, G., Bi, Z., Liu, Y.-H., Zhao, Y., Chen, N.-N., Wang, F.-Q., Wang, Y.-Z., & Wang, X.-X. (2019) · Biochimica et Biophysica Acta. Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.06.008 · Cited by 57
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Wang, F., & Tong, Q. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00422.2007 · Cited by 63
MicroRNAs in obesity-associated disorders
Abente, E. J., Subramanian, M., Ramachandran, V., & Najafi-Shoushtari, S. H. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.09.018 · Cited by 63
Lipid‐sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome
Vacca, M., Degirolamo, C., Mariani‐Costantini, R., Palasciano, G., & Moschetta, A. (2011) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.137 · Cited by 66
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Vila‐Bedmar, R., Cruces‐Sande, M., Lucas, E., Willemen, H. L. D. M., Heijnen, C. J., Kavelaars, A., Mayor, F., & Murga, C. (2015) · Science Signaling · doi:10.1126/scisignal.aaa4374 · Cited by 62
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Hormone-sensitive lipase modulates adipose metabolism through PPARγ
Shen, W., Yu, Z., Patel, S., Jue, D., Liu, L.-F., & Kraemer, F. B. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.10.001 · Cited by 65
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Perfluorooctanesulfonate Mediates Renal Tubular Cell Apoptosis through PPARgamma Inactivation
Wen, L.-L., Lin, C., Chou, H., Chang, C., Lo, H.-Y., & Juan, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155190 · Cited by 64
Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action
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“Extracellular signals regulate RAP1 through several regulatory proteins, and it might be involved in various processes, ranging from modulation of growth, differentiation, cell adhesion, and morphogenesis [60].”
Background
Isotretinoin and FoxO1: A scientific hypothesis.
Melnik, B. C. (2011) · Europe PMC (PubMed Central) · doi:10.4161/derm.3.3.15331 · Cited by 62
White adipocytes: More than just fat depots
Henry, S. L., Bensley, J. G., Wood‐Bradley, R. J., Cullen‐McEwen, L. A., Bertram, J. F., & Armitage, J. A. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.12.011 · Cited by 60
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“Several studies confirmed that numerous biological processes control adipogenesis, including transcriptional mechanisms, and epigenetic alterations [55].”
Background
A simplified and defined serum-free medium for cultivating fat across species
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“An empirically derived adipogenic differentiation protocol is more commonly used and activates a signaling cascade and subsequent gene expression toward an adipocyte phenotype.(22) It consists of a combination of three or four adipogenic inducers that are added to the medium typically in three phases: induction, progr…”
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Heme induced oxidative stress attenuates sirtuin1 and enhances adipogenesis in mesenchymal stem cells and mouse pre‐adipocytes
Puri, N., Sodhi, K., Haarstad, M., Kim, D.-H., Bohinc, S., Foglio, E., Favero, G., & Abraham, N. G. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24061 · Cited by 61
Sildenafil promotes adipogenesis through a PKG pathway
Zhang, X., Ji, J., Yan, G., Wu, J., Sun, X., Shen, J., Jiang, H., & Wang, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.064 · Cited by 63
Adipose tissue lipogenic gene networks due to lipid feeding and milk fat depression in lactating cows
Thering, B. J., Graugnard, D. E., Piantoni, P., & Loor, J. J. (2009) · Journal of Dairy Science · doi:10.3168/jds.2008-2000 · Cited by 61
The many facets of PPARγ: novel insights for the skeleton
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TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β
Romero, M., Sabaté-Pérez, A., Francis, V. A., Castrillon‐Rodríguez, I., Díaz‐Ramos, A., Sánchez‐Feutrie, M., Durán, X., Palacín, M., Moreno‐Navarrete, J. M., Gustafson, B., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0072-9 · Cited by 60
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“Adipogenesis is a highly coordinated process regulated by extracellular signals and transcriptional cascades [116].”
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Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated β-catenin stabilization
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Cross Talk between Insulin and Bone Morphogenetic Protein Signaling Systems in Brown Adipogenesis
Zhang, H., Schulz, T. J., Espinoza, D., Huang, T. L., Emanuelli, B., Kristiansen, K., & Tseng, Y. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00363-10 · Cited by 61
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Shuai, L., Zhang, L.-N., Li, B., Tang, C., Wu, L., Li, J., & Li, J. (2019) · Diabetes · doi:10.2337/db18-1103 · Cited by 61
“Adipocyte differentiation is a broadly studied area in adipose biology and is regulated by a complex network of transcription factors, cofactors, and other signaling factors, including peroxisome proliferator–activated receptor g (PPARg) and the C/EBP family members (C/EBPa, C/EBPb, and C/EBPd) (8,9).”
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“Despite this difference in MSC origin, adipogenesis in both white and brown adipocytes involves the activation of the same key transcription factors: peroxisome proliferator-activated receptor g (PPARg) and CCAAT/enhancer-binding proteins (C/EBP) (28, 29).”
Background
KLF13 promotes porcine adipocyte differentiation through PPARγ activation
Jiang, S., Wei, H., Song, T., Yang, Y., Zhang, F., Zhou, Y., Peng, J., & Jiang, S. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0016-z · Cited by 58
3T3‐L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator‐activated receptor‐γ‐dependent and mediated by the caspase‐3‐dependent apoptotic pathway
Xiao, Y., Yuan, T., Yao, W., & Liao, K. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07514.x · Cited by 57
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Graugnard, D. E., Berger, L. L., Faulkner, D. B., & Loor, J. J. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509992789 · Cited by 58
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Skeletal aging and the adipocyte program
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The requirement for SNF5/INI1 in adipocyte differentiation highlights new features of malignant rhabdoid tumors
Caramel, J., Medjkane, S., Quignon, F., & Delattre, O. (2007) · Oncogene · doi:10.1038/sj.onc.1210847 · Cited by 58
Activation of PPARγ induces profound multilocularization of adipocytes in adult mouse white adipose tissues
Koh, Y. J., Park, B., Park, J., Han, J., Lee, I., Park, J., & Koh, G. Y. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.12.094 · Cited by 63

Authors: Rosen, E. D., & MacDougald, O. A.
Affiliations: Beth Israel Deaconess Medical Center (US)
University of Michigan (US)
Corresponding author: Rosen, Evan D.
ORCID: Rosen, Evan D.
MacDougald, Ormond A.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2006-12-01
Volume: 7
Issue: 12
Pages: 885-896
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2066
OpenAlex: W2059992589
Cited by: 2,607
References: 154
Citations by year: 2026: 60 · 2025: 86 · 2024: 118 · 2023: 129 · 2022: 115 · 2021: 146 · 2020: 145 · 2019: 149 · 2018: 159 · 2017: 156 · 2016: 155 · 2015: 174 · 2014: 190 · 2013: 175 · 2012: 146
FWCI: 9.41
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: adipogenesis, transcription factors, signaling pathways, mesenchymal stem cells, metabolic disorders, obesity, adipose tissue biology
MeSH terms: Animals, Humans, Obesity, Transcription Factors, Transcription, Genetic, Signal Transduction, Adipocytes, Adipogenesis, Mesenchymal Stem Cells

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