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Adipocyte differentiation from the inside out
Abstract
Improved knowledge of all aspects of adipose biology will be required to counter the burgeoning epidemic of obesity. Interest in adipogenesis has increased markedly over the past few years with emphasis on the intersection between extracellular signals and the transcriptional cascade that regulates adipocyte differentiation. Many different events contribute to the commitment of a mesenchymal stem cell to the adipocyte lineage including the coordination of a complex network of transcription factors, cofactors and signalling intermediates from numerous pathways.
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“At the molecular level, brown fat differentiation involves mechanisms common to both brown and white adipocyte differentiation, as well as some specific factors 89,165–167.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [165]
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Metadata
- Authors
- Rosen, E. D., & MacDougald, O. A.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- University of Michigan (US)
- Corresponding author
- Rosen, Evan D.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2006-12-01
- Volume
- 7
- Issue
- 12
- Pages
- 885-896
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2059992589
- Cited by
- 2,607
- References
- 154
- Citations by year
- 2026: 60 · 2025: 86 · 2024: 118 · 2023: 129 · 2022: 115 · 2021: 146 · 2020: 145 · 2019: 149 · 2018: 159 · 2017: 156 · 2016: 155 · 2015: 174 · 2014: 190 · 2013: 175 · 2012: 146
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- adipogenesis, transcription factors, signaling pathways, mesenchymal stem cells, metabolic disorders, obesity, adipose tissue biology
- MeSH terms
- Animals, Humans, Obesity, Transcription Factors, Transcription, Genetic, Signal Transduction, Adipocytes, Adipogenesis, Mesenchymal Stem Cells
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