Cited by 356Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceNeurobiology and Insect Physiology Research

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Endocrine regulation of ageing

Russell, Steven J., Kahn, C. Ronald·2007·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm2234

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Abstract

Over the past 15 years it has become clear that mutations in genes that regulate endocrine signalling pathways can prolong lifespan. Lifespan can be increased by altered endocrine signalling in a group of cells or a single tissue, which indicates that crosstalk between tissues functions to coordinate ageing of the organism. These endocrine pathways might serve as targets for the manipulation of the ageing process and prevention of age-related diseases.

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Authors: Russell, S. J., & Kahn, C. R.
Affiliations: Joslin Diabetes Center (US)
ORCID: Russell, Steven J.
Kahn, C. Ronald
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2007-09
Volume: 8
Issue: 9
Pages: 681-691
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2234
OpenAlex: W1991210531
Cited by: 356
References: 131
Citations by year: 2026: 3 · 2025: 11 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 20 · 2019: 14 · 2018: 12 · 2017: 20 · 2016: 12 · 2015: 16 · 2014: 27 · 2013: 26 · 2012: 32
FWCI: 2.99
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: hormone signaling, aging, lifespan extension, age-related diseases, tissue crosstalk, endocrine pathways, genetic mutations
MeSH terms: Klotho Proteins, Aging, Animals, Endocrine System, Glucuronidase, Humans, Insulin, Longevity, Signal Transduction

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