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Reprogramming aging and progeria

Freije, José MP, López-Otín, Carlos·2012·Current Opinion in Cell Biology
DOI 10.1016/j.ceb.2012.08.009
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Abstract

The aging rate of an organism depends on the ratio of tissue degeneration to tissue repair. As a consequence, molecular alterations that tip this balance toward degeneration cause accelerated aging. Conversely, interventions can be pursued to reduce tissue degeneration or to increase tissue repair with the aim of delaying the onset of age-associated manifestations. Recent studies on the biology of stem cells in aging have revealed the influence of systemic factors on their functionality and demonstrated the feasibility of reprogramming aged and progeroid cells. These results illustrate the reversibility of some aspects of the aging process and encourage the search for new anti-aging and anti-progeria interventions.

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Metadata

Authors
Freije, J. M., & López-Otín, C.
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2012-12
Volume
24
Issue
6
Pages
757-764
ISSN
0955-0674
DOI
10.1016/j.ceb.2012.08.009
Cited by
46
References
32
Language
en
Licence
Funders
  • Ministerio de Economía y Competitividad-Spain
  • Fundación Botín
  • Obra Social Cajastur-Asturias and Red de Centros de Cáncer-Instituto Carlos III, Spain

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