Endocrine regulation of ageing

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160

Broken Limits to Life Expectancy

Oeppen, J., & Vaupel, J. W. (2002) · Science · doi:10.1126/science.1069675 · Cited by 2,819

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109

Estrogen plus Progestin and the Risk of Coronary Heart Disease

Manson, J. E., Hsia, J., Johnson, K. C., Rossouw, J. E., Assaf, A. R., Lasser, N. L., Trevisan, M., Black, H. R., Heckbert, S. R., Detrano, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030808 · Cited by 2,065

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

Tatar, M., Kopelman, A. H., Epstein, D., Tu, M., Yin, C. ‐., & Garofalo, R. S. (2001) · Science · doi:10.1126/science.1057987 · Cited by 1,630

Adipose Tissue as an Endocrine Organ

Ahima, R. S., & Flier, J. S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00301-5 · Cited by 1,608

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterström, R. H., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80900-9 · Cited by 1,534

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

Shimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K., & Yamashita, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19081 · Cited by 1,503

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,501

Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction

Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487

Regulation of Fibroblast Growth Factor-23 Signaling by Klotho

Kurosu, H., Ogawa, Y., Miyoshi, M., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Baum, M. G., Schiavi, S. C., Hu, M. C., Moe, O. W., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c500457200 · Cited by 1,381

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Shimada, T., Kakitani, M., Yamazaki, Y., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419081 · Cited by 1,368

The plasticity of aging: insights from long-lived mutants

Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338

Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction

Haigis, M. C., & Guarente, L. P. (2006) · Genes & Development · doi:10.1101/gad.1467506 · Cited by 1,295

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

Blüher, M., Kahn, B. B., & Kahn, C. R. (2003) · Science · doi:10.1126/science.1078223 · Cited by 1,155

Dwarf mice and the ageing process

Brown‐Borg, H. M., Borg, K. E., Meliska, C. J., & Bartke, A. (1996) · Nature · doi:10.1038/384033a0 · Cited by 1,091

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

Lin, K., Hsin, H., Libina, N., & Kenyon, C. J. (2001) · Nature Genetics · doi:10.1038/88850 · Cited by 1,027

Signals from the reproductive system regulate the lifespan of C. elegans

Hsin, H., & Kenyon, C. J. (1999) · Nature · doi:10.1038/20694 · Cited by 1,014

Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals: A Randomized Controlled Trial

Heilbronn, L. K., de Jonge, L., Frisard, M. I., DeLany, J. P., Larson-Meyer, D. E., Rood, J., Nguyen, T., Martin, C. K., Volaufova, J., Most, M. M., et al. (2006) · JAMA · doi:10.1001/jama.295.13.1539 · Cited by 969

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

Henderson, S. T., & Johnson, T. E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00594-2 · Cited by 949

Functional ecdysone receptor is the product of EcR and Ultraspiracle genes

Yao, T., FORMAN, B. M., Jiang, Z., Cherbas, L., Chen, J.-D., McKeown, M., Cherbas, P. T., & Evans, R. M. (1993) · Nature · doi:10.1038/366476a0 · Cited by 947

Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

Hwangbo, D., Gersham, B., Tu, M., Palmer, M., & Tatar, M. (2004) · Nature · doi:10.1038/nature02549 · Cited by 944

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

Morris, J. Z., Tissenbaum, H. A., & Ruvkun, G. (1996) · Nature · doi:10.1038/382536a0 · Cited by 891

Overview of caloric restriction and ageing

Masoro, E. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.012 · Cited by 879

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

Böhni, R., Riesgo‐Escovar, J. R., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B. F., Beckingham, K., & Hafen, E. (1999) · Cell · doi:10.1016/s0092-8674(00)80799-0 · Cited by 840

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826

Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

Libina, N., Berman, J. R., & Kenyon, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00889-4 · Cited by 820

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

Blüher, M., Michael, M. D., Peroni, O. D., Ueki, K., Carter, N., Kahn, B. B., & Kahn, C. R. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00199-5 · Cited by 806

Regulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦

Yamamoto, M., Clark, J. D., Pastor, J. V., Gurnani, P., Nandi, A., Kurosu, H., Miyoshi, M., Ogawa, Y., Castrillón, D. H., Rosenblatt, K. P., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509039200 · Cited by 736

The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation

Nakae, J., Kitamura, T., Kitamura, Y., Biggs, W., Arden, K. C., & Accili, D. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00401-x · Cited by 729

Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

Gems, D., Sutton, A. J., Sundermeyer, M. L., Albert, P. S., King, K. V., Edgley, M. L., Larsen, P. L., & Riddle, D. L. (1998) · Genetics · doi:10.1093/genetics/150.1.129 · Cited by 718

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Bordone, L., Motta, M. C., Picard, F., Robinson, A., Jhala, U. S., Apfeld, J., McDonagh, T., Lemieux, M., McBurney, M., Szilvasi, A., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0040031 · Cited by 715

FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes

Biddinger, S. B., & Kahn, C. R. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.124723 · Cited by 714

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

Wolkow, C. A., Kimura, K. D., Lee, M. S., & Ruvkun, G. (2000) · Science · doi:10.1126/science.290.5489.147 · Cited by 681

DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism

Lee, S. S., Kennedy, S., Tolonen, A. C., & Ruvkun, G. (2003) · Science · doi:10.1126/science.1083614 · Cited by 669

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

Nakae, J., Kitamura, T., Silver, D. L., & Accili, D. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12876 · Cited by 652

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

Nakae, J., Kitamura, T., Silver, D. L., & Accili, D. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112876 · Cited by 652

Regulation of DAF-2 receptor signaling by human insulin and ins-1 , a member of the unusually large and diverse C. elegans insulin gene familyPreprint

Pierce, S. B., Costa, M. A., Wisotzkey, R. G., Devadhar, S., Homburger, S. A., Buchman, A. R., Ferguson, K. C., Heller, J., Platt, D., Pasquinelli, A. E., et al. (2001) · Genes & Development · doi:10.1101/gad.867301 · Cited by 651

Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice

Moynihan, K. A., Grimm, A. A., Plueger, M. M., Bernal‐Mizrachi, E., Ford, E. L., CRAS-MÉNEUR, C. M. H., Permutt, M. A., & Imai, S. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.07.001 · Cited by 638

Sirtuins in aging and age-related disease

Longo, V. D., & Kennedy, B. K. (2006) · Cell · doi:10.1016/j.cell.2006.07.002 · Cited by 628

The ß-Glucuronidase Klotho Hydrolyzes and Activates the TRPV5 Channel

Chang, Q., Hoefs, S. J. G., van der Kemp, A. W., Topala, C. N., Bindels, R. J. M., & Hoenderop, J. G. J. (2005) · Science · doi:10.1126/science.1114245 · Cited by 624

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

Nakae, J., Biggs, W., Kitamura, T., Cavenee, W. K., Wright, C. V. E., Arden, K. C., & Accili, D. (2002) · Nature Genetics · doi:10.1038/ng890 · Cited by 617

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice 1

Coschigano, K. T., Clemmons, D., Bellush, L. L., & Kopchick, J. J. (2000) · Endocrinology · doi:10.1210/endo.141.7.7586 · Cited by 611

The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

McBurney, M. W., Yang, X., Jardine, K., Hixon, M., Boekelheide, K., Webb, J. R., Lansdorp, P. M., & Lemieux, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.38-54.2003 · Cited by 611

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

Accili, D., Drago, J., Lee, E. J., Johnson, M. D., Cool, M. H., Salvatore, P., Asico, L. D., José, P. A., Taylor, S. I., & Westphal, H. (1996) · Nature Genetics · doi:10.1038/ng0196-106 · Cited by 594

Insulin resistance as a predictor of age-related diseases

Facchini, F. S., Hua, N., Abbasi, F., & Reaven, G. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7763 · Cited by 594

Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body

Giannakou, M. E., Goss, M. W., Jünger, M. A., Hafen, E., Leevers, S. J., & Partridge, L. (2004) · Science · doi:10.1126/science.1098219 · Cited by 577

Calorie Restriction, Aging, and Cancer Prevention: Mechanisms of Action and Applicability to Humans

Hursting, S. D., Lavigne, J. A., Berrigan, D. A., Perkins, S. N., & Barrett, J. C. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152156 · Cited by 558

Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane

Imura, A., Iwano, A., Tohyama, O., Tsuji, Y., Nozaki, K., Hashimoto, N., Fujimori, T., & Nabeshima, Y. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.03.090 · Cited by 542

Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans

Arantes-Oliveira, N., Apfeld, J., Dillin, A. G., & Kenyon, C. J. (2002) · Science · doi:10.1126/science.1065768 · Cited by 530

Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis

Taguchi, A., Wartschow, L. M., & White, M. F. (2007) · Science · doi:10.1126/science.1142179 · Cited by 523

Interacting genes in nematode dauer larva formation

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Deletion, But Not Antagonism, of the Mouse Growth Hormone Receptor Results in Severely Decreased Body Weights, Insulin, and Insulin-Like Growth Factor I Levels and Increased Life Span

Coschigano, K. T., Holland, A. N., Riders, M. E., List, E. O., Flyvbjerg, A., & Kopchick, J. J. (2003) · Endocrinology · doi:10.1210/en.2003-0374 · Cited by 510

Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

Tsujikawa, H., Kurotaki, Y., Fujimori, T., Fukuda, K., & Nabeshima, Y. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0048 · Cited by 501

SIRT2 Regulates Adipocyte Differentiation through FoxO1 Acetylation/Deacetylation

Jing, E., Gesta, S., & Kahn, C. R. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.07.003 · Cited by 500

Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans

Motola, D., Cummins, C. L., Rottiers, V., Sharma, K. K., Li, T., Li, Y., Suino-Powell, K. M., Xu, H. E., Auchus, R. J., Antebi, A., et al. (2006) · Cell · doi:10.1016/j.cell.2006.01.037 · Cited by 498

Association of human aging with a functional variant of klotho

Arking, D. E., Krebsová, A., Maçek, M., Maçek, M., Arking, A., Mian, S. I., Fried, L. F., Hamosh, A., Dey, S., McIntosh, I., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022484299 · Cited by 491

Hormonal pleiotropy and the juvenile hormone regulation ofDrosophila development and life history

Flatt, T., Tu, M., & Tatar, M. (2005) · BioEssays · doi:10.1002/bies.20290 · Cited by 490

Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems

Mattson, M. P., & Wan, R. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.12.007 · Cited by 464

Timing Requirements for Insulin/IGF-1 Signaling in C. elegans

Dillin, A., Crawford, D. K., & Kenyon, C. (2002) · Science · doi:10.1126/science.1074240 · Cited by 443

C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span

Berdichevsky, A., Viswanathan, M., Horvitz, H. R., & Guarente, L. (2006) · Cell · doi:10.1016/j.cell.2006.04.036 · Cited by 402

A Hormonal Signaling Pathway Influencing C. elegans Metabolism, Reproductive Development, and Life Span

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Non-ageing developmental variant of Caenorhabditis elegans

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Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span

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Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation

Oh, S. W., Mukhopadhyay, A., Dixit, B. L., Raha, T., Green, M. R., & Tissenbaum, H. A. (2005) · Nature Genetics · doi:10.1038/ng1723 · Cited by 374

C. elegans SGK-1 Is the Critical Component in the Akt/PKB Kinase Complex to Control Stress Response and Life Span

Hertweck, M., Göbel, C., & Baumeister, R. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00095-4 · Cited by 368

Transcriptional feedback control of insulin receptor by dFOXO/FOXO1Preprint

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Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial

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Nuclear Receptors CAR and PXR Cross Talk with FOXO1 To Regulate Genes That Encode Drug-Metabolizing and Gluconeogenic Enzymes

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Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein 1

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Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

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Steroid hormones and neurosteroids in normal and pathological aging of the nervous system

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Ultraspiracle: An invertebrate nuclear receptor for juvenile hormones

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Association Between a Functional Variant of the KLOTHO Gene and High-Density Lipoprotein Cholesterol, Blood Pressure, Stroke, and Longevity

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Steroid Control of Longevity in Drosophila melanogaster

Simon, A. F., Shih, C., Mack, A., & Benzer, S. (2003) · Science · doi:10.1126/science.1080539 · Cited by 265

DAF-9, a cytochrome P450 regulatingC. eleganslarval development and adult longevity

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Mortality and Morbidity in Laboratory-maintained Rhesus Monkeys and Effects of Long-term Dietary Restriction

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A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling

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Inherited Ateliotic Dwarfism in Mice: Characteristics of the mutation, little, on Chromosome 6

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