Ras oncogenes: split personalities
DOI 10.1038/nrm2438
Cited by (1,000)
Items 301–400 of 1,000
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- Molecular Characteristics of Clostridium perfringens TpeL Toxin and Consequences of Mono-O-GlcNAcylation of Ras in Living CellsGregor Guttenberg, Sven Hornei, Thomas Jank, Carsten Schwan, Wei Lü, Oliver Einsle, Panagiotis Papatheodorou, Klaus Aktories · 2012 · Journal of Biological Chemistry
- Identification of a Small GTPase Inhibitor Using a High-Throughput Flow Cytometry Bead-Based Multiplex AssayZurab Surviladze, Anna Waller, Yang Wu, Elsa Romero, Bruce S. Edwards, Angela Wandinger‐Ness, Larry A. Sklar · 2009 · SLAS DISCOVERY
- Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell linesVartanian, Steffan, Bentley, Carolyn, Brauer, Matthew J., Li, Li, Shirasawa, Senji, Sasazuki, Takehiko, Kim, Jung-Sik, Haverty, Pete, Stawiski, Eric, Modrusan, Zora et al. · 2013 · Journal of Biological Chemistry
- Extracellular vesicles from apoptotic BMSCs ameliorate osteoporosis via transporting regenerative signalsMaojiao Li, Qi Tang, Chengcheng Liao, Zhuo Wang, Siyuan Zhang, Qingqing Liang, Cheng Liang, Xiaodong Liu, Jingyi Zhang, Weidong Tian et al. · 2024 · Theranostics
- Update on the molecular profile of the MDA-MB-453 cell line as a model for apocrine breast carcinoma studiesSemir Vranić, Zoran Gatalica, Zhaoyi Wang · 2011 · Oncology Letters
- Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteinsYuanhao Wang, Dong Ji, Chaoyu Lei, Yingfei Chen, Yuran Qiu, Xinyi Li, Mingyu Li, Duan Ni, Jun Pu, Jian Zhang et al. · 2021 · Computational and Structural Biotechnology Journal
- Segregation of Negatively Charged Phospholipids by the Polycationic and Farnesylated Membrane Anchor of KrasLorant Janosi, Alemayehu Abebe Gorfe · 2010 · Biophysical Journal
- DAB2IP in cancerLiang Liu, Cong Xu, Jer‐Tsong Hsieh, Jianping Gong, Daxing Xie · 2015 · Oncotarget
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- The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesisGalit Lazer, Yulia Idelchuk, Vered Schapira, Eli Pikarsky, Shulamit Katzav · 2009 · The Journal of Pathology
- Rational Design of Small Molecule Inhibitors Targeting the Ras GEF, SOS1Chris R. Evelyn, Xin Duan, Jacek Biesiada, William L. Seibel, Jarek Meller, Yi Zheng · 2014 · Chemistry & Biology
- Emerging biological functions of the vaccinia-related kinase (VRK) family.Elke P.F. Klerkx, Pedro A. Lazo, Peter Askjaer · 2009 · PubMed
- RAS Transformation Requires CUX1-Dependent Repair of Oxidative DNA DamageZubaidah M. Ramdzan, Charles Vadnais, Ranjana Pal, Guillaume Vandal, Chantal Cadieux, Lam Leduy, Sayeh Davoudi, Laura Hulea, Lu Yao, Anthony Nicholas Karnezis et al. · 2014 · PLoS Biology
- Interfering with RAS–effector protein interactions prevent RAS-dependent tumour initiation and causes stop–start control of cancer growthTomoyuki U Tanaka, Terence Howard Rabbitts · 2010 · Oncogene
- H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in miceTaeko Ichise, Nobuaki Yoshida, Hirotake Ichise · 2010 · Development
- Dynamics of Membrane-Bound G12V-KRAS from Simulations and Single-Molecule FRET in Native NanodiscsPriyanka Prakash, Douglas B. Litwin, Liang Hong, Suparna Sarkar‐Banerjee, Drew M. Dolino, Yong Zhou, John F. Hancock, Vasanthi Jayaraman, Alemayehu Abebe Gorfe · 2018 · Biophysical Journal
- K-Ras G-domain binding with signaling lipid phosphatidylinositol (4,5)-phosphate (PIP2): membrane association, protein orientation, and functionShufen Cao, Stacey Chung, SoonJeung Kim, Zhenlu Li, Danny Manor, Matthias Buck · 2019 · Journal of Biological Chemistry
- ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cellsSen, Madhobi, Wang, Xin, Hamdan, Feda H., Rapp, Jacobe, Eggert, Jessica, Kosinsky, Robyn Laura, Wegwitz, Florian, Kutschat, Ana Patricia, Younesi, Fereshteh S., Gaedcke, Jochen et al. · 2019 · Clinical Epigenetics
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- Formation and Domain Partitioning of H-ras Peptide Nanoclusters: Effects of Peptide Concentration and Lipid CompositionZhenlong Li, Lorant Janosi, Alemayehu Abebe Gorfe · 2012 · Journal of the American Chemical Society
- The Ras–Membrane Interface: Isoform-Specific Differences in the Catalytic DomainJillian A. Parker, Carla Mattos · 2015 · Molecular Cancer Research
- One-way membrane trafficking of SOS in receptor-triggered Ras activationSune M. Christensen, Hsiung‐Lin Tu, Jesse E. Jun, Steven A. Alvarez, Meredith Gahn Triplet, Jeffrey S. Iwig, Kamlesh Kumar Yadav, Dafna Bar‐Sagi, Jeroen P. Roose, Jay T. Groves · 2016 · Nature Structural & Molecular Biology
- Structure of two G-quadruplexes in equilibrium in the KRAS promoterJulien Marquevielle, Coralie Robert, Olivier Lagrabette, Mona Wahid, Anne Bourdoncle, Luigi Emilio Xodo, Jean‐Louis Mergny, Gilmar F. J. Salgado · 2020 · Nucleic Acids Research
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- The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to MetastasisBarbara Mátyási, Zsolt Farkas, László Kopper, Anna Réka Sebestyén, Mathieu Boissan, Anil Mehta, Krisztina Takács‐Vellai · 2020 · Pathology & Oncology Research
- The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulatesKRASexpression in pancreatic ductal adenocarcinoma cellsSuravi Pramanik, Yingling Chen, Heyu Song, Irine Khutsishvili, Luis A. Marky, Sutapa Ray, Amarnath Natarajan, Pankaj K. Singh, Kishor K. Bhakat · 2022 · Nucleic Acids Research
- Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagySara Alves, Lisandra Castro, Maria Sofia Fernandes, Rita Francisco, P.J.T.D. Castro, Muriel Priault, Susana Rodrigues Chaves, Mary Pat Moyer, Carla Oliveíra, Raquel Seruca et al. · 2015 · Oncotarget
- RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPaseSongqing Tang, Taoyong Chen, Yu Zhou, Xuhui Zhu, Mingjin Yang, Bin Xie, Nan Li, Xuetao Cao, Jianli Wang · 2014 · Nature Communications
- Transmembrane signaling in Saccharomyces cerevisiae as a model for signaling in metazoans: State of the art after 25yearsDavid Engelberg, Riki Perlman, Alexander Levitzki · 2014 · Cellular Signalling
- Functional Redundancy of Sos1 and Sos2 for Lymphopoiesis and Organismal Homeostasis and SurvivalFernando C. Baltanás, Martín Pérez‐Andrés, Alicia Ginel-Picardo, David Díaz, David Jimeno, Pilar Liceras-Boillos, Robert L. Kortum, Lawrence E. Samelson, Alberto Órfão, Eugenio Santos · 2013 · Molecular and Cellular Biology
- Ras Activation Induces Expression of Raet1 Family NK Receptor LigandsXi V. Liu, Samantha S.W. Ho, James J. Tan, Neha Kamran, Stephan Gasser · 2012 · The Journal of Immunology
- Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic MiceMaria E. Balasis, Kara D. Forinash, Y. Ann Chen, William J. Fulp, Domenico Coppola, Andrew D. Hamilton, Jin Quan Cheng, Saı̈d M. Sebti · 2011 · Clinical Cancer Research
- Arteriovenous Malformations and Other Vascular Malformation SyndromesKevin J. Whitehead, Matthew C. P. Smith, D. Y. Li · 2012 · Cold Spring Harbor Perspectives in Medicine
- RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomasSerrano, César, Romagosa, Cleofé, Hernández‐Losa, Javier, Simonetti, Sara, Valverde, Claudia, Moliné, Teresa, Somoza, Rosa, Pérez, Manuel, Vélez, Roberto, Vergés, Ramona et al. · 2016 · Cancer
- Unraveling the interplay between RAS/RAF/MEK/ERK signaling pathway and autophagy in cancer: From molecular mechanisms to targeted therapyYunli Huang, Yongqi Zhen, Yanmei Chen, Shaoguang Sui, Lan Zhang · 2023 · Biochemical Pharmacology
- The role of the small GTP ase Rab31 in cancerChristelle En Lin Chua, Bor Luen Tang · 2014 · Journal of Cellular and Molecular Medicine
- Lack of evidence for KRAS oncogenic mutations in triple-negative breast cancerAlfonso Sánchez‐Muñoz, Elena Gallego, Vanessa de Luque, Luis Gustavo Perez‐Rivas, Luís Vicioso, Nuria Ribelles, José Lozano, Emilio Alba · 2010 · BMC Cancer
- The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human TumorigenesisGiulia Cazzanelli, Flávia Dayana Silva Pereira, Sara Alves, Rita Francisco, Luı́sa Azevedo, Patrícia Dias Carvalho, Ana F. Almeida, Manuela Côrte‐Real, María José Oliveira, Cândida Lucas et al. · 2018 · Cells
- Chronicles of the GTPase switchJacqueline Cherfils, Mahel Zeghouf · 2011 · Nature Chemical Biology
- Endometrial Carcinoma: Specific Targeted PathwaysNúria Eritja, Andrée Yeramian, Bo‐Juen Chen, David Llobet‐Navàs, Eugenia Ortega, Eva Colás, Miguel Abal, Xavier Dolcet, Jaume Reventós, Xavier Matías‐Guiu · 2016 · Advances in experimental medicine and biology
- Reciprocal regulation of YAP/TAZ by the Hippo pathway and the Small GTPase pathwayJuwon Jang, Min‐Kyu Kim, Suk‐Chul Bae · 2018 · Small GTPases
- Synthetic Lethal Therapy for KRAS Mutant Non-small-cell Lung Carcinoma with Nanoparticle-mediated CDK4 siRNA DeliveryChengqiong Mao, Menghua Xiong, Yang Liu, Song Shen, Xiao‐Jiao Du, Xianzhu Yang, Shuang Dou, Peizhuo Zhang, Jun Wang · 2014 · Molecular Therapy
- A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochoresDevinderjit Kaur Moudgil, Nathan P. Westcott, Jakub K. Famulski, Kinjal Patel, Dawn Macdonald, Howard C. Hang, Gordon K. T. Chan · 2015 · The Journal of Cell Biology
- Selective requirement for Mediator MED23 in Ras-active lung cancerYang Xu, Meng Liang Zhao, Min Hao Xia, Yuting Liu, Jun Yan, Hongbin Ji, Gang Wang · 2012 · Proceedings of the National Academy of Sciences
- The Crosstalk of RAS with the TGF-β Family During Carcinoma Progression and its Implications for Targeted Cancer TherapyMichael Grusch, Michaela Petz, Thomas Metzner, Deniz Gülfem Öztürk, Doris Schneller, Wolfgang Mikulits · 2010 · Current Cancer Drug Targets
- Dock GEFs and their therapeutic potential: Neuroprotection and axon regenerationNamekata, Kazuhiko, Kimura, Atsuko, Kawamura, Kazuto, Harada, Chikako, Harada, Takayuki · 2014 · Progress in Retinal and Eye Research
- The Plasma Membrane as a Competitive Inhibitor and Positive Allosteric Modulator of KRas4B SignalingNeale, Chris, García, Angel E. · 2020 · Biophysical Journal
- KRAS Mutation Subtypes and Their Association with Other Driver Mutations in Oncogenic PathwaysKoushik Mondal, Mahesh Kumar Posa, Revathi Panduranga Shenoy, Susanta Roychoudhury · 2024 · Cells
- Improving the Limit of Detection for Sanger Sequencing: A Comparison of Methodologies for KRAS Variant DetectionColin J. Davidson, Emily Zeringer, Kristen J. Champion, Marie‐Pierre L. Gauthier, Fawn Wang, Jerry Boonyaratanakornkit, Julie R. Jones, Edgar H. Schreiber · 2012 · BioTechniques
- Thrombospondin-1 mediates oncogenic Ras–induced senescence in premalignant lung tumorsKwan‐Hyuck Baek, Dong‐Ha Bhang, Alexander Zaslavsky, Liang-Chuan Wang, Anil Vachani, Carla F. Kim, Steven Μ. Albelda, Gérard I. Evan, Sandra W. Ryeom · 2013 · Journal of Clinical Investigation
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- Synergistic function of Kras mutation and HBx in initiation and progression of hepatocellular carcinoma in miceH Ye, Chen‐Yu Zhang, B-J Wang, X-H Tan, W-P Zhang, Y Teng, Xiao Yi Yang · 2013 · Oncogene
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- Prognostic value of RKIP and p-ERK in gastric cancerYoshitaka Fujimori, Mikito Inokuchi, Yoko Takagi, Keiji Kato, Kazuyuki Kojima, Kenichi Sugihara · 2012 · Journal of Experimental & Clinical Cancer Research
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- Conformational SERS Classification of K‐Ras Point Mutations for Cancer DiagnosticsJudit Morlà‐Folch, Patricia Gisbert‐Quilis, Matteo Masetti, Eduardo García‐Rico, Ramón A. Álvarez‐Puebla, Luca Guerrini · 2017 · Angewandte Chemie International Edition
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- Mapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary AlgorithmRudy Clausen, Buyong Ma, Ruth Nussinov, Amarda Shehu · 2015 · PLoS Computational Biology
- Post-translational modification of KRAS: potential targets for cancer therapyWeihua Wang, Tao Yuan, Meijia Qian, Fangjie Yan, Liu Yang, Qiaojun He, Bo Yang, Jin‐Jian Lu, Hong Zhu · 2020 · Acta Pharmacologica Sinica
- Enhanced MET Translation and Signaling Sustains K-Ras–Driven Proliferation under Anchorage-Independent Growth ConditionsSaori Fujita-Sato, Jacqueline Galeas, Morgan Truitt, Cameron Pitt, Anatoly Urisman, Sourav Bandyopadhyay, Davide Ruggero, Frank P. McCormick · 2015 · Cancer Research
- Blocking oncogenic RAS enhances tumour cell surface MHC class I expression but does not alter susceptibility to cytotoxic lymphocytesJehan J. El‐Jawhari, Yasser Mohamed El-Sherbiny, Gina B. Scott, Ruth S.M. Morgan, Robin J D Prestwich, Paul A. Bowles, G. Eric Blair, Tomoyuki U Tanaka, Terence Howard Rabbitts, Josephine L. Meade et al. · 2013 · Molecular Immunology
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- Compartmentalized Ras Proteins Transform NIH 3T3 Cells with Different EfficienciesChiang-Min Cheng, Huiling Li, Stéphane Gasman, Jian Huang, Rachel Schiff, Eric C. Chang · 2010 · Molecular and Cellular Biology
- The c-Jun NH2-Terminal Kinase 2 Plays a Dominant Role in Human Epidermal NeoplasiaHengning Ke, Rebecca Harris, Jonathan L. Coloff, Jane Y. Jin, Benjamin Leshin, Paula L. Miliani de Marval, Shiying Tao, Jeffrey C. Rathmell, Russell P. Hall, Jennifer Y. Zhang · 2010 · Cancer Research
- Adjuvant FOLFOX +/− cetuximab in fullRAS andBRAF wildtype stage III colon cancer patientsJulien Taı̈eb, Ralyath Balogoun, Karine Le Malicot, Josep M. Tabernero, Enrico Mini, Gunnar Folprecht, Jean‐Luc Van Laethem, J.-F. Emile, Claire Mulot, Serge Fratté et al. · 2016 · Annals of Oncology
- Genotype and phenotype spectrum of NRAS germline variantsFranziska Altmüller, Christina Lißewski, Débora Romeo Bertola, Elisabetta Flex, Zornitza Stark, Stephanie Spranger, Gareth S Baynam, Michelle Buscarilli, Sarah Dyack, Jane Gillis et al. · 2017 · European Journal of Human Genetics
- WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradationWoo-Jeong Jeong, Jong‐Chan Park, Woo-Shin Kim, Eun Ji Ro, Soung Hoo Jeon, Sang‐Kyu Lee, Young Nyun Park, Do Sik Min, Kang‐Yell Choi · 2019 · Nature Communications
- USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven CancerJulia M. Fraile, Eusebio Manchado, Amaia Lujambio, Vı́ctor Quesada, Diana Campos-Iglesias, Thomas R. Webb, Scott W. Lowe, Carlos López-Otı́n, José M.P. Freije · 2017 · Journal of Biological Chemistry
- MicroRNA-30a attenuates mutant KRAS-driven colorectal tumorigenesis via direct suppression of ME1Hongxing Shen, Chuan Xing, Kaisa Cui, Yunxiao Li, Jinxiang Zhang, Run‐Lei Du, Xiaodong Zhang, Youjun Li · 2017 · Cell Death and Differentiation
- bFGF-mediated pluripotency maintenance in human induced pluripotent stem cells is associated with NRAS-MAPK signalingFereshteh Haghighi, Julia Dahlmann, Saeideh Nakhaei‐Rad, Alexander Lang, Ingo Kutschka, Martin Zenker, George Kensah, Roland P. Piekorz, Mohammad Reza Ahmadian · 2018 · Cell Communication and Signaling
- Prognostic and Predictive Significance of MYC and KRAS Alterations in Breast Cancer from Women Treated with Neoadjuvant ChemotherapyCynthia Brito Lins Pereira, Mariana Ferreira Leal, Carolina Rosal Teixeira de Souza, Raquel Carvalho Montenegro, JUAN ANTONIO REY, Antônio Alberto Carvalho, Paulo Pimentel de Assumpção, André Salim Khayat, Giovanny Rebouças Pinto, Sâmia Demachki et al. · 2013 · PLoS ONE
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- Ras signaling regulates osteoprogenitor cell proliferation and bone formationGaryfallia Papaioannou, Fatemeh Mirzamohammadi, Tatsuya Kobayashi · 2016 · Cell Death and Disease
- The Interplay of Dysregulated pH and Electrolyte Imbalance in CancerKhalid Omer Alfarouk, Samrein B. M. Ahmed, Ahmed Ahmed, Robert Lange Elliott, Muntaser Eltayeb Ibrahim, Heyam Saad Ali, Christian C. Wales, Ibrahim Nourwali, Ahmed N. Aljarbou, Adil H. H. Bashir et al. · 2020 · Cancers
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- Probing the Conformational and Energy Landscapes of KRAS Membrane OrientationPriyanka Prakash, Alemayehu Abebe Gorfe · 2019 · The Journal of Physical Chemistry B
- The regulation of shrimp metabolism by the white spot syndrome virus (WSSV)Ramya Kumar, Jiun‐Yan Huang, Yen Siong Ng, Cong-Yan Chen, Han‐Ching Wang · 2021 · Reviews in Aquaculture
- The therapeutic potential of neurofibromin signaling pathways and binding partnersJuan Báez-Flores, Mario Rodríguez-Martín, Jesús Lacal · 2023 · Communications Biology
- κB-Ras Proteins Regulate Both NF-κB-Dependent Inflammation and Ral-Dependent ProliferationAndrea Oeckinghaus, Thomas S. Postler, Ping Rao, Heike Schmitt, Verena Schmitt, Yenkel Grinberg‐Bleyer, Lars I. Kühn, Christian W. Gruber, Gustav E. Lienhard, Sankar Ghosh · 2014 · Cell Reports
- TCR-Induced Activation of Ras Proceeds at the Plasma Membrane and Requires Palmitoylation of N-RasIgnacio Rubio, Stefan Grund, Shu-Ping Song, Christoph U. Biskup, Sabine Bandemer, Melanie Fricke, Martin Förster, Andrea Graziani, Ute Wittig, Stefanie Kliche · 2010 · The Journal of Immunology
- KRAS mutant lung cancer: progress thus far on an elusive therapeutic targetSaveri Bhattacharya, Mark A. Socinski, Timothy Francis Burns · 2015 · Clinical and Translational Medicine
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- Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12VChristian Schmees, Roberto Villaseñor, Wei Zheng, H. Ma, Marino Zerial, Carl‐Henrik Heldin, Carina B. Hellberg · 2012 · Molecular Biology of the Cell
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- A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to FerroptosisRuiqing Lu, Yi-Nan Jiang, Xianxin Lai, Shujie Liu, Litao Sun, Zhongwei Zhou · 2021 · International Journal of Molecular Sciences