Ras oncogenes: split personalities

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Phosphatidylinositol-3-OH kinase direct target of Ras

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

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The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

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Modelling Cooperative Tumorigenesis in Drosophila

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Hedgehog pathway and smoothened inhibitors in cancer therapies

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ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition

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Ras signals principally via Erk in G1 but cooperates with PI3K/Akt for Cyclin D induction and S-phase entry

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Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers

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KRAS driven expression signature has prognostic power superior to mutation status in non‐small cell lung cancer

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Small GTPase RBJ Mediates Nuclear Entrapment of MEK1/MEK2 in Tumor Progression

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Nuclear G Protein Signaling

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Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators

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Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth

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Targeting the anaphase promoting complex: common pathways for viral infection and cancer therapy

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Phosphoproteomics Identifies Oncogenic Ras Signaling Targets and Their Involvement in Lung Adenocarcinomas

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Folate levels modulate oncogene‐induced replication stress and tumorigenicity

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EGFR phosphorylates FAM129B to promote Ras activation

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Approaches to inhibiting oncogenic K-Ras

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Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells

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EGFR-RAS-MAPK signaling is confined to the plasma membrane and associated endorecycling protrusions

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Pathology and genetics of uveal melanoma

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R-RAS2 overexpression in tumors of the human central nervous system

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Roles of Tetrahydrobiopterin in Promoting Tumor Angiogenesis

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Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer

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The Long Noncoding RNA OIP5-AS1 Is Involved in the Regulation of Cell Proliferation

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Protein kinase 2 (CK2): a potential regulator of immune cell development and function in cancer

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Regulation and functional significance of CDC42 alternative splicing in ovarian cancer

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Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition

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Functional Cross-talk between Ras and Rho Pathways

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Development and Characterization of Six New Human Papillary Thyroid Carcinoma Cell Lines

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Dietary olive oil and corn oil differentially affect experimental breast cancer through distinct modulation of the p21Ras signaling and the proliferation-apoptosis balance

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Involvement of activation-induced cytidine deaminase in skin cancer development

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Intermediate progenitor cells provide a transition between hematopoietic progenitors and their differentiated descendants

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Predictive Biomarkers for Immune-Checkpoint Inhibitor Treatment Response in Patients with Hepatocellular Carcinoma

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pMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound Proteins

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Strategies for Overcoming Resistance in Tumours Harboring BRAF Mutations

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Comparative Nucleotide-Dependent Interactome Analysis Reveals Shared and Differential Properties of KRas4a and KRas4b

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Low DMT1 Expression Associates With Increased Oxidative Phosphorylation and Early Recurrence in Hepatocellular Carcinoma

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Queen Conch (Strombus gigas) Testis Regresses during the Reproductive Season at Nearshore Sites in the Florida Keys

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Merlin Inhibits Neurite Outgrowth in the CNS

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MicroRNA-mediated regulation of KRAS in cancer

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The Nogo-B receptor promotes Ras plasma membrane localization and activation

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Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer

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KRAS-Mutant Lung Cancer: Targeting Molecular and Immunologic Pathways, Therapeutic Advantages and Restrictions

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Selective cytotoxicity of a bicyclic Ras inhibitor in cancer cells expressing K-RasG13D

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Cationic Lipid-Assisted Polymeric Nanoparticle Mediated GATA2 siRNA Delivery for Synthetic Lethal Therapy of KRAS Mutant Non-Small-Cell Lung Carcinoma

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Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1α pathway

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AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer

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MEK nuclear localization promotes YAP stability via sequestering β-TrCP in KRAS mutant cancer cells

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Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification

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Viable pigs with a conditionally-activated oncogenic KRAS mutation

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Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation

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Pumping the brakes on RAS – negative regulators and death effectors of RAS

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Validation of the Ion Torrent PGM sequencing for the prospective routine molecular diagnostic of colorectal cancer

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Personalized Therapy of Non-small Cell Lung Cancer (NSCLC)

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Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth

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RasIns: Genetically Encoded Intrabodies of Activated Ras Proteins

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Dissecting cellular senescence and SASP in Drosophila

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Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses

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Annexin A6 is down-regulated through promoter methylation in gastric cancer.

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Distribution of KRAS and BRAF mutations in Moroccan patients with advanced colorectal cancer

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Functional analysis of a duplication (p.E63_D69dup) in the switch II region of HRAS: new aspects of the molecular pathogenesis underlying Costello syndrome

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MicroRNAs: Modulators of theRasOncogenes in Oral Cancer

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Inhibition of nuclear factor-kappa B enhances the tumor growth of ovarian cancer cell line derived from a low-grade papillary serous carcinoma in p53-independent pathway

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MEK inhibitors against MET-amplified non-small cell lung cancer

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The RAL Enigma: Distinct Roles of RALA and RALB in Cancer

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Effects of Hypoxanthine Substitution in Peptide Nucleic Acids TargetingKRAS2Oncogenic mRNA Molecules: Theory and Experiment

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Silencing KRAS Overexpression in Arsenic-Transformed Prostate Epithelial and Stem Cells Partially Mitigates Malignant Phenotype

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Yorkie overexpression in the posterior silk gland improves silk yield in Bombyx mori

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Retrospective Case Series Analysis of RAF Family Alterations in Pancreatic Cancer: Real-World Outcomes From Targeted and Standard Therapies

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Overview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras

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CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling

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The Role of Embryonic Stem Cell-expressed RAS (ERAS) in the Maintenance of Quiescent Hepatic Stellate Cells

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Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells

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Dihydrosanguinarine suppresses pancreatic cancer cells via regulation of mut-p53/WT-p53 and the Ras/Raf/Mek/Erk pathway

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Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer

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Blimp1 Activation by AP-1 in Human Lung Cancer Cells Promotes a Migratory Phenotype and Is Inhibited by the Lysyl Oxidase Propeptide

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Regulation of CD38 Expression in Human Airway Smooth Muscle Cells

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Developmental lineage priming in Dictyostelium by heterogeneous Ras activation

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KRAS-Mutant Lung Cancers in the Era of Targeted Therapy

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Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation

Ni, D., Song, K., Zhang, J., & Lu, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112249 · Cited by 30

Nuclear Receptor Coactivator 2 Promotes Human Breast Cancer Cell Growth by Positively Regulating the MAPK/ERK Pathway

Cai, M., Liang, X., Sun, X., Chen, H., Dong, Y., Wu, L., Gu, S., & Han, S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00164 · Cited by 30

Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis

Mikawa, T., Shibata, E., Shimada, M., Ito, K., Ito, T., Kanda, H., Takubo, K., LLeonart, M. E., Inagaki, N., Yokode, M., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101306 · Cited by 30

Molecular Determinants of Thyroid Nodules with Indeterminate Cytology and RAS Mutations

Hernandez-Prera, J. C., Valderrábano, P., Creed, J. H., de la Iglesia, J. V., Slebos, R. J. C., Centeno, B. A., Tarasova, V. D., Johnson, J. E. H., Veloski, C., Otto, K. J., et al. (2020) · Thyroid · doi:10.1089/thy.2019.0650 · Cited by 30

Oncolytic viruses and pancreatic cancer

Hamidi-Sofiani, V., Rakhshi, R., Moradi, N., Zeynali, P., Nakhaie, M., & Behboudi, E. (2022) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2022.100563 · Cited by 30

An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences

Gripp, K. W., Sol‐Church, K., Smpokou, P., Graham, G. E., Stevenson, D. A., Hanson, H., Viskochil, D. H., Baker, L., Russo, B., Gardner, N., et al. (2015) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37128 · Cited by 30

PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer

Deb, S., Do, H., Byrne, D. J., Jene, N., kConFab Investigators, Dobrovic, A., & Fox, S. B. (2013) · Breast Cancer Research · doi:10.1186/bcr3463 · Cited by 30

FOLFOX4 Plus Cetuximab for Patients With Previously Untreated Metastatic Colorectal Cancer According to Tumor RAS and BRAF Mutation Status: Updated Analysis of the CECOG/CORE 1.2.002 Study

Kaczirek, K., Ciuleanu, T., Vrbanec, D., Márton, E., Messinger, D., Liegl‐Atzwanger, B., Wrba, F., Knittelfelder, R., Lindner, E., Zielinski, C. C., et al. (2014) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2014.12.003 · Cited by 29

Overexpression of DDX43 Mediates MEK Inhibitor Resistance through RAS Upregulation in Uveal Melanoma Cells

Ambrosini, G., Khanin, R., Carvajal, R. D., & Schwartz, G. K. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0095 · Cited by 29

Diffusion Tensor Analysis by Two-Dimensional Pair Correlation of Fluorescence Fluctuations in Cells

Rienzo, C. D., Cardarelli, F., Luca, M. D., Beltram, F., & Gratton, E. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2016.07.005 · Cited by 29

IL-17 Exerts Anti-Apoptotic Effect via miR-155-5p Downregulation in Experimental Autoimmune Encephalomyelitis

Ksiazek-Winiarek, D., Szpakowski, P., Turniak, M., Szemraj, J., & Glabinski, A. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0981-2 · Cited by 26

PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas

Klein, C. H., Truxius, D. C., Vogel, H. A., Harizanova, J., Murarka, S., Martín‐Gago, P., & Bastiaens, P. I. H. (2018) · International Journal of Cancer · doi:10.1002/ijc.31859 · Cited by 31

Characterization With KRAS Mutant Is a Critical Determinant in Immunotherapy and Other Multiple Therapies for Non-Small Cell Lung Cancer

Shen, M., Qi, R., Ren, J., Lv, D., & Yang, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.780655 · Cited by 31

Chloroquine enhances the efficacy of chemotherapy drugs against acute myeloid leukemia by inactivating the autophagy pathway

Wang, H., Li, J., Kan, W., Xu, G., Luo, G.-H., Song, N., Wu, W., Feng, B., Fu, J.-F., Tu, Y., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01112-8 · Cited by 29

Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells

Zaganjor, E., Osborne, J. K., Weil, L. M., Díaz-Martínez, L. A., Gonzales, J. X., Singel, S. M., Larsen, J. E., Girard, L., Minna, J. D., & Cobb, M. H. (2013) · Oncogene · doi:10.1038/onc.2013.486 · Cited by 29

Downregulation of P-gp, Ras and p-ERK1/2 contributes to the arsenic trioxide-induced reduction in drug resistance towards doxorubicin in gastric cancer cell lines

Zhao, Y., Li, Y., LIU, B.-L., He, X., & ZHANG, B.-Y. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4367 · Cited by 29

Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells

Bazzazi, H., & Popel, A. S. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005332 · Cited by 30

Targeted sequencing of a specific gene panel detects a high frequency of ARID1A and PIK3CA mutations in ovarian clear cell carcinoma

Su, Y.-F., Tsai, E., Chen, C.-C., Wu, C., & Er, T. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.03.003 · Cited by 29

Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2

Kidger, A. M., Munck, J. M., Saini, H. K., Balmanno, K., Minihane, E., Courtin, A., Graham, B. L., O’Reilly, M., Odle, R., & Cook, S. J. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-19-0505 · Cited by 30

KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET‐expressing tumor cells

Leiser, D., Medová, M., Mikami, K., Nisa, L., Stroka, D., Blaukat, A., Bladt, F., Aebersold, D. M., & Zimmer, Y. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.04.001 · Cited by 28

MicroRNA‑143‑3p suppresses cell growth and invasion in laryngeal squamous cell carcinoma via targeting the k‑Ras/Raf/MEK/ERK signaling pathway

Zhang, F., & Cao, H. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4655 · Cited by 28

Deregulated Ras signaling in developmental disorders: new tricks for an old dog

Schubbert, S., Bollag, G. E., & Shannon, K. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.12.004 · Cited by 117

RESEARCH CHALLENGES IN STAGE III AND IV RAS-ASSOCIATED CANCERS: A Narrative Review of the Complexities and Functions of the Family of RAS Genes and Ras Proteins in Housekeeping and Tumorigenesis

McDonald, R. A., Varela-Ramı́rez, A., & Ashley, A. K. (2025) · Biology · doi:10.3390/biology14080936 · Cited by 2

Abstract IA16: RASopathies: the other face of RAS signaling upregulation

Tartaglia, M. (2023) · Molecular Cancer Research · doi:10.1158/1557-3125.ras23-ia16

Hyperactive Ras in developmental disorders and cancer

Schubbert, S., Shannon, K., & Bollag, G. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2109 · Cited by 1,583

Ras in Cancer and Developmental Diseases

Fernández‐Medarde, A., & Santos, E. (2011) · Genes & Cancer · doi:10.1177/1947601911411084 · Cited by 1,001