Ras oncogenes: split personalities

Karnoub, Antoine E., Weinberg, Robert A.·2008·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm2438

Cited by (1,000)

Items 801–900 of 1,000

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KRAS and VEGF gene 3'-UTR single nucleotide polymorphisms predicted susceptibility in colorectal cancer
Minnan Yang, Xiuli Xiao, Xiaorui Xing, Xin Li, Tian Xia, Hanan Long · 2017 · PLoS ONE
Acceleration or Brakes: Which Is Rational for Cell Cycle-Targeting Neuroblastoma Therapy?
Kiyohiro Ando, Akira Nakagawara · 2021 · Biomolecules
Design, Structure Optimization, and Preclinical Characterization of JAB-21822, a Covalent Inhibitor of KRAS G12C
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Ras transformation uncouples the kinesin-coordinated cellular nutrient response
Elma Zaganjor, Lauren M. Weil, Joshua X. Gonzales, John Dorrance Minna, Melanie H. Cobb · 2014 · Proceedings of the National Academy of Sciences
The cell competition-based high-throughput screening identifies small compounds that promote the elimination of RasV12-transformed cells from epithelia
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Dariel Ashton‐Beaucage, Marc Therrien · 2016 · Methods in molecular biology
Non-Redundant and Overlapping Oncogenic Readouts of Non-Canonical and Novel Colorectal Cancer KRAS and NRAS Mutants
Krizelle Mae M. Alcantara, Joshua Reginald P. Malapit, Ryan Timothy D. Yu, Jose Antonio Ma. G. Garrido, John Paul T. Rigor, Arlou Kristina Angeles, Eva Maria Cutiongco‐de la Paz, Reynaldo L. Garcia · 2019 · Cells
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Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat
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Anusha Amaravathi, Janet L. Oblinger, D. Bradley Welling, Alan Douglas Kinghorn, Long‐Sheng Chang · 2021 · Frontiers in Oncology
Understanding the influence of AMG 510 on the structure of KRAS G12C empowered by molecular dynamics simulation
Yu Li, Lei Han, Ziding Zhang · 2022 · Computational and Structural Biotechnology Journal
The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties
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PTEN ablation in RasHa/Fos skin carcinogenesis invokes p53-dependent p21 to delay conversion while p53-independent p21 limits progression via cyclin D1/E2 inhibition
Freya MacDonald, Denggao Yao, Jean A. Quinn, David A. Greenhalgh · 2013 · Oncogene
Cancer-Selective Apoptosis by Tumor Suppressor Par-4
Nikhil Hebbar, Tripti Shrestha-Bhattarai, Vivek M. Rangnekar · 2014 · Advances in experimental medicine and biology
Probing the wild-type HRas activation mechanism using steered molecular dynamics, understanding the energy barrier and role of water in the activation
Neeru Sharma, Uddhavesh Sonavane, Rajendra Joshi · 2014 · European Biophysics Journal
Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007 – present)
Elena Sacco, Michela Spinelli, Marco Vanoni · 2012 · Expert Opinion on Therapeutic Patents
K-Ras, H-Ras, N-Ras and B-Raf mutation and expression analysis in Wilms tumors: association with tumor growth
Efterpi Dalpa, Victor Gourvas, Nikolaos Soulitzis, Demetrios A. Spandidos · 2016 · Medical Oncology
A large-scale RNA interference screen identifies genes that regulate autophagy at different stages
Sujuan Guo, Kevin J. Pridham, Ching-Man A. Virbasius, Bin He, Liqing Zhang, Hanne Varmark, Michael R. Green, Zhi Sheng · 2018 · Scientific Reports
Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel
Ying Hui Jin, Wenquan Hu, Tong Liu, Ujala Rana, Irene Aguilera‐Barrantes, Amanda L. Kong, Suresh N. Kumar, Bei Wang, Pin Gao, Xiang Wang et al. · 2018 · Cancer Letters
The microdomain-organizing protein MPP1 is required for insulin-stimulated activation of H-Ras
Joanna Podkalicka, Agnieszka Biernatowska, Paulina Olszewska, Sabina Tabaczar, Aleksander F. Sikorski · 2018 · Oncotarget
miR‑193b exhibits mutual interaction with MYC, and suppresses growth and metastasis of osteosarcoma
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Molecular pathology and biomarkers of bladder cancer
Bogdan A. Czerniak · 2011 · Cancer Biomarkers
Critical Roles of Interactions among Switch I-preceding Residues and between Switch II and Its Neighboring α-Helix in Conformational Dynamics of the GTP-bound Ras Family Small GTPases
Kousuke Matsumoto, Fumi Shima, Shin Muraoka, Mitsugu Araki, Lizhi Hu, Yuichi Ijiri, Rina Hirai, Jingling Liao, Takashi Yoshioka, Takashi Kumasaka et al. · 2011 · Journal of Biological Chemistry
KRAS-driven ROS promote malignant transformation
Yongjoon Suh, Su‐Jae Lee · 2015 · Molecular & Cellular Oncology
The Overexpression of Kinesin Superfamily Protein 2A (KIF2A) was Associated with the Proliferation and Prognosis of Esophageal Squamous Cell Carcinoma
Demao Li, Huijie Sun, Linglei Meng, Deshang Li · 2020 · Cancer Management and Research · Retracted
Significance of EGFR/HER2 Expression and PIK3CA Mutations in Giant Cell Tumour of Bone Development
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Pyrogallol acts as a novel anticancer factor to enhance the sensitivity to cisplatin in ovarian cancer cells through inducing miR-15a upregulation
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Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications
Sami Azrak, Alicia Ginel-Picardo, Matthias Drosten, Mariano Barbacid, Eugenio Santos · 2013 · BMC Genomics
Synthesis and biological evaluation of farnesylthiosalicylamides as potential anti-tumor agents
Yong Ling, Zhiqiang Wang, Hongyan Zhu, Xuemin Wang, Wei Zhang, Xinyang Wang, Li Chen, Zhangjian Huang, Yihua Zhang · 2013 · Bioorganic & Medicinal Chemistry
A possible role for long non-coding RNA in modulating signaling pathways
Barak Rotblat, Gabriel Leprivier, Poul H. B. Sorensen · 2011 · Medical Hypotheses
H-Ras Localizes to Cell Nuclei and Varies with the Cell Cycle
Sara Contente, T.-J. A. Yeh, R. M. Friedman · 2011 · Genes & Cancer
Intracellular NF-HEV/IL-33 harbors essential roles in Ras-induced cellular transformation by contributing to cyclin D1 protein synthesis
Satoshi Ohta, Kenji Tago, Megumi Funakoshi‐Tago, Jitsuhiro Matsugi, Ken Yanagisawa · 2016 · Cellular Signalling
Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans
Jiaojiao Ji, Yuan Gang Jiang, Xiaoyu Guo, Ruifang Ji, Qinghua Quan, Mei Ding, Xia Li, Yonggang Liu · 2019 · Cancer Cell International
The Roles And Signaling Pathways Of Phosphatidylethanolamine-Binding Protein 4 In Tumors
Zi-Kang Luo, Qiongfeng Chen, Xiaoqin Qu, Xiaoyan Zhou · 2019 · OncoTargets and Therapy
M-Ras is Muscle-Ras, Moderate-Ras, Mineral-Ras, Migration-Ras, and Many More-Ras
Takeshi Endo · 2020 · Experimental Cell Research
Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research
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Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis
Imran Khan, Catherine B. MarElia, Julia E. Lefler, Mariyam Zuberi, Eric Denbaum, Akiko Koide, Dean M. Connor, Ann‐Marie Broome, Thierry Pécot, Cynthia Dawn Timmers et al. · 2021 · Small GTPases
Effects of NRAS Mutations on Leukemogenesis and Targeting of Children With Acute Lymphoblastic Leukemia
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Jinghai Wu, Xin Liu, Julie W. Reeser, Anthony J. Trimboli, Thierry Pécot, Gina M. Sizemore, Shan K. Naidu, Soledad Fernández, Lianbo Yu, Michael T. Hallett et al. · 2022 · Molecular Cancer Research
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Sujoy Bose, Puja Sakhuja, Lavanaya Bezawada, Anil Agarwal, Syed Naqui Kazim, Luqman Ahmad Khan, Shiv Kumar Sarin, Gayatri Ramakrishna · 2010 · Journal of Gastroenterology and Hepatology
KRAS G>A mutation favors poor tumor differentiation but may not be associated with prognosis in patients with curatively resected duodenal adenocarcinoma
Tao Fu, Angela A. Guzzetta, Jana Jeschke, Rajita J. Vatapalli, Pujan Dave, Craig M. Hooker, Richard Morgan, Christine A. Iacobuzio–Donahue, Baohua Liu, Nita Ahuja · 2012 · International Journal of Cancer
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Savvas Petanidis, Margarita Hadzopoulou‐Cladaras, Athanasios Salifoglou · 2013 · Journal of Inorganic Biochemistry
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K. Moriya, Takuya Tsubota, N. Ishibashi, A. Yafune, Takashi Suzuki, J. Kobayashi, Takahiro Shiotsuki, Toshihiko Utsumi · 2009 · Insect Molecular Biology
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Sook In Chung, Hyuk Moon, Hye-Lim Ju, Dae Yeong Kim, Kyung Joo Cho, Silvia Ribback, Frank Dombrowski, Diego Francesco Calvisi, Simon Weonsang Ro · 2016 · Oncotarget
Nucleotide Binding Affects Intrinsic Dynamics and Structural Communication in Ras GTPases
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Jing Wang, Xiaoqian Leng, Guiping Wang, Xiaoyang Wan, Hong Cao · 2017 · Scientific Reports
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Yifan Duan, Dongfeng Li, Yan‐Hui Liu, Ping Mei, Yuxuan Qin, Liangfang Li, Qiu‐Xiong Lin, Zijun Li · 2013 · Hepatobiliary & pancreatic diseases international
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Hong Chen, Jiyi Zhao, Xuchen Qian, Zhengyuan Cheng, Yang Liu, Zhi Wang · 2015 · Asian Pacific Journal of Cancer Prevention
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Brantley Coleman, Irini Topalidou, Michael Ailion · 2018 · Genetics
Identification of lysine methylation in the core GTPase domain by GoMADScan
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An Activating Mutation in ERK Causes Hyperplastic Tumors in a scribble Mutant Tissue in Drosophila
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Functional Specificity of the Members of the Sos Family of Ras-GEF Activators: Novel Role of Sos2 in Control of Epidermal Stem Cell Homeostasis
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Rebecca D. Dodd · 2015 · Cancer
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A comparative survey of functional footprints of EGFR pathway mutations in human cancers
Adam Lane, Aldo Segura‐Cabrera, Kakajan Komurov · 2013 · Oncogene
Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets
Matthias Drosten, Mariano Barbacid · 2015 · Journal of Molecular Medicine
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Peng Liu, Ziwen Lu, Yanfang Wu, Dongsheng Shang, Zhicong Zhao, Yanting Shen, Yafei Zhang, Feifei Zhu, Hanqing Liu, Zhigang Tu · 2018 · Current Cancer Drug Targets
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Lipid raft protein flotillin‐1 is important for the interaction between SOS1 and H‐Ras / K‐Ras , leading to Ras activation
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Pei‐Shan Wang, Jing Wang, Yi Zheng, Catherine J. Pallen · 2012 · Journal of Biological Chemistry
Cis-acting elements in its 3′ UTR mediate post-transcriptional regulation ofKRAS
Minlee Kim, Nicole Kogan, Frank John Slack · 2016 · Oncotarget
H-Ras Isoform Mediates Protection Against Pressure Overload–Induced Cardiac Dysfunction in Part Through Activation of AKT
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