Cited by 1,467Protein Kinase Regulation and GTPase SignalingProtein Tyrosine PhosphatasesCellular transport and secretion

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Ras oncogenes: split personalities

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Karnoub, Antoine E., Weinberg, Robert A.·2008·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm2438PMC PMC3915522

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Abstract

Extensive research on the Ras proteins and their functions in cell physiology over the past 30 years has led to numerous insights that have revealed the involvement of Ras not only in tumorigenesis but also in many developmental disorders. Despite great strides in our understanding of the molecular and cellular mechanisms of action of the Ras proteins, the expanding roster of their downstream effectors and the complexity of the signalling cascades that they regulate indicate that much remains to be learnt.

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Authors: Karnoub, A. E., & Weinberg, R. A.
Affiliations: Whitehead Institute for Biomedical Research (US)
ORCID: Karnoub, Antoine E.
Weinberg, Robert A.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2008-07
Volume: 9
Issue: 7
Pages: 517-531
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2438
PMC: PMC3915522
OpenAlex: W2004774286
Cited by: 1,467
References: 234
Citations by year: 2026: 28 · 2025: 48 · 2024: 58 · 2023: 60 · 2022: 67 · 2021: 89 · 2020: 74 · 2019: 87 · 2018: 93 · 2017: 95 · 2016: 103 · 2015: 118 · 2014: 100 · 2013: 108 · 2012: 94
FWCI: 6.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P01 CA08111, U54 CA12515, P01CA080111, P50CA089393)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: oncogenic Ras, carcinogenesis, developmental disorders, downstream effectors, cell physiology, Ras proteins
MeSH terms: Amino Acid Sequence, Animals, Cell Transformation, Neoplastic, DNA-Binding Proteins, Enzyme Activation, Gene Expression Regulation, Humans, Models, Molecular, Molecular Sequence Data, Phylogeny, Protein Conformation, Protein Processing, Post-Translational, Genes, ras, Transcription Factors, Signal Transduction, Sequence Alignment, ras Proteins, Phosphatidylinositol 3-Kinases, GTPase-Activating Proteins, Mitogen-Activated Protein Kinases

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