Ras oncogenes: split personalities

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G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

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Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

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Creation of human tumour cells with defined genetic elements

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Phosphatidylinositol-3-OH kinase direct target of Ras

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Mammalian Ras interacts directly with the serine/threonine kinase raf

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

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The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

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Ras functional proximity proteomics establishes mTORC2 as new direct ras effector

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Proximal Protein Interaction Landscape of RAS Paralogs

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Resistance to Cetuximab in EGFR-Overexpressing Esophageal Squamous Cell Carcinoma Xenografts Due to FGFR2 Amplification and Overexpression

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In vivo and in vitro expression of the RASAL1 gene in human gastric adenocarcinoma and its clinicopathological significance

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Reduced HRASG12V-Driven Tumorigenesis of Cell Lines Expressing KRASC118S

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PRG3 induces Ras-dependent oncogenic cooperation in gliomas

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Informing materials: drugs as tools for exploring cancer mechanisms and pathways

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Genetic analysis of Ras genes in epidermal development and tumorigenesis

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Endocrinology and metabolism 2011

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Cytoplasmic Protein Serine/Threonine Kinases

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Bimodality in Ras signaling originates from processivity of the Ras activator SOS without deterministic bistability

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Inhibition and degradation of NRAS with a pan-NRAS monobody

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Integrative genomic approaches to understanding cancer

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Outcome analysis of Phase I trial patients with metastaticKRASand/orTP53mutant non-small cell lung cancer

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Possible predisposition for colorectal carcinogenesis due to altered gene expressions in normal appearing mucosa from patients with colorectal neoplasia

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Blockade of PD-L1/PD-1 signaling promotes osteo-/odontogenic differentiation through Ras activation

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Assessing Long Non-coding RNAs in Tobacco-associated Oral Cancer

Sehgal, S., Mishra, M. K., Gupta, S., & Shivangi (2022) · Current Cancer Drug Targets · doi:10.2174/1568009622666220623115234 · Cited by 11

Combining single-cell RNA sequencing data and transcriptomic data to unravel potential mechanisms and signature genes of the progression of idiopathic pulmonary fibrosis to lung adenocarcinoma and predict therapeutic agents

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MicroRNA‐Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer

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MK2 Regulates Ras Oncogenesis through Stimulating ROS Production

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CDK2 knockdown enhances head and neck cancer cell radiosensitivity

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Oncogenes and Signal Transduction

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Platform-Independent Genome-Wide Pattern of DNA Copy-Number Alterations Predicting Astrocytoma Survival and Response to Treatment Revealed by the GSVD Formulated as a Comparative Spectral Decomposition

Aiello, K. A., & Alter, O. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164546 · Cited by 11

Association between the KRAS Gene Polymorphisms and Papillary Thyroid Carcinoma in a Chinese Han Population

Ning, L., Rao, W., Yu, Y., Liu, X., Pan, Y., Ma, Y., Liu, R., Zhang, S., Sun, H., & Yu, Q. (2016) · Journal of Cancer · doi:10.7150/jca.16507 · Cited by 11

A phase I study of the farnesyltransferase inhibitor Tipifarnib in combination with the epidermal growth factor tyrosine kinase inhibitor Erlotinib in patients with advanced solid tumors

Jazieh, K., Molina, J. R., Allred, J. B., Yin, J., Reid, J. M., Goetz, M. P., Lim, V.-S., Kaufmann, S. H., & Adjei, A. A. (2018) · Investigational New Drugs · doi:10.1007/s10637-018-0662-1 · Cited by 11

EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells

Chen, Y., Lv, H., Shen, N., Wang, X., Tang, S., Xiong, B., Ding, J., Geng, M., & Huang, M. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0268-y · Cited by 11

Beyond the Genomic Mutation: Rethinking the Molecular Biomarkers of K-RAS Dependency in Pancreatic Cancers

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PLPP/CIN-mediated NF2-serine 10 dephosphorylation regulates F-actin stability and Mdm2 degradation in an activity-dependent manner

Kim, J., Lee, D.-S., Kim, T. H., Park, H., Kim, M.-J., & Kang, T. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03325-9 · Cited by 11

Pan RAS-binding compounds selected from a chemical library by inhibiting interaction between RAS and a reduced affinity intracellular antibody

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Self-assemblies of Rab- and Arf-family small GTPases on lipid bilayers in membrane tethering

Mima, J. (2021) · Biophysical Reviews · doi:10.1007/s12551-021-00819-4 · Cited by 11

Protein–Protein Interaction Inhibitors: Case Studies on Small Molecules and Natural Compounds

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Total synthesis of the natural isoprenylcysteine carboxyl methyltransferase inhibitor spermatinamine

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Degradation of Activated K-Ras Orthologue via K-Ras-specific Lysine Residues Is Required for Cytokinesis

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Reduced expression of SynGAP, a neuronal GTPase-activating protein, enhances capsaicin-induced peripheral sensitization

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Impact of RAS/RAF mutations on clinical and prognostic outcomes in metastatic colorectal cancer

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Ras effector switching as a developmental strategy

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Early-stage structure-based drug discovery for small GTPases by NMR spectroscopy

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Construction of a prognostic immune-related lncRNA model and identification of the immune microenvironment in middle- or advanced-stage lung squamous carcinoma patients

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Role of Host Small GTPases in Apicomplexan Parasite Infection

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Live-Cell Microscopy Reveals Small Molecule Inhibitor Effects on MAPK Pathway Dynamics

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Molecular genetics of lung cancer

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Regulation of the Small GTPase Ras and Its Relevance to Human Disease

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Structural and utational nalysis of ember-pecific STAT unctions

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Ras Multimers on the Membrane: Many Ways for a Heart-to-Heart Conversation

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Cardiac rehabilitation in coronary artery bypass grafting patients: Effect of eight weeks of moderate-intensity continuous training versus high-intensity interval training

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Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasm of the Pancreas

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Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer

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Histone demethylase Jmjd3 modulates osteoblast apoptosis induced by tumor necrosis factor-alpha through directly targeting RASSF5

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Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo

Sawyer, J. K., Kabiri, Z., Montague, R. A., Allen, S. R., Stewart, R. K., Paramore, S. V., Cohen, E., Zaribafzadeh, H., Counter, C. M., & Fox, D. T. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009228 · Cited by 11

Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant

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Adipose-derived mesenchymal stem cells may reduce intestinal epithelial damage in ulcerative colitis by communicating with macrophages and blocking inflammatory pathways: an analysis in silico

Zhang, N., Chen, Y., Huang, C., Wei, M., Li, T., Lv, Y., Song, Q., & Mo, S. (2022) · Aging · doi:10.18632/aging.203964 · Cited by 10

Capturing ctDNA from Unaltered Stationary and Flowing Plasma with dCas9

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Emerging genetic biomarkers in lung adenocarcinoma

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The switch states of the GDP-bound HRAS affected by point mutations: a study from Gaussian accelerated molecular dynamics simulations and free energy landscapes

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RASAL2: Wrestling in the Combat of Ras Activation

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A mechanism of catalyzed GTP hydrolysis by Ras protein through magnesium ion

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Characterisation of HRas local signal transduction networks using engineered site-specific exchange factors

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ST2 gene products critically contribute to cellular transformation caused by an oncogenic Ras mutant

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What drives the clustering of membrane-bound Ras?

Li, Z., & Gorfe, A. A. (2012) · Small GTPases · doi:10.4161/sgtp.21829 · Cited by 10

Growth Signaling Networks Orchestrate Cancer Metabolic NetworksPreprint

Manning, B. D., & Dibble, C. C. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041543 · Cited by 11

Signaling Lipids

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_2 · Cited by 9

KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development

Tinsley, S. L., Chianis, E. R. D., Shelley, R. A., Mall, G. K., Dhiman, A., Baral, G., Kothandaraman, H., Thoma, M. C., English, I. A., Daniel, C. J., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03196-w · Cited by 9

ECM stiffness regulates lung fibroblast survival through RasGRF1-dependent signaling

Monaghan-Benson, E., Aureille, J., & Guilluy, C. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108161 · Cited by 9

Mutation Analysis of TMB ‐High Colorectal Cancer: Insights Into Molecular Pathways and Clinical Implications

Chikaishi, Y., Matsuoka, H., Sugihara, E., Takeda, M., Sumitomo, M., Yamada, S., Inaguma, G., Omura, Y., Cheong, Y., Kobayashi, Y., et al. (2025) · Cancer Science · doi:10.1111/cas.16455 · Cited by 11

Nucleic acid-based reference materials: A “ruler” for precision molecular diagnostics

Li, K., Guo, Y., Qi, X., Li, F., Li, F., Yang, M., Zhou, J., Zhou, H., Liu, G., & Li, L. (2025) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2025.118268 · Cited by 9

Protein–protein interactions of ASPP2: an emerging therapeutic target

Iosub‐Amir, A., & Friedler, A. (2014) · MedChemComm · doi:10.1039/c4md00147h · Cited by 9

Emerging Target Families: Intractable Targets

Knapp, S. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_28 · Cited by 9

Lung Cancer Genomics in the Era of Accelerated Targeted Drug Development

Wijesinghe, P., & Bollig-Fischer, A. B. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-24932-2_1 · Cited by 9

In‐silico identification of small molecules targeting H‐Ras and in‐vitro cytotoxicity with caspase‐mediated apoptosis in carcinoma cells

Shah, H. D., Saranath, D., Das, S., Kharkar, P. S., & Karande, A. A. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27836 · Cited by 9

Hyperactive HRAS dysregulates energetic metabolism in fibroblasts from patients with Costello syndrome via enhanced production of reactive oxidizing species

Carpentieri, G., Leoni, C., Pietraforte, D., Cecchetti, S., Iorio, E., Belardo, A., Pietrucci, D., Nottia, M. D., Pajalunga, D., Megiorni, F., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab270 · Cited by 9

Retroviral Antisense Transcripts and Genes: 33 Years after First Predicted, a Silent Retroviral Revolution?

Miller, R., Zimmer, A., Moutot, G., Mesnard, J.-M., & Chazal, N. (2021) · Viruses · doi:10.3390/v13112221 · Cited by 11

HRAS Q61L Mutation as a Possible Target for Non-Small Cell Lung Cancer: Case Series and Review of Literature

Mathiot, L., Herbreteau, G., Robin, S., Fenat, C., Bennouna, J., Blanquart, C., Denis, M. G., & Tostivint, E. P. (2022) · Current Oncology · doi:10.3390/curroncol29050300 · Cited by 9

The Nanotechnology-Based Approaches against Kirsten Rat Sarcoma-Mutated Cancers

Andrade, F., German-Cortés, J., Montero, S., Carcavilla, P., Baranda-Martínez-Abascal, D., Moltó‐Abad, M., Seras‐Franzoso, J., Díaz‐Riascos, Z. V., Rafael, D. F. D. S., & Abasolo, I. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061686 · Cited by 9

Conformational ensemble-dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases

Araya, M. K., & Gorfe, A. A. (2023) · Communications Biology · doi:10.1038/s42003-023-05487-6 · Cited by 9

Combined targeting of EGFR/HER promotes anti-tumor efficacy in subsets of KRAS mutant lung cancer resistant to single EGFR blockade

Umelo, I. A., Wever, O. D., Kronenberger, P., Deun, J. V., Noor, A., Singh, K., Teugels, E., Chen, G., Bracke, M., & Grève, J. D. (2015) · Oncotarget · doi:10.18632/oncotarget.3853 · Cited by 9

Krüppel‐like factor 6 interferes with cellular transformation induced by the H‐ ras oncogene

Trucco, L. D., Andreoli, V., Núñez, N. G., Maccioni, M., & Bocco, J. L. (2014) · The FASEB Journal · doi:10.1096/fj.14-251884 · Cited by 9

Post-Transcriptional Regulation of Connexin43 in H-Ras-Transformed Cells

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NMR Study to Identify a Ligand-Binding Pocket in Ras

Maurer, T., & Wang, W. (2013) · The Enzymes · doi:10.1016/b978-0-12-416749-0.00002-6 · Cited by 9

Docking optimization, variance and promiscuity for large-scale drug-like chemical space using high performance computing architectures

Trager, R. E., Giblock, P., Soltani, S., Upadhyay, A. A., Rekapalli, B., & Peterson, Y. K. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.06.023 · Cited by 9

The Inhibitory NKR-P1B:Clr-b Recognition Axis Facilitates Detection of Oncogenic Transformation and Cancer Immunosurveillance

Tanaka, M., Fine, J. H., Kirkham, C. L., Aguilar, O. A., Belcheva, A., Martín, A., Ketela, T. W., Moffat, J., Allan, D., & Carlyle, J. R. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-1688 · Cited by 9

Crystal structure and function of Rbj: A constitutively GTP-bound small G protein with an extra DnaJ domain

Gao, Z., Xing, K., Zhang, C., Qi, J., Wang, L., Gao, S., & Lai, R. (2019) · Protein & Cell · doi:10.1007/s13238-019-0622-3 · Cited by 9

Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescence

Ito, T., & Igaki, T. (2021) · Science Signaling · doi:10.1126/scisignal.aaz3578 · Cited by 10

Conformational SERS Classification of K‐Ras Point Mutations for Cancer Diagnostics

Morlà‐Folch, J., Gisbert‐Quilis, P., Masetti, M., García‐Rico, E., Álvarez‐Puebla, R. A., & Guerrini, L. (2017) · Angewandte Chemie · doi:10.1002/ange.201611243 · Cited by 9

Increased osteoclastogenesis contributes to bone loss in the Costello syndrome Hras G12V mouse model

Nandi, S., Chennappan, S., Andrasch, Y., Fidan, M., Engler, M., Ahmad, M., Tuckermann, J. P., Zenker, M., & Cirstea, I. C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1000575 · Cited by 10

Doxycycline enhances the Ras‐MAPK signaling and proliferation of mouse thymic epithelial cells

Chen, X., Xia, S., Li, R., Liu, H., Huang, Y., Qian, X., Xiao, X., Xu, X., Lin, X., Tian, Y., et al. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22147 · Cited by 9

Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation

Ikonomou, G., Kostourou, V., Shirasawa, S., Sasazuki, T., Samiotaki, M. K., & Panayotou, G. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.06.038 · Cited by 9

Synthetic Lethal Genetic Screens in Ras Mutant Cancers

Yu, B., & Luo, J. (2013) · The Enzymes · doi:10.1016/b978-0-12-420146-0.00009-3 · Cited by 9

Multiple mechanisms involved in a low concentration of FL118 enhancement of AMR-MeOAc to induce pancreatic cancer cell apoptosis and growth inhibition.

Rabi, T., & Li, F. (2018) · Europe PMC (PubMed Central) · Cited by 9

PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes

Anta, B., Pérez-Rodríguez, A., Castro, J. P., Domínguez, C. A. G., Ibiza, S., Martínez, N., Dura, L. M., Hernandez, S. F., Gragera, T., Peña-Jiménez, D., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.219 · Cited by 9

Busy traveling Ras

Cheng, C.-M., & Chang, E. C. (2011) · Cell Cycle · doi:10.4161/cc.10.8.15259 · Cited by 9

The Abundance of KRAS and RAS Gene Mutations in Cancer

Stites, E. C. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3822-4_2 · Cited by 8

Simultaneous targeted delivery of doxorubicin and KRAS suppression by a hybrid molecule containing miR-143 and AS1411 aptamer

Laowichuwakonnukul, K., Soontornworajit, B., Arunpanichlert, J., & Rotkrua, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-94159-y · Cited by 8

Cytoplasmic Protein Tyrosine Kinases

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_4 · Cited by 8

BRAF and MEK Gene Rearrangements in Melanoma: Implications for Targeted Therapy

Madureira, P., & de Mello, R. A. (2014) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-013-0081-0 · Cited by 8

KRAS-targeted therapy in the treatment of non-small cell lung cancer

Yun, J., Nakagawa, R., & Tham, K. W. (2022) · Journal of Oncology Pharmacy Practice · doi:10.1177/10781552221118848 · Cited by 10

Comparative Transcriptome Analysis of Babesia bigemina Attenuated Vaccine and Virulent Strains of Mexican Origin

Santamaria-Espinosa, R. M., Estrada, K., López, M. E., Rojas, E., Martínez-García, G., Alcalá-Canto, Y., Rojas-Martínez, C., Álvarez, J. A., Lira-Amaya, J. J., Espinosa, T. V. S., et al. (2024) · Vaccines · doi:10.3390/vaccines12030309 · Cited by 8

MEK inhibitors in oncology: a patent review and update (2016 – present)

Suryavanshi, A., Vandana, Shukla, Y. K., Kumar, V., Gupta, P., Asati, V., Mahapatra, D. K., Keservani, R. K., Jain, S. K., & Bharti, S. K. (2024) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2024.2403634 · Cited by 8

From Protein Communication to Drug Discovery

Persico, M., Dato, A. D., Orteca, N., Fattorusso, C., Novellino, E., Andreoli, M., & Ferlini, C. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150519102257 · Cited by 8

Structural basis for intramolecular interaction of post‐translationally modified H‐Ras• GTP prepared by protein ligation

Ke, H., Matsumoto, S., Murashima, Y., Taniguchi‐Tamura, H., Miyamoto, R., Yoshikawa, Y., Tsuda, C., Kumasaka, T., Mizohata, E., Edamatsu, H., et al. (2017) · FEBS Letters · doi:10.1002/1873-3468.12759 · Cited by 8

Comparative MD simulations and advanced analytics based studies on wild-type and hot-spot mutant A59G HRas

Sharma, N., Sonavane, U., & Joshi, R. (2020) · PLOS ONE · doi:10.1371/journal.pone.0234836 · Cited by 7

Deregulated Ras signaling in developmental disorders: new tricks for an old dog

Schubbert, S., Bollag, G. E., & Shannon, K. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.12.004 · Cited by 117

RESEARCH CHALLENGES IN STAGE III AND IV RAS-ASSOCIATED CANCERS: A Narrative Review of the Complexities and Functions of the Family of RAS Genes and Ras Proteins in Housekeeping and Tumorigenesis

McDonald, R. A., Varela-Ramı́rez, A., & Ashley, A. K. (2025) · Biology · doi:10.3390/biology14080936 · Cited by 2

Abstract IA16: RASopathies: the other face of RAS signaling upregulation

Tartaglia, M. (2023) · Molecular Cancer Research · doi:10.1158/1557-3125.ras23-ia16

Hyperactive Ras in developmental disorders and cancer

Schubbert, S., Shannon, K., & Bollag, G. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2109 · Cited by 1,583

Ras in Cancer and Developmental Diseases

Fernández‐Medarde, A., & Santos, E. (2011) · Genes & Cancer · doi:10.1177/1947601911411084 · Cited by 1,001