Ras oncogenes: split personalities
DOI 10.1038/nrm2438
Cited by (1,000)
Items 601–700 of 1,000
- KRAS Codon 12 Mutation is Associated with More Aggressive Invasiveness in Synchronous Metastatic Colorectal Cancer (mCRC): Retrospective ResearchKang He, Yajing Wang, Yuejiao Zhong, Xiaohua Pan, Lixiang Si, Jianwei Lu · 2020 · OncoTargets and Therapy
- Small-Molecule RAS Inhibitors as Anticancer Agents: Discovery, Development, and Mechanistic StudiesShaila A. Shetu, Debasish Bandyopadhyay · 2022 · International Journal of Molecular Sciences
- Targeting oncogenic KRAS in non-small cell lung cancer with EGFR aptamer-conjugated multifunctional RNA nanoparticlesLinlin Yang, Zhefeng Li, Daniel W. Binzel, Peixuan Guo, Terence Marques Williams · 2023 · Molecular Therapy — Nucleic Acids
- Computational allosteric ligand binding site identification on Ras proteinsMichael J. McCarthy, Priyanka Prakash, Alemayehu Abebe Gorfe · 2015 · Acta Biochimica et Biophysica Sinica
- κB-Ras Is a Nuclear-Cytoplasmic Small GTPase That Inhibits NF-κB Activation through the Suppression of Transcriptional Activation of p65/RelAKenji Tago, Megumi Funakoshi‐Tago, Masaki Sakinawa, Norikazu Mizuno, Hiroshi Itoh · 2010 · Journal of Biological Chemistry
- RASAL1 influences the proliferation and invasion of gastric cancer cells by regulating the RAS/ERK signaling pathwayHong Chen, Zhengyuan Cheng, Ying Pan, Zhi Wang, Yang Liu, Jin-Qi Zhang · 2014 · Human Cell
- Transforming growth factor-beta signaling network regulates plasticity and lineage commitment of lung cancer cellsIrene Ischenko, J Liu, Oleksi Petrenko, Michael J. Hayman · 2014 · Cell Death and Differentiation
- Novel Candidate Key Drivers in the Integrative Network of Genes, MicroRNAs, Methylations, and Copy Number Variations in Squamous Cell Lung CarcinomaTao Huang, Yang Jing, Yu‐Dong Cai · 2015 · BioMed Research International
- K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomasWei Feng, Yan Liu, Anita C. Bellail, Jeffrey J. Olson, Shi Yong Sun, Guoyue Lu, Lijuan Ding, Changji Yuan, Guangyi Wang, Chunhai Hao · 2012 · Cancer Letters
- Noonan syndrome‐like disorder with loose anagen hair: A second case with neuroblastomaLivia Garavelli, Viviana Cordeddu, Stefania Errico, Patrizia Bertolini, Maria Elisabeth Street, Simonetta Rosato, Marzia Pollazzon, Anita Wischmeijer, Ivan P. Ivanovski, Paola Daniele et al. · 2015 · American Journal of Medical Genetics Part A
- Mixed-Probe Simulation and Probe-Derived Surface Topography Map Analysis for Ligand Binding Site IdentificationAbdallah Sayyed–Ahmad, Alemayehu Abebe Gorfe · 2017 · Journal of Chemical Theory and Computation
- Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3Sung Yong Ahn, Ji Hye Yang, Nam Hee Kim, Kyungro Lee, Yong Hoon Cha, Jun Seop Yun, Hee Eun Kang, Yoonmi Lee, Jiwon Choi, Hyun Sil Kim et al. · 2017 · Oncotarget
- K-ras Mutations as the Earliest Driving Force in a Subset of Colorectal CarcinomasNikolaos Margetis, Myrsini Kouloukoussa, KYRIAKI PAVLOU, Spyridon Vrakas, Theodoros D. Mariolis-Sapsakos · 2017 · In Vivo
- Targeting autophagy with small molecules for cancer therapySree Karani Kondapuram, Sailu Sarvagalla, Mohane Selvaraj Coumar · 2019 · Journal of Cancer Metastasis and Treatment
- New druggable targets in the Ras pathway?David Matallanas, Piero Crespo · 2010 · PubMed
- AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancerYe, Hua, Liu, Yi, Wu, Kefeng, Luo, Hui, Cui, Liao · 2020 · Cell Communication and Signaling
- Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signallingShu-Ping Song, Anne Hennig, Katja Schubert, Robby Markwart, Philipp Schmidt, Ian A. Prior, Frank-Dietmar Böhmer, Ignacio Rubio · 2013 · Biochemical Journal
- Signal transduction pathway mutations in gastrointestinal (GI) cancers: a systematic review and meta-analysisAlireza Tabibzadeh, Fahimeh Safarnezhad Tameshkel, Yousef Moradi, Saber Soltani, Maziar Moradi‐Lakeh, Gholam Hossein Ashrafi, Nima Motamed, Farhad Zamani, Seyed Abbas Motevalian, Mahshid Panahi et al. · 2020 · Scientific Reports
- A CRISPR-Cas9 repressor for epigenetic silencing of KRASJingwen Liu, Meiyan Sun, Kwang Bog Cho, Xiang Gao, Bin Guo · 2020 · Pharmacological Research
- GINS1 Induced Sorafenib Resistance by Promoting Cancer Stem Properties in Human Hepatocellular Cancer CellsSheng Li, Lina Wu, Hong Zhang, Xijuan Liu, Zilei Wang, Bin Dong, Guang Cao · 2021 · Frontiers in Cell and Developmental Biology
- Cyclin‐dependent kinases as therapeutic targets in melanomaDavid Michael Miller, Keith T. Flaherty · 2014 · Pigment Cell & Melanoma Research
- Ras and Rheb Signaling in Survival and Cell DeathAnja Ehrkamp, Christian Herrmann, Raphael Stoll, Rolf Heumann · 2013 · Cancers
- Combined treatment with bexarotene and rosuvastatin reduces angiotensin‐ II ‐induced abdominal aortic aneurysm in apo E −/− mice and angiogenesisP. Escudero, A Navarro, Carlos Ferrando, Elena Furió, Herminia González Navarro, Marina Juez, María‐Jesús Sanz, Laura Piqueras · 2015 · British Journal of Pharmacology
- LvRas and LvRap are both important for WSSV replication in Litopenaeus vannameiYi-Ting Tseng, Ramya Kumar, Han‐Ching Wang · 2019 · Fish & Shellfish Immunology
- Insights into the classification of small GTPasesDominik Heider, Hauke, Pyka, Keßler · 2010 · Advances and Applications in Bioinformatics and Chemistry
- Decreased bone mineral density in Costello syndromeChiara Leoni, David A. Stevenson, Lucilla Martini, Roberto De Sanctis, Giovanna Mascolo, Francesca Pantaleoni, Sara De Santis, Ilaria La Torraca, Silvia Persichilli, Paolo Caradonna et al. · 2013 · Molecular Genetics and Metabolism
- In Vivo Regulation of TGF-β by R-Ras2 Revealed through Loss of the RasGAP Protein NF1Deanna M. Patmore, Sara Welch, Patricia C. Fulkerson, Jianqiang Wu, Kwangmin Choi, David W. Eaves, Jennifer J. Kordich, Margaret H. Collins, Timothy P. Cripe, Nancy Ratner · 2012 · Cancer Research
- Current status of the development of Ras inhibitorsFumi Shima, Shigeyuki Matsumoto, Yoko Yoshikawa, Takashi Kawamura, Masayuki Isa, Tohru Kataoka · 2015 · The Journal of Biochemistry
- MicroRNA-630 suppresses epithelial-to-mesenchymal transition by regulating FoxM1 in gastric cancer cellsJing Feng, Xiaojuan Wang, Weihua Zhu, Si Chen, Changwei Feng · 2017 · Biochemistry (Moscow)
- Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85α Regulatory Subunit of PI3Kα: Implication for PI3Kα Activation by CalmodulinDuan Ni, Dingyu Liu, Jian Zhang, Shaoyong Lu · 2018 · International Journal of Molecular Sciences
- TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancerAnastasios Ntavatzikos, Aris Spathis, Paul Patapis, Nikolaos Machairas, Georgia Vourli, George Peros, Iordanis N. Papadopoulos, Ioannis G Panayiotides, Anna A. Koumarianou · 2019 · World Journal of Gastrointestinal Oncology
- Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related DiseasesMisa Belser, David W. Walker · 2021 · Frontiers in Genetics
- Probing mutation-induced conformational transformation of the GTP/M-RAS complex through Gaussian accelerated molecular dynamics simulationsHuayin Bao, Wei Wang, Haibo Sun, Jianzhong Chen · 2023 · Journal of Enzyme Inhibition and Medicinal Chemistry
- Translating biology into clinic: the case of glioblastomaMaria Maddalena Lino, Adrian Merlo · 2009 · Current Opinion in Cell Biology
- Cancer therapy targeted at cellular signal transduction mechanisms: Strategies, clinical results, and unresolved issuesThoralf Christoffersen, Tormod Kyrre Guren, Karen‐Lise Garm Spindler, Olav Dahl, Per Eystein Lønning, Bjørn Tore Gjertsen · 2009 · European Journal of Pharmacology
- H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory SequencesMatthias Drosten, Lucía Simón-Carrasco, Isabel Hernández-Porras, Carmen G. Lechuga, María Teresa Blasco, Harrys K.C. Jacob, Salvatore Fabbiano, Nicoletta Potenza, Xosé R. Bustelo, Carmen E. Guerra et al. · 2016 · Cancer Research
- A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamicsJohn C. Rose, Po‐Ssu Huang, Nathan D. Camp, Jordan Ye, Andrew M. Leidal, Inna Goreshnik, Bridget M. Trevillian, Miles Sasha Dickinson, Daniel Cunningham‐Bryant, Jayanta Debnath et al. · 2016 · Nature Chemical Biology
- Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancerTakatoshi Fujishita, Tatsuro Okamoto, Takaki Akamine, Shinkichi Takamori, Kazuki Takada, Masakazu Katsura, Gouji Toyokawa, Fumihiro Shoji, Mototsugu Shimokawa, Yoshinao Oda et al. · 2017 · Lung Cancer
- MISTIC2: comprehensive server to study coevolution in protein familiesEloy A Colell, Javier Iserte, Franco L. Simonetti, Cristina Marino‐Buslje · 2018 · Nucleic Acids Research
- Molecular characterization and biomarker identification in colorectal cancer: Toward realization of the precision medicine dreamGaurav Goel · 2018 · Cancer Management and Research
- Proof of concept for poor inhibitor binding and efficient formation of covalent adducts of KRAS G12C and ARS compoundsMaria G. Khrenova, Anna M. Kulakova, Alexander V. Nemukhin · 2020 · Organic & Biomolecular Chemistry
- Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discoveryGyula Pálfy, Dóra K. Menyhárd, András Perczel · 2020 · Cancer and Metastasis Reviews
- Gene-expression profiles in lung adenocarcinomas related to chronic wood smoke or tobacco exposureAlette Ortega-Gómez, Claudia Rangel‐Escareño, Camilo Molina-Romero, Eleazar Omar Macedo-Pérez, Alejandro Avilés‐Salas, Alejandra Lara-García, Gerardo J. Alanis-Funes, Rubén Rodríguez‐Bautista, Alfredo Hidalgo‐Miranda, Oscar G. Arrieta · 2016 · Respiratory Research
- Advances in the treatment of KRASG12C mutant non–small cell lung cancerKhvaramze Shaverdashvili, Timothy Francis Burns · 2025 · Cancer
- Inhibiting the RAS–PI3K Pathway in Cancer TherapyClare Sheridan, Julian Downward · 2013 · The Enzymes
- Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteinsYuan Zhang, Zhihua Wang, Xiaoyao Ma, Shengnan Yang, Xueyan Hu, Jin Tao, Yuanyuan Hou, Gang Bai · 2018 · Acta Pharmaceutica Sinica B
- Regulation of HMGA2 and KRAS genes in epithelial ovarian cancer by miRNA hsa-let-7d-3pTuba Günel, Berkcan Doğan, Ece Gümüşoğlu-Acar, Mohammad Kazem Hosseini, Samet Topuz, Kılıç Aydinli · 2019 · Journal of Cancer Research and Therapeutics
- Targeting RAS-RAF pathway significantly improves antitumor activity of Rigosertib-derived platinum(IV) complexes and overcomes cisplatin resistanceZhikun Liu, Meng Wang, Heng‐Shan Wang, Lei Fang, Shaohua Gou · 2020 · European Journal of Medicinal Chemistry
- AGO2 promotes tumor progression in KRAS-driven mouse models of non–small cell lung cancerJean Ching-Yi Tien, Seema Chugh, Andrew E. Goodrum, Yunhui Cheng, Rahul Mannan, Yuping Zhang, Lisha Wang, Vijaya L. Dommeti, Xiaoming Wang, Alice Xu et al. · 2021 · Proceedings of the National Academy of Sciences
- Realgar‑induced KRAS mutation lung cancer cell death via KRAS/Raf/MAPK mediates ferroptosisXiaofeng Liu, Yang Hai, Jinqu Dong, Lan Xu, Wenqian Hou, Jing Su, Weiyu Ren, Dongling Liu · 2022 · International Journal of Oncology
- Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancerXiao-Mei Qi, Congying Xie, Songwang Hou, Gang Li, Ning B. Yin, Lei Dong, Adrienne Lepp, Marla A. Chesnik, Shama P. Mirza, Anikó Szabó et al. · 2014 · Oncotarget
- Interferon-β Signaling Contributes to Ras TransformationYu‐Chen Tsai, Sidney Pestka, Lu‐Hai Wang, Loren Warren Runnels, Shan Wan, Yi Lisa Lyu, Leroy F. Liu · 2011 · PLoS ONE
- Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in KRAS -Mutant Cancer CellsJohanna Erber, Joachim David Steiner, Jörg Isensee, Leonard A. Lobbes, André Toschka, Filippo Beleggia, Anna Schmitt, Rainer W. J. Kaiser, Florian Siedek, Thorsten Persigehl et al. · 2019 · Cancer Research
- Benzo[a]pyrene at human blood equivalent level induces human lung epithelial cell invasion and migration via aryl hydrocarbon receptor signalingHan Gao, Guozhu Ye, Yi Lin, Yulang Chi, Sijun Dong · 2020 · Journal of Applied Toxicology
- Ras, Rac1, and phosphatidylinositol-3-kinase (PI3K) signaling in nitric oxide induced endothelial cell migrationRoberta Eller Borges, Wagner Luiz Batista, Paulo Eduardo da Costa, Rita Tokikawa, Marli F. Curcio, Scheilla Teixeira Strumillo, Adriano Sartori, Miriam Santos de Moraes, Graciele Almeida de Oliveira, Murched Omar Taha et al. · 2015 · Nitric Oxide
- Targeting signaling pathways with andrographolide in cancer therapy (Review)Nur Shahirah Shaharudin, Gurmeet Kaur Surindar Singh, Teh Kek, Sadia Sultan · 2024 · Molecular and Clinical Oncology
- Monitoring the Waiting Time Sequence of Single Ras GTPase Activation Events Using Liposome Functionalized Zero-Mode WaveguidesSune M. Christensen, Meredith Gahn Triplet, Christopher Rhodes, Jeffrey S. Iwig, Hsiung‐Lin Tu, Dimitrios G. Stamou, Jay T. Groves · 2016 · Nano Letters
- A Survey of Computational Treatments of Biomolecules by Robotics-Inspired Methods Modeling Equilibrium Structure and DynamicAmarda Shehu, Erion Plaku · 2016 · Journal of Artificial Intelligence Research
- KRAS G12C fragment screening renders new binding pocketsMagali Mathieu, Valérie Steier, Florence Fassy, Cécile Delorme, David Papin, Bruno Genêt, Francis Duffieux, Thomas Bertrand, Laure Delarbre, Hélène Le-Borgne et al. · 2021 · Small GTPases
- Inhibition of Ras Signaling by Blocking Ras–Effector Interactions with Cyclic PeptidesPunit Upadhyaya, Ziqing Qian, Nicholas G. Selner, Sarah R. Clippinger, Zhengrong Wu, Roger Briesewitz, Dehua Pei · 2015 · Angewandte Chemie
- The down-regulation of GNAO1 and its promoting role in hepatocellular carcinomaXiaoyu Pei, Jun Zhang, Lijun Wu, Bin Lü, Xiaojiao Zhang, Dongqin Yang, Jie Liu · 2013 · Bioscience Reports
- Identification and Expression Analysis of Ras Gene in Silkworm, Bombyx moriTakehiko Ogura, Anjiang Tan, Takuya Tsubota, Takayo Nakakura, Takahiro Shiotsuki · 2009 · PLoS ONE
- Activated Ras alters lens and corneal development through induction of distinct downstream targetsDaniel J Burgess, Yan Zhang, Ed Siefker, R. A. Vaca, Murali R. Kuracha, Lixing W. Reneker, Paul A. Overbeek, Venkatesh Govindarajan · 2010 · BMC Developmental Biology
- Reduced expression of RAS protein activator like‐1 in gastric cancerMotoko Seto, Miki Ohta, Tsuneo Ikenoue, Takafumi Sugimoto, Yoshinari Asaoka, Motohisa Tada, Dai Mohri, Yotaro Kudo, Hideaki Ijichi, Keisuke Tateishi et al. · 2010 · International Journal of Cancer
- Significance of Ras Signaling in Cancer and Strategies for its ControlArun Bahadur Gurung, Atanu Bhattacharjee, Researcher · 2015 · touchREVIEWS in Oncology & Haematology
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- Solubility survey of fragments of the neurofibromatosis type 1 protein neurofibrominFabien Bonneau, Esther D. Lenherr, Vladimir Peña, Darren J. Hart, Klaus Scheffzek · 2008 · Protein Expression and Purification
- A novel HRAS substitution (c.266C>G; p.S89C) resulting in decreased downstream signaling suggests a new dimension of RAS pathway dysregulation in human developmentKaren Webster Gripp, Eugenia Bifeld, Deborah L. Stabley, Elizabeth Hopkins, Stefanie Meien, Kathy M. B. Vinette, Katia Sol‐Church, Georg Rosenberger · 2012 · American Journal of Medical Genetics Part A
- Mutations in the KRAS gene in ovarian tumors.Bożena Dobrzycka, Slawomir Jerzy Terlikowski, Oksana Kowalczuk, Wiesława Niklińska, L Chyczewski, M Kulikowski · 2009 · Folia Histochemica et Cytobiologica
- RAS-Mutant Follicular Thyroid Tumors: A Continuous Challenge for PathologistsJuan Carlos Hernandez-Prera, Bruce M. Wenig · 2024 · Endocrine Pathology
- Panitumumab in Metastatic Colorectal Cancer: The Importance of Tumour RAS StatusMarc Peeters, Meinolf Karthaus, Fernando Rivera, Jan-Henrik Terwey, Jean‐Yves Douillard · 2015 · Drugs
- Computing energy landscape maps and structural excursions of proteinsEmmanuel Sapin, Daniel B. Carr, Kenneth Alan De Jong, Amarda Shehu · 2016 · BMC Genomics
- Prognostic Characteristics and Immunotherapy Response of Patients With Nonsquamous NSCLC With Kras Mutation in East Asian Populations: A Single-Center Cohort Study in TaiwanShang‐Gin Wu, Wei‐Yu Liao, Kang‐Yi Su, Sung‐Liang Yu, Yen-Lin Huang, Chong‐Jen Yu, James Chih‐Hsin Yang, Jin‐Yuan Shih · 2020 · JTO Clinical and Research Reports
- Determinants of Membrane Orientation Dynamics in Lipid-Modified Small GTPasesPriyanka Prakash, Alemayehu Abebe Gorfe · 2021 · JACS Au
- Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutantsImran Khan, Akiko Koide, Mariyam Zuberi, Gayatri Ketavarapu, Eric Denbaum, Kai Wen Teng, Joshua Matthew Rhett, Russell Spencer-Smith, G. Aaron Hobbs, Ernest Ramsay Camp et al. · 2022 · Cell Reports
- Aberrant MAPK Signaling Offers Therapeutic Potential for Treatment of Ovarian CarcinomaEva Colic, Preya U. Patel, Oliver A. Kent · 2022 · OncoTargets and Therapy
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- Downregulated adaptor protein p66Shc mitigates autophagy process by low nutrient and enhances apoptotic resistance in human lung adenocarcinoma A549 cellsZhichao Zheng, Jie Yang, Dan Zhao, Dan Gao, Xiaojie Yan, Zhi Yao, Zhe Liu, Zhenyi Ma · 2013 · FEBS Journal
- A New Dimension to Ras Function: A Novel Role for Nucleotide-Free Ras in Class II Phosphatidylinositol 3-Kinase Beta (PI3KC2β) RegulationKaty Ann Wong, Angela Russo, Xuerong Wang, Yun-Ju Chen, Arnon Lavie, John P. O’Bryan · 2012 · PLoS ONE
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- Ras-Mediated Activation of NF-κB and DNA Damage Response in CarcinogenesisAnas Ahmad, Haseeb Ahsan · 2020 · Cancer Investigation
- RETRACTED: Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signallingYingqi Liu, Lingling Li, Xiaoqing Liu, Yibo Wang, Lu Peng, Jiayuan Liu, Lingling Li, Lian Zhang, Guannan Wang, Hongyuan Li et al. · 2020 · eLife · Retracted
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- A comprehensive analysis of somatic alterations in Chinese ovarian cancer patientsYingli Zhang, Xiaoliang Shi, Jiejie Zhang, Xi Chen, Peng Zhang, Angen Liu, Tao Zhu · 2021 · Scientific Reports
- A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partnersSoheila Rezaei Adariani, Neda S. Kazemein Jasemi, Farhad Bazgir, Christoph Wittich, Ehsan Amin, Claus A. M. Seidel, Radovan Dvorský, Mohammad Reza Ahmadian · 2021 · Journal of Biological Chemistry
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- Ras and Nox: Linked signaling networks?Ru Feng Wu, Lance S. Terada · 2009 · Free Radical Biology and Medicine
- Identification of Structurally Novel KRAS G12C Inhibitors through Covalent DNA-Encoded Library ScreeningDavid S. Huang, Francesco Manoni, Zhen Sun, Rongfeng Liu, Jennifer R. Allen, Abhisek Banerjee, Victor J. Cee, Josephine Eshon, Michael J. Frohn, Matthew R. Kaller et al. · 2025 · Journal of Medicinal Chemistry
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- Emerging RAS-directed therapies for cancerMichael R. Conroy, Darren Cowzer, Walter Kölch, Austin G. Duffy · 2021 · Cancer Drug Resistance
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