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Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
Abstract
Genetic studies have identified the key signalling pathways and developmentally regulated transcription factors that govern cell lineage allocation and axis patterning in the early mammalian embryo. Recent advances have uncovered details of the molecular circuits that tightly control cell growth and differentiation in the mammalian embryo from the blastocyst stage, through the establishment of initial anterior-posterior polarity, to gastrulation, when the germ cells are set aside and the three primary germ layers are specified. Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning.
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“Expression of markers of embryonic (em)VE, and anterior visceral endoderm (AVE), a specialized cellular cohort of emVE exhibiting an intra-epithelial, distal-to-anterior migratory behavior between E5.5 and E6.0, including Lefty1, Cer1 and Hhex30–32, suggested these EPI descendants resembled emVE and AVE (Fig. 2c, Extended Data Fig. 6e)33.”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [33]
In the citing paper
“The early post-implantation (E5.5, Fig. 1) mouse embryo is radially symmetrical, and the VE appears morphologically uniform around its proximal-distal axis4,33.”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [33]
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Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a
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InfluentialGeminin Is Required for Epithelial to Mesenchymal Transition at Gastrulation
Emmett, L. S. D. B., & O’Shea, K. S. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0483 · Cited by 19
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“In addition to metabolic function, the VE plays a crucial role in patterning of the embryo (Beddington and Robertson, 1999; Arnold and Robertson, 2009; Rossant and Tam, 2009).”
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Making the first decision: lessons from the mouse
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Extracellular vesicles synchronize cellular phenotypes of differentiating cells
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Pluripotency Factors on Their Lineage Move
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The epigenetic modifier Fam208a is required to maintain epiblast cell fitness
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Decisive points for pregnancy losses in beef cattle
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Targeting melanoma with front-line therapy does not abrogate Nodal-expressing tumor cells
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Determinant molecular markers for peri-gastrulating bovine embryo development
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Histone Deacetylase 1 and 3 Regulate the Mesodermal Lineage Commitment of Mouse Embryonic Stem Cells
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“…not contain other Alb+ cells of extra-embryonic tissues in DE method (Gouon-Evans et al., 2006; Keller, 2005), while ES cell-derived Alb+ hepatic cells could mix with ES cell-derived Alb+ visceral endoderm by the EB method (Arnold and Robertson, 2009; Barbacci et al., 1999; Haumaitre et al., 2003).”
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Live Imaging Fluorescent Proteins in Early Mouse Embryos
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“…comprises of a dynamic three-dimensional orchestration of cellular interactions, including proliferation, apoptosis, movement, and differentiation, which occur in a temporally and spatially regulated manner (Arnold and Robertson, 2009; Nowotschin and Hadjantonakis, 2010; Rossant and Tam, 2009).”
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“…have shown that the BMP andWNT signaling pathways activate Eomes transcription and that transcription factors such as NANOG (nanog homeobox), OCT4, and SOX2 also bind to the enhancer of the Eomes gene and activate its transcription (Arnold and Robertson, 2009; Teo et al., 2011; Tosic et al., 2019).”
BackgroundHuman embryoids: A new strategy of recreating the first steps of embryonic development in vitro
Zhang, M., Reis, A. H., & Simunovic, M. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.07.003 · Cited by 13
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“Conversely, NANOG expression, which maintains pluripotency in epiblast progenitors, was downregulated (Arnold & Robertson, 2009; Kalmar et al., 2009; Madeja et al., 2013).”
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“In mammalian development, gastrulation is the first differentiation event of the embryo proper (Arnold and Robertson, 2009; Bardot and Hadjantonakis, 2020), where the pluripotent epiblast differentiates into the three germ layers of the embryo: ectoderm, mesoderm, and endoderm.”
BackgroundUnveiling how vitrification affects the porcine blastocyst: clues from a transcriptomic study
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“After the SCNT blastocyst implants into the uterus, TE cells undergo proliferation and form extraembryonic tissues including the placenta, and ICM cells develop into the embryo proper and yolk sac tissue (Arnold and Robertson, 2009; Rossant and Tam, 2009).”
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“5, a Nodal gradient becomes established in the EPI leading to the emergence of the proximal-distal axis (Arnold and Robertson, 2009).”
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Metadata
- Authors
- Arnold, S. J., & Robertson, E. J.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Robertson, Elizabeth J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2009-01-08
- Volume
- 10
- Issue
- 2
- Pages
- 91-103
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2070700342
- Cited by
- 816
- References
- 147
- Citations by year
- 2026: 39 · 2025: 52 · 2024: 46 · 2023: 45 · 2022: 55 · 2021: 66 · 2020: 49 · 2019: 56 · 2018: 60 · 2017: 48 · 2016: 46 · 2015: 35 · 2014: 56 · 2013: 41 · 2012: 39
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (059312)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- early mouse embryo, anterior-posterior polarity, gastrulation, germ layer specification, germ cell specification, signaling pathways, transcription factors, blastocyst, in vivo imaging, developmental conservation, lower vertebrates
- MeSH terms
- Positive Regulatory Domain I-Binding Factor 1, Animals, DNA-Binding Proteins, Embryo, Mammalian, Morphogenesis, Transcription Factors, Signal Transduction, RNA-Binding Proteins, Cell Lineage, Bone Morphogenetic Proteins, Body Patterning, Mice, Smad Proteins, Gastrulation
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