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Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
Abstract
Genetic studies have identified the key signalling pathways and developmentally regulated transcription factors that govern cell lineage allocation and axis patterning in the early mammalian embryo. Recent advances have uncovered details of the molecular circuits that tightly control cell growth and differentiation in the mammalian embryo from the blastocyst stage, through the establishment of initial anterior-posterior polarity, to gastrulation, when the germ cells are set aside and the three primary germ layers are specified. Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning.
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“Expression of markers of embryonic (em)VE, and anterior visceral endoderm (AVE), a specialized cellular cohort of emVE exhibiting an intra-epithelial, distal-to-anterior migratory behavior between E5.5 and E6.0, including Lefty1, Cer1 and Hhex30–32, suggested these EPI descendants resembled emVE and AVE (Fig. 2c, Extended Data Fig. 6e)33.”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [33]
In the citing paper
“The early post-implantation (E5.5, Fig. 1) mouse embryo is radially symmetrical, and the VE appears morphologically uniform around its proximal-distal axis4,33.”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [33]
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InfluentialIn Vivo Human Somitogenesis Guides Somite Development from hPSCs
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“DVE cells are specified from a subset of emVE based on exposure to low levels of Nodal signaling (Arnold and Robertson, 2009; Lu and Robertson, 2004; Takaoka et al., 2017).”
BackgroundA Role for the Long Noncoding RNA SENCR in Commitment and Function of Endothelial Cells
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“Lastly, for those readers who are interested in mouse embryo development beyond the blastocyst stage, particularly regarding the molecular regulations of germ layer formation, we recommend several recent review articles (Tam and Loebel, 2007; Arnold and Robertson, 2009; Rossant and Tam, 2009).”
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“…signaling center emitting the anteriorization/anti-posteriorization signals (e.g. LEFTY1 against NODAL, DKK1 against WNT, Cerberus-like against BMP, etc.; Arnold & Robertson 2009), Prdm1 expression expands into all the epiblast cells contacting the ExE, as well as those locating much more distally.”
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“Between 13 and 16 h, the layer formed by the egressing cells had almost extended to the distal tip, similar to PS formation in embryos (Arnold and Robertson, 2009).”
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“Lineage choice is governed by the expression of key lineage-specific transcription factors that regulate downstream signaling pathways (reviewed by Arnold and Robertson, 2009; Niwa, 2007; Rossant and Tam, 2009), such that ES cells can be converted into TS-like (Niwa et al., 2005) or XENlike…”
BackgroundIntegrating developmental signals: a Hippo in the (path)way
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Metadata
- Authors
- Arnold, S. J., & Robertson, E. J.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Robertson, Elizabeth J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2009-01-08
- Volume
- 10
- Issue
- 2
- Pages
- 91-103
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2070700342
- Cited by
- 816
- References
- 147
- Citations by year
- 2026: 39 · 2025: 52 · 2024: 46 · 2023: 45 · 2022: 55 · 2021: 66 · 2020: 49 · 2019: 56 · 2018: 60 · 2017: 48 · 2016: 46 · 2015: 35 · 2014: 56 · 2013: 41 · 2012: 39
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (059312)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- early mouse embryo, anterior-posterior polarity, gastrulation, germ layer specification, germ cell specification, signaling pathways, transcription factors, blastocyst, in vivo imaging, developmental conservation, lower vertebrates
- MeSH terms
- Positive Regulatory Domain I-Binding Factor 1, Animals, DNA-Binding Proteins, Embryo, Mammalian, Morphogenesis, Transcription Factors, Signal Transduction, RNA-Binding Proteins, Cell Lineage, Bone Morphogenetic Proteins, Body Patterning, Mice, Smad Proteins, Gastrulation
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