The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
Abstract
Genetic studies have identified the key signalling pathways and developmentally regulated transcription factors that govern cell lineage allocation and axis patterning in the early mammalian embryo. Recent advances have uncovered details of the molecular circuits that tightly control cell growth and differentiation in the mammalian embryo from the blastocyst stage, through the establishment of initial anterior-posterior polarity, to gastrulation, when the germ cells are set aside and the three primary germ layers are specified. Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning.
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“Expression of markers of embryonic (em)VE, and anterior visceral endoderm (AVE), a specialized cellular cohort of emVE exhibiting an intra-epithelial, distal-to-anterior migratory behavior between E5.5 and E6.0, including Lefty1, Cer1 and Hhex30–32, suggested these EPI descendants resembled emVE and AVE (Fig. 2c, Extended Data Fig. 6e)33.”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [33]
In the citing paper
“The early post-implantation (E5.5, Fig. 1) mouse embryo is radially symmetrical, and the VE appears morphologically uniform around its proximal-distal axis4,33.”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [33]
Citations
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Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells
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The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
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Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
Yang, J., & Weinberg, R. A. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.05.009 · Cited by 3,079
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New cell lines from mouse epiblast share defining features with human embryonic stem cells
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Derivation of pluripotent epiblast stem cells from mammalian embryos
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Building Muscle: Molecular Regulation of MyogenesisPreprint
Bentzinger, C. F., Wang, Y. X., & Rudnicki, M. A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008342 · Cited by 1,270
A method to recapitulate early embryonic spatial patterning in human embryonic stem cells
Warmflash, A., Sorre, B., Etoc, F., Siggia, E. D., & Brivanlou, A. H. (2014) · Nature Methods · doi:10.1038/nmeth.3016 · Cited by 885
Molecular Signals of Epigenetic States
Bonasio, R., Tu, S., & Reinberg, D. (2010) · Science · doi:10.1126/science.1191078 · Cited by 912
The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway
Varelas, X., Samavarchi‐Tehrani, P., Narimatsu, M., Weiss, A., Cockburn, K., Larsen, B. G., Rossant, J., & Wrana, J. L. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.11.012 · Cited by 725
Burridge, P. W., Keller, G., Gold, J. D., & Wu, J. C. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.12.013 · Cited by 670
“Cardiomyogenesis begins with the generation of mesoderm via the process of gastrulation, which has been best studied in the mouse (Arnold and Robertson, 2009; Buckingham et al., 2005; Tam and Loebel, 2007) (Figure 1).”
Metadata
- Authors
- Arnold, S. J., & Robertson, E. J.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Robertson, Elizabeth J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2009-01-08
- Volume
- 10
- Issue
- 2
- Pages
- 91-103
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2070700342
- Cited by
- 816
- References
- 147
- Citations by year
- 2026: 39 · 2025: 52 · 2024: 46 · 2023: 45 · 2022: 55 · 2021: 66 · 2020: 49 · 2019: 56 · 2018: 60 · 2017: 48 · 2016: 46 · 2015: 35 · 2014: 56 · 2013: 41 · 2012: 39
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (059312)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- early mouse embryo, anterior-posterior polarity, gastrulation, germ layer specification, germ cell specification, signaling pathways, transcription factors, blastocyst, in vivo imaging, developmental conservation, lower vertebrates
- MeSH terms
- Positive Regulatory Domain I-Binding Factor 1, Animals, DNA-Binding Proteins, Embryo, Mammalian, Morphogenesis, Transcription Factors, Signal Transduction, RNA-Binding Proteins, Cell Lineage, Bone Morphogenetic Proteins, Body Patterning, Mice, Smad Proteins, Gastrulation
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