Cited by 816Developmental Biology and Gene RegulationPluripotent Stem Cells ResearchReproductive Biology and Fertility

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Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo

Arnold, Sebastian J., Robertson, Elizabeth J.·2009·Nature Reviews Molecular Cell Biology

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Abstract

Genetic studies have identified the key signalling pathways and developmentally regulated transcription factors that govern cell lineage allocation and axis patterning in the early mammalian embryo. Recent advances have uncovered details of the molecular circuits that tightly control cell growth and differentiation in the mammalian embryo from the blastocyst stage, through the establishment of initial anterior-posterior polarity, to gastrulation, when the germ cells are set aside and the three primary germ layers are specified. Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning.

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“Cardiomyogenesis begins with the generation of mesoderm via the process of gastrulation, which has been best studied in the mouse (Arnold and Robertson, 2009; Buckingham et al., 2005; Tam and Loebel, 2007) (Figure 1).”

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Authors: Arnold, S. J., & Robertson, E. J.
Affiliations: University of Oxford (GB)
Corresponding author: Robertson, Elizabeth J.
ORCID: Arnold, Sebastian J.
Robertson, Elizabeth J.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2009-01-08
Volume: 10
Issue: 2
Pages: 91-103
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2618
OpenAlex: W2070700342
Cited by: 816
References: 147
Citations by year: 2026: 39 · 2025: 52 · 2024: 46 · 2023: 45 · 2022: 55 · 2021: 66 · 2020: 49 · 2019: 56 · 2018: 60 · 2017: 48 · 2016: 46 · 2015: 35 · 2014: 56 · 2013: 41 · 2012: 39
FWCI: 3.14
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (059312)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: early mouse embryo, anterior-posterior polarity, gastrulation, germ layer specification, germ cell specification, signaling pathways, transcription factors, blastocyst, in vivo imaging, developmental conservation, lower vertebrates
MeSH terms: Positive Regulatory Domain I-Binding Factor 1, Animals, DNA-Binding Proteins, Embryo, Mammalian, Morphogenesis, Transcription Factors, Signal Transduction, RNA-Binding Proteins, Cell Lineage, Bone Morphogenetic Proteins, Body Patterning, Mice, Smad Proteins, Gastrulation

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Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo

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