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Minimizing the damage: repair pathways keep mitochondrial DNA intact

Kazak, Lawrence, Reyes, Aurelio, Holt, Ian J.·2012·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm3439
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Abstract

Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the accurate replication, transmission and preservation of its integrity throughout the life of the organism. Although mtDNA was originally thought to lack DNA repair activity, four decades of research on mitochondria have revealed multiple mtDNA repair pathways, including base excision repair, single-strand break repair, mismatch repair and possibly homologous recombination. These mtDNA repair pathways are mediated by enzymes that are similar in activity to those operating in the nucleus, and in all cases identified so far in mammals, they are encoded by nuclear genes.

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Metadata

Authors
Kazak, L., Reyes, A., & Holt, I. J.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2012-09-20
Volume
13
Issue
10
Pages
659-671
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm3439
Cited by
388
References
6
Language
en
Update notices
erratum (2012-10-03)
Licence

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