The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Specificity and nonspecificity in RNA–protein interactions
Open accessAbstract
To fully understand the regulation of gene expression, it is critical to quantitatively define whether and how RNA-binding proteins (RBPs) discriminate between alternative binding sites in RNAs. Here, we describe new methods that measure protein binding to large numbers of RNA variants, and ways to analyse and interpret data obtained by these approaches, including affinity distributions and free energy landscapes. We discuss how the new methodologies and the associated concepts enable the development of inclusive, quantitative models for RNA–protein interactions that transcend the traditional binary classification of RBPs as either specific or nonspecific.
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RNA-binding proteins in tumor progression
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CLIP and complementary methods
Hafner, M., Katsantoni, M., Köster, T., Marks, J., Mukherjee, J., Staiger, D., Ule, J., & Zavolan, M. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00018-1 · Cited by 365
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Metadata
- Authors
- Jankowsky, E., & Harris, M. E.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2015-08-19
- Volume
- 16
- Issue
- 9
- Pages
- 533-544
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1842452185
- Cited by
- 283
- References
- 133
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- green
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