Cited by 3,510SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesViral Infections and Outbreaks Research

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SARS and MERS: recent insights into emerging coronaviruses

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de Wit, Emmie, van Doremalen, Neeltje, Falzarano, Darryl, Munster, Vincent J.·2016·Nature Reviews Microbiology

DOI 10.1038/nrmicro.2016.81PMC PMC7097822

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Abstract

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. The continuing introductions of MERS-CoV from dromedary camels, the subsequent travel-related viral spread, the unprecedented nosocomial outbreaks and the high case-fatality rates highlight the need for prophylactic and therapeutic measures. Scientific advancements since the 2002-2003 severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic allowed for rapid progress in our understanding of the epidemiology and pathogenesis of MERS-CoV and the development of therapeutics. In this Review, we detail our present understanding of the transmission and pathogenesis of SARS-CoV and MERS-CoV, and discuss the current state of development of measures to combat emerging coronaviruses.

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Corrections
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Masters, P. S. & Perlman, S. in Fields Virology (eds Knipe, D. M. & Howley, P. M.) 825–858 (Wolters Kluwer, 2013).

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286
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See all 3,510

Authors: de Wit, E., van Doremalen, N., Falzarano, D., & Munster, V. J.
Affiliations: National Institutes of Health (US)
University of Saskatchewan (CA)
Corresponding author: Munster, Vincent J.
ORCID: de Wit, Emmie
van Doremalen, Neeltje
Falzarano, Darryl
Munster, Vincent J.
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2016-06-27
Volume: 14
Issue: 8
Pages: 523-534
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/nrmicro.2016.81
PMC: PMC7097822
OpenAlex: W2470646526
Cited by: 3,510
References: 158
Citations by year: 2026: 63 · 2025: 107 · 2024: 173 · 2023: 276 · 2022: 421 · 2021: 893 · 2020: 1432 · 2019: 52 · 2018: 37 · 2017: 46 · 2016: 8
FWCI: 7.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
Keywords: SARS-CoV, MERS-CoV, emerging coronaviruses, virus transmission, pathogenesis, Camelus dromedarius, hospital outbreak, case fatality, prophylaxis, antiviral agents
MeSH terms: Animals, Camelus, Cross Infection, Disease Outbreaks, Humans, Travel, Virus Replication, Coronavirus Infections, Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome, Severe acute respiratory syndrome-related coronavirus, Immune Evasion, Pandemics, Middle East Respiratory Syndrome Coronavirus

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