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The abundance and variety of carbohydrate-active enzymes in the human gut microbiota
Abstract
Descriptions of the microbial communities that live on and in the human body have progressed at a spectacular rate over the past 5 years, fuelled primarily by highly parallel DNA-sequencing technologies and associated advances in bioinformatics, and by the expectation that understanding how to manipulate the structure and functions of our microbiota will allow us to affect health and prevent or treat diseases. Among the myriad of genes that have been identified in the human gut microbiome, those that encode carbohydrate-active enzymes (CAZymes) are of particular interest, as these enzymes are required to digest most of our complex repertoire of dietary polysaccharides. In this Analysis article, we examine the carbohydrate-digestive capacity of a simplified but representative mini-microbiome in order to highlight the abundance and variety of bacterial CAZymes that are represented in the human gut microbiota.
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“the fermentation of dietary fibre represents one of the dominant microbial metabolic activities in the colon”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [36]
In the citing paper
“Dietary fiber passes undigested from the small intestine into the colonic environment [171] and the gut microbiota relies on these fibers for energy, which they target for disassembly with a combined ‘toolkit’ of thousands of enzymes [204].”
From The athletic gut microbiota (2020) · cites this paper as [204]
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Metadata
- Authors
- Kaoutari, A. E., Armougom, F., Gordon, J. I., Raoult, D., & Henrissat, B.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Washington University in St. Louis (US)
- University of Copenhagen (DK)
- Corresponding author
- Henrissat, Bernard
- Venue
- Nature Reviews Microbiology
- Published
- 2013-06-10
- Volume
- 11
- Issue
- 7
- Pages
- 497-504
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W1991497480
- Cited by
- 1,683
- References
- 51
- Citations by year
- 2026: 111 · 2025: 156 · 2024: 206 · 2023: 167 · 2022: 198 · 2021: 226 · 2020: 153 · 2019: 127 · 2018: 100 · 2017: 84 · 2016: 70 · 2015: 41 · 2014: 38 · 2013: 6
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Keywords
- carbohydrate-active enzymes, human gut microbiome, polysaccharide digestion, bacterial carbohydrate metabolism, dietary polysaccharides, host-microbe interactions
- MeSH terms
- Bacteria, Glycoside Hydrolases, Humans, Polysaccharide-Lyases, Glycosyltransferases, Gastrointestinal Tract, Metagenome
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