Cited by 1,683Gut microbiota and healthEnzyme Production and CharacterizationBiofuel production and bioconversion

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The abundance and variety of carbohydrate-active enzymes in the human gut microbiota

Kaoutari, Abdessamad El, Armougom, Fabrice, Gordon, Jeffrey I., Raoult, Didier, Henrissat, Bernard·2013·Nature Reviews Microbiology

DOI 10.1038/nrmicro3050

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Abstract

Descriptions of the microbial communities that live on and in the human body have progressed at a spectacular rate over the past 5 years, fuelled primarily by highly parallel DNA-sequencing technologies and associated advances in bioinformatics, and by the expectation that understanding how to manipulate the structure and functions of our microbiota will allow us to affect health and prevent or treat diseases. Among the myriad of genes that have been identified in the human gut microbiome, those that encode carbohydrate-active enzymes (CAZymes) are of particular interest, as these enzymes are required to digest most of our complex repertoire of dietary polysaccharides. In this Analysis article, we examine the carbohydrate-digestive capacity of a simplified but representative mini-microbiome in order to highlight the abundance and variety of bacterial CAZymes that are represented in the human gut microbiota.

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Authors: Kaoutari, A. E., Armougom, F., Gordon, J. I., Raoult, D., & Henrissat, B.
Affiliations: Centre National de la Recherche Scientifique (FR)
Washington University in St. Louis (US)
University of Copenhagen (DK)
Corresponding author: Henrissat, Bernard
ORCID: Kaoutari, Abdessamad El
Armougom, Fabrice
Gordon, Jeffrey I.
Raoult, Didier
Henrissat, Bernard
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2013-06-10
Volume: 11
Issue: 7
Pages: 497-504
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/nrmicro3050
OpenAlex: W1991497480
Cited by: 1,683
References: 51
Citations by year: 2026: 111 · 2025: 156 · 2024: 206 · 2023: 167 · 2022: 198 · 2021: 226 · 2020: 153 · 2019: 127 · 2018: 100 · 2017: 84 · 2016: 70 · 2015: 41 · 2014: 38 · 2013: 6
FWCI: 4.76
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
Keywords: carbohydrate-active enzymes, human gut microbiome, polysaccharide digestion, bacterial carbohydrate metabolism, dietary polysaccharides, host-microbe interactions
MeSH terms: Bacteria, Glycoside Hydrolases, Humans, Polysaccharide-Lyases, Glycosyltransferases, Gastrointestinal Tract, Metagenome

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The abundance and variety of carbohydrate-active enzymes in the human gut microbiota

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