Cited by 636Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

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Not just amyloid: physiological functions of the amyloid precursor protein family

Müller, Ulrike C., Deller, Thomas, Korte, Martin·2017·Nature Reviews Neuroscience

DOI 10.1038/nrn.2017.29

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Abstract

Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP and the closely related APP-like proteins (APLPs) remain less well understood. Studying these physiological functions has been challenging and has required a careful long-term strategy, including the analysis of different App-knockout and Aplp-knockout mice. In this Review, we summarize these findings, focusing on the in vivo roles of APP family members and their processing products for CNS development, synapse formation and function, brain injury and neuroprotection, as well as ageing. In addition, we discuss the implications of APP physiology for therapeutic approaches.

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Additional file 3 of TaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA
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Additional file 4 of TaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA
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Additional file 1 of TaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA
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Authors: Müller, U. C., Deller, T., & Korte, M.
Affiliations: Heidelberg University (DE)
Goethe University Frankfurt (DE)
Corresponding author: Müller, Ulrike C.
ORCID: Müller, Ulrike C.
Deller, Thomas
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2017-03-31
Volume: 18
Issue: 5
Pages: 281-298
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn.2017.29
OpenAlex: W2599851926
Cited by: 634
References: 212
Citations by year: 2026: 49 · 2025: 59 · 2024: 88 · 2023: 69 · 2022: 79 · 2021: 84 · 2020: 62 · 2019: 73 · 2018: 50 · 2017: 21
FWCI: 6.88
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: amyloid precursor protein, amyloid-beta, Alzheimer's disease, central nervous system development, synaptogenesis, synaptic function, brain injury, neuroprotection, aging, APP knockout mice, APP processing, treatment options
MeSH terms: Animals, Brain, Humans, Amyloid beta-Protein Precursor, Mice

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Not just amyloid: physiological functions of the amyloid precursor protein family

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