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Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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The Cellular Phase of Alzheimer’s Disease

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Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

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A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

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Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory

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Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

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Transmissible Endosomal Intoxication: A Balance between Exosomes and Lysosomes at the Basis of Intercellular Amyloid Propagation

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UsingDrosophilaModels of Amyloid Toxicity to Study Autophagy in the Pathogenesis of Alzheimer’s Disease

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Neuronanomedicine for Alzheimer’s and Parkinson’s disease: Current progress and a guide to improve clinical translation

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Age‐dependent NMDA receptor function is regulated by the amyloid precursor protein

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Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions

Westi, E. W., Andersen, J. V., & Aldana, B. I. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106145 · Cited by 23

Are large simple trials for dementia prevention possible?

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Comprehensive analysis of O-glycosylation of amyloid precursor protein (APP) using targeted and multi-fragmentation MS strategy

Shi, J., Ku, X., Zou, X., Hou, J., Yan, W., & Zhang, Y. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2021.129954 · Cited by 22

Ketogenic Diet: A Promising Neuroprotective Composition for Managing Alzheimer’s Diseases and its Pathological Mechanisms

Sridharan, B., & Lee, M. (2021) · Current Molecular Medicine · doi:10.2174/1566524021666211004104703 · Cited by 22

The temporal balance between self-renewal and differentiation of human neural stem cells requires the amyloid precursor protein

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Glutamate in Male and Female Sexual Behavior: Receptors, Transporters, and Steroid Independence

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Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition

Liang, W. G., Wijaya, J., Wei, H., Noble, A. J., Mancl, J. M., Mo, S., Lee, D. E., King, J. V. L., Pan, M., Liu, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29322-4 · Cited by 21

The Impairment of Blood-Brain Barrier in Alzheimer’s Disease: Challenges and Opportunities with Stem Cells

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Spatiotemporal insights of APP function

Dunot, J., Ribera, A., Pousinha, P. A., & Marie, H. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102754 · Cited by 23

Peptides isolated from animal venom as a platform for new therapeutics for the treatment of Alzheimer's disease

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Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β

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Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease

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Targeting the APP-Mint2 Protein–Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation

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Emerging contributions of formyl peptide receptors to neurodegenerative diseases

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Low molecular weight chondroitin sulfate ameliorates pathological changes in 5XFAD mice by improving various functions in the brain

Zhao, N., Wu, L., Zhang, X., Jiang, W., & Wang, F. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108796 · Cited by 21

APP‐derived peptides reflect neurodegeneration in frontotemporal dementia

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Solubility of Aβ40 peptide

Lattanzi, V., Bernfur, K., Sparr, E., Olsson, U., & Linse, S. S. (2021) · JCIS Open · doi:10.1016/j.jciso.2021.100024 · Cited by 20

The positive impact of 12 weeks of dance and balance training on the circulating amyloid precursor protein and serotonin concentration as well as physical and cognitive abilities in elderly women

Rodziewicz-Flis, E. A., Kawa, M., Skrobot, W. R., Flis, D. J., Wilczyńska, D. M., Szaro-Truchan, M., Bolek-Adamek, J., & Kaczor, J. J. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111746 · Cited by 20

Lack of N-glycosylation increases amyloidogenic processing of the amyloid precursor protein

Lin, T., van Husen, L. S., Yu, Y., Tjernberg, L. O., & Schedin‐Weiss, S. (2022) · Glycobiology · doi:10.1093/glycob/cwac009 · Cited by 20

Novel melatonin-trientine conjugate as potential therapeutic agents for Alzheimer’s disease

Li, L., Fan, Y., Wu, W., Bai, C., Jia, M., Hu, J.-P., Gao, H., Wang, T., Zhong, M., Huang, X., et al. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106100 · Cited by 20

Amyloidogenesis: What Do We Know So Far?

Alraawi, Z., Banerjee, N., Mohanty, S., & Kumar, T. K. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213970 · Cited by 22

Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity

Schilling, S., Pradhan, A., Heesch, A., Helbig, A., Blennow, K., Koch, C., Bertgen, L., Koo, E. H., Brinkmalm, G., Zetterberg, H., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01577-y · Cited by 21

Aβ42 Peptide Promotes Proliferation and Gliogenesis in Human Neural Stem Cells

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Copper Transporters? Glutathione Reactivity of Products of Cu–Aβ Digestion by Neprilysin

Stefaniak, E., Płonka, D., Szczerba, P., Wezynfeld, N. E., & Bal, W. (2020) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.0c00427 · Cited by 23

The Genetics of Alzheimer’s Disease in the Chinese Population

Gan, C., Zhang, T., & Lee, T. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072381 · Cited by 21

Activated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Missorting and Synaptotoxicity

Moosecker, S., Gomes, P., Dioli, C., Yu, S., Sotiropoulos, I., & Almeida, O. F. X. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00239 · Cited by 20

The role of ferroptosis in Alzheimer's disease: Mechanisms and therapeutic potential (Review)

Zeng, H., & Jin, Z. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13557 · Cited by 19

Disrupted Maturation of Prefrontal Layer 5 Neuronal Circuits in an Alzheimer’s Mouse Model of Amyloid Deposition

Chen, C., Wei, J., Ma, X., Xia, B., Shakir, N., Zhang, J. K., Zhang, L., Cui, Y., Ferguson, D., Qiu, S., et al. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00951-5 · Cited by 20

The stem region of α1,6-fucosyltransferase FUT8 is required for multimer formation but not catalytic activity

Tomida, S., Nagae, M., & Kizuka, Y. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102676 · Cited by 19

Reduction in GABAB on glia induce Alzheimer’s disease related changes

Osse, A. M. L., Pandey, R. S., Wirt, R. A., Ortiz, A. A., Salazar, A., Kimmich, M. J., Strom, E. N. T., Oblak, A. L., Lamb, B. T., Hyman, J. M., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.03.002 · Cited by 21

Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus

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Mitogen-activated protein kinase phosphatase 1 protects PC12 cells from amyloid beta-induced neurotoxicity

Li, X., Gu, Y., Ma, L., Bai, X., Jie, J., Zhang, X.-F., & Chen, D. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.238621 · Cited by 19

Charge effects at nano-bio interfaces: a model of charged gold nanoclusters on amylin fibrillation

Tang, X., Gao, G., Zhang, T., Li, J., Yu, M. S., He, M., & Sun, T. (2020) · Nanoscale · doi:10.1039/d0nr03877f · Cited by 19

The endosomal protein sorting nexin 4 is a synaptic protein

Vazquez‐Sanchez, S., Gonzalez‐Lozano, M. A., Walfenzao, A., Li, K. W., & van Weering, J. R. T. (2020) · Scientific Reports · doi:10.1038/s41598-020-74694-6 · Cited by 19

Choroid plexus APP regulates adult brain proliferation and animal behavior

Arnaud, K., Moreira, V. O., Vincent, J., Dallérac, G., Dubreuil, C., Dupont, E., Richter, M., Müller, U. C., Rondi-Reig, L., Prochiantz, A., et al. (2021) · Life Science Alliance · doi:10.26508/lsa.202000703 · Cited by 17

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

Ahmadi, S., Khaledi, S., Ahmadi, K., & Hassanzadeh, K. (2025) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.70688 · Cited by 20

Fe65 is the sole member of its family that mediates transcription regulated by the amyloid precursor protein

Probst, S., Krüger, M., Kägi, L., Thöni, S., Schuppli, D., Nitsch, R. M., & Konietzko, U. (2020) · Journal of Cell Science · doi:10.1242/jcs.242917 · Cited by 18

Fe65: A Scaffolding Protein of Actin Regulators

Augustin, V., & Kins, S. (2021) · Cells · doi:10.3390/cells10071599 · Cited by 18

Alzheimer’s disease: an axonal injury disease?

Liang, D., & Zhang, Z. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1264448 · Cited by 21

Distinctive contribution of two additional residues in protein aggregation of Aβ42 and Aβ40 isoforms

Im, D., & Choi, T. S. (2024) · BMB Reports · doi:10.5483/bmbrep.2024-0044 · Cited by 19

Diastolic dysfunction in Alzheimer’s disease model mice is associated with Aβ-amyloid aggregate formation and mitochondrial dysfunction

Aishwarya, R., Abdullah, C. S., Remex, N. S., Bhuiyan, M. A. N., Lu, X., Dhanesha, N., Stokes, K. Y., Orr, A. W., Kevil, C. G., & Bhuiyan, M. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-67638-x · Cited by 18

Microglia CREB-Phosphorylation Mediates Amyloid-β-Induced Neuronal Toxicity

Gao, Y., Liu, E.-J., Wang, W.-J., Wang, Y., Li, X., Wang, X., Li, S., Zhang, S., Li, M., Zhou, Q., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180286 · Cited by 18

Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?

Haass, C., & Willem, M. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.058 · Cited by 18

From Hybrids to New Scaffolds: The Latest Medicinal Chemistry Goals in Multi-target Directed Ligands for Alzheimers Disease

Alarcón‐Espósito, J., Mallea, M., & Rodríguez-Lavado, J. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200914155951 · Cited by 19

Improving Mouse Models for Dementia. Are All the Effects in Tau Mouse Models Due to Overexpression?Preprint

Joel, Z., Izquierdo, P., Salih, D. A. M., Richardson, J. C., Cummings, D. M., & Edwards, F. A. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037531 · Cited by 18

The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish

Chebli, J., Rahmati, M., Lashley, T., Edeman, B., Oldfors, A., Zetterberg, H., & Abramsson, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-98487-7 · Cited by 17

Neurexin‐β mediates the synaptogenic activity of amyloid precursor protein

Cvetkovska, V., Ge, Y., Xu, Q., Li, S., Zhang, P., & Craig, A. M. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.0511-21.2022 · Cited by 17

Revisiting APP secretases: an overview on the holistic effects of retinoic acid receptor stimulation in APP processing

Vitória, J. J. M., Trigo, D., & Silva, O. A. B. D. C. E. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04090-4 · Cited by 19

APPsα Rescues Tau-Induced Synaptic Pathology

Bold, C. S., Baltissen, D., Ludewig, S., Back, M. K., Just, J., Kilian, L., Erdinger, S., Banićević, M., Rehra, L., Almouhanna, F., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.2200-21.2022 · Cited by 17

Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity

Rem, P. D., Sereikaité, V., Fernández‐Fernández, D., Reinartz, S., Ulrich, D., Fritzius, T., Trovò, L., Roux, S., Chen, Z., Rondard, P., et al. (2023) · eLife · doi:10.7554/elife.82082 · Cited by 17

APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice

Baltissen, D., Bold, C. S., Rehra, L., Banićević, M., Fricke, J., Just, J., Ludewig, S., Buchholz, C. J., Körte, M., & Müller, U. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1106176 · Cited by 18

Ethnobotanical significance of medicinal plants: Beta‐amyloid and tau aggregation inhibitors against Alzheimer's disease

Anand Ganapathy, A., Haripriya, V. M., Acharya, N. S., Somappa, S. B., & Kumaran, A. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23339 · Cited by 17

Protein Misfolding in Pregnancy: Current Insights, Potential Mechanisms, and Implications for the Pathogenesis of Preeclampsia

Fagla, B. M., & Buhimschi, I. A. (2024) · Molecules · doi:10.3390/molecules29030610 · Cited by 17

Celebrating the Birthday of AMPA Receptor Nanodomains: Illuminating the Nanoscale Organization of Excitatory Synapses with 10 Nanocandles

Fukata, Y., Fukata, M., MacGillavry, H. D., Nair, D. K., & Hosy, E. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.2104-23.2024 · Cited by 18

Neuronal function of Alzheimer's protein

Körte, M. (2019) · Science · doi:10.1126/science.aaw0636 · Cited by 17

Abnormal platelet amyloid‐β precursor protein metabolism in SAMP8 mice: Evidence for peripheral marker in Alzheimer's disease

Chen, L., Xu, S., Wu, T., Shao, Y., Luo, L., Zhou, L., Ou, S., Tang, H., Huang, W., Guo, K., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28921 · Cited by 17

More than just a ticket canceller: the mitochondrial processing peptidase tailors complex precursor proteins at internal cleavage sites

Friedl, J., Knopp, M. R., Groh, C., Paz, E., Gould, S. B., Herrmann, J. M., & Boos, F. (2020) · Molecular Biology of the Cell · doi:10.1091/mbc.e20-08-0524 · Cited by 18

MT5‐MMP controls APP and β‐CTF/C99 metabolism through proteolytic‐dependent and ‐independent mechanisms relevant for Alzheimer's disease

García‐González, L., Paumier, J., Louis, L., Pilat, D., Bernard, A., Stephan, D., Jullien, N., Checler, F., Nivet, E., Khrestchatisky, M., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202100593r · Cited by 16

Trans‐synaptic mechanisms orchestrated by mammalian synaptic cell adhesion molecules

Kim, J., Wulschner, L. E. G., Oh, W. C., & Ko, J. (2022) · BioEssays · doi:10.1002/bies.202200134 · Cited by 19

Characterization of the contactin 5 protein and its risk‐associated polymorphic variant throughout the Alzheimer's disease spectrum

Dauar, M. T., Labonté, A., Picard, C., Miron, J., Rosa‐Neto, P., Zetterberg, H., Blennow, K., Villeneuve, S., & Poirier, J. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12868 · Cited by 17

Amyloid Precursor Protein (APP) Regulates Gliogenesis and Neurogenesis of Human Neural Stem Cells by Several Signaling Pathways

Coronel, R., Bernabeu-Zornoza, A., Palmer, C., González-Sastre, R., Rosca, A., Mateos-Martínez, P., López-Alonso, V., & Liste, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612964 · Cited by 16

Acanthopanax senticosus improves cognitive impairment in Alzheimer’s disease by promoting the phosphorylation of the MAPK signaling pathway

Zhang, Z., Wu, Y., Shi, D., Jiang, C., Cao, H., Jiang, F., Bao, X., Shen, Y., & Shi, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1383464 · Cited by 17

Interplay of mitochondria-associated membrane proteins and autophagy: Implications in neurodegeneration

Kulkarni, P. G., Mohire, V. M., Waghmare, P. P., & Banerjee, T. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101874 · Cited by 16

Recent advances in Alzheimer’s disease therapy: clinical trials and literature review of novel enzyme inhibitors targeting amyloid precursor protein

Antony, D., Sheth, P., Swenson, A., Smoller, C., Maguire, K., & Grossberg, G. T. (2024) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2024.2438317 · Cited by 16

Spatiotemporal relationship between subthreshold amyloid accumulation and aerobic glycolysis in the human brain

Goyal, M. S., Gordon, B. A., Couture, L. E., Flores, S. E., Xiong, C., Morris, J. C., Raichle, M. E., Benzinger, T. L. S., & Vlassenko, A. G. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.08.019 · Cited by 16

Smart treatment strategies for alleviating tauopathy and neuroinflammation to improve clinical outcome in Alzheimer's disease

Tatiparti, K., Sau, S., Rauf, M. A., & Iyer, A. K. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.09.025 · Cited by 16

A genome-wide association study identifies a gene network associated with paranoid schizophrenia and antipsychotics-induced tardive dyskinesia

Levchenko, А., Kanapin, A. A., Samsonova, A. A., Fedorenko, O. Y., Kornetova, E. G., Nurgaliev, T., Mazo, G. E., Semke, A. V., Kibitov, A. O., Bokhan, N. A., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110134 · Cited by 16

Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanisms

Cheng, F., Gao, H., Yan, B., Chen, F., & Lei, P. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118551 · Cited by 15

Alzheimer’s disease: Pathophysiology and dental pulp stem cells therapeutic prospects

Xiong, W., Liu, Y., Zhou, H., Jing, S., He, Y., & Ye, Q. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.999024 · Cited by 15

Sensor‐integrated brain‐on‐a‐chip platforms: Improving the predictive validity in neurodegenerative research

Spitz, S., Schobesberger, S., Brandauer, K., & Ertl, P. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10604 · Cited by 17

Genetic and environmental risk factors for dementia in African adults: A systematic review

Donkor, D. M., Marfo, E., Bockarie, A. S., Tettevi, E. J., Antwi, M. H., Dogah, J., Osei, G. N., & Simpong, D. L. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70220 · Cited by 15

Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations

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The impact of capsaicinoids on APP processing in Alzheimer’s disease in SH-SY5Y cells

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