The DOI matches its Crossref record; 212 of the 212 references it cites were found in a registry or an index.
Not just amyloid: physiological functions of the amyloid precursor protein family
Abstract
Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP and the closely related APP-like proteins (APLPs) remain less well understood. Studying these physiological functions has been challenging and has required a careful long-term strategy, including the analysis of different App-knockout and Aplp-knockout mice. In this Review, we summarize these findings, focusing on the in vivo roles of APP family members and their processing products for CNS development, synapse formation and function, brain injury and neuroprotection, as well as ageing. In addition, we discuss the implications of APP physiology for therapeutic approaches.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A growing body of evidence also suggests a physiological role for APP in synaptic functions [96], potentially through cell adhesion.”
From The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis? (2019) · cites this paper as [96]
Citations
Cites
1 retracted
RETRACTED ARTICLE: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
Nikolaev, A., McLaughlin, T., O’Leary, D. D. M., & Tessier-Lavigne, M. (2009) · Nature · doi:10.1038/nature07767 · Cited by 992
RetractedThe precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685
The Cellular Phase of Alzheimer’s Disease
De Strooper, B., & Karran, E. (2016) · Cell · doi:10.1016/j.cell.2015.12.056 · Cited by 1,990
Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus
Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., & Neve, R. L. (1987) · Science · doi:10.1126/science.2949367 · Cited by 1,611
Goldgaber, D., Lerman, M. I., McBride, O. W., Saffiotti, U., & Gajdusek, D. C. (1987) · Science · doi:10.1126/science.3810169 · Cited by 1,359
A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60
Cao, X., & Südhof, T. C. (2001) · Science · doi:10.1126/science.1058783 · Cited by 1,202
Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory
Panatier, A., Theodosis, D. T., Mothet, J.-P., Touquet, B., Pollegioni, L., Poulain, D. A., & Oliet, S. H. R. (2006) · Cell · doi:10.1016/j.cell.2006.02.051 · Cited by 934
Nitsch, R. M., Slack, B. E., Wurtman, R. J., & Growdon, J. H. (1992) · Science · doi:10.1126/science.1411529 · Cited by 898
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–636 of 636
Moreira-de-Sá, A. (2024) · theses.fr (ABES) · doi:10.70675/3e418ab2ze9a3z43e4z9d87ze5870aefddac
Die Amyloid-Forschung zieht weitere Kreise und nimmt Fahrt auf
Behl, C. (2026) · Springer eBooks · doi:10.1007/978-3-662-72210-7_14
Khan, M. A., & Shaibah, H. S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27093978
Association of the APP rs463946 Polymorphism with Epilepsy Risk: A Case-Control Study from Georgia
Vashadze, S., Beridze, M., Kvirkvelia, N., Gorgiladze, K., & Kekenadze, M. (2026) · Georgian Medical Journal · doi:10.66636/gmj.v1.i2.a110
Kulatunga, D. C. M., Ranaraja, U., Kim, E. G., Ji, K., Choi, H. Y., Yoon, J., Park, K., & Kim, M. S. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05928-3
Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis
Kawase, H., Liu, S., Kurz, S., Bengelsdorff, V., Bonnavion, R., Jin, Y., Roquid, K. A., Cho, H., Liang, G., Banićević, M., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeh0301
Self-citationMa, F., Akolkar, H., Benosman, R. B., & Herrup, K. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71493
Alipour, M., Verdom, B. H., Ashrafi, F., Roodsari, S. R., Nohesara, S., Zali, A., & Ashrafi, F. (2026) · ADMET & DMPK · doi:10.5599/admet.3366 · Cited by 1
Persistent PirB cleavage drives Golgi-directed trafficking deficits underlying neurodegeneration
Han, W.-B., Liu, X.-D., Tang, C.-F., Zheng, J., Xu, T.-L., Xu, N., & Sun, S. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00553-5
Belahusna, D. F., Santoso, P., & Rahayu, R. (2026) · Biointerface Research in Applied Chemistry · doi:10.33263/briac163.075
Das, D., & Mitra, P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.05.736582
Apolipoprotein D acts as a chaperone of Aβ peptide delaying its assembly into amyloid aggregates
Mondejar-Duran, J., Dı́az-Quintana, A., Ganfornina, M. D., & Sánchez, D. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06339-2
ALBAYRAK, İ. G. (2026) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.4278
Miaja, P., Martinez-Baños, M., Martín‐Bermejo, M. J., Moreno, I., Dominguez, M., & Bovolenta, P. (2026) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70301
Hernández, D. L. P., Sánchez, Á. A. L., & Juárez, R. G. (2026) · Casos y Revisiones de Salud · doi:10.22201/fesz.26831422e.2026.8.1.6
Valledor, M., Smith, K., Lawrence, J. B., & Sosa, L. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.05.742240
Amyloid Precursor Protein as a Functional Hub of Synaptic Plasticity
САБУРОВА, Е. А., Sarantseva, S. V., & Krivoi, I. I. (2026) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093026040174
Artificial Synthetic Protein Mimetics As Pathology-Targeted Therapeutics
Dohoney, R. A. (2026) · Digital Commons - DU (University of Denver) · doi:10.56902/etdcrp.2026.62
Bhattacharya, H., Chakraborty, P., & Dewanjee, S. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.08.022
Zeng, Y., Wei, S., Hu, K., Zhao, R., Yu, S., Yu, T., Huang, B., Duan, L., & Zhao, X. (2026) · Biomedicines · doi:10.3390/biomedicines14102293
Said, G., da Silva, A. S. R., & Rodrigues, G. D. S. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103415
Smith, Z. M., & Vonhoff, F. (2026) · iScience · doi:10.1016/j.isci.2026.117781
Shi, X., Chen, G., Wang, X., Ma, R., & Li, G. (2026) · Biomolecules · doi:10.3390/biom16101494
Female microglia show heightened responses to aging and amyloid pathology in mice and humansPreprint
Cox, J. E. J., Poljanska, E., Ray, S., Forsgren, M., Ko, S.-H., Świergiel, P., Wright, Z., Thomas, M. A., Freeman, W. M., Nouh, C. D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.13.758897
AI-based structural modelling and pathogenic variant mapping across the human protein interactomePreprint
Ille, A. M., Ille, A. L., Lamont, H., & Holyoak, T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.28.762585
Physiological APP processing is required for synaptic plasticity and cognition
Kilian, L., Bengelsdorff, V., Just, J., Stork, S., Galanis, C., Banićević, M., Amrein, I., Back, M., Jungenitz, T., Fellenz, M., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-09378-6
Self-citationVasiliu, O. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.2011267
Metadata
- Authors
- Müller, U. C., Deller, T., & Korte, M.
- Affiliations
- Heidelberg University (DE)
- Goethe University Frankfurt (DE)
- Corresponding author
- Müller, Ulrike C.
- Venue
- Nature Reviews Neuroscience
- Published
- 2017-03-31
- Volume
- 18
- Issue
- 5
- Pages
- 281-298
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2599851926
- Cited by
- 634
- References
- 212
- Citations by year
- 2026: 49 · 2025: 59 · 2024: 88 · 2023: 69 · 2022: 79 · 2021: 84 · 2020: 62 · 2019: 73 · 2018: 50 · 2017: 21
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- amyloid precursor protein, amyloid-beta, Alzheimer's disease, central nervous system development, synaptogenesis, synaptic function, brain injury, neuroprotection, aging, APP knockout mice, APP processing, treatment options
- MeSH terms
- Animals, Brain, Humans, Amyloid beta-Protein Precursor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
