A critical period for auditory thalamocortical connectivity
Open accessAbstract
Neural circuits are shaped by experience during periods of heightened brain plasticity in early postnatal life. Exposure to acoustic features produces age-dependent changes through largely unresolved cellular mechanisms and sites of origin. We isolated the refinement of auditory thalamocortical connectivity by in vivo recordings and day-by-day voltage-sensitive dye imaging in an acute brain slice preparation. Passive tone-rearing modified response strength and topography in mouse primary auditory cortex (A1) during a brief, 3-d window, but did not alter tonotopic maps in the thalamus. Gene-targeted deletion of a forebrain-specific cell-adhesion molecule (Icam5) accelerated plasticity in this critical period. Consistent with its normal role of slowing spinogenesis, loss of Icam5 induced precocious stubby spine maturation on pyramidal cell dendrites in neocortical layer 4 (L4), identifying a primary locus of change for the tonotopic plasticity. The evolving postnatal connectivity between thalamus and cortex in the days following hearing onset may therefore determine a critical period for auditory processing.
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The choroid plexus, acting through cerebrospinal fluid, may regulate critical-period plasticity generally, including in the amygdala, auditory cortex, and prefrontal cortex, which have critical periods that are shifted or shorter than that of primary visual cortex.
“Thus, one striking implication is that the choroid plexus, via the CSF, may be a general regulator of CP plasticity, including the amygdala (Gogolla et al., 2009), auditory (Barkat et al., 2011) or prefrontal cortex (Belforte et al., 2010; Yang et al., 2012) – structures with shifted or shorter critical periods than V1.”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Barkat et al., 2011
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- Authors
- Barkat, T. R., Polley, D. B., & Hensch, T. K.
- Affiliations
- Harvard University (US)
- Massachusetts Eye and Ear Infirmary (US)
- Corresponding author
- Hensch, Takao K
- Venue
- Nature Neuroscience
- Published
- 2011-07-31
- Volume
- 14
- Issue
- 9
- Pages
- 1189-1194
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3419581
- OpenAlex
- W2048549637
- Cited by
- 252
- References
- 51
- Citations by year
- 2026: 9 · 2025: 23 · 2024: 11 · 2023: 7 · 2022: 8 · 2021: 21 · 2020: 18 · 2019: 18 · 2018: 20 · 2017: 21 · 2016: 11 · 2015: 18 · 2014: 16 · 2013: 31 · 2012: 17
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (009836)
- National Institute on Deafness and Other Communication Disorders (R01DC009836)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- critical period, auditory plasticity, primary auditory cortex, tonotopic map, ICAM-5, adhesion molecules, dendritic spine maturation, spinogenesis, thalamus, postnatal development, mice
- MeSH terms
- Acoustic Stimulation, Action Potentials, Age Factors, Amino Acids, Analysis of Variance, Animals, Animals, Newborn, Auditory Cortex, Auditory Pathways, Auditory Perception, Critical Period, Psychological, Evoked Potentials, Auditory, Membrane Glycoproteins, Nerve Tissue Proteins, Sound, Thalamus, Patch-Clamp Techniques, Mice, In Vitro Techniques
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