The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Cell-cycle control and cortical development
Abstract
The spatio-temporal timing of the last round of mitosis, followed by the migration of neuroblasts to the cortical plate leads to the formation of the six-layered cortex that is subdivided into functionally defined cortical areas. Whereas many of the cellular and molecular mechanisms have been established in rodents, there are a number of unique features that require further elucidation in primates. Recent findings both in rodents and in primates indicate that regulation of the cell cycle, specifically of the G1 phase has a crucial role in controlling area-specific rates of neuron production and the generation of cytoarchitectonic maps.
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“oRGs are present in large numbers in gyrencephalic primates22,23,40–44 and are considered pivotal to the evolutionary increase in human cortex size and complexity45,46.”
From The use of brain organoids to investigate neural development and disease (2017) · cites this paper as [43]
In the citing paper
“Interestingly, G1/S transition rates might be associated with these cell decisions as symmetric divisions can have shorter G1/S transition times than asymmetric divisions [93, 101].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [93]
Citations
Cites
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Specification of Cerebral Cortical Areas
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“Because these distinct proliferative programmes generate areal differences prior to the arrival of thalamic fibres, they imply the presence of an intrinsic, defined developmental programme and are compatible with the concept of the protomap theor”
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The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Neurons derived from radial glial cells establish radial units in neocortex
Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R. (2001) · Nature · doi:10.1038/35055553 · Cited by 2,016
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Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
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Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
Chenn, A., & Walsh, C. A. (2002) · Science · doi:10.1126/science.1074192 · Cited by 1,431
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
Research works printed but not linked: 2
- Polleux, F., Dehay, C. & Kennedy, H. Gradients and timing of the arrival of thalamic axons in the mouse neocortex. Soc. Neurosci. Abstr. 22, 1012 (1996).
- Kennedy, H., Douglas, R. J., Knoblauch, K. & Dehay, C. Self-organization and pattern formation in cortical networks in the primate. Novartis Found. Symp. in the press.
Cited by
Sorted by citations
Evolution of the neocortex: a perspective from developmental biology
Rakic, P. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2719 · Cited by 1,565
“It is counterintuitive that such a large increase in neocortical size is achieved by a substantial prolongation, rather than reduction in duration of the cell cycl”
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
Lim, S., & Kaldis, P. (2013) · Development · doi:10.1242/dev.091744 · Cited by 1,558
“However, it remains unclear how prolonging G1 induces differentiation mechanistically, other than the hypothesis that because G1 is the period of the cell cycle in which cells are exposed to extrinsic differentiating stimuli, spending more time in G1 should arguably lead to an accumulation of cell fate determinants to…”
BackgroundThe maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
Choi, G. B., Yim, Y. S., Wong, H., Kim, S., Kim, H., Kim, S. V., Hoeffer, C. A., Littman, D. R., & Huh, J. R. (2016) · Science · doi:10.1126/science.aad0314 · Cited by 1,214
“1, H and I); (ii) cortical development starts at about E11 (20), which aligns well with the time points of potential fetal exposure to MIA (7); (iii) disorganized cortex and focal patches of abnormal laminar cytoarchitecture have been found in RESEARCH SCIENCE sciencemag.org 26 FEBRUARY 2016 • VOL 351 ISSUE 6276 933 1…”
BackgroundThe origin and specification of cortical interneurons
Wonders, C. P., & Anderson, S. A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1954 · Cited by 980
“Through various morphogens that induce cell divisions along the apical surface of the ventricular zone, cortical progenitors are born from radial glia and undergo a series of symmetric and asymmetric cell divisions to give rise to the cellular diversity throughout the cortex (Dehay and Kennedy 2007).”
BackgroundDevelopment of the human cerebral cortex: Boulder Committee revisited
Bystron, I., Blakemore, C., & Rakic, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2252 · Cited by 977
“Attempts have been made to integrate more recent observations into the Boulder Commitee's schem”
Metadata
- Authors
- Dehay, C., & Kennedy, H.
- Affiliations
- Lyon 1 Université (FR)
- Corresponding author
- Dehay, Colette
- Venue
- Nature Reviews Neuroscience
- Published
- 2007-06
- Volume
- 8
- Issue
- 6
- Pages
- 438-450
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2010852678
- Cited by
- 655
- References
- 170
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 17 · 2023: 28 · 2022: 18 · 2021: 30 · 2020: 39 · 2019: 30 · 2018: 47 · 2017: 36 · 2016: 39 · 2015: 34 · 2014: 61 · 2013: 52 · 2012: 47
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- cortical development, cell cycle regulation, G1 phase, neuronal proliferation, neuronal differentiation, neuroblast migration, cortical plate, cortical lamination, cortical regions, cytoarchitecture, primate cortex, rodent cortex
- MeSH terms
- Animals, Cell Communication, Cell Cycle, Cell Differentiation, Cerebral Cortex, Humans, Neurons, Stem Cells, Signal Transduction, G1 Phase, Cell Cycle Proteins, Cell Proliferation
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