Cited by 1,400Epigenetics and DNA MethylationNeuroscience and Neuropharmacology ResearchGenomics and Chromatin Dynamics

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Epigenetic regulation in psychiatric disorders

Tsankova, Nadia, Renthal, William, Kumar, Arvind, Nestler, Eric J.·2007·Nature reviews. Neuroscience

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Abstract

Many neurological and most psychiatric disorders are not due to mutations in a single gene; rather, they involve molecular disturbances entailing multiple genes and signals that control their expression. Recent research has demonstrated that complex 'epigenetic' mechanisms, which regulate gene activity without altering the DNA code, have long-lasting effects within mature neurons. This review summarizes recent evidence for the existence of sustained epigenetic mechanisms of gene regulation in neurons that have been implicated in the regulation of complex behaviour, including abnormalities in several psychiatric disorders such as depression, drug addiction and schizophrenia.

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Authors: Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Nestler, Eric J.
ORCID: Renthal, William
Kumar, Arvind
Nestler, Eric J.
Venue: Nature reviews. Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2007-05
Volume: 8
Issue: 5
Pages: 355-367
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2132
OpenAlex: W2052714177
Cited by: 1,400
References: 107
Citations by year: 2026: 14 · 2025: 33 · 2024: 33 · 2023: 28 · 2022: 25 · 2021: 51 · 2020: 45 · 2019: 56 · 2018: 64 · 2017: 71 · 2016: 100 · 2015: 91 · 2014: 108 · 2013: 122 · 2012: 123
FWCI: 8.12
Type: journal article
Language: en
Update notices: correction (2018-12-13)
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: epigenetic regulation, mental illness, gene expression, neurons, learning and memory, depression, drug addiction, schizophrenia, complex behavior, brain development
MeSH terms: Animals, Mental Disorders, Brain, Gene Expression Regulation, Humans, Models, Biological, Neurons, Epigenesis, Genetic

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