Epigenetic regulation in psychiatric disorders

Translating the Histone Code

Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756

Epigenetic programming by maternal behavior

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785

Neurobiology of Depression

Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217

NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory

Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647

Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G., Levine, S. S., Kumar, R., Chevalier, B. S., Johnstone, S. E., Cole, M. F., Isono, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.043 · Cited by 2,296

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780

Neuronal plasticity and antidepressant actions

Castrén, E., & Hen, R. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.12.010 · Cited by 243

Biochemical, Molecular and Epigenetic Mechanisms of Valproic Acid Neuroprotection

Monti, B., Polazzi, E., & Contestabile, A. (2009) · Current Molecular Pharmacology · doi:10.2174/1874467210902010095 · Cited by 244

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

Qin, L., Ma, K., Wang, Z.-J., Hu, Z., Matas, E., Wei, J., & Yan, Z. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0110-8 · Cited by 240

Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology

Csoka, A. B., & Szyf, M. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2008.10.039 · Cited by 245

REST, a master transcriptional regulator in neurodegenerative disease

Hwang, J.-Y., & Zukin, R. S. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.12.008 · Cited by 247

Beyond transcription factors: The role of chromatin modifying enzymes in regulating transcription required for memoryPreprint

Barrett, R. M., & Wood, M. A. (2008) · Learning & Memory · doi:10.1101/lm.917508 · Cited by 247

Autism Spectrum Disorders and Epigenetics

Grafodatskaya, D., Chung, B., Szatmari, P., & Weksberg, R. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.05.005 · Cited by 235

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex

Cheung, I., Shulha, H. P., Jiang, Y., Matevossian, A., Wang, J., Weng, Z., & Akbarian, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001702107 · Cited by 235

ΔFosB Mediates Epigenetic Desensitization of the c-fosGene After Chronic Amphetamine Exposure

Renthal, W. R., Carle, T. L., Maze, I. S., Covington, H. E., Truong, H.-T., Alibhai, I. N., Kumar, A., Montgomery, R. L., Olson, E. N., & Nestler, E. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1043-08.2008 · Cited by 242

Microbes & neurodevelopment – Absence of microbiota during early life increases activity-related transcriptional pathways in the amygdala

Stilling, R. M., Ryan, F. J., Hoban, A. E., Shanahan, F., Clarke, G., Claesson, M. J., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.009 · Cited by 233

Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232

Chromatin Remodeling BAF (SWI/SNF) Complexes in Neural Development and Disorders

Sokpor, G., Xie, Y., Rosenbusch, J., & Tuoc, T. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00243 · Cited by 230

Epigenetics of stress adaptations in the brain

Stankiewicz, A. M., Swiergiel, A. H., & Lisowski, P. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.07.003 · Cited by 220

How does the social environment ‘get into the mind’? Epigenetics at the intersection of social and psychiatric epidemiology

Toyokawa, S., Uddin, M., Koenen, K. C., & Galea, S. (2011) · Social Science & Medicine · doi:10.1016/j.socscimed.2011.09.036 · Cited by 223

Epigenetic Alterations Are Critical for Fear Memory Consolidation and Synaptic Plasticity in the Lateral Amygdala

Monsey, M. S., Ota, K. T., Akingbade, I. F., Hong, E. S., & Schafe, G. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019958 · Cited by 225

The Integration of Genetic Propensities into Social-Control Models of Delinquency and Violence among Male Youths

Guo, G., Roettger, M. E., & Cai, T. (2008) · American Sociological Review · doi:10.1177/000312240807300402 · Cited by 218

Epigenetic Regulation in Human Brain—Focus on Histone Lysine Methylation

Akbarian, S., & Huang, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.015 · Cited by 216

Epigenetics in the Nervous System: Figure 1.

Jiang, Y., Langley, B. C., Lubin, F. D., Renthal, W. R., Wood, M. A., Yasui, D. H., Kumar, A., Nestler, E. J., Akbarian, S., & Beckel-Mitchener, A. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3797-08.2008 · Cited by 216

Increased serotonin transporter gene ( SERT ) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins

Ouellet-Morin, I., Wong, C. C. Y., Danese, A., Pariante, C. M., Papadopoulos, A. S., Mill, J., & Arseneault, L. (2013) · Psychological Medicine · doi:10.1017/s0033291712002784 · Cited by 207

Sodium Butyrate Abolishes Lipopolysaccharide-Induced Depression-like Behaviors and Hippocampal Microglial Activation in Mice

Yamawaki, Y., Yoshioka, N., Nozaki, K., Ito, H., Oda, K., Harada, K., Shirawachi, S., Asano, S., Aizawa, H., Yamawaki, S., et al. (2018) · Brain Research · doi:10.1016/j.brainres.2017.12.004 · Cited by 204

Cellular Circadian Clocks in Mood Disorders

McCarthy, M. J., & Welsh, D. K. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412456367 · Cited by 203

Protein Phosphatase 1 Regulates the Histone Code for Long-Term Memory

Koshibu, K., Gräff, J., Beullens, M., Heitz, F. D., Berchtold, D., Russig, H., Farinelli, M., Bollen, M., & Mansuy, I. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3610-09.2009 · Cited by 216

Epigenetic mechanisms in neurological and neurodegenerative diseases

Landgrave-Gómez, J., Mercado-Gómez, O. F., & Guevara‐Guzmán, R. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00058 · Cited by 208

Abuse and dependence liability of benzodiazepine-type drugs: GABAA receptor modulation and beyond

Licata, S. C., & Rowlett, J. K. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.01.001 · Cited by 203

Ionotropic Glutamate Receptors & CNS Disorders

Bowie, D. (2008) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152708784083821 · Cited by 207

Mechanisms of specificity in neuronal activity-regulated gene transcription

Lyons, M. R., & West, A. E. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.003 · Cited by 209

Advances in behavioral genetics: mouse models of autism

Moy, S. S., & Nadler, J. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002082 · Cited by 204

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair

Yu, H., Su, Y., Shin, J., Zhong, C., Guo, J. U., Weng, Y., Gao, F., Geschwind, D. H., Coppola, G., Ming, G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4008 · Cited by 199

The neuropathobiology of multiple sclerosis

Woo, M. S., Engler, J. B., & Friese, M. A. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00823-z · Cited by 205

Isolation of neuronal chromatin from brain tissue

Jiang, Y., Matevossian, A., Huang, H.-S., Straubhaar, J., & Akbarian, S. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-42 · Cited by 193

Selective DNA Methylation of BDNF Promoter in Bipolar Disorder: Differences Among Patients with BDI and BDII

D'Addario, C., Dell'Osso, B., Palazzo, M. C., Benatti, B., Lietti, L., Cattaneo, E., Galimberti, D., Fenoglio, C., Cortini, F., Scarpini, E., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.10 · Cited by 192

Lamarck rises from his grave: parental environment‐induced epigenetic inheritance in model organisms and humans

Wang, Y., Liu, H., & Sun, Z. S. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12322 · Cited by 200

Neuronal network plasticity and recovery from depression

Castrén, E. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1 · Cited by 190

Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons

Iwamoto, K., Bundo, M., Ueda, J., Oldham, M. C., Ukai, W., Hashimoto, E., Saito, T., Geschwind, D. H., & Kato, T. (2011) · Genome Research · doi:10.1101/gr.112755.110 · Cited by 189

Mice selected for high versus low stress reactivity: A new animal model for affective disorders

Touma, C., Bunck, M., Glasl, L., Nußbaumer, M., Palme, R., Stein, H., Wolferstätter, M., Zeh, R., Zimbelmann, M., Holsboer, F., et al. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.013 · Cited by 194

Rodent models in depression research: Classical strategies and new directions

Pollak, D. D., Rey, C. E., & Monje, F. J. (2010) · Annals of Medicine · doi:10.3109/07853891003769957 · Cited by 190

Antidepressant-like effect of sodium butyrate is associated with an increase in tet1 and in 5-hydroxymethylation levels in the BDNF gene

Wei, Y. B., Melas, P. A., Wegener, G., Mathe, A. A., & Lavebratt, C. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu032 · Cited by 186

Vitamin D and Depression: Cellular and Regulatory Mechanisms

Berridge, M. J. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013227 · Cited by 194

Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset

Melas, P. A., Rogdaki, M., Ösby, U., Schalling, M., Lavebratt, C., & Ekström, T. J. (2012) · The FASEB Journal · doi:10.1096/fj.11-202069 · Cited by 186

Altered gene expression of histone deacetylases in mood disorder patients

Hobara, T., Uchida, S., Otsuki, K., Matsubara, T., Funato, H., Matsuo, K., Suetsugi, M., & Watanabe, Y. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.08.015 · Cited by 185

Scrutinizing the epigenetics revolution

Meloni, M., & Testa, G. (2014) · BioSocieties · doi:10.1057/biosoc.2014.22 · Cited by 189

Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability

Richetto, J., & Meyer, U. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.03.008 · Cited by 189

Emergence of sex differences in the development of substance use and abuse during adolescence

Kuhn, C. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.003 · Cited by 192

Epigenetic mechanisms of major depression: Targeting neuronal plasticity

Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181

The Role of DNA Methylation in the Central Nervous System and Neuropsychiatric Disorders

Feng, J., & Fan, G. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)89004-1 · Cited by 179

Epigenetics and the Biological Basis of Gene × Environment Interactions

Bagot, R. C., & Meaney, M. J. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.06.001 · Cited by 177

How can we realize the promise of personalized antidepressant medicines?

Holsboer, F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2453 · Cited by 177

Chronic Cocaine-Induced H3 Acetylation and Transcriptional Activation of CaMKIIα in the Nucleus Accumbens Is Critical for Motivation for Drug Reinforcement

Wang, L., Lv, Z., Hu, Z., Sheng, J., Hui, B., Sun, J., & Ma, L. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.193 · Cited by 183

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

Schwer, B., Schumacher, B., Lombard, D. B., Xiao, C., Kurtev, M. V., Gao, J., Schneider, J. I., Chai, H., Bronson, R. T., Tsai, L., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016306107 · Cited by 179

Plastic and neuroprotective mechanisms involved in the therapeutic effects of cannabidiol in psychiatric disorders

Campos, A. C., Fogaça, M. V., Scarante, F. F., Joca, S. R. L., Sales, A. J., Gomes, F. V., Sonego, A. B., Rodrigues, N. S., Galve-Roperh, I., & Guimarães, F. S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00269 · Cited by 175

Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions

Mirkovic, B., Laurent‐Levinson, C., Podlipski, M.-A., Frébourg, T., Cohen, D., & Gérardin, P. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00158 · Cited by 183

Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders

Grayson, D. R., Kundakovic, M., & Sharma, R. P. (2010) · Molecular Pharmacology · doi:10.1124/mol.109.061333 · Cited by 171

Depression research: where are we now?

Lee, S., Jeong, J., Kwak, Y., & Park, S. K. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-8 · Cited by 187

Epigenetic mechanisms in schizophrenia

Roth, T. L., Lubin, F. D., Sodhi, M., & Kleinman, J. E. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.009 · Cited by 176

Sex-Specific Differences in Expression of Histone DemethylasesUtxandUtyin Mouse Brain and Neurons

Xu, J., Deng, X., Watkins, R., & Distèche, C. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5382-07.2008 · Cited by 173

Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression

Massart, R., Mongeau, R., & Lanfumey, L. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0212 · Cited by 177

Epigenetics, brain evolution and behaviour

Keverne, E. B., & Curley, J. P. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.03.001 · Cited by 168

Gene–Environment Interaction in Major Depression: Focus on Experience-Dependent Biological Systems

Lopizzo, N., Bocchio‐Chiavetto, L., Cattane, N., Plazzotta, G., Tarazi, F. I., Pariante, C. M., Riva, M. A., & Cattaneo, A. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00068 · Cited by 182

Epigenetic dysregulation in cognitive disorders

Gräff, J., & Mansuy, I. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06787.x · Cited by 167

Chromatin remodeling — a novel strategy to control excessive alcohol drinking

Warnault, V., Darcq, E., Levine, A. A., Barak, S., & Dorit Ron, A. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.4 · Cited by 163

Escalated or Suppressed Cocaine Reward, Tegmental BDNF, and Accumbal Dopamine Caused by Episodic versus Continuous Social Stress in Rats

Miczek, K. A., Nikulina, E. M., Shimamoto, A., & Covington, H. E. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0637-11.2011 · Cited by 162

Neuroscience of alcoholism: molecular and cellular mechanisms

Moonat, S., Starkman, B. G., Sakharkar, A. J., & Pandey, S. C. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0135-y · Cited by 169

Epigenetic alterations in depression and antidepressant treatment

Menke, A., & Binder, E. B. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/amenke · Cited by 161

Hypertensive disorders during pregnancy and health outcomes in the offspring: a systematic review

Pinheiro, T. V., Brunetto, S., Ramos, J. G. L., Bernardi, J. R., & Goldani, M. Z. (2016) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174416000209 · Cited by 168

Committee on the Prevention of Mental Disorders and Substance Abuse Among Children, Youth, and Young Adults: Research Advances and Promising Interventions

PromisingInterventions, O’Connell, M. E., Boat, T. F., & Warner, K. E. (2009) · Cited by 159

Drugs and addiction: an introduction to epigenetics

Wong, C. C. Y., Mill, J. S., & Fernandes, C. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.03321.x · Cited by 166

GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia

Xu, M., & Wong, A. H. C. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.172 · Cited by 168

The social brain meets the reactive genome: neuroscience, epigenetics and the new social biology

Meloni, M. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00309 · Cited by 169

Neurobiology of dysregulated motivational systems in drug addiction

Edwards, S., & Koob, G. F. (2010) · Future Neurology · doi:10.2217/fnl.10.14 · Cited by 157

Genome wide analysis reveals association of a FTO gene variant with epigenetic changes

Almén, M. S., Jacobsson, J. A., Moschonis, G., Benedict, C., Chrousos, G. P., Fredriksson, R., & Schiöth, H. B. (2012) · Genomics · doi:10.1016/j.ygeno.2011.12.007 · Cited by 161

Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies

Yao, Y., Chen, P., Diao, J., Cheng, G., Deng, L., Anglin, J. L., Prasad, B. V. V., & Song, Y. (2011) · Journal of the American Chemical Society · doi:10.1021/ja206312b · Cited by 157

Aberrant Histone Deacetylase2–Mediated Histone Modifications and Synaptic Plasticity in the Amygdala Predisposes to Anxiety and Alcoholism

Moonat, S., Sakharkar, A. J., Zhang, H., Tang, L., & Pandey, S. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.012 · Cited by 162

A review of DNA methylation in depression

Chen, D., Meng, L., Pei, F., Zheng, Y., & Leng, J. (2017) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2017.05.022 · Cited by 160

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function

Kennedy, A. J., Rahn, E. J., Paulukaitis, B. S., Savell, K. E., Kordasiewicz, H. B., Wang, J., Lewis, J. W., Posey, J. L., Strange, S. K., Karlsson, M. G., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.004 · Cited by 153

Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease

Bürli, R. W., Luckhurst, C. A., Aziz, O., Matthews, K. L., Yates, D., Lyons, K. A., Beconi, M., McAllister, G., Breccia, P., Stott, A. J., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm4011884 · Cited by 153

DNA methylation impacts on learning and memory in aging

Liu, L., van Groen, T., Kadish, I., & Tollefsbol, T. O. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.020 · Cited by 152

Development and the epigenome: the ‘synapse’ of gene–environment interplay

Boyce, W. T., & Kobor, M. S. (2014) · Developmental Science · doi:10.1111/desc.12282 · Cited by 160

Epigenetics of early-life lead exposure and effects on brain development

Senut, M.-C., Cingolani, P., Sen, A., Kruger, A., Shaik, A., Hirsch, H., Suhr, S. T., & Ruden, D. (2012) · Epigenomics · doi:10.2217/epi.12.58 · Cited by 151

Escalation of drug self-administration as a hallmark of persistent addiction liability

Edwards, S., & Koob, G. F. (2013) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283644d15 · Cited by 151

The Reelin and GAD67 Promoters Are Activated by Epigenetic Drugs That Facilitate the Disruption of Local Repressor Complexes

Kundaković, M., Chen, Y., Guidotti, A., & Grayson, D. R. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.051763 · Cited by 149

Genome-Wide Association Scan of Trait Depression

Terracciano, A., Tanaka, T., Sutin, A. R., Sanna, S., Deiana, B., Lai, S., Uda, M., Schlessinger, D., Abecasis, G. R., Ferrucci, L., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.030 · Cited by 150

The Biological Underpinnings of Peer Victimization: Understanding Why and How the Effects of Bullying Can Last a Lifetime

Vaillancourt, T., Hymel, S. C., & McDougall, P. (2013) · Theory Into Practice · doi:10.1080/00405841.2013.829726 · Cited by 167

Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity

Giralt, A., Puigdellívol, M., Carretón, O., Paoletti, P., Valero, J., Parra‐Damas, A., Saura, C. A., Alberch, J., & Ginés, S. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr552 · Cited by 157

Antidepressant‐like effect induced by systemic and intra‐hippocampal administration of DNA methylation inhibitors

Sales, A. J., Biojone, C., Terceti, M. S., Guimarães, F. S., Gomes, M. V., & Joca, S. R. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01489.x · Cited by 147

Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases

Karnib, N., El-Ghandour, R., Hayek, L. E., Nasrallah, P., Khalifeh, M., Barmo, N., Jabre, V., Ibrahim, P., Bilen, M., Stephan, J. S., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0313-z · Cited by 147

Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders

Delgado‐Morales, R., Agís‐Balboa, R. C., Esteller, M., & Berdasco, M. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0365-z · Cited by 147

Early-Life Stress Reduces DNA Methylation of the Pomc Gene in Male Mice

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