The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Plasticity during stroke recovery: from synapse to behaviour
Abstract
Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which results in damage to neuronal networks and the impairment of sensation, movement or cognition. Evidence from animal models suggests that a time-limited window of neuroplasticity opens following a stroke, during which the greatest gains in recovery occur. Plasticity mechanisms include activity-dependent rewiring and synapse strengthening. The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury.
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In the citing paper
“While neuronal plasticity is actively inhibited during adulthood, a crucial time window opens in the post-acute ischaemic phase that is characterised by intense neuronal sprouting.1,2”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [2]
In the citing paper
“The promotion of brain remodelling and plasticity is not limited to a sharp and well defined therapeutic window.1–3”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [2]
Citations
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Research works printed but not linked: 1
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Langhorne, P., Bernhardt, J., & Kwakkel, G. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60325-5 · Cited by 2,726
The Science of Stroke: Mechanisms in Search of Treatments
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What Is the Evidence for Physical Therapy Poststroke? A Systematic Review and Meta-Analysis
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Brain–machine interface in chronic stroke rehabilitation: A controlled study
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Metadata
- Authors
- Murphy, T. H., & Corbett, D.
- Affiliations
- University of British Columbia (CA)
- Memorial University of Newfoundland (CA)
- Venue
- Nature Reviews Neuroscience
- Published
- 2009-11-04
- Volume
- 10
- Issue
- 12
- Pages
- 861-872
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2045421141
- Cited by
- 1,938
- References
- 168
- Citations by year
- 2026: 126 · 2025: 120 · 2024: 125 · 2023: 135 · 2022: 120 · 2021: 161 · 2020: 135 · 2019: 131 · 2018: 125 · 2017: 146 · 2016: 101 · 2015: 114 · 2014: 120 · 2013: 99 · 2012: 67
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of British Columbia and Yukon
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- stroke recovery, neuroplasticity, behavioral recovery, developmental plasticity, animal models of stroke
- MeSH terms
- Animals, Brain Ischemia, Disease Models, Animal, Humans, Learning, Neuronal Plasticity, Synapses, Recovery of Function, Stroke
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