Cited by 1,938Stroke Rehabilitation and RecoveryAcute Ischemic Stroke ManagementNeurogenesis and neuroplasticity mechanisms

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Plasticity during stroke recovery: from synapse to behaviour

Murphy, Timothy H., Corbett, Dale·2009·Nature Reviews Neuroscience

DOI 10.1038/nrn2735

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Abstract

Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which results in damage to neuronal networks and the impairment of sensation, movement or cognition. Evidence from animal models suggests that a time-limited window of neuroplasticity opens following a stroke, during which the greatest gains in recovery occur. Plasticity mechanisms include activity-dependent rewiring and synapse strengthening. The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury.

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Authors: Murphy, T. H., & Corbett, D.
Affiliations: University of British Columbia (CA)
Memorial University of Newfoundland (CA)
ORCID: Murphy, Timothy H.
Corbett, Dale
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2009-11-04
Volume: 10
Issue: 12
Pages: 861-872
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2735
OpenAlex: W2045421141
Cited by: 1,938
References: 168
Citations by year: 2026: 126 · 2025: 120 · 2024: 125 · 2023: 135 · 2022: 120 · 2021: 161 · 2020: 135 · 2019: 131 · 2018: 125 · 2017: 146 · 2016: 101 · 2015: 114 · 2014: 120 · 2013: 99 · 2012: 67
FWCI: 7.83
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Heart and Stroke Foundation of British Columbia and Yukon
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: stroke recovery, neuroplasticity, behavioral recovery, developmental plasticity, animal models of stroke
MeSH terms: Animals, Brain Ischemia, Disease Models, Animal, Humans, Learning, Neuronal Plasticity, Synapses, Recovery of Function, Stroke

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Plasticity during stroke recovery: from synapse to behaviour

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