Neuronal circuitry for pain processing in the dorsal horn

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Androgen receptors expressed in the primary sensory neurons regulate mechanical pain sensitivity

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c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy

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A dedicated skin-to-brain circuit for cool sensation in mice

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Generation of a NK1R‐CreER knockin mouse strain to study cells involved in Neurokinin 1 Receptor signaling

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Orexin B Modulates Spontaneous Excitatory and Inhibitory Transmission in Lamina II Neurons of Adult Rat Spinal Cord

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Mediation of Cardiac Macrophage Activity via Auricular Vagal Nerve Stimulation Ameliorates Cardiac Ischemia/Reperfusion Injury

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The Neuropeptide Cortistatin Alleviates Neuropathic Pain in Experimental Models of Peripheral Nerve Injury

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Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing

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Model-based analysis of subthreshold mechanisms of spinal cord stimulation for pain

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Changes in the Expressions of Iba1 and Calcitonin Gene-Related Peptide in Adjacent Lumbar Spinal Segments after Lumbar Disc Herniation in a Rat Model

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Minocycline enhances inhibitory transmission to substantia gelatinosa neurons of the rat spinal dorsal horn

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Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury

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Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B

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Colokinetic effect of somatostatin in the spinal defecation center in rats

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Analgesia by deletion of spinal neurokinin 1 receptor expressing neurons using a bioengineered substance P- Pseudomonas exotoxin conjugate

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Parabrachial-to-amygdala control of aversive learning

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Photoswitchable ORG25543 Congener Enables Optical Control of Glycine Transporter 2

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Spinal Excitatory Dynorphinergic Interneurons Contribute to Burn Injury-Induced Nociception Mediated by Phosphorylated Histone 3 at Serine 10 in Rodents

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Responses of neurons in rostral ventromedial medulla to nociceptive stimulation of craniofacial region and tail in rats

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Endogenous μ-opioid—Neuropeptide Y Y1 receptor synergy silences chronic postoperative pain in mice

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Calcium-binding protein parvalbumin in the spinal cord and dorsal root ganglia

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Microglial Refinement of A-Fiber Projections in the Postnatal Spinal Cord Dorsal Horn Is Required for Normal Maturation of Dynamic Touch

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Acute PAR2 activation reduces GABAergic inhibition in the spinal dorsal horn

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Pacemaker Neurons and the Development of Nociception

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Central Nervous System Pain Pathways

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Evaluation of Neuropathic Pain in a Rat Model of Total Brachial Plexus Avulsion from Behavior to Brain Metabolism

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Kappa Opioid Signaling at the Crossroads of Chronic Pain and Opioid Addiction

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Central regulatory mechanisms of visceral sensation in response to colonic distension with special reference to brain orexin

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MiR-30d Participates in Vincristine-Induced Neuropathic Pain by Down-Regulating GAD67

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Contribution of µ Opioid Receptor–expressing Dorsal Horn Interneurons to Neuropathic Pain–like Behavior in Mice

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Store‐operated calcium entry mediates hyperalgesic responses during neuropathy

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Optogenetic inhibition of spinal inhibitory neurons facilitates mechanical responses of spinal wide dynamic range neurons and causes mechanical hypersensitivity

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The efficacy of the analgesic GlyT2 inhibitor, ORG25543 , is determined by two connected allosteric sites

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Role of Somatostatin and Somatostatin Receptor type 2 in Postincisional Nociception in Rats

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Changes in the disposition of substance P in the rostral ventromedial medulla after inflammatory injury in the rat

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Microvascular Decompression for Trigeminal Neuralgia: The Role of Mechanical Allodynia

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Impaired sensitivity to pain stimuli in plasma membrane calcium ATPase 2 (PMCA2) heterozygous mice: a possible modality‐ and sex‐specific role for PMCA2 in nociception

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Alterations in regional homogeneity of resting-state cerebral activity in patients with chronic prostatitis/chronic pelvic pain syndrome

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Electrical Synapses are Involved in Orofacial Neuropathic Pain

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Aging alters signaling properties in the mouse spinal dorsal horn

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Projecting neurons in spinal dorsal horn send collateral projections to dorsal midline/intralaminar thalamic complex and parabrachial nucleus

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Brainstem injection of lidocaine releases the descending pain-inhibitory mechanisms in a rat model of mononeuropathy

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Neurons in the lateral part of the lumbar spinal cord show distinct novel axon trajectories and are excited by short propriospinal ascending inputs

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Peripheral nerve injury induces aquaporin-4 expression and astrocytic enlargement in spinal cord

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Experimental behaviour testing: pain

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A bioinspired multimodal nociceptive system enabling graded pressure–damage pain perception for adaptive robotic interaction

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Antiallodynic Action of 1-(3-(9H-Carbazol-9-yl)-1-propyl)-4-(2-methyoxyphenyl)-4-piperidinol (NNC05-2090), a Betaine/GABA Transporter Inhibitor

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Immunofluorescence characterization of spinal cord dorsal horn microglia and astrocytes in horses

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Dendritic Spines and Pain Memory

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Clinical thresholds in pain-related facial activity linked to differences in cortical network activation in neonates

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Neural Circuitry Polarization in the Spinal Dorsal Horn (SDH): A Novel Form of Dysregulated Circuitry Plasticity during Pain Pathogenesis

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The Antinociceptive Effects and Sex-Specific Neurotransmitter Modulation of Metformin in a Mouse Model of Fibromyalgia

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Marine-derived bioactive compounds for neuropathic pain: pharmacology and therapeutic potential

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Differential Neuronal Activation of Nociceptive Pathways in Neuropathic Pain After Spinal Cord Injury

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Neuroanatomy of spinal nociception and pain in dogs and cats: a practical review for the veterinary clinician

Pedersen, T. R., Berendt, M., & Rusbridge, C. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1534685 · Cited by 11

Inhibition of temporomandibular joint input to medullary dorsal horn neurons by 5HT3 receptor antagonist in female rats

Okamoto, K., Katagiri, A., Rahman, M., Thompson, R., & Bereiter, D. A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.037 · Cited by 11

Painful Cervical Facet Joint Injury Is Accompanied by Changes in the Number of Excitatory and Inhibitory Synapses in the Superficial Dorsal Horn That Differentially Relate to Local Tissue Injury Severity

Ita, M. E., Crosby, N. D., Bulka, B. A., & Winkelstein, B. A. (2016) · Spine · doi:10.1097/brs.0000000000001934 · Cited by 11

Enhanced Postsynaptic GABAB Receptor Signaling in Adult Spinal Projection Neurons after Neonatal Injury

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Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B‐p38MAPK/EPAC1 pathway in an animal model of postoperative pain

Wong, S. S. C., Sun, L., Qiu, Q., Gu, P., Li, Q., Wang, X., & Cheung, C. W. (2018) · European Journal of Pain · doi:10.1002/ejp.1349 · Cited by 11

The Stage-Specific Plasticity of Descending Modulatory Controls in a Rodent Model of Cancer-Induced Bone Pain

Kucharczyk, M. W., Derrien, D., Dickenson, A. H., & Bannister, K. (2020) · Cancers · doi:10.3390/cancers12113286 · Cited by 11

Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model

Fan, H., Wu, Z.-Y., Zhu, D.-Y., Gu, J., Xu, M., Zhang, M., Duan, H.-K., Li, Y.-Q., & Chen, T. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.804722 · Cited by 11

GABAA and Glycine Receptor-Mediated Inhibitory Synaptic Transmission onto Adult Rat Lamina IIi PKCγ-Interneurons: Pharmacological but Not Anatomical Specialization

Khoueiry, C. E., Alba‐Delgado, C., Antri, M., Gutièrrez‐Mecinas, M., Todd, A. J., Artola, A., & Dallel, R. (2022) · Cells · doi:10.3390/cells11081356 · Cited by 11

Characterisation of NPFF-expressing neurons in the superficial dorsal horn of the mouse spinal cord

Quillet, R., Dickie, A. C., Polgár, E., Gutièrrez‐Mecinas, M., Bell, A. M., Goffin, L., Watanabe, M., & Todd, A. J. (2023) · Scientific Reports · doi:10.1038/s41598-023-32720-3 · Cited by 11

Dissecting neural circuits from rostral ventromedial medulla to spinal trigeminal nucleus bidirectionally modulating craniofacial mechanical sensitivity

Xue, Y., Mo, S., Li, Y., Cao, Y., Xu, X., & Xie, Q. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102561 · Cited by 11

Functional remodeling of presynaptic voltage-gated calcium channels in superficial layers of the dorsal horn during neuropathic pain

Ferron, L., Harding, E. K., Gandini, M. A., Brideau, C., Stys, P. K., & Zamponi, G. W. (2024) · iScience · doi:10.1016/j.isci.2024.109973 · Cited by 11

Computational modeling of Adelta-fiber-mediated nociceptive detection of electrocutaneous stimulation

Yang, H., Meijer, H. G. E., Doll, R. J., Buitenweg, J. R., & van Gils, S. A. (2015) · Biological Cybernetics · doi:10.1007/s00422-015-0656-4 · Cited by 11

Chronic Pain and Decreased Opioid Efficacy: An Inflammatory Link

Giron, S. E., Griffis, C. A., & Burkard, J. F. (2015) · Pain Management Nursing · doi:10.1016/j.pmn.2015.04.001 · Cited by 11

Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord

Cagle, M. C., & Honig, M. G. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23422 · Cited by 11

J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain

Park, T. S. W., Khan, N., Kuo, A., Nicholson, J. R., Corradini, L., & Smith, M. T. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109056 · Cited by 11

Cellular Mechanisms for Antinociception Produced by Oxytocin and Orexins in the Rat Spinal Lamina II—Comparison with Those of Other Endogenous Pain Modulators

Kumamoto, E. (2019) · Pharmaceuticals · doi:10.3390/ph12030136 · Cited by 11

Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain

Choi, S., Beitz, A. J., & Lee, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01439 · Cited by 11

Alterations of voluntary behavior in the course of disease progress and pharmacotherapy in mice with collagen-induced arthritis

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Perineural application of resiniferatoxin on uninjured L3 and L4 nerves completely alleviates thermal and mechanical hypersensitivity following L5 nerve injury in rats

Javed, H., Rehmathulla, S., Tariq, S., Emerald, B. S., Ljubisavljević, M., & Shehab, S. A. S. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24884 · Cited by 11

The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavity

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Microglia-derived TNF-α inhibiting GABAergic neurons in the anterior lateral bed nucleus of the stria terminalis precipitates visceral hypersensitivity induced by colorectal distension in rats

Ji, N., Meng, Q., Wang, Y., Zhou, Z.-M., Song, Y., Hua, R., & Zhang, Y.-M. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100449 · Cited by 12

The Somatosensory System

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Connections between EM2- and SP-containing terminals and GABAergic neurons in the mouse spinal dorsal horn

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Inhibitory Action of Antidepressants on Mouse Betaine/GABA Transporter (BGT1) Heterologously Expressed in Cell Cultures

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Neuropathic pain following spinal cord hemisection induced by the reorganization in primary somatosensory cortex and regulated by neuronal activity of lateral parabrachial nucleus

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Nociceptor activity induces nonionotropic NMDA receptor signaling to enable spinal reconsolidation and reverse pathological pain

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Anatomical evidence that the uninjured adjacent L4 nerve plays a significant role in the development of peripheral neuropathic pain after L5 spinal nerve ligation in rats

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Electroacupuncture effects on the P2X4R pathway in microglia regulating the excitability of neurons in the substantia gelatinosa region of rats with spinal nerve ligation

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Dorsal Horn Pain Mechanisms

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Synaptic Transmission of Pain in the Dorsal Horn

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Sensory plasticity of dorsal horn silent neurons as a critical mechanism for neuropathic pain

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