Cited by 1,475Pain Mechanisms and TreatmentsNeuroscience and Neuropharmacology ResearchPain Management and Treatment

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Neuronal circuitry for pain processing in the dorsal horn

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Todd, Andrew J.·2010·Nature Reviews Neuroscience

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Abstract

Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region.

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Todd, A. J. in Handbook of Clinical Neurology 3rd Series, Pain. (Eds Cervero, F. and Jensen, T. S.) 61–76 (Elsevier, Edinburgh, 2006).

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Authors: Todd, A. J.
Affiliations: University of Glasgow (GB)
Corresponding author: Todd, Andrew J.
ORCID: Todd, Andrew J.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2010-11-11
Volume: 11
Issue: 12
Pages: 823-836
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2947
PMC: PMC3277941
OpenAlex: W2059635921
Cited by: 1,475
References: 162
Citations by year: 2026: 100 · 2025: 114 · 2024: 95 · 2023: 108 · 2022: 122 · 2021: 137 · 2020: 106 · 2019: 125 · 2018: 85 · 2017: 85 · 2016: 90 · 2015: 86 · 2014: 75 · 2013: 76 · 2012: 39
FWCI: 4.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
Funders: Wellcome Trust (076976)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: dorsal horn, spinal cord, pain processing, neural circuits, hyperalgesia, allodynia, sensory neurons, analgesic targets, nerve injury, inflammation, pain perception
MeSH terms: Afferent Pathways, Animals, Brain, Disease Models, Animal, Humans, Nerve Net, Nociceptors, Pain, Posterior Horn Cells

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Neuronal circuitry for pain processing in the dorsal horn

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