The DOI matches its Crossref record; 163 of the 164 references it cites were found in a registry or an index.
The brain reward circuitry in mood disorders
Open accessAbstract
Mood disorders are common and debilitating conditions characterized in part by profound deficits in reward-related behavioural domains. A recent literature has identified important structural and functional alterations within the brain's reward circuitry--particularly in the ventral tegmental area-nucleus accumbens pathway--that are associated with symptoms such as anhedonia and aberrant reward-associated perception and memory. This Review synthesizes recent data from human and rodent studies from which emerges a circuit-level framework for understanding reward deficits in depression. We also discuss some of the molecular and cellular underpinnings of this framework, ranging from adaptations in glutamatergic synapses and neurotrophic factors to transcriptional and epigenetic mechanisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“For example, dopaminergic projections from the VTA to the nucleus accumbens (NAc), prefrontal cortex (PFC), amygdala and hippocampus that regulate responses to rewarding or aversive stimuli are reportedly dysregulated in people with MDD as well as in rodent models of chronic stress39–42.”
From Central regulation of stress-evoked peripheral immune responses (2023) · cites this paper as [40]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Notably, several of these bone marrow-innervating brain regions have been implicated in stress responses, reward processing and the pathogenesis of depression and anxiety disorders.”
From Central regulation of stress-evoked peripheral immune responses (2023) · cites this paper as [40]
The cited source says what the claim attributes to it.
In the citing paper
“The NAc plays a crucial role in stress responses and mood disorders including MDD28.”
From Social stress induces neurovascular pathology promoting depression (2017) · cites this paper as [28]
In the citing paper
“Susceptible and resilient mice show distinct cellular and circuit alterations between the NAcc and other brain regions within the reward circuitry”
From Social functioning in major depressive disorder (2016) · cites this paper as Russo and Nestler, 2013
In the citing paper
“demonstrating a causal role for plasticity in this circuit in mediating social anhedonia in a mouse model of depression”
From Social functioning in major depressive disorder (2016) · cites this paper as Russo and Nestler, 2013
In the citing paper
“A grossly oversimplified overview of these circuits is that the prefrontal cortices and hippocampus are devoted to detecting and decoding specific features of stimuli and the environment, including the social environment, to guide decision-making and ensure adaptive, flexible, and predictive responses to rewarding stimuli, whereas the lateral hypothalamus-lateral habenula circuits predominantly En”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [51]
In the citing paper
“Prairie voles strongly express OXTR in regions of the MLR, a conserved neural network (75) involved in reward processing and implicated in numerous human psychiatric disorders including depression (76), addiction (77), and schizophrenia (78).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [75]
In the citing paper
“Depressive behavior is mediated in part by increased NAc BDNF signaling (reviewed in ref. [66]).”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [66]
In the citing paper
“The mesolimbic dopamine system, composed of dopamine neurons of the ventral tegmental area (VTA) and their projections to the nucleus accumbens (NAc), is most often associated with the rewarding effects of food and sex and plays an essential role in stress-induced anhedonia and other depression-related behavioral abnormalities [87, 88].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [88]
In the citing paper
“The mesolimbic dopamine system, composed of dopamine neurons of the ventral tegmental area (VTA) and their projections to the nucleus accumbens (NAc), is most often associated with the rewarding effects of food and sex and plays an essential role in stress-induced anhedonia and other depression-related behavioral abnormalities [87, 88].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [88]
In the citing paper
“One of the sources of DA in the hippocampus derives from DAergic neurons in the VTA17.”
From Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease (2017) · cites this paper as [17]
In the citing paper
“VTA DAergic neurons also target the nucleus accumbens (NAc) and cerebral cortex, mediating the control of incentive motivation and reward processing17.”
From Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease (2017) · cites this paper as [17]
In the citing paper
“Frontostriatal circuits subserving reward processes are modulated by the neurotransmitter dopamine (DA) The primary reward circuit includes dopaminergic projections from the ventral tegmental area (VTA) to the nucleus accumbens, which release dopamine in response to reward-related stimuli (Russo and Nestler, 2013).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Russo and Nestler, 2013
In the citing paper
“Molecular changes within specific cell types of the brain's reward regions shape the ways in which adolescents respond to changes in the environment, determining either resilience or susceptibility (Russo and Nestler, 2013).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Russo and Nestler, 2013
In the citing paper
“Vulnerability for depression, risk taking, or other psychopathologies may be determined by molecular changes in cells that occur following stressors (see Russo and Nestler, 2013).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Russo and Nestler, 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307
Self-citationEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
Self-citationTHE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION
Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Flagged first, then by citations
1 of the 164 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 301–400 of 1,005
Beyond the neuron: Role of non-neuronal cells in stress disorders
Cathomas, F., Holt, L. M., Parise, E. M., Liu, J., Murrough, J. W., Casaccia, P., Nestler, E. J., & Russo, S. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.033 · Cited by 72
Self-citationThe nucleus accumbens in reward and aversion processing: insights and implications
Xu, Y., Lin, Y., Yu, M., & Zhou, K. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1420028 · Cited by 86
Altered functional connectivity within the central reward network in overweight and obese women
Coveleskie, K., Gupta, A., Kilpatrick, L. A., Mayer, E. D., Ashe-McNalley, C., Stains, J., Labus, J. S., & Mayer, E. A. (2015) · Nutrition and Diabetes · doi:10.1038/nutd.2014.45 · Cited by 74
Steinman, M. Q., Laredo, S. A., Lopez, E. M., Manning, C. E., Hao, R. C., Doig, I. E., Campi, K. L., Flowers, A. E., Knight, J. K., & Trainor, B. C. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.009 · Cited by 73
Changed Synaptic Plasticity in Neural Circuits of Depressive-Like and Escitalopram-Treated Rats
Li, X., Yuan, Y., Xu, H., Wu, D., Gong, W.-G., Geng, L., Wu, F., Tang, H., Xu, L., & Zhang, Z. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv046 · Cited by 72
Corticostriatal Regulation of Acute Pain
Martinez, E., Lin, H. H., Zhou, H., Dale, J., Liu, K., & Wang, J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00146 · Cited by 72
Anhedonia in depression and bipolar disorder
Whitton, A. E., & Pizzagalli, D. A. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_323 · Cited by 80
Landgraf, D., Long, J. E., & Welsh, D. K. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13085 · Cited by 72
Krashia, P., Nobili, A., & D’Amelio, M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00123 · Cited by 70
Social neuroscience and its potential contribution to psychiatry
Cacioppo, J. T., Cacioppo, S., Dulawa, S. C., & Palmer, A. A. (2014) · World Psychiatry · doi:10.1002/wps.20118 · Cited by 76
Hussein, A., Guevara, C. A., Valle, P. D., Gupta, S., Benson, D. L., & Huntley, G. W. (2021) · The Neuroscientist · doi:10.1177/10738584211011979 · Cited by 78
Novello, M., Bosman, L. W. J., & Zeeuw, C. I. D. (2022) · The Cerebellum · doi:10.1007/s12311-022-01499-w · Cited by 78
Synaptic Regulation of a Thalamocortical Circuit Controls Depression-Related Behavior
Miller, O. H., Bruns, A., Ammar, I. B., Mueggler, T., & Hall, B. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.002 · Cited by 69
Morris, L. S., Kundu, P., Costi, S., Collins, A. B., Schneider, M., Verma, G., Balchandani, P., & Murrough, J. W. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0425-6 · Cited by 67
Empana, J. P., Boutouyrie, P., Lemogne, C., Jouven, X., & van Sloten, T. T. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.04.012 · Cited by 71
Smith, C. M., Walker, A. W., Hosken, I. T., Chua, B. E., Zhang, C., Haidar, M., & Gundlach, A. L. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00046 · Cited by 69
Charbogne, P., Gardon, O., Martín‐García, E., Keyworth, H. L., Matsui, A., Mechling, A. E., Bienert, T., Nasseef, M. T., Robé, A., Moquin, L., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.022 · Cited by 75
Biological Aging and the Future of Geriatric Psychiatry
Rutherford, B. R., Taylor, W. D., Brown, P. J., Sneed, J. R., & Roose, S. P. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw241 · Cited by 75
Neural Mechanisms Linking Emotion with Cardiovascular Disease
Kraynak, T. E., Marsland, A. L., & Gianaros, P. J. (2018) · Current Cardiology Reports · doi:10.1007/s11886-018-1071-y · Cited by 70
Weger, M., Alpern, D., Cherix, A., Ghosal, S., Grosse, J., Russeil, J., Rolf Gruetter, A., de Kloet, E. R., Deplancke, B., & Sandi, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-75326-9 · Cited by 71
Elevated striatal reactivity across monetary and social rewards in bipolar I disorder.
Dutra, S. J., Cunningham, W. A., Hedy Kober, A., & Gruber, J. (2015) · Journal of Abnormal Psychology · doi:10.1037/abn0000092 · Cited by 74
The role of the gut microbiome in opioid use
Ren, M., & Lotfipour, S. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000538 · Cited by 69
Kokkosis, A. G., Madeira, M. M., Mullahy, M., & Tsirka, S. E. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01512-y · Cited by 73
Sturm, M., Becker, A., Schroeder, A., Bilkei‐Gorzó, A., & Zimmer, A. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12208 · Cited by 68
The habenula as a critical node in chronic stress-related anxiety
Jacinto, L., Mata, R., Novais, A., Marques, F., & Sousa, N. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.12.003 · Cited by 71
Brancato, A., Bregman, D., Ahn, H. F., Pfau, M. L., Ménard, C., Cannizzaro, C., Russo, S. J., & Hodes, G. E. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.03.014 · Cited by 73
Self-citationImplications of Circadian Rhythm in Dopamine and Mood Regulation
Kim, J., Jang, S.-W., Choe, H. K., Chung, S., Son, G. H., & Kim, K. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.0065 · Cited by 70
Reward Circuitry Plasticity in Pain Perception and Modulation
DosSantos, M. F. H., Moura, B. D. S., & DaSilva, A. F. M. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00790 · Cited by 71
Social instability is an effective chronic stress paradigm for both male and female mice
Yohn, C. N., Ashamalla, S. A., Bokka, L., Gergues, M. M., Garino, A., & Samuels, B. A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107780 · Cited by 71
Depression and substance use disorders: Clinical comorbidity and shared neurobiology
Calarco, C. A., & Lobo, M. K. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.09.004 · Cited by 74
The serotonin 5-HT 2C receptor and the non-addictive nature of classic hallucinogens
Canal, C. E., & Murnane, K. S. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116677104 · Cited by 73
Zhou, H., Martinez, E., Lin, H. H., Yang, R., Dale, J., Liu, K., Huang, D., & Wang, J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00240 · Cited by 70
Shuto, T., Kuroiwa, M., Sotogaku, N., Kawahara, Y., Oh, Y., Jang, J.-H., Shin, C.-H., Ohnishi, Y. N., Hanada, Y., Miyakawa, T., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0316-x · Cited by 64
Hein, T. C., Goetschius, L. G., McLoyd, V. C., Jeanne Brooks-gunn, B., McLanahan, S., Mitchell, C. M., Lopez‐Duran, N. L., Hyde, L. W., & Monk, C. S. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa144 · Cited by 76
Mul, J. D., Soto, M., Cahill, M. E., Ryan, R. E., Takahashi, H., So, K., Zheng, J., Croote, D. E., Hirshman, M. F., la Fleur, S. E., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0103-z · Cited by 67
Self-citationZimmermann, T., Bartsch, J., Beer, A., Lomazzo, E., Guggenhuber, S., Lange, M. D., Bîndilă, L., Pape, H., & Lutz, B. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0274-7 · Cited by 68
On the early life origins of vulnerability to opioid addiction
Levis, S. C., Bentzley, B. S., Molet, J., Bolton, J. L., Perrone, C. R., Baram, T. Z., & Mahler, S. V. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0628-5 · Cited by 73
The Formation and Function of the VTA Dopamine System
Hou, G., Hao, M., Duan, J., & Han, M.-H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073875 · Cited by 65
Modulation of amygdala reactivity following rapidly acting interventions for major depression
Loureiro, J. R., Leaver, A. M., Vasavada, M. M., Sahib, A. K., Kubicki, A., Joshi, S. H., Woods, R. P., Wade, B., Congdon, E. L., Espinoza, R. T., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.24895 · Cited by 64
Circadian insights into the biology of depression: Symptoms, treatments and animal models
Mendoza, J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112186 · Cited by 67
Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior
Yu, X., Ba, W., Zhao, G., Ma, Y., Harding, E. C., Yin, L., Wang, D., Li, H., Zhang, P., Shi, Y., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0810-9 · Cited by 65
Psychedelic‐inspired approaches for treating neurodegenerative disorders
Saeger, H. N., & Olson, D. E. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15544 · Cited by 72
Estrous Cycle Mediates Midbrain Neuron Excitability Altering Social Behavior upon Stress
Shanley, M. R., Miura, Y., Guevara, C. A., Onoichenco, A., Kore, R., Ustundag, E., Darwish, R., Renzoni, L., Sanchez, A. M. S., Blicker, E., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1504-22.2022 · Cited by 66
Baeken, C., Marinazzo, D., Schuerbeek, P. V., Wu, G., Mey, J. D., Luypaert, R., & Raedt, R. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095740 · Cited by 68
Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins
Maher, M. P., Matta, J. A., Gu, S., Seierstad, M., & Bredt, D. S. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.001 · Cited by 64
Cocaine-Induced Structural Plasticity in Input Regions to Distinct Cell Types in Nucleus Accumbens
Barrientos, C., Knowland, D., Wu, M. M. J., Lilascharoen, V., Huang, K. W., Malenka, R. C., & Lim, B. K. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.04.019 · Cited by 63
Lee, Y. L., Subramaniapillai, M., Brietzke, E. M., Mansur, R. B., Ho, R., Yim, S. J., & McIntyre, R. S. (2018) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125318791944 · Cited by 68
GluN2A mediates ketamine-induced rapid antidepressant-like responses
Su, T., Lu, Y., Fu, C., Geng, Y., & Chen, Y. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01436-y · Cited by 64
Neural Circuit Mechanisms Underlying Emotional Regulation of Homeostatic Feeding
Sweeney, P., & Yang, Y. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.02.006 · Cited by 67
An emerging role for the lateral habenula in aggressive behavior
Flanigan, M. E., Aleyasin, H., Takahashi, A., Golden, S. A., & Russo, S. J. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.05.003 · Cited by 61
Self-citationDirect dopamine terminal regulation by local striatal microcircuitry
Nolan, S. O., Zachry, J. E., Johnson, A. R., Brady, L. J., Siciliano, C. A., & Calipari, E. S. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15034 · Cited by 72
Lahti, L., Haugas, M., Tikker, L., Airavaara, M., Voutilainen, M. H., Anttila, J., Kumar, S., Inkinen, C., Salminen, M., & Partanen, J. (2015) · Development · doi:10.1242/dev.129957 · Cited by 62
Accelerated aging of the putamen in patients with major depressive disorder
Sacchet, M. D., Camacho, M. C., Livermore, E. E., Thomas, E. A. C., & Gotlib, I. H. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160010 · Cited by 63
Settell, M. L., Testini, P., Cho, S., Lee, J. H., Blaha, C. D., Jo, H. J., Lee, K. H., & Min, H.-K. P. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00104 · Cited by 60
A comparison of the electrocortical response to monetary and social reward
Distefano, A., Jackson, F. L., Levinson, A. R., Infantolino, Z. P., Jarcho, J. M., & Nelson, B. D. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy006 · Cited by 67
Relating structural and functional brainstem connectivity to disease measures in epilepsy
Englot, D. J., González, H. F. J., Reynolds, B. B., Konrad, P. E., Jacobs, M. L., Gore, J. C., Landman, B. A., & Morgan, V. L. (2018) · Neurology · doi:10.1212/wnl.0000000000005733 · Cited by 62
Francis, T. C., Gaynor, A., Chandra, R., Fox, M. E., & Lobo, M. K. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.007 · Cited by 61
Bittar, T. P., Pelaez, M. C., Silva, J. C. H., Quessy, F., Lavigne, A.-A., Morency, D., Blanchette, L.-J., Arsenault, E., Chérasse, Y., Seigneur, J., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.02.014 · Cited by 68
Chaudhary, S., Zhornitsky, S., Chao, H. H., van Dyck, C. H., & Li, C. R. (2022) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175221082834 · Cited by 66
Ehrlich, A. T., Maroteaux, G., Robé, A., Ventéo, L., Nasseef, M. T., van Kempen, L. C. L. T., Mechawar, N., Turecki, G., Darcq, E., & Kieffer, B. L. (2018) · Communications Biology · doi:10.1038/s42003-018-0106-7 · Cited by 61
Kokane, S. S., Armant, R. J., Bolaños‐Guzmán, C. A., & Perrotti, L. I. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112548 · Cited by 63
Pignatelli, M., Tejeda, H. A., Barker, D. J., Bontempi, L., Wu, J., Lopez, A., Ribeiro, S. P., Lucantonio, F., Parise, E. M., Torres‐Berrío, A., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0686-8 · Cited by 60
Self-citationPino, J. M. V., da Luz, M. H. M., Antunes, H. K. M., Giampá, S. Q. D. C., Martins, V. R., & Lee, K. S. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00145 · Cited by 60
Rincón‐Cortés, M., & Grace, A. A. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100839 · Cited by 67
Circuit selectivity in drug versus natural reward seeking behaviors
Nall, R. W., Heinsbroek, J. A., Nentwig, T. B., Kalivas, P. W., & Bobadilla, A. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15297 · Cited by 64
Nelson, B. D., & Jarcho, J. M. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab055 · Cited by 59
A computational analysis of mouse behavior in the sucrose preference test
Verharen, J. P. H., de Jong, J. W., Zhu, Y., & Lammel, S. (2023) · Nature Communications · doi:10.1038/s41467-023-38028-0 · Cited by 65
Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience
Turner, B. D., Kashima, D. T., Manz, K. M., Grueter, C. A., & Grueter, B. A. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00420 · Cited by 62
Massaly, N., Morón, J. A., & Al-Hasani, R. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00480 · Cited by 59
The microbiota-gut-brain axis in stress and depression
Tan, H.-E. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1151478 · Cited by 67
Tao, C., Zhang, G., Huang, J., Li, Z., Tao, H. W., & Zhang, L. I. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01397-2 · Cited by 62
Resting-state dynamic functional connectivity in major depressive disorder: A systematic review
Sun, S., Yan, C., Qu, S., Luo, G., Liu, X., Tian, F., Dong, Q., Li, X., & Hu, B. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111076 · Cited by 61
Auguste, S., Fisette, A., Fernandes, M. F., Hryhorczuk, C., Poitout, V., Alquier, T., & Fulton, S. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw014 · Cited by 59
Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors
Feng, J., Pena, C. J., Purushothaman, I., Engmann, O., Walker, D., Brown, A. N., Issler, O., Doyle, M., Harrigan, E., Mouzon, E., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.6 · Cited by 58
Self-citationLee, Y., Zhang, Y., Kim, S., & Han, K. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0028-y · Cited by 60
Ridder, D. D., & Vanneste, S. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.07.012 · Cited by 60
Malvestio, R. B., de Medeiros, P. S., Negrini-Ferrari, S. E., Oliveira-Silva, M., Medeiros, A. C., Padovan, C. M., Luongo, L., Maione, S., Coimbra, N. C., & de Freitas, R. L. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.06.017 · Cited by 60
Warren, B. L., Sial, O. K., Parise, L. F., Greenwood, M. A., Brewer, J. S., Rozofsky, J. P., Parise, E. M., & Bolaños‐Guzmán, C. A. (2014) · Developmental Neuroscience · doi:10.1159/000362875 · Cited by 64
Torrente, F. M., Yoris, A., Low, D. M., López, P. L., Bekinschtein, P., Manes, F. F., & Cetkovich, M. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.124 · Cited by 59
Update on GPCR-based targets for the development of novel antidepressants
Mantas, I., Saarinen, M., Xu, Q., & Svenningsson, P. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01040-1 · Cited by 61
Verbascoside: A neuroprotective phenylethanoid glycosides with anti-depressive properties
Zhao, Y. P., Wang, S., Pan, J., & Ma, K. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155027 · Cited by 59
Mechanisms of epigenetic memory and addiction
Tuesta, L. M., & Zhang, Y. (2014) · The EMBO Journal · doi:10.1002/embj.201488106 · Cited by 58
Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks
Hamida, S. B., Mendonça-Netto, S., Arefin, T. M., Nasseef, M. T., Boulos, L., McNicholas, M., Ehrlich, A. T., Clarke, E., Moquin, L., Gratton, A. P., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.026 · Cited by 58
Behavioral and neuropsychiatric disorders in Alzheimer's disease
Cortés, N., Andrade, V., & Maccioni, R. B. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180005 · Cited by 57
Itoga, C. A., Chen, Y., Fateri, C., Echeverry, P. A., Lai, J. M., Delgado, J., Badhon, S., Short, A. K., Baram, T. Z., & Xu, X. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24676 · Cited by 61
Alexopoulos, G. S., Raue, P. J., Banerjee, S., Marino, P., Renn, B. N., Solomonov, N., Adeagbo, A., Sirey, J. A., Hull, T. D., Kiosses, D. N., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-0832-3 · Cited by 56
PPARα modulation of mesolimbic dopamine transmission rescues depression-related behaviors
Scheggi, S., Melis, M., De Felice, M., Aroni, S., Muntoni, A. L., Pelliccia, T., Gambarana, C., De Montis, M. G., & Pistis, M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.024 · Cited by 56
Neural correlates of successful psychotherapy of depression in adolescents
Straub, J., Plener, P. L., Sproeber, N., Sprenger, L., Kölch, M. G., Groen, G., & Abler, B. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.05.020 · Cited by 58
Bath, K. G., Russo, S. J., Pleil, K. E., Wohleb, E. S., Duman, R. S., & Radley, J. J. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.05.001 · Cited by 59
Self-citationDandekar, M. P., Saxena, A., Scaini, G., Shin, J. H., Migut, A., Giridharan, V. V., Zhou, Y., Barichello, T., Soares, J. C., Quevedo, J., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1381-5 · Cited by 58
Martínez-Rivera, A., Hao, J., Tropea, T. F., Giordano, T. P., Kosovsky, M., Rice, R. C., Lee, A., Huganir, R. L., Striessnig, J., Addy, N. A., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.9 · Cited by 55
Peciña, M., Martínez-Jauand, M., Love, T., Heffernan, J., Montoya, P., Hodgkinson, C. A., Stohler, C. S., Goldman, D. A., & Zubieta, J.-K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2152-13.2014 · Cited by 55
Kessel, E. M., Dougherty, L. R., Kujawa, A., Hajcak, G., Carlson, G. A., & Klein, D. N. (2016) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2015.0071 · Cited by 54
Fenoy, A. J., Quevedo, J., & Soares, J. C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01100-6 · Cited by 61
Mendes-Pinheiro, B., Soares‐Cunha, C., Marote, A., Loureiro‐Campos, E., Campos, J., Barata‐Antunes, S., Monteiro‐Fernandes, D., Santos, D. J., Duarte‐Silva, S., Pinto, L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111530 · Cited by 60
Histone and DNA Modifications as Regulators of Neuronal Development and FunctionPreprint
Lomvardas, S., & Maniatis, T. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a024208 · Cited by 56
Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin
Christoffel, D. J., Walsh, J. J., Hoerbelt, P., Heifets, B. D., Llorach, P., Lopez, R. C., Ramakrishnan, C., Deisseroth, K., & Malenka, R. C. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2106648118 · Cited by 54
Cassel, J., Ferraris, M., Quilichini, P., Cholvin, T., Boch, L., Stéphan, A., & de Vasconcelos, A. P. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.023 · Cited by 56
Neurovascular adaptations modulating cognition, mood, and stress responses
Dion‐Albert, L., Dudek, K., Russo, S. J., Campbell, M., & Ménard, C. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.01.005 · Cited by 58
Self-citationDudek, K., Paton, S. E. J., Binder, L. B., Collignon, A., Dion‐Albert, L., Cadoret, A., Lebel, M., Lavoie, O., Bouchard, J., Kaufmann, F. N., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01891-9 · Cited by 59
Metadata
- Authors
- Russo, S. J., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Russo, Scott J.
- Venue
- Nature Reviews Neuroscience
- Published
- 2013-08-14
- Volume
- 14
- Issue
- 9
- Pages
- 609-625
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3867253
- OpenAlex
- W2071815275
- Cited by
- 1,870
- References
- 164
- Citations by year
- 2026: 129 · 2025: 144 · 2024: 169 · 2023: 156 · 2022: 143 · 2021: 175 · 2020: 160 · 2019: 147 · 2018: 147 · 2017: 159 · 2016: 140 · 2015: 122 · 2014: 74 · 2013: 4
- FWCI
- 11.54
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-08-20)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH090264, P50MH096890, R01 MH-51399, R01MH051399, P50-MH96890)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- brain reward system, mood disorders, depression, anhedonia, ventral tegmental area, nucleus accumbens, glutamatergic synapses, neurotrophic factors, epigenetic mechanisms, transcriptional regulation, animal models of depression
- MeSH terms
- Animals, Brain, Humans, Neural Pathways, Reward, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
