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The brain reward circuitry in mood disorders
Open accessAbstract
Mood disorders are common and debilitating conditions characterized in part by profound deficits in reward-related behavioural domains. A recent literature has identified important structural and functional alterations within the brain's reward circuitry--particularly in the ventral tegmental area-nucleus accumbens pathway--that are associated with symptoms such as anhedonia and aberrant reward-associated perception and memory. This Review synthesizes recent data from human and rodent studies from which emerges a circuit-level framework for understanding reward deficits in depression. We also discuss some of the molecular and cellular underpinnings of this framework, ranging from adaptations in glutamatergic synapses and neurotrophic factors to transcriptional and epigenetic mechanisms.
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“For example, dopaminergic projections from the VTA to the nucleus accumbens (NAc), prefrontal cortex (PFC), amygdala and hippocampus that regulate responses to rewarding or aversive stimuli are reportedly dysregulated in people with MDD as well as in rodent models of chronic stress39–42.”
From Central regulation of stress-evoked peripheral immune responses (2023) · cites this paper as [40]
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In the citing paper
“Notably, several of these bone marrow-innervating brain regions have been implicated in stress responses, reward processing and the pathogenesis of depression and anxiety disorders.”
From Central regulation of stress-evoked peripheral immune responses (2023) · cites this paper as [40]
The cited source says what the claim attributes to it.
In the citing paper
“The NAc plays a crucial role in stress responses and mood disorders including MDD28.”
From Social stress induces neurovascular pathology promoting depression (2017) · cites this paper as [28]
In the citing paper
“Susceptible and resilient mice show distinct cellular and circuit alterations between the NAcc and other brain regions within the reward circuitry”
From Social functioning in major depressive disorder (2016) · cites this paper as Russo and Nestler, 2013
In the citing paper
“demonstrating a causal role for plasticity in this circuit in mediating social anhedonia in a mouse model of depression”
From Social functioning in major depressive disorder (2016) · cites this paper as Russo and Nestler, 2013
In the citing paper
“A grossly oversimplified overview of these circuits is that the prefrontal cortices and hippocampus are devoted to detecting and decoding specific features of stimuli and the environment, including the social environment, to guide decision-making and ensure adaptive, flexible, and predictive responses to rewarding stimuli, whereas the lateral hypothalamus-lateral habenula circuits predominantly En”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [51]
In the citing paper
“Prairie voles strongly express OXTR in regions of the MLR, a conserved neural network (75) involved in reward processing and implicated in numerous human psychiatric disorders including depression (76), addiction (77), and schizophrenia (78).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [75]
In the citing paper
“Depressive behavior is mediated in part by increased NAc BDNF signaling (reviewed in ref. [66]).”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [66]
In the citing paper
“The mesolimbic dopamine system, composed of dopamine neurons of the ventral tegmental area (VTA) and their projections to the nucleus accumbens (NAc), is most often associated with the rewarding effects of food and sex and plays an essential role in stress-induced anhedonia and other depression-related behavioral abnormalities [87, 88].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [88]
In the citing paper
“The mesolimbic dopamine system, composed of dopamine neurons of the ventral tegmental area (VTA) and their projections to the nucleus accumbens (NAc), is most often associated with the rewarding effects of food and sex and plays an essential role in stress-induced anhedonia and other depression-related behavioral abnormalities [87, 88].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [88]
In the citing paper
“One of the sources of DA in the hippocampus derives from DAergic neurons in the VTA17.”
From Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease (2017) · cites this paper as [17]
In the citing paper
“VTA DAergic neurons also target the nucleus accumbens (NAc) and cerebral cortex, mediating the control of incentive motivation and reward processing17.”
From Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease (2017) · cites this paper as [17]
In the citing paper
“Frontostriatal circuits subserving reward processes are modulated by the neurotransmitter dopamine (DA) The primary reward circuit includes dopaminergic projections from the ventral tegmental area (VTA) to the nucleus accumbens, which release dopamine in response to reward-related stimuli (Russo and Nestler, 2013).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Russo and Nestler, 2013
In the citing paper
“Molecular changes within specific cell types of the brain's reward regions shape the ways in which adolescents respond to changes in the environment, determining either resilience or susceptibility (Russo and Nestler, 2013).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Russo and Nestler, 2013
In the citing paper
“Vulnerability for depression, risk taking, or other psychopathologies may be determined by molecular changes in cells that occur following stressors (see Russo and Nestler, 2013).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Russo and Nestler, 2013
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Citations
Cites
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307
Self-citationEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
Self-citationTHE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION
Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
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Items 501–600 of 1,005
Wei, Y., Wang, G., Wang, H., He, J., Zhang, N., Wu, Z., Xiao, L., & Yang, C. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.04.034 · Cited by 43
Allichon, M., Ortiz, V., Pousinha, P. A., Andrianarivelo, A., Petitbon, A., Heck, N., Trifilieff, P., Barik, J., & Vanhoutte, P. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.799274 · Cited by 43
Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder
Team7, T. 2. R., Li, X., Luo, Z., Gu, C., Hall, L. S., McIntosh, A. M., Zeng, Y., Porteous, D. J., Hayward, C., Li, M., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0078-9 · Cited by 41
Hu, Y., Zhao, C., Zhao, H., & Qiao, J. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04693-0 · Cited by 46
John, W. S., Banala, A. K., Newman, A. H., & Nader, M. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3760-6 · Cited by 41
Verheij, M. M. M., Vendruscolo, L. F., Caffino, L., Giannotti, G., Cazorla, M., Fumagalli, F., Riva, M. A., Homberg, J. R., Koob, G. F., & Contet, C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2711-14.2016 · Cited by 42
Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?
Mul, J. D. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0165 · Cited by 43
Jin, C., Kang, H., Ryu, J. R., Kim, S., Zhang, Y., Lee, Y., Kim, Y., & Han, K. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00250 · Cited by 40
Lee, E. H., & Han, P. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.014 · Cited by 41
Beta-Adrenergic Signaling in Tumor Immunology and Immunotherapy
Wang, W., & Cao, X. (2019) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2019031188 · Cited by 43
WILLIAMS, E. S., Mazei‐Robison, M. S., & Robison, A. J. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a039198 · Cited by 44
Plasticity of synapses and reward circuit function in the genesis and treatment of depression
Thompson, S. M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01422-1 · Cited by 40
Bore, M. C., Liu, X., Huang, X., Kendrick, K. M., Zhou, B., Zhang, J., Klugah‐Brown, B., & Becker, B. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105835 · Cited by 40
Edemann-Callesen, H., Voget, M., Empl, L., Vogel, M., Wieske, F., Rummel, J., Heinz, A., Mathé, A. A., Hadar, R., & Winter, C. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.02.009 · Cited by 44
Altered functioning of reward circuitry in youth offspring of parents with bipolar disorder
Manelis, A., Ladouceur, C. D., Graur, S., Monk, K., Bonar, L. K., Hickey, M. B., Dwojak, A., Axelson, D., Goldstein, B., Goldstein, T. R., et al. (2015) · Psychological Medicine · doi:10.1017/s003329171500166x · Cited by 42
Sun, H., Martin, J. A., Werner, C. T., Wang, Z.-J., Damez-Werno, D. M., Scobie, K. N., Shao, N., Dias, C., Rabkin, J., Koo, J. W., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3254-15.2016 · Cited by 39
Self-citationPesarico, A. P., Sartori, G., Brüning, C. A., Mantovani, A. C., Duarte, T., Zeni, G. R., & Nogueira, C. W. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.049 · Cited by 42
Amiri, S., Alijanpour, S., Tirgar, F., Haj‐Mirzaian, A., Amini-Khoei, H., Rahimi-Balaei, M., Rastegar, M., Ghaderi, M., Ghazi‐Khansari, M., & Zarrindast, M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.003 · Cited by 41
Biological Sex, Estradiol and Striatal Medium Spiny Neuron Physiology: A Mini-Review
Krentzel, A. A., & Meitzen, J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00492 · Cited by 44
Yao, Z., Zhang, Z., Zhang, J., Cai, X., Zheng, Z., Huang, Y., & Qu, S. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.01.005 · Cited by 42
Zhang, T., Hong, J., Di, T., & Chen, L. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00101 · Cited by 39
Cannizzaro, E., Ramaci, T., Cirrincione, L., & Plescia, F. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16204031 · Cited by 39
Neural and Endocrine Correlates of Early Life Abuse in Youth With Depression and Obesity
Sun, K., Watson, K. T., Angal, S., Bakkila, B. F., Gorelik, A. J., Leslie, S. M., Rasgon, N., & Singh, M. K. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00721 · Cited by 39
Computational perspectives on human fear and anxiety
Yamamori, Y., & Robinson, O. J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104959 · Cited by 46
Gu, S., Xu, D., Huang, J., Zhou, X., Liu, Y., & Zhang, Z. (2025) · Nature Communications · doi:10.1038/s41467-025-60148-y · Cited by 39
Altered reward sensitivity in female offspring of cocaine-exposed fathers
Fischer, D. K., Rice, R. C., Martínez-Rivera, A., Donohoe, M. E., & Rajadhyaksha, A. M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.054 · Cited by 39
Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases
Choudhury, A., Sahu, T., Ramanujam, P. L., Banerjee, A. K., Chakraborty, I., Arun Kumar, R., & Arora, N. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000361 · Cited by 41
Does Anhedonia Presage Increased Risk of Posttraumatic Stress Disorder?
Risbrough, V. B., Glynn, L. M., Davis, E. P., Sandman, C. A., Obenaus, A., Stern, H. S., Keator, D. B., Yassa, M. A., Baram, T. Z., & Baker, D. G. (2018) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_51 · Cited by 38
Zwamborn, R. A. J., Snijders, C., An, N., Thomson, A. C., Rutten, B. P. F., & de Nijs, L. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.04.005 · Cited by 37
The VTA dopaminergic system as diagnostic and therapeutical target for Alzheimer's disease
Krashia, P., Spoleti, E., & D’Amelio, M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1039725 · Cited by 41
Social defeat-induced anhedonia: effects on operant sucrose-seeking behavior
Riga, D., Theijs, J. T., Vries, T. J. D., Smit, A. B., & Spijker, S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00195 · Cited by 41
Yan, D., Liu, B., Wei, X., Ou, W., Liao, M., Ji, S., Peng, Y., Liu, J., Wu, S., Wang, M., et al. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114867 · Cited by 38
The projection-specific signals that establish functionally segregated dopaminergic synapses
Terauchi, A., Yee, P., Johnson‐Venkatesh, E., Seiglie, M. P., Kim, L., Pitino, J. C., Kritzer, E., Zhang, Q., Zhou, J., Li, Y., et al. (2023) · Cell · doi:10.1016/j.cell.2023.07.023 · Cited by 38
BDNF in Neuropathic Pain; the Culprit that Cannot be Apprehended
Smith, P. A. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.02.020 · Cited by 40
Visible rodent brain-wide networks at single-neuron resolution
Yuan, J., Gong, H., Li, A., Li, X., Chen, S., Zeng, S., & Luo, Q. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00070 · Cited by 37
Antidepressant drug development: Focus on triple monoamine reuptake inhibition
Lane, R. M. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114553252 · Cited by 41
Cota, V. R., Drabowski, B. M. B., de Oliveira, J. C., & Moraes, M. F. D. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23741 · Cited by 38
Inverse changes in L1 retrotransposons between blood and brain in major depressive disorder
Liu, S., Du, T., Liu, Z., Shen, Y., Xiu, J., & Xu, Q. (2016) · Scientific Reports · doi:10.1038/srep37530 · Cited by 39
Reward Network Immediate Early Gene Expression in Mood Disorders
Manning, C., WILLIAMS, E. S., & Robison, A. J. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00077 · Cited by 37
Cannizzaro, C., Talani, G., Brancato, A., Mulas, G., Spiga, S., Luca, M. A. D., Sanna, A., Marino, R. A. M., Biggio, G., Sanna, E., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1377-18.2018 · Cited by 37
Parekh, P. K., Logan, R. W., Ketchesin, K. D., Becker‐Krail, D. D., Shelton, M. A., Hildebrand, M. A., Barko, K., Huang, Y. H., & McClung, C. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2233-18.2019 · Cited by 42
Contreras, J. A., Aslanyan, V., Sweeney, M. D., Sanders, L. M. J., Sagare, A. P., Zloković, B. V., Toga, A. W., Han, S. D., Morris, J. C., Fagan, A. M., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.013 · Cited by 42
Choi, J., Kim, J., Kim, T.-K., Park, J. Y., Lee, J. E., Kim, H., Lee, E. H., & Han, P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.03.030 · Cited by 38
Kuniishi, H., Ichisaka, S., Matsuda, S., Futora, E., Harada, R., & Hata, Y. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00250 · Cited by 34
Nucleus accumbens in the pathogenesis of major depressive disorder: A brief review
Yajie, J., Zou, M., Wang, Y., & Wang, Y. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.03.004 · Cited by 41
Zhu, C., Lan, X., Wei, Z., Yu, J., & Zhang, J. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.07.020 · Cited by 39
Reyes‐Gibby, C. C., Yuan, C. W.-Y., Wang, J., Yeung, S. J., & Shete, S. S. (2015) · BMC Systems Biology · doi:10.1186/s12918-015-0167-x · Cited by 37
Environmental Health Factors and Sexually Dimorphic Differences in Behavioral Disruptions
Rosenfeld, C. S., & Trainor, B. C. (2014) · Current Environmental Health Reports · doi:10.1007/s40572-014-0027-7 · Cited by 39
McInerney, S. J., McNeely, H. E., Geraci, J., Giacobbe, P., Rizvi, S. J., Ceniti, A. K., Cyriac, A., Mayberg, H. S., Lozano, A. M., & Kennedy, S. H. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00074 · Cited by 37
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Ghasemi, M., Claunch, J. D., & Niu, K. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.06.002 · Cited by 37
Maternal Overnutrition Programs Central Inflammation and Addiction-Like Behavior in Offspring
Montalvo-Martínez, L., Maldonado‐Ruiz, R., Cárdenas‐Tueme, M., Reséndez‐Pérez, D., & Camacho‐Morales, A. (2018) · BioMed Research International · doi:10.1155/2018/8061389 · Cited by 42
Caruso, M. J., Seemiller, L. R., Fetherston, T. B., Miller, C. N., Reiss, D. E., Cavigelli, S. A., & Kamens, H. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-28381-2 · Cited by 37
Group-level analysis of induced electric field in deep brain regions by different TMS coils
Gomez-Tames, J. D., Hamasaka, A., Hirata, A., Laakso, I., Lu, M., & Ueno, S. (2019) · Physics in Medicine and Biology · doi:10.1088/1361-6560/ab5e4a · Cited by 38
Fernández-Pérez, E. J., Gallegos, S., Armijo‐Weingart, L., Araya, A., Riffo-Lepe, N., Cayumán, F., & Aguayo, L. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-76456-w · Cited by 38
Ketamine for post-traumatic stress disorders and it's possible therapeutic mechanism
Asim, M., Wang, B., Hao, B., & Wang, X. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105044 · Cited by 37
The paraventricular thalamus input to central amygdala controls depression-related behaviors
Zhao, D., Liu, C., Cui, M., Liu, J., Meng, F., Lian, H., Wang, D., Hu, F., Liu, D., & Li, C. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113744 · Cited by 41
Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression
Eren‐Koçak, E., & Dalkara, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.777607 · Cited by 39
Rodier, J.-A., Mclain, C., Minerva, A. R., Rashford, R. L., Bennett, S. N., Rogers, F. D., & Peña, C. J. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0016-23.2023 · Cited by 40
Furlanetti, L. L., Coenen, V. A., & Döbrössy, M. D. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.11.036 · Cited by 43
Li, H., Liu, Y., Chen, H., Wang, J., Li, Y., Zhao, Y., Sun, R., He, J., Wang, F., & Chen, J. (2023) · Advanced Science · doi:10.1002/advs.202301110 · Cited by 35
A neuronal coping mechanism linking stress-induced anxiety to motivation for reward
Klenowski, P. M., Zhao-Shea, R., Freels, T. G., Molas, S., Zinter, M., M'angale, P. G., Xiao, C., Martínez‐Núñez, L., Thomson, T., & Tapper, A. R. (2023) · Science Advances · doi:10.1126/sciadv.adh9620 · Cited by 38
Mono-methylation of lysine 27 at histone 3 confers lifelong susceptibility to stress
Torres‐Berrío, A., Estill, M. S., Patel, V., Ramakrishnan, A., Kronman, H. G., Minier-Toribio, A. M., Issler, O., Browne, C. J., Parise, E. M., van der Zee, Y. Y., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.06.006 · Cited by 34
Self-citationSerotonin release in the habenula during emotional contagion promotes resilience
Mondoloni, S., Molina, P., Lecca, S., Wu, C.-H., Michel, L., Osypenko, D., Cachin, F., Flanigan, M. E., Congiu, M., Lalive, A. L., et al. (2024) · Science · doi:10.1126/science.adp3897 · Cited by 34
Putamen Volume Differences Among Older Adults: Depression Status, Melancholia, and Age
Sachs‐Ericsson, N., Hajcak, G., Sheffler, J., Stanley, I. H., Selby, E. A., Potter, G. G., & Steffens, D. C. (2017) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988717747049 · Cited by 36
Effort-based decision-making is affected by overweight/obesity in major depressive disorder
Mansur, R. B., Subramaniapillai, M., Zuckerman, H., Park, C., Iacobucci, M., Lee, Y. L., Tuineag, M., Hawco, C. S., Frey, B. N., Rasgon, N., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.06.002 · Cited by 42
Moriya, H., Tiger, M., Tateno, A., Sakayori, T., Masuoka, T., Kim, W., Arakawa, R., & Okubo, Y. (2020) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13020 · Cited by 36
Döbrössy, M. D., Ramanathan, C., Vajari, D. A., Tong, Y., Schlaepfer, T. E., & Coenen, V. A. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14975 · Cited by 37
Larval Zebrafish as a Model for Mechanistic Discovery in Mental Health
Tan, J. X. M., Ang, R. J. W., & Wee, C. L. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.900213 · Cited by 36
Zheng, Z., Liu, Y., Mu, R., Guo, X., Feng, Y., Chen, G., Yang, L., Qiu, W., Zhang, Q., Yang, W., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.09.012 · Cited by 36
Ago, Y., Hasebe, S., Nishiyama, S., Oka, S., Onaka, Y., Hashimoto, H., Takuma, K., & Matsuda, T. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv062 · Cited by 34
Genetic and neuroendocrine regulation of the postpartum brain
Gammie, S. C., Driessen, T. M., Zhao, C., Saul, M. C., & Eisinger, B. E. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.05.002 · Cited by 36
Integrative Analysis of Sex-Specific microRNA Networks Following Stress in Mouse Nucleus Accumbens
Pfau, M. L., Purushothaman, I., Feng, J., Golden, S. A., Aleyasin, H., Lorsch, Z. S., Cates, H. M., Flanigan, M. E., Ménard, C., Heshmati, M., et al. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00144 · Cited by 36
Self-citationKo, M. Y., Jang, E. Y., Lee, J. Y., Kim, S. P., Whang, S. H., Lee, B. H., Kim, H. Y., Yang, C. H., Cho, H. J., & Gwak, Y. S. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5381 · Cited by 36
Thiele, S., Furlanetti, L. L., Pfeiffer, L.-M., Coenen, V. A., & Döbrössy, M. D. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.02.002 · Cited by 35
Achterberg, M., Bakermans‐Kranenburg, M. J., van IJzendoorn, M. H., van der Meulen, M., Tottenham, N., & Crone, E. A. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.03.076 · Cited by 35
Li, M., Xu, H., Chen, G., Sun, S., Wang, Q., Liu, B., Wu, X., Zhou, L., Chai, Z., Sun, X., et al. (2019) · Brain · doi:10.1093/brain/awz243 · Cited by 35
Microstructural changes in the reward system are associated with post-stroke depression
Oestreich, L., Wright, P. K., & O'Sullivan, M. J. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102360 · Cited by 36
Yu, H., Villanueva, N., Bittar, T. P., Arsenault, E., Labonté, B., & Huan, T. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.09.051 · Cited by 36
Kalafatakis, K., Russell, G. M., Ferguson, S. G., Grabski, M., Harmer, C. J., Munafo, M. R., Marchant, N., Wilson, A., Brooks, J. C. W., Thakrar, J., et al. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105096 · Cited by 33
Xu, H., Li, H., Liu, D., Wen, W., Xu, M., Frank, J. A., Chen, J., Zhu, H., Grahame, N. J., & Luo, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.614396 · Cited by 34
Cooper, J. A., Nuutinen, M. R., Lawlor, V. M., DeVries, B. A. M., Barrick, E. M., Hossein, S., Cole, D. J., Leonard, C. V., Hahn, E. C., Teer, A. P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23284-9 · Cited by 36
Thoma, P., Norra, C., Juckel, G., Boris Suchan, A., & Bellebaum, C. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.06.002 · Cited by 36
Furlanetti, L. L., Coenen, V. A., Aranda, I. A. A., & Döbrössy, M. D. (2015) · Experimental Brain Research · doi:10.1007/s00221-015-4375-9 · Cited by 40
Shi, J., Geng, J., Yan, R., Liu, X., Chen, Y., Zhu, R., Wang, X., Shao, J., Bi, K., Xiao, M., et al. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02586 · Cited by 34
Sun, X., Huang, W., Wang, J., Xu, R., Zhang, X., Zhou, J., Zhu, J., & Qian, Y. (2023) · Psychological Medicine · doi:10.1017/s0033291722003750 · Cited by 33
Shoji, H., Ikeda, K., & Miyakawa, T. (2023) · Molecular Brain · doi:10.1186/s13041-023-01020-2 · Cited by 38
Banis, S., Geerligs, L., & Lorist, M. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095690 · Cited by 35
Siahposht-Khachaki, A., Fatahi, Z., Yans, A., Khodagholi, F., & Haghparast, A. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0371-2 · Cited by 34
Multiple faces of pain: effects of chronic pain on the brain regulation of facial expression
Vachon‐Presseau, É., Roy, M., Woo, C., Miriam Kunz, A., Martel, M. O., Sullivan, M. J. L., Jackson, P. L., Wager, T. D., & Rainville, P. (2016) · Pain · doi:10.1097/j.pain.0000000000000587 · Cited by 37
Amygdala and Emotion: The Bright Side of It
Weymar, M., & Schwabe, L. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00224 · Cited by 41
The prevalence of depression and the accuracy of depression screening tools in migraine patients
Amoozegar, F., Patten, S. B., Becker, W. J., Bulloch, A. G. M., Fiest, K. M., Davenport, W. J., Carroll, C. R., & Jetté, N. (2017) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2017.06.006 · Cited by 34
Affective disorders and sexual function
Barata, B. C. (2017) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000362 · Cited by 34
Presence of Inhibitory Glycinergic Transmission in Medium Spiny Neurons in the Nucleus Accumbens
Muñoz, B., Yévenes, G. E., Förstera, B., Lovinger, D. M., & Aguayo, L. G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00228 · Cited by 34
Pei, H., Patterson, C. M., Sutton, A. K., Burnett, K. H., Myers, M. G., & Olson, D. P. (2018) · Endocrinology · doi:10.1210/en.2018-00747 · Cited by 34
Neuropharmacology of the mesolimbic system and associated circuits on social hierarchies
Ghosal, S., Sandi, C., & van der Kooij, M. A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.01.013 · Cited by 32
McCall, N. M., de Velasco, E. M. F., & Wickman, K. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.3101-18.2019 · Cited by 34
Ma, K., Zhang, H., Wei, G., Dong, Z., Zhao, H., Han, X., Song, X., Zhang, H., Zong, X., Baloch, Z., et al. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s200264 · Cited by 32
Sex-Specific Effects of Stress on Mood-Related Gene Expression
Barko, K., Paden, W., Cahill, K. M., Seney, M. L., & Logan, R. W. (2019) · Complex Psychiatry · doi:10.1159/000499105 · Cited by 35
Zhuang, P.-C., Tan, Z.-N., Jia, Z.-Y., Wang, B., Grady, J. J., & Ma, X. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00093 · Cited by 34
Han, S., Cui, Q., Wang, X., Chen, Y., Li, D., Li, L., Guo, X., Fan, Y., Guo, J., Sheng, W., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109865 · Cited by 32
Metadata
- Authors
- Russo, S. J., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Russo, Scott J.
- Venue
- Nature Reviews Neuroscience
- Published
- 2013-08-14
- Volume
- 14
- Issue
- 9
- Pages
- 609-625
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3867253
- OpenAlex
- W2071815275
- Cited by
- 1,870
- References
- 164
- Citations by year
- 2026: 129 · 2025: 144 · 2024: 169 · 2023: 156 · 2022: 143 · 2021: 175 · 2020: 160 · 2019: 147 · 2018: 147 · 2017: 159 · 2016: 140 · 2015: 122 · 2014: 74 · 2013: 4
- FWCI
- 11.54
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-08-20)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH090264, P50MH096890, R01 MH-51399, R01MH051399, P50-MH96890)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- brain reward system, mood disorders, depression, anhedonia, ventral tegmental area, nucleus accumbens, glutamatergic synapses, neurotrophic factors, epigenetic mechanisms, transcriptional regulation, animal models of depression
- MeSH terms
- Animals, Brain, Humans, Neural Pathways, Reward, Mood Disorders
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