Anhedonia in depression and bipolar disorder

Whitton, Alexis E.; Pizzagalli, Diego A.

doi:10.1007/7854_2022_323

Cited by 81Bipolar Disorder and TreatmentTreatment of Major DepressionNeural and Behavioral Psychology Studies

Anhedonia in depression and bipolar disorder

Whitton, Alexis E., Pizzagalli, Diego A.·2022·Current topics in behavioral neurosciences

DOI 10.1007/7854_2022_323

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Abstract

Anhedonia is a hallmark feature of depression and is highly prevalent among individuals with mood disorders. The history and neurobiology of anhedonia has been most extensively studied in the context of unipolar Major Depressive Disorder (MDD), with converging lines of evidence indicating that marked anhedonia heralds a more chronic and treatment-refractory illness course. Furthermore, findings from neuroimaging studies suggest that anhedonia in MDD is associated with aberrant reward-related activation in key brain reward regions, particularly blunted reward anticipation-related activation in the ventral striatum. However, the ongoing clinical challenge of treating anhedonia in the context of Bipolar Disorder (BD) also highlights important gaps in our understanding of anhedonia's prevalence, severity, and pathophysiology along the entire mood disorder spectrum. In addition, although current theoretical models posit a key role for reward hyposensitivity in BD depression, unlike studies in MDD, studies in BD do not clearly show evidence for reduced reward-related activation in striatal or other brain regions. Although further research is needed, the evidence to date hints at a divergent pathophysiology for anhedonia in unipolar and bipolar mood disorders, which, if better understood, could lead to significant improvements in the diagnosis and treatment of MDD and BD.

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Anhedonia experienced in bipolar disorder has partially distinct neurophysiology from that in unipolar depression.
“Anhedonia experienced in bipolar disorder has been found to have partially distinct neurophysiology to that in unipolar depression (77).”
From Predictive coding and neurocomputational psychiatry: a mechanistic framework for understanding mental disorders (2026) · cites this paper as [77]
The positive valence system is often hyporesponsive in those with anxiety or depression.
“Hypo-responsivity of the positive valence system characterizes depression(22) and some forms of anxiety(23) (most notably social anxiety disorder(24) and post-traumatic stress disorder(25)) – evidenced by low positive affect,(24) diminished approach motivation and behavior,(26, 27) and reduced activation in mesolimbic circuits during reward processing,(25, 28) including anticipation of social Rewa”
From Amplification of Positivity Treatment for Anxiety and Depression: A Randomized Experimental Therapeutics Trial Targeting Social Reward Sensitivity to Enhance Social Connectedness (2024) · cites this paper as [22]
Hypo-responsivity of the positive valence system characterizes depression and some forms of anxiety, evidenced by low positive affect, diminished approach motivation and behavior, and reduced activation in mesolimbic circuits during reward processing, including anticipation of social rewards.
“Hypo-responsivity of the positive valence system characterizes depression(22) and some forms of anxiety(23) (most notably social anxiety disorder(24) and post-traumatic stress disorder(25)) – evidenced by low positive affect,(24) diminished approach motivation and behavior,(26, 27) and reduced activation in mesolimbic circuits during reward processing,(25, 28) including anticipation of social Rewa”
From Amplification of Positivity Treatment for Anxiety and Depression: A Randomized Experimental Therapeutics Trial Targeting Social Reward Sensitivity to Enhance Social Connectedness (2024) · cites this paper as [22]

Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
The varieties of religious experience: A study in human nature.
James, W. (1902) · doi:10.1037/10004-000 · Cited by 5,204 · see citing works
The reward circuit: linking primate anatomy and human imaging
Haber, S. N., & Knutson, B. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.129 · Cited by 3,718 · see citing works
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
The neurobiology of anhedonia and other reward-related deficits
Der-Avakian, A., & Markou, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.005 · Cited by 1,130 · see citing works
Time-related predictors of suicide in major affective disorder
FAWCETT, J. A., Scheftner, W. A., Fogg, L., Clark, D. C., Young, M. A., Hedeker, D., & Gibbons, R. D. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.9.1189 · Cited by 1,058 · see citing works
Long-Term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
Perlis, R. H., Miyahara, S., Marangell, L. B., Wisniewski, S. R., Ostacher, M., DelBello, M. P., Bowden, C. L., Sachs, G. S., & Nierenberg, A. A. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.01.022 · Cited by 852 · see citing works
Neuroscience of apathy and anhedonia: a transdiagnostic approach
Husain, M., & Roiser, J. P. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0029-9 · Cited by 642 · see citing works
Endogenomorphic Depression
Klein, D. F. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760160005001 · Cited by 601 · see citing works
Altered Striatal Activation Predicting Real-World Positive Affect in Adolescent Major Depressive Disorder
Forbes, E. E., Hariri, A. R., Martin, S. L., Silk, J. S., Moyles, D. L., Fisher, P. M., Brown, S. M., Ryan, N. D., Birmaher, B., Axelson, D. A., et al. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07081336 · Cited by 582 · see citing works
Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies
Keren, H., O’Callaghan, G., Vidal-Ribas, P., Buzzell, G. A., Brotman, M. A., Leibenluft, E., Pan, P. M., Meffert, L., Kaiser, A., Wolke, S., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17101124 · Cited by 521 · see citing works
Expected value and prediction error abnormalities in depression and schizophrenia
Gradin, V. B., Kumar, P., Waiter, G., Ahearn, T., Stickle, C., Milders, M., Reid, I., Hall, J., & Steele, J. D. (2011) · Brain · doi:10.1093/brain/awr059 · Cited by 485 · see citing works
Lack of Ventral Striatal Response to Positive Stimuli in Depressed Versus Normal Subjects
Epstein, J., Pan, H., Kocsis, J. H., Yang, Y., Butler, T., Chusid, J., Hochberg, H., Murrough, J., Strohmayer, E., Stern, E., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.10.1784 · Cited by 464 · see citing works
Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment-resistant depression
McMakin, D. L., Olino, T. M., Porta, G., Dietz, L. J., Emslie, G., Clarke, G., Wagner, K. D., Asarnow, J. R., Ryan, N. D., Birmaher, B., et al. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.01.011 · Cited by 448 · see citing works
Reduced Reward Learning Predicts Outcome in Major Depressive Disorder
Vrieze, E., Pizzagalli, D. A., Demyttenaere, K., Hompes, T., Sienaert, P. A., de Boer, P., Schmidt, M. E., & Claes, S. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.014 · Cited by 443 · see citing works
Melancholia: a Clinical Survey of Depressive States
Lewis, A. J. (1934) · Journal of Mental Science · doi:10.1192/bjp.80.329.277 · Cited by 438 · see citing works
Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms
Uher, R., Perlis, R. H., Henigsberg, N., Zobel, A., Rietschel, M., Mors, O., Hauser, J., Dernovsek, M. Z., Souery, D., Bajs, M., et al. (2012) · Psychological Medicine · doi:10.1017/s0033291711001905 · Cited by 420 · see citing works
Treatment for Anhedonia: A Neuroscience Driven Approach: 2015 ADAA Scientific Research Symposium: Treatment for Anhedonia
Craske, M. G., Meuret, A. E., Ritz, T., Treanor, M., & Dour, H. J. (2016) · Depression and Anxiety · doi:10.1002/da.22490 · Cited by 387 · see citing works
Abnormal temporal difference reward-learning signals in major depression
Kumar, P., Waiter, G., Ahearn, T., Milders, M., Reid, I., & Steele, J. D. (2008) · Brain · doi:10.1093/brain/awn136 · Cited by 374 · see citing works
Anhedonia and Reward-Circuit Connectivity Distinguish Nonresponders from Responders to Dorsomedial Prefrontal Repetitive Transcranial Magnetic Stimulation in Major Depression
Downar, J. H., Geraci, J., Salomons, T. V., Dunlop, K., Wheeler, S. M., McAndrews, M. P., Bakker, N., Blumberger, D. M., Daskalakis, Z. J., Kennedy, S. H., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.026 · Cited by 338 · see citing works
The Brain’s Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample
Stringaris, A., Vidal-Ribas Belil, P., Artiges, E., Lemaitre, H., Gollier-Briant, F., Wolke, S., Vulser, H., Miranda, R., Penttilä, J., Struve, M., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14101298 · Cited by 322 · see citing works
Anhedonia is associated with suicidal ideation independently of depression: A meta-analysis
Ducasse, D., Loas, G., Dassa, D., Gramaglia, C. M., Zeppegno, P., Guillaume, S., Olié, É., & Courtet, P. (2017) · Depression and Anxiety · doi:10.1002/da.22709 · Cited by 270 · see citing works
The clinical features of bipolar depression: a comparison with matched major depressive disorder patients.
Mitchell, P. B., Wilhelm, K. A., Parker, G. B., Austin, M., Rutgers, P., & Malhi, G. S. (2001) · PubMed · Cited by 262 · see citing works
Determinants of poor 1-year outcome of DSM-III-R major depression in the general population: results of the Netherlands mental health survey and incidence study (NEMESIS)
Spijker, J., Bijl, R. V., De Graaf, R., & Nolen, W. A. (2001) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2001.103002122.x · Cited by 254 · see citing works
Circuit Mechanisms of Reward, Anhedonia, and Depression
Höflich, A., Michenthaler, P., Kasper, S., & Lanzenberger, R. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy081 · Cited by 253 · see citing works
Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression
Satterthwaite, T. D., Kable, J. W., Vandekar, L., Katchmar, N., Bassett, D. S., Baldassano, C. F., Ruparel, K., Elliott, M. A., Sheline, Y. I., Gur, R. C., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.75 · Cited by 249 · see citing works
Waiting to win: elevated striatal and orbitofrontal cortical activity during reward anticipation in euthymic bipolar disorder adults
Nusslock, R., Almeida, J., Forbes, E. E., Versace, A., Frank, E., LaBarbara, E. J., Klein, C. R., & Phillips, M. L. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01012.x · Cited by 238 · see citing works
Ventral Striatum Activity in Response to Reward: Differences Between Bipolar I and II Disorders
Caseras, X., Lawrence, N., Murphy, K., Wise, R. G., & Phillips, M. L. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12020169 · Cited by 235 · see citing works
The Clinical Features of Bipolar Depression
Mitchell, P. B. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n0314a · Cited by 234 · see citing works
Clinical Features of Bipolar Depression Versus Major Depressive Disorder in Large Multicenter Trials
Perlis, R. H., Brown, E., Baker, R. W., & Nierenberg, A. A. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.2.225 · Cited by 225 · see citing works
Impaired reward prediction error encoding and striatal-midbrain connectivity in depression
Kumar, P., Goer, F., Murray, L., Dillon, D. G., Beltzer, M. L., Cohen, A. L., Brooks, N. H., & Pizzagalli, D. A. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0032-x · Cited by 219 · see citing works
Association of neural and emotional impacts of reward prediction errors with major depression
Rutledge, R. B., Moutoussis, M., Smittenaar, P., Zeidman, P., Taylor, T., Hrynkiewicz, L., Lam, J., Skandali, N., Siegel, J. Z., Ousdal, O. T., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.1713 · Cited by 209 · see citing works
Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression
Borsini, A., Wallis, A. S. J., Zunszain, P., Pariante, C. M., & Kempton, M. J. (2020) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-020-00804-6 · Cited by 207 · see citing works
Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey
Chevance, A., Ravaud, P., Tomlinson, A., Le Berre, C., Teufer, B., Touboul, S., Fried, E. I., Gartlehner, G., Cipriani, A., & Tran, V. T. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30191-7 · Cited by 193 · see citing works
Euthymic Patients with Bipolar Disorder Show Decreased Reward Learning in a Probabilistic Reward Task
Pizzagalli, D. A., Davis, E., Ostacher, M. J., Iosifescu, D. V., & Perlis, R. H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.12.001 · Cited by 188 · see citing works
Neural response to reward as a predictor of increases in depressive symptoms in adolescence
Morgan, J. K., Olino, T. M., McMakin, D. L., Ryan, N. D., & Forbes, E. E. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.039 · Cited by 185 · see citing works
Neural signatures of the risk for bipolar disorder: A meta‐analysis of structural and functional neuroimaging studies
Cattarinussi, G., Giorgio, A. D., Wolf, R. C., Balestrieri, M., & Sambataro, F. (2018) · Bipolar Disorders · doi:10.1111/bdi.12720 · Cited by 171 · see citing works
Remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes
Dichter, G. S., Kozink, R. V., McClernon, F. J., & Smoski, M. J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.09.048 · Cited by 170 · see citing works
Altered neural reward and loss processing and prediction error signalling in depression
Ubl, B., Kuehner, C., Kirsch, P., Ruttorf, M., Diener, C., & Flor, H. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu158 · Cited by 165 · see citing works
Reward processing in unipolar and bipolar depression: A functional MRI study
Redlich, R., Dohm, K., Grotegerd, D., Opel, N., Zwitserlood, P., Heindel, W., Arolt, V., Kugel, H., & Dannlowski, U. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.110 · Cited by 164 · see citing works
Dissociable patterns of abnormal frontal cortical activation during anticipation of an uncertain reward or loss in bipolar versus major depression
Chase, H. W., Nusslock, R., Almeida, J., Forbes, E., Labarbara, E. J., & Phillips, M. L. (2013) · Bipolar Disorders · doi:10.1111/bdi.12132 · Cited by 156 · see citing works
Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample
Pan, P. M., Sato, J. R., Salum, G. A., Rohde, L. A., Gadelha, A., Zugman, A., Mari, J., Jackowski, A., Picon, F., Miguel, E. C., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17040430 · Cited by 156 · cited 2× · see citing works
“2016), with PFC over-recruitment thought to reflect overcompensation for reduced striatal activation (Forbes et al. 2009; O’Callaghan and Stringaris 2019; Pan et al. 2017).”
Background
Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis
Zhang, B., Lin, P., Shi, H., Öngür, D., Auerbach, R. P., Wang, X., Yao, S., & Wang, X. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9457-6 · Cited by 152 · see citing works
Reduced reward anticipation in youth at high-risk for unipolar depression: A preliminary study
Olino, T. M., McMakin, D. L., Morgan, J. K., Silk, J. S., Birmaher, B. B., Axelson, D., Williamson, D. E., Dahl, R. E., Ryan, N. D., & Forbes, E. E. (2013) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2013.11.005 · Cited by 149 · see citing works
Anhedonia, but not Irritability, Is Associated with Illness Severity Outcomes in Adolescent Major Depression
Gabbay, V., Johnson, A. R., Alonso, C. M., Evans, L. K., Babb, J. S., & KLEIN, R. G. (2015) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2014.0105 · Cited by 148 · see citing works
Anhedonia as a clinical correlate of suicidal thoughts in clinical ketamine trials
Ballard, E. D., Wills, K. E., Lally, N., Richards, E. M., Luckenbaugh, D. A., Walls, T. L., Ameli, R., Niciu, M. J., Brutsché, N. E., Park, L., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.04.057 · Cited by 146 · see citing works
Which clinical factors predict response to prophylactic lithium? A systematic review for bipolar disorders
Kleindienst, N., Engel, R. R., & Greil, W. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00244.x · Cited by 144 · see citing works
The efficacy of vortioxetine on anhedonia in patients with major depressive disorder
Cao, B., Park, C., Subramaniapillai, M., Lee, Y., Iacobucci, M., Mansur, R. B., Zuckerman, H., Phan, L., & McIntyre, R. S. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00017 · Cited by 139 · see citing works
A systematic review and meta‐analysis of clinical predictors of lithium response in bipolar disorder
Hui, T. P., Kandola, A. A., Shen, L., Lewis, G., Osborn, D., Geddes, J. R., & Hayes, J. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13062 · Cited by 138 · see citing works
Understanding anhedonia: a qualitative study exploring loss of interest and pleasure in adolescent depression
Watson, R., Harvey, K., McCabe, C., & Reynolds, S. A. (2019) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-019-01364-y · Cited by 135 · see citing works
Altered representation of expected value in the orbitofrontal cortex in mania
Bermpohl, F., Kahnt, T., Dalanay, U., Hägele, C., Sajonz, B., Wegner, T., Stoy, M., Adli, M., Krüger, S., Wrase, J., et al. (2009) · Human Brain Mapping · doi:10.1002/hbm.20909 · Cited by 133 · see citing works
Neural mechanisms of reinforcement learning in unmedicated patients with major depressive disorder
Rothkirch, M., Tonn, J., Köhler, S., & Sterzer, P. (2017) · Brain · doi:10.1093/brain/awx025 · Cited by 124 · see citing works
Increased Medial Orbitofrontal and Amygdala Activation: Evidence for a Systems-Level Endophenotype of Bipolar I Disorder
Linke, J. O., King, A. V., Rietschel, M., Strohmaier, J., Hennerici, M. G., Gass, A., Meyer‐Lindenberg, A., & Wessa, M. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11050711 · Cited by 119 · see citing works
Anhedonia and general distress show dissociable ventromedial prefrontal cortex connectivity in major depressive disorder
Young, C. B., Chen, T., Nusslock, R., Keller, J., Schatzberg, A. F., & Menon, V (2016) · Translational Psychiatry · doi:10.1038/tp.2016.80 · Cited by 108 · see citing works
Baseline reward processing and ventrostriatal dopamine function are associated with pramipexole response in depression
Whitton, A. E., Reinen, J., Slifstein, M., Ang, Y., McGrath, P. J., Iosifescu, D. V., Abi‐Dargham, A., Pizzagalli, D. A., & Schneier, F. R. (2020) · Brain · doi:10.1093/brain/awaa002 · Cited by 100 · see citing works
Decision-making and trait impulsivity in bipolar disorder are associated with reduced prefrontal regulation of striatal reward valuation
Mason, L., O’Sullivan, N., Montaldi, D., Bentall, R. P., & El‐Deredy, W. (2014) · Brain · doi:10.1093/brain/awu152 · Cited by 97 · see citing works
Reduced hedonic capacity in euthymic bipolar subjects: a trait-like feature
Di Nicola, M., De Risio, L., Battaglia, C., Camardese, G., Tedeschi, D., Mazza, M., Martinotti, G., Pozzi, G., Niolu, C., Di Giannantonio, M., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.10.004 · Cited by 87 · see citing works
Characteristics of bipolar I and II disorder: A study of 8766 individuals
Karanti, A., Kardell, M., Joas, E., Runeson, B., Pålsson, E., & Landén, M. (2019) · Bipolar Disorders · doi:10.1111/bdi.12867 · Cited by 87 · see citing works
fMRI evidence of a relationship between hypomania and both increased goal-sensitivity and positive outcome-expectancy bias
O’Sullivan, N., Szczepanowski, R., El‐Deredy, W., Mason, L., & Bentall, R. P. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.06.008 · Cited by 82 · see citing works
Patients with major depressive disorder exhibit reduced reward size coding in the striatum
Takamura, M., Okamoto, Y., Okada, G., Toki, S., Yamamoto, T., Ichikawa, N., Mori, A., Minagawa, H., Takaishi, Y., Fujii, Y., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.006 · Cited by 81 · see citing works
Blunted medial prefrontal cortico-limbic reward-related effective connectivity and depression
Rupprechter, S., Romaniuk, L., Series, P., Hirose, Y., Hawkins, E., Sandu, A.-L., Waiter, G. D., McNeil, C. J., Shen, X., Harris, M. A., et al. (2020) · Brain · doi:10.1093/brain/awaa106 · Cited by 80 · see citing works
Association between anhedonia and suicidal events in patients with mood disorders: A 3‐year prospective study
Ducasse, D., Dubois, J., Jaussent, I., Azorin, J., Étain, B., Gard, S., Henry, C., Bougerol, T., Kahn, J., Aubin, V., et al. (2020) · Depression and Anxiety · doi:10.1002/da.23072 · Cited by 70 · see citing works
Effort–cost computation in a transdiagnostic psychiatric sample: Differences among patients with schizophrenia, bipolar disorder, and major depressive disorder
Zou, Y.-M., Ni, K., Wang, Y., Yu, E. Y., Lui, S. S. Y., Zhou, F., Yang, H., Cohen, A. S., Strauss, G. P., Cheung, E. F. C., et al. (2019) · PsyCh Journal · doi:10.1002/pchj.316 · Cited by 68 · see citing works
The 341 737 ways of qualifying for the melancholic specifier
Fried, E. I., Coomans, F., & Lorenzo‐Luaces, L. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30169-3 · Cited by 68 · see citing works
Impaired reward-related learning signals in remitted unmedicated patients with recurrent depression
Geugies, H., Mocking, R. J. T., Figueroa, C. A., Groot, P. F. C., Marsman, J.-B. C., Servaas, M. N., Steele, J. D., Schene, A. H., & Ruhé, H. G. (2019) · Brain · doi:10.1093/brain/awz167 · Cited by 67 · see citing works
Transdiagnostic Prediction of Affective, Cognitive, and Social Function Through Brain Reward Anticipation in Schizophrenia, Bipolar Disorder, Major Depression, and Autism Spectrum Diagnoses
Schwarz, K., Moessnang, C., Schweiger, J. I., Baumeister, S., Plichta, M. M., Brandeis, D., Banaschewski, T., Wackerhagen, C., Erk, S., Walter, H., et al. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz075 · Cited by 66 · see citing works
Reward Processing in Adolescent Depression Across Neuroimaging Modalities: A Review
O’Callaghan, G., & Stringaris, A. (2019) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000663 · Cited by 63 · see citing works
Clinical, behavioral, and neural measures of reward processing correlate with escitalopram response in depression: a Canadian Biomarker Integration Network in Depression (CAN-BIND-1) Report
Dunlop, K., Rizvi, S. J., Kennedy, S. H., Hassel, S., Strother, S. C., Harris, J. K., Zamyadi, M., Arnott, S. R., Davis, A. D., Mansouri, F., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0688-x · Cited by 60 · see citing works
Corticostriatal pathways contribute to the natural time course of positive mood
Admon, R., & Pizzagalli, D. A. (2015) · Nature Communications · doi:10.1038/ncomms10065 · Cited by 57 · see citing works
Self-citation
Attenuation of Frontostriatal Connectivity During Reward Processing Predicts Response to Psychotherapy in Major Depressive Disorder
Walsh, E. C., Carl, H., Eisenlohr-Moul, T. A., Minkel, J. D., Crowther, A., Moore, T. M., Gibbs, D. E., Petty, C., Bizzell, J., Smoski, M. J., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.179 · Cited by 56 · see citing works
Effect of aripiprazole on self-reported anhedonia in bipolar depressed patients
Mazza, M., Squillacioti, M. R., Pecora, R. D., Janiri, L., & Bria, P. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2008.05.003 · Cited by 54 · see citing works
Anhedonia Reduction and the Association Between Left Ventral Striatal Reward Response and 6-Month Improvement in Life Satisfaction Among Young Adults
Eckstrand, K. L., Forbes, E. E., Bertocci, M. A., Chase, H. W., Greenberg, T., Lockovich, J., Stiffler, R., Aslam, H. A., Graur, S., Bebko, G., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.0864 · Cited by 51 · see citing works
Depression across mood disorders: review and analysis in a clinical sample
Souery, D., Zaninotto, L., Calati, R., Linotte, S., Mendlewicz, J., Sentissi, O., & Serretti, A. (2011) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2011.01.010 · Cited by 44 · see citing works
Pretreatment Reward Sensitivity and Frontostriatal Resting-State Functional Connectivity Are Associated With Response to Bupropion After Sertraline Nonresponse
Ang, Y., Kaiser, R. H., Deckersbach, T., Almeida, J., Phillips, M. L., Chase, H. W., Webb, C. A., Parsey, R. V., D, M. F. M., McGrath, P. J., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.04.009 · Cited by 43 · see citing works
Physical and social anhedonia are associated with suicidality in major depression, but not in schizophrenia
Šagud, M., Tudor, L., Šimunić, L., Jezernik, D., Madžarac, Z., Jakšić, N., Peleš, A. M., Vuksan‐Ćusa, B., Filipčić, I. Š., Stefanović, I., et al. (2020) · Suicide and Life-Threatening Behavior · doi:10.1111/sltb.12724 · Cited by 41 · see citing works
Clinical predictors of non‐response to lithium treatment in the Pharmacogenomics of Bipolar Disorder (PGBD) study
Lin, Y., Maihofer, A. X., Stapp, E. K., Ritchey, M., Alliey‐Rodriguez, N., Anand, A., Balaraman, Y., Berrettini, W. H., Bertram, H. S., Bhattacharjee, A. K., et al. (2021) · Bipolar Disorders · doi:10.1111/bdi.13078 · Cited by 38 · see citing works
Stress and reward processing in bipolar disorder: a functional magnetic resonance imaging study
Berghorst, L. H., Kumar, P., Greve, D. N., Deckersbach, T., Öngür, D., Dutra, S. J., & Pizzagalli, D. A. (2016) · Bipolar Disorders · doi:10.1111/bdi.12444 · Cited by 36 · see citing works
Distinguishing Bipolar Depression from Unipolar Depression in Youth: Preliminary Findings
Diler, R. S., Goldstein, T. R., Hafeman, D., Merranko, J. A., Liao, F., Goldstein, B. I., Hower, H. M., Gill, M. K., Hunt, J., Yen, S., et al. (2017) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2016.0154 · Cited by 36 · see citing works
Reward-Related Neural Predictors and Mechanisms of Symptom Change in Cognitive Behavioral Therapy for Depressed Adolescent Girls
Webb, C. A., Auerbach, R. P., Bondy, E., Stanton, C. H., Appleman, L., & Pizzagalli, D. A. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.07.010 · Cited by 31 · see citing works
Severe anhedonia among adolescents with bipolar disorder is common and associated with increased psychiatric symptom burden
Dimick, M. K., Hird, M. A., Fıksenbaum, L., Mitchell, R. H. B., & Goldstein, B. I. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.12.031 · Cited by 29 · see citing works
Distinguishing affective depersonalization from anhedonia in major depression and bipolar disorder
Mula, M., Pini, S., Calugi, S., Preve, M., Masini, M., Giovannini, I., Rucci, P., & Cassano, G. B. (2009) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2009.03.009 · Cited by 25 · see citing works
Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration
Bart, C. P., Titone, M. K., Ng, T. H., Nusslock, R., & Alloy, L. B. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102035 · Cited by 25 · see citing works
Mapping Disease Course Across the Mood Disorder Spectrum Through a Research Domain Criteria Framework
Whitton, A. E., Kumar, P., Treadway, M. T., Rutherford, A. V., Ironside, M. L., Foti, D., Fitzmaurice, G. M., Du, F., & Pizzagalli, D. A. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.01.004 · Cited by 19 · see citing works
Trait sensation seeking is associated with heightened beta-band oscillatory dynamics over left ventrolateral prefrontal cortex during reward expectancy
Coffman, B. A., Torrence, N., Murphy, T. K., Bebko, G. M., Graur, S., Chase, H. W., Salisbury, D. F., & Phillips, M. L. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.05.029 · Cited by 15 · see citing works
Striatal Functional Connectivity Alterations After Two-Week Antidepressant Treatment Associated to Enduring Clinical Improvement in Major Depressive Disorder
An, J., Li, L., Wang, L., Su, Y., Wang, Y., Li, K., Zeng, Y., Kong, Q., Yan, C., & Si, T. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00884 · Cited by 12 · see citing works
A Text-Book of Mental Diseases, with Special Reference to the Pathological Aspects of Insanity.
(1890) · JAMA · doi:10.1001/jama.1890.02410400035019 · Cited by 7 · see citing works

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Anhedonia and Depressive Disorders
Serretti, A. (2023) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.23.1086 · Cited by 151 · see citing works
Positive affect and reward processing in the treatment of depression, anxiety and trauma
Craske, M. G., Dunn, B. D., Meuret, A. E., Rizvi, S. J., & Taylor, C. T. (2024) · Nature Reviews Psychology · doi:10.1038/s44159-024-00355-4 · Cited by 105 · see citing works
Anhedonia: Preclinical, Translational, and Clinical Integration
(2022) · Current topics in behavioral neurosciences · doi:10.1007/978-3-031-09683-9 · Cited by 64 · see citing works
Amplification of Positivity Treatment for Anxiety and Depression: A Randomized Experimental Therapeutics Trial Targeting Social Reward Sensitivity to Enhance Social Connectedness
Taylor, C. T., Stein, M. B., Simmons, A. N., He, F., Oveis, C., Shakya, H. B., Sieber, W. J., Fowler, J. H., & Jain, S. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.07.024 · Cited by 53 · see citing works
Probabilistic Reinforcement Learning and Anhedonia
Kangas, B. D., Der‐Avakian, A., & Pizzagalli, D. A. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_349 · Cited by 34 · see citing works
The computational structure of consummatory anhedonia
Hall, A., Browning, M. D., & Huys, Q. J. M. (2024) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2024.01.006 · Cited by 29 · see citing works
Anhedonia Across and Beyond the Schizophrenia Spectrum
Chan, R. C. K., Wang, L., Huang, J., Wang, Y., & Lui, S. S. Y. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae165 · Cited by 18 · see citing works
Anhedonia relates to reduced striatal reward anticipation in depression but not in schizophrenia or bipolar disorder: A transdiagnostic study
Daniels, A., Wellan, S., Beck, A., Erk, S., Wackerhagen, C., Romanczuk-Seiferth, N., Schwarz, K., Schweiger, J. I., Meyer-Lindenberg, A., Heinz, A., et al. (2025) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-024-01261-1 · Cited by 17 · see citing works
Anhedonia: Current and future treatments
Serretti, A. (2025) · Psychiatry and Clinical Neurosciences Reports · doi:10.1002/pcn5.70088 · Cited by 17 · see citing works
Validation of a touchscreen probabilistic reward task for mice: A reverse-translated assay with cross-species continuity
Luc, O. T., & Kangas, B. D. (2023) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-023-01128-x · Cited by 17 · see citing works
The impacts of anhedonia on brain functional alterations in patients with major depressive disorder: A resting-state functional magnetic resonance imaging study of regional homogeneity
Fang, Z., Mu, Q., Wu, C., Jia, L., Wang, Z., Hu, S., Xu, Y., Huang, M., & Lu, S. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.10.028 · Cited by 15 · see citing works
Enhancing pre-trained contextual embeddings with triplet loss as an effective fine-tuning method for extracting clinical features from electronic health record derived mental health clinical notes
Kulkarni, D. S., Ghosh, A., Girdhari, A., Liu, S., Vance, L. A., Unruh, M., & Sarkar, J. (2023) · Natural Language Processing Journal · doi:10.1016/j.nlp.2023.100045 · Cited by 14 · see citing works
The Use of Ketamine for the Treatment of Anhedonia in Depression
Patarroyo-Rodríguez, L., Cavalcanti, S., Voort, J. L. V., & Singh, B. (2024) · CNS Drugs · doi:10.1007/s40263-024-01099-8 · Cited by 13 · see citing works
Using the experience sampling methodology to measure anhedonia and its correlates in mental health research: A systematic review
Beames, J. R., Uyttebroek, L., Edwards, C., Eisele, G. V., Kemme, N. D. F., Collier, O., van Roekel, E., Kwapil, T. R., Kirtley, O. J., & Myin‐Germeys, I. (2025) · Clinical Psychology Review · doi:10.1016/j.cpr.2025.102590 · Cited by 13 · see citing works
Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats
Varela, R. B., Macpherson, H. K., Walker, A. J., Houghton, T., Yates, C. G., Yates, N. J., Daygon, V. D., & Tye, S. J. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.03.001 · Cited by 11 · see citing works
Volume changes of the subcortical limbic structures in major depressive disorder patients with and without anhedonia
Mu, Q., Cui, D., Zhang, K., Ru, Y., Wu, C., Fang, Z., Jia, L., Hu, S., Huang, M., & Lu, S. (2023) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2023.111747 · Cited by 10 · see citing works
From anxiety to depression: A longitudinal investigation into the role of anhedonia
Collins, A. C., Gallagher, M. R., Calafiore, C., Jordan, D. G., & Winer, E. S. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.03.074 · Cited by 10 · see citing works
Predictive coding and neurocomputational psychiatry: a mechanistic framework for understanding mental disorders
Shaw, A. D., Sumner, R. L., & Berndt, L. C. S. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1713833 · Cited by 9 · see citing works
“Anhedonia experienced in bipolar disorder has been found to have partially distinct neurophysiology to that in unipolar depression (77).”
Natural language processing to identify suicidal ideation and anhedonia in major depressive disorder
Vance, L. A., Way, L., Kulkarni, D. S., Palmer, E. O. C., Ghosh, A., Unruh, M., Chan, K. M. Y., Girdhari, A., & Sarkar, J. (2025) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-025-02851-w · Cited by 9 · see citing works
The dual-continua model of mental health in daily life: momentary associations between distress and wellbeing in clinical and non-clinical populations
Stephens, J. M., Sgherza, T. R., DeMarree, K. G., & Naragon‐Gainey, K. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119432 · Cited by 11 · see citing works
Effect of Cariprazine on Anhedonia in Patients with Bipolar I Depression: Post Hoc Analysis of Three Randomized Placebo-Controlled Clinical Trials
McIntyre, R. S., Llorca, P., Aronin, L. C., Yu, J., & Nguyen, H. (2024) · Advances in Therapy · doi:10.1007/s12325-024-03009-2 · Cited by 8 · see citing works
Abnormal Structure–Function Coupling in Major Depressive Disorder Patients With and Without Anhedonia
Mu, Q., Wu, C., Chen, Y., Xu, Y., Zhang, K., Zhu, C., Hu, S., Huang, M., Zhang, P., Cui, D., et al. (2025) · Depression and Anxiety · doi:10.1155/da/1925158 · Cited by 8 · see citing works
The effect of adjunctive cariprazine on symptoms of anhedonia in patients with major depressive disorder
McIntyre, R. S., Maletic, V., Masand, P. S., Wilson, A. C., Yu, J., Adams, J. L., & Kerolous, M. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.05.026 · Cited by 9 · see citing works
Active versus sham DLPFC-NAc rTMS for depressed adolescents with anhedonia using resting-state functional magnetic resonance imaging (fMRI): a study protocol for a randomized placebo-controlled trial
Lv, R., Cai, M., Tang, N., Shi, Y., Zhang, Y., Liu, N., Han, T., Zhang, Y., & Wang, H. (2024) · Trials · doi:10.1186/s13063-023-07814-y · Cited by 8 · see citing works
Using data processing to understand inconsistency in smartphone behavior among patients with serious mental illness: Results of a digital phenotyping biomarker study
Langholm, C., Breitinger, S. A., Gray, L., Goes, F. S., Walker, A., Xiong, A. E., Stopel, C., Zandi, P. P., Frye, M. A., & Torous, J. B. (2024) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2024.100105 · Cited by 7 · see citing works
Differences in resting-state functional connectivity between depressed bipolar and major depressive disorder patients: A machine learning study
Calesella, F., Serra, E., Palladini, M., Colombo, F., Bravi, B., Fortaner-Uyà, L., Monopoli, C., Tassi, E., Brambilla, P., Colombo, C., et al. (2025) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2025.05.011 · Cited by 7 · see citing works
Neural substrates of predicting anhedonia symptoms in major depressive disorder via connectome‐based modeling
Yang, T., Ou, Y., Li, H., Liu, F., Li, P., Xie, G., Zhao, J., Cui, X., & Guo, W. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14871 · Cited by 6 · see citing works
Delivering a new generation of translational animal models for depression research
Robinson, E. S. J. (2025) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000819 · Cited by 6 · see citing works
A Multimodal Preclinical Assessment of MDMA in Female and Male Rats: Prohedonic, Cognition Disruptive, and Prosocial Effects
Adam, A. S., LaMalfa, K. S., Razavi, Y., Kohut, S. J., & Kangas, B. D. (2024) · Psychedelic Medicine · doi:10.1089/psymed.2023.0049 · Cited by 6 · see citing works
Treatment-resistant recurrent unipolar and bipolar depression: associative learning abnormalities
Suveges, S., Wang, Y., Tolomeo, S., Gilbertson, T., & Steele, J. D. (2025) · Brain · doi:10.1093/brain/awaf280 · Cited by 5 · see citing works
Efficacy and target engagement of dopamine agonist pramipexole for anhedonic depression: a randomized placebo-controlled trial
Ventorp, F., Asp, M., Olsson, S., Lindahl, J., Möller, S., Svensson, M., Ängeby, F., Pravdinske, A., Tjernberg, J., Schrey, S., et al. (2026) · Nature Medicine · doi:10.1038/s41591-026-04465-9 · Cited by 5 · see citing works
Sex-specific immune-inflammatory markers and lipoprotein profile in patients with anhedonia with unipolar and bipolar depression
Lin, S., Liu, R., Zhang, Z., Liu, F., Qin, S., Wei, Y., & Wang, F. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-05378-4 · Cited by 5 · see citing works
Comparison of whole-brain structural connectivity between bipolar disorder and major depressive disorder: A DTI-based connectome analysis
Zhang, R., Ren, J., Fu, L., Lei, X., Wang, Y., Guo, C., Teng, X., Wu, Z., Yu, L., Wu, Y., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119388 · Cited by 4 · see citing works
Association of anhedonia with comorbid mental disorders, suicidality and personality traits in patients with depression
Rukavishnikov, G. V., Kasyanov, E. D., Shishkovskaia, T. I., Olychik, I. V., Незнанов, Н. Г., Kibitov, A. O., & Mazo, G. E. (2023) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202312311285 · Cited by 4 · see citing works
Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial ExpressionPreprint
Coley, A. A., Batra, K., Delahanty, J., Keyes, L. R., Pamintuan, R., Ramot, A., Hagemann, J., Lee, C. R., Liu, V., Adivikolanu, H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.18.629202 · Cited by 3 · see citing works
Addressing altered anticipation as a transdiagnostic target through computational psychiatry
Sepúlveda, P., Aitsahalia, I., Kumar, K., Atkin, T., & Iigaya, K. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.02.014 · Cited by 3 · see citing works
Selective KOR antagonist alters functional patch sizes in individualized brain system: results from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS)
Fung, H., Potash, R. M., Krystal, A. D., Pizzagalli, D. A., & Sacchet, M. D. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02125-z · Cited by 3 · see citing works
fNIRS-Based characterization of adolescent depression using dynamic functional connectivity biomarkers in a verbal fluency task
Li, T., Dong, Y., Jiao, Q., Chu, L., Qiu, J., Fu, Y., Gao, Y., Ma, Z., Sun, X., & Zhang, Y. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-07799-3 · Cited by 3 · see citing works
Anhedonia as a Core Symptom of Depression and a Construct for Biological Research
Al‐Soleiti, M., Voort, J. L. V., & Singh, B. (2025) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20240050 · Cited by 4 · see citing works
The Effect of Anhedonia on Suicidal Ideation: The Moderated Mediation Effect of Emotional Intelligence Through Loneliness
Lee, S., & Bae, S. (2025) · Psychiatry Investigation · doi:10.30773/pi.2024.0388 · Cited by 2 · see citing works
Exploring pleasure as a mediator of outcomes in music therapy
Bolger, L., Hillman, K. B., & McFerran, K. S. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-05140-1 · Cited by 2 · see citing works
Unraveling the molecular pathways linking polystyrene exposure and depression
Murthy, M. K. (2025) · Environmental Science and Pollution Research · doi:10.1007/s11356-025-37184-8 · Cited by 2 · see citing works
Anhedonia in Acne Vulgaris: A Cross-Sectional Study of 104 Consecutive Acne Patients
Szepietowska, M., Stefaniak, A. A., Krajewski, P. K., & Matusiak, Ł. (2024) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s451927 · Cited by 2 · see citing works
The real-world impact of cariprazine on short- and long-term disability outcomes among commercially insured patients in the United States
Masand, P. S., Parikh, M., Ta, J. T., Zanardo, E., Lejeune, D., Martínez, C., Laliberté, F., & Nabulsi, N. A. (2025) · Journal of Medical Economics · doi:10.1080/13696998.2025.2470014 · Cited by 2 · see citing works
Conveying depression: Is a reduced relative preference for happiness a way depressed people convince themselves of their depressed identity?
Wahlers, J. N., Wahlers, D. E., & Hart, W. (2024) · Journal of Social and Clinical Psychology · doi:10.1521/jscp.2024.43.3.227 · Cited by 1 · see citing works
The association between anhedonia and speech features in depression: A cross-sectional study
Yang, Q., Li, N., Liu, Y., Wang, S., Ma, J., Wang, J., Liu, P., He, Z., Wang, G., & Feng, L. (2025) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2025.03.013 · Cited by 1 · see citing works
Neutral sentiment on patient's speech can predict the depressive symptom severity transdiagnostically
Mineur, L., Horstmann, S., Arslan, B., Andreou, C., Heide, M., Eickhoff, S., Avram, M., Berg, K., Hedelt, K. S., Franzen, L., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119990 · Cited by 1 · see citing works
Polygenic predisposition to transdiagnostic symptom dimensions and treatment outcomes across psychiatric disorders
Abondio, P., Fanelli, G., Baldini, V., Bacalini, M. G., Kasper, S., Zohar, J., Souery, D., Montgomery, S., Albani, D., Forloni, G., et al. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111512 · Cited by 1 · see citing works
Associations between polygenic risk for anhedonia and functional brain activity during reward processing
Schäfer, N., Awasthi, S., Ripke, S., Daniels, A., Meyer‐Lindenberg, A., Tost, H., Heinz, A., Walter, H., & Erk, S. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120900 · Cited by 1 · see citing works
Normative brain variability, clinical dimension, and molecular‐transcriptomic correlates of bipolar risk in depressed patients
Shao, J., Wang, T., Zhang, W., Xue, L., Wang, X., Hua, L., Chen, Z., Pei, C., Liao, Q., Wang, Y., et al. (2026) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.70028 · Cited by 1 · see citing works
Efficacy and Clinical Relevance of Adjunctive Cariprazine Treatment in Patients with Major Depressive Disorder: Post Hoc Analyses from a Phase III Study
Papakostas, G. I., Masand, P. S., Clayton, A., Maletic, V., Adams, J., Rekeda, L., Singh, M. K., & Kerolous, M. (2026) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s561112 · Cited by 1 · see citing works
Relationship between psychological resilience and internalizing/externalizing behaviors in adolescents: the mediating role of anhedonia and ostracism
ARSLAN, Z., & KAYIRAN, D. (2026) · BMC Psychology · doi:10.1186/s40359-026-04611-5 · Cited by 1 · see citing works
Anhedonia in patients with major depressive disorder (MDD): State-of-the-art consensus review
Cutler, A. J., Clayton, A. H., Krystal, A. D., Maletic, V., McIntyre, R. S., & Nemeroff, C. B. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.117225 · Cited by 3 · see citing works
Psychedelics produce enduring enhancement of reward responsiveness in male rats
Thomas, C. W., LaMalfa, K. S., Whelan, T. P., Blackmore, T., Golden, C. T., Pizzagalli, D. A., Bergman, J., Gilmour, G., & Kangas, B. D. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02475-2 · Cited by 1 · see citing works
Early anhedonia distinguishes behavioral variant frontotemporal dementia from Alzheimer's disease
Shaw, S., Warren, S. L., Teng, C., Huynh, J., Ahmed, R. M., Piguet, O., Whitton, A. E., & Irish, M. (2026) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70501 · Cited by 1 · see citing works
Unravelling the Role of the Dopamine D1 Receptor in Anhedonia, Asociality, and Avolition
Witt, K. (2023) · doi:10.26686/wgtn.24646128 · Cited by 1 · see citing works
Additional file 1 of Active versus sham DLPFC-NAc rTMS for depressed adolescents with anhedonia using resting-state functional magnetic resonance imaging (fMRI): a study protocol for a randomized placebo-controlled trial
Lv, R., Cai, M., Tang, N., Shi, Y., Zhang, Y., Liu, N., Han, T., Zhang, Y., & Wang, H. (2024) · Figshare · doi:10.6084/m9.figshare.24995477
Reduced Subjective and Behavioral Responses to Cuteness in AnhedoniaPreprint
Takamatsu, R., & Nittono, H. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4815387
Cross-species dissection of the modular role of the ventral tegmental area in depressive disorders
Morris, L. S., Beltran, J., Murrough, J. W., & Morel, C. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.02.008
A review on the validity of animal models for neuropsychiatric disorders: an exploration of anhedonia
Witt, K. M., Harper, D. N., & Ellenbroek, B. A. (2025) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000816
Reduced Subjective and Behavioral Responses to Cuteness in Relation to Anhedonia
Takamatsu, R., & Nittono, H. (2025) · Japanese Psychological Research · doi:10.1111/jpr.12594
Protein tyrosine phosphatase receptor type D - A convergent risk gene for MDD, BPD, and ADHD and regulator of dopaminergic neuroplasticity in reward associated circuits; A multivariate GWAS, brain tissue and cell type enrichment, and gene fine-mappingPreprint
Lawrence, C., & Hansen, T. F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.17.676918
Additional file 1 of Sex-specific immune-inflammatory markers and lipoprotein profile in patients with anhedonia with unipolar and bipolar depression
Lin, S., Liu, R., Zhang, Z., Liu, F., Qin, S., Wei, Y., & Wang, F. (2023) · Figshare · doi:10.6084/m9.figshare.24647146
Additional file 2 of Active versus sham DLPFC-NAc rTMS for depressed adolescents with anhedonia using resting-state functional magnetic resonance imaging (fMRI): a study protocol for a randomized placebo-controlled trial
Lv, R., Cai, M., Tang, N., Shi, Y., Zhang, Y., Liu, N., Han, T., Zhang, Y., & Wang, H. (2024) · Figshare · doi:10.6084/m9.figshare.24995565
Expressing the depressed self: depression, self-concordance with sadness, and sadness regulation goals
Wahlers, J. N., Hart, W., Garrison, K., & Wahlers, D. E. (2026) · Current Psychology · doi:10.1007/s12144-025-08563-8
Anhedonia and Daily Emotional Experiences Among Mothers of Preschool Children: an Experiential Sampling Study
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Differential associations of childhood abuse and neglect with neural responses to social reward and punishment in adults with anxiety or depression
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Du, L., Zong, X., He, J., Feng, M., Li, H., Tan, Y., Dong, L., Sun, X., Zhang, Y., Yin, S., et al. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1748315
Validation of the specific loss of interest and pleasure scale in non-clinical and clinical populations
Xu, Y., Liu, W., Liu, L., Wang, C., Li, T., Yan, C., & Yang, X. (2026) · Frontiers in Psychology · doi:10.3389/fpsyg.2026.1706503
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He, J.-Y., Huang, Y.-T., Zheng, T.-X., Lv, Q., Yi, Z., Zhu, N.-J., & Yan, C. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-08013-0
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Díaz‐Zuluaga, A. M., Anderberg, J. L., Ramirez-Diaz, A. M., Marques, A. H., Rast, C. E., Bustamante, D., Jonker, D., Echeverry, J. V., Kyebuzibwa, J., Muñoz, J. S., et al. (2026) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.70019
Baseline inability-to-feel severity is associated with fewer first-year days well in bipolar disorder: A STEP-BD analysis
Serretti, A. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.122119
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Yoon, H., Kim, H. S., Lee, S., Choi, T. Y., Sung-Won, J., Yoon, H., Kim, H.-S., Yang, H. J., Jeong, N., Moon, E., et al. (2026) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2026.105062
Treatment-related associations of nucleus accumbens connectivity within mesocorticolimbic circuits in depression
Li, H., Wang, J., Li, J., Pan, J., & Xu, Y. J. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.122275
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Demyttenaere, K., Alassiry, M. Z., Bobrowska, A., Fagiolini, A. M., Gorwood, P. A. P. M., Kambarov, Y., Makhoul, S., Reif, A., Riise, J., Werner‐Kiechle, T., et al. (2026) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2026.112902
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Lee, E., Sim, S. H., Park, C., Kim, H., Ahn, W., & Park, C. H. K. (2026) · medRxiv · doi:10.64898/2026.07.19.26358451
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Broer, M. I., Barendse, M. E. A., van den Brink-Steinmann, L. J., Snijders, A. L., Meijer, M. N., Paludanus, S., van der Weijden-Germann, M., Bilder, R. M., Ophoff, R. A., & van Haren, N. E. M. (2025) · JMIR Formative Research · doi:10.2196/86998
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Cervantes-Constantino, F., Acuña, A., Fernandez, C., Guillen, M., Mendaro, L., Brandani, A., Morales, S., Pérez, A., Mattos, J., Cuña, E., et al. (2026) · Imaging neuroscience · doi:10.1162/imag.a.1363
Towards precision psychiatry: initial foundations and future directions
Etkin, A., O’Donnell, P., Ressler, K. J., & Manji, H. K. (2026) · Nature Reviews Drug Discovery · doi:10.1038/s41573-026-01509-0 · Cited by 1 · see citing works
Comparative efficacy of interventions for transdiagnostic anhedonia: a network meta-analysis
Wang, Y.-M., Chen, F., Hou, Y.-W., & Zhang, M. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.117435
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Kaczmarek, E. S., Wong, S., Chisamore, N., Stern, M. A., Doyle, Z., Johnson, D. E., McIntyre, R. S., & Rosenblat, J. D. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.10.023

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Raafat, N., Fouad, A. A., Salaheldin, M., & Khalil, Y. A. (2025) · Zagazig University Medical Journal · doi:10.21608/zumj.2025.402371.4043
Presentation and Neurobiology of Anhedonia in Mood Disorders: Commonalities and Distinctions
Rizvi, S. J., Lambert, C. M., & Kennedy, S. H. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0877-z · Cited by 44 · see citing works
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Daniels, A., Wellan, S., Beck, A., Erk, S., Wackerhagen, C., Romanczuk-Seiferth, N., Schwarz, K., Schweiger, J. I., Meyer-Lindenberg, A., Heinz, A., et al. (2025) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-024-01261-1 · Cited by 17 · see citing works
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Borsini, A., Wallis, A. S. J., Zunszain, P., Pariante, C. M., & Kempton, M. J. (2020) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-020-00804-6 · Cited by 207 · see citing works
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works

Authors: Whitton, A. E., & Pizzagalli, D. A.
Affiliations: Black Dog Institute (AU)
Harvard University (US)
Corresponding author: Pizzagalli, Diego A.
ORCID: Whitton, Alexis E.
Pizzagalli, Diego A.
Venue: Current topics in behavioral neurosciences
Publisher: Springer International Publishing
Published: 2022
Volume: 58
Pages: 111-127
ISSN: 1866-3370 (ISSN-L)
1866-3389
DOI: 10.1007/7854_2022_323
OpenAlex: W4223540410
Cited by: 80
References: 86
Citations by year: 2026: 24 · 2025: 29 · 2024: 15 · 2023: 9 · 2022: 3
FWCI: 76.39
Type: book chapter
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Current topics in behavioral neurosciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (P50MH119467, R01MH095809, R37MH068376)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: anhedonia, major depressive disorder, bipolar disorder, reward processing, ventral striatum, reward anticipation, treatment-resistant depression, mood disorders
MeSH terms: Bipolar Disorder, Depression, Major Depressive Disorder, Humans, Magnetic Resonance Imaging, Reward, Anhedonia, Ventral Striatum

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