Role of the Brain's Reward Circuitry in Depression
Open accessAbstract
Increasing evidence supports an important role for the brain's reward circuitry in controlling mood under normal conditions and contributing importantly to the pathophysiology and symptomatology of a range of mood disorders, such as depression. Here we focus on the nucleus accumbens (NAc), a critical component of the brain's reward circuitry, in depression and other stress-related disorders. The prominence of anhedonia, reduced motivation, and decreased energy level in most individuals with depression supports the involvement of the NAc in these conditions. We concentrate on several transcription factors (CREB, ΔFosB, SRF, NFκB, and β-catenin), which are altered in the NAc in rodent depression models--and in some cases in the NAc of depressed humans, and which produce robust depression- or antidepressant-like effects when manipulated in the NAc in animal models. These studies of the NAc have established novel approaches toward modeling key symptoms of depression in animals and could enable the development of antidepressant medications with fundamentally new mechanisms of action.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In rodent models of depression and depressive-like behaviors, multiple behavioral assays in addition to social interaction test, including sucrose preference, tail suspension, and forced swim tests are often used.
“In rodent models of depression and depressive-like behaviors, multiple behavioral assays in addition to social interaction test, including sucrose preference, tail suspension, and forced swim tests are often used [7, 20, 29].”
From A nucleus accumbens-projecting prefrontal cortex circuit underlies chronic social stress-induced depression-like behaviors (2026) · cites this paper as [29]
Section 3.1 describes several rodent stress assays and changes in responses to sucrose; the References include a study using the forced swim test. These support the general point that multiple behavioral measures are used, but the copy does not identify a sucrose-preference test, tail-suspension test, or social-interaction test as such. Page numbers were not supplied. (LLM, conf=0.82)
Experimental — accuracy not yet measuredPrevious work implicates mPFC dysfunction in depression.
“Our results also expand on other previous work implicating mPFC dysfunction in depression [7, 9, 29, 30]”
From A nucleus accumbens-projecting prefrontal cortex circuit underlies chronic social stress-induced depression-like behaviors (2026) · cites this paper as [29]
The ventral capsule/ventral striatum is a central hub in the reward circuitry with dopaminergic inputs from the ventral tegmental area, and serving as a relay between prefrontal cortex (OFC, vmPFC, ACC), ventral striatum and the amygdala and hippocampus.
“The VC/VS is a central hub in the reward circuitry with dopaminergic inputs from the ventral tegmental area (VTA), and serving as a relay between prefrontal cortex (OFC, vmPFC, ACC), ventral striatum and the amygdala and hippocampus [55,56] (Fig. 4).”
From Deep brain stimulation for depression. (2022) · cites this paper as [55]
A number of brain regions, such as the frontal cortex and the hippocampus, provide glutamatergic input to the VTA and NAc.
“It has been described that a number of brain regions, such as the frontal cortex and the hippocampus, provide glutamatergic input to the VTA and NAc (Nestler, 2015).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Nestler, 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,769 · see citing works
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
Self-citationDrug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953 · see citing works
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647 · see citing works
Self-citationKrishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works
Self-citationEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Self-citationThe mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works
Self-citationThe brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Self-citationNew approaches to antidepressant drug discovery: beyond monoamines
Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589 · see citing works
Self-citationCarlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works
Self-citationRapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156 · see citing works
Self-citationDepression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model
Pizzagalli, D. A. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185606 · Cited by 1,155 · see citing works
Dopamine neurons modulate neural encoding and expression of depression-related behaviour
Tye, K. M., Mirzabekov, J. J., Warden, M. R., Ferenczi, E. A., Tsai, H.-C., Finkelstein, J., Kim, S.-Y., Adhikari, A., Thompson, K. R., Andalman, A. S., et al. (2013) · Nature · doi:10.1038/nature11740 · Cited by 1,073 · see citing works
Neuroleptics and operant behavior: The anhedonia hypothesis
Wise, R. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00010372 · Cited by 1,022 · see citing works
Reward and aversion in a heterogeneous midbrain dopamine system
Lammel, S., Lim, B. K., & Malenka, R. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.019 · Cited by 804 · see citing works
Regulation of cocaine reward by CREB
Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767 · see citing works
Self-citationPsychomotor stimulant addiction: a neural systems perspective
Everitt, B. J., & Wolf, M. E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03312.2002 · Cited by 700 · see citing works
Wittmann, B. C., Schott, B. H., Guderian, S., Frey, J. U., Heinze, H.-J., & Düzel, E. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.010 · Cited by 698 · see citing works
Drug-activation of brain reward pathways
Wise, R. A. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00063-5 · Cited by 684 · see citing works
Regulation of gene expression and cocaine reward by CREB and ΔFosB
McClung, C. A., & Nestler, E. J. (2003) · Nature Neuroscience · doi:10.1038/nn1143 · Cited by 625 · see citing works
Self-citationAntidepressant Actions of Histone Deacetylase Inhibitors
Covington, H. E., Maze, I., LaPlant, Q. C., Vialou, V. F., Ohnishi, Y. N., Berton, O., Fass, D. M., Renthal, W., Rush, A. J., Wu, E. Y., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1758-09.2009 · Cited by 624 · see citing works
Self-citationDnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
LaPlant, Q., Vialou, V., Covington, H. E., Dumitriu, D., Feng, J., Warren, B. L., Maze, I., Dietz, D. M., Watts, E. L., Iñiguez, S. D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2619 · Cited by 612 · see citing works
Self-citationHistone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli
Renthal, W., Maze, I., Krishnan, V., Covington, H. E., Xiao, G., Kumar, A., Russo, S. J., Graham, A., Tsankova, N., Kippin, T. E., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.032 · Cited by 599 · see citing works
Self-citationThe dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors
Bruchas, M. R., Land, B. B., & Chavkin, C. (2010) · Brain Research · doi:10.1016/j.brainres.2009.08.062 · Cited by 544 · see citing works
Arnsten, A. F. T., Wang, M. J., & Paspalas, C. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.038 · Cited by 538 · see citing works
Mesolimbic dopaminergic pathways in fear conditioning
Pezze, M. A., & Feldon, J. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.004 · Cited by 510 · see citing works
Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07397.2001 · Cited by 509 · see citing works
Self-citationBarrot, M., Olivier, J. D. A., Perrotti, L. I., DiLeone, R. J., Berton, O., Eisch, A. J., Impey, S., Storm, D. R., Neve, R. L., Yin, J. C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172091899 · Cited by 508 · see citing works
Self-citationΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses
Vialou, V., Robison, A. J., LaPlant, Q. C., Covington, H. E., Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., Watts, E. L., Wallace, D. L., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2551 · Cited by 479 · see citing works
Self-citationEpigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413 · see citing works
Self-citationTranscriptional mechanisms of addiction: role of ΔFosB
Nestler, E. J. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0067 · Cited by 392 · see citing works
Self-citationThe current state of the neurogenic theory of depression and anxiety
Miller, B. R., & Hen, R. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.08.012 · Cited by 386 · see citing works
Francis, T. C., Chandra, R., Friend, D. M., Finkel, E., Dayrit, G., Miranda, J., Brooks, J. M., Iñiguez, S. D., O’Donnell, P., Kravitz, A., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.021 · Cited by 379 · see citing works
The Role of CREB in Depression and Antidepressant Treatment
Blendy, J. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.003 · Cited by 365 · see citing works
CREB modulates excitability of nucleus accumbens neurons
Dong, Y., Green, T. A., Saal, D. B., Marie, H., Neve, R. L., Nestler, E. J., & Malenka, R. C. (2006) · Nature Neuroscience · doi:10.1038/nn1661 · Cited by 356 · see citing works
Self-citationGlutamate systems in cocaine addiction
Kalivas, P. W. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.11.002 · Cited by 349 · see citing works
Wallace, D. L., Han, M.-H., Graham, D. L., Green, T. A., Vialou, V., Iñiguez, S. D., Cao, J.-L., Kirk, A., Chakravarty, S., Kumar, A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2257 · Cited by 342 · see citing works
Self-citationTremblay, L. K., Naranjo, C. A., Graham, S. J., Herrmann, N., Mayberg, H. S., Hevenor, S., & Busto, U. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.11.1228 · Cited by 340 · see citing works
Induction of ΔFosB in Reward-Related Brain Structures after Chronic Stress
Perrotti, L. I., Hadeishi, Y., Ulery, P. G., Barrot, M., Monteggia, L. M., Duman, R. S., & Nestler, E. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2542-04.2004 · Cited by 330 · see citing works
Self-citationConti, A. C., Cryan, J. F., Dalvi, A., Lucki, I., & Blendy, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03262.2002 · Cited by 328 · see citing works
Newton, S. S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger, L., Sakai, N., Chen, J., Neve, R., Nestler, E. J., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10883.2002 · Cited by 313 · see citing works
Self-citationA Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress
Covington, H. E., Maze, I., Sun, H., Bomze, H. M., DeMaio, K. D., Wu, E. Y., Dietz, D. M., Lobo, M. K., Ghose, S., Mouzon, E., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.007 · Cited by 289 · see citing works
Self-citationVialou, V., Bagot, R. C., Cahill, M. E., Ferguson, D., Robison, A. J., Dietz, D. M., Fallon, B., Mazei-Robison, M., Ku, S. M., Harrigan, E., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1787-13.2014 · Cited by 283 · see citing works
Self-citationEpigenetic Mechanisms of Depression and Antidepressant Action
Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134540 · Cited by 277 · see citing works
Self-citationIκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity
Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M.-H., Ables, J. L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4763-10.2011 · Cited by 267 · see citing works
An essential role for ΔFosB in the nucleus accumbens in morphine action
Zachariou, V., Bolaños, C. A., Selley, D. E., Theobald, D. E. H., Cassidy, M. P., Kelz, M. B., Shaw-Lutchman, T., Berton, O., Sim‐Selley, L. J., Dileone, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1636 · Cited by 266 · see citing works
Self-citationWilkinson, M. B., Xiao, G., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T. J., & Nestler, E. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0932-09.2009 · Cited by 262 · see citing works
Self-citationRole of kappa-opioid receptors in stress and anxiety-related behavior
Veer, A. V., & Carlezon, W. A. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3195-5 · Cited by 254 · see citing works
Nuclear Factor κB Signaling Regulates Neuronal Morphology and Cocaine Reward
Russo, S. J., Wilkinson, M. B., Mazei‐Robison, M. S., Dietz, D., Maze, I. S., Krishnan, V., Renthal, W. R., Graham, A., Birnbaum, S. G., Green, T. A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6173-08.2009 · Cited by 248 · see citing works
Self-citationLobo, M. K., Zaman, S., Damez-Werno, D. M., Koo, J. W., Bagot, R. C., DiNieri, J. A., Nugent, A., Finkel, E., Chaudhury, D., Chandra, R., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1875-13.2013 · Cited by 245 · see citing works
Self-citationβ-catenin mediates stress resilience through Dicer1/microRNA regulation
Dias, C., Feng, J., Sun, H., Shao, N. Y., Mazei-Robison, M. S., Damez-Werno, D., Scobie, K., Bagot, R., LaBonté, B., Ribeiro, E., et al. (2014) · Nature · doi:10.1038/nature13976 · Cited by 240 · see citing works
Self-citationFosB differentially modulates nucleus accumbens direct and indirect pathway function
Grueter, B. A., Robison, A. J., Neve, R. L., Nestler, E. J., & Malenka, R. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221742110 · Cited by 191 · see citing works
Self-citationDudman, J. T., Eaton, M. E., Rajadhyaksha, A. M., Macias‐Konstantopoulos, W., Taher, M., Barczak, A. K., Kameyama, K., Huganir, R. L., & Konradi, C. L. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02067.x · Cited by 170 · see citing works
Wilkinson, M. B., Dias, C., Magida, J., Mazei-Robison, M., Lobo, M., Kennedy, P., Dietz, D., Covington, H., Russo, S., Neve, R., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0039-11.2011 · Cited by 170 · see citing works
Self-citationEpigenetic Signaling in Psychiatric Disorders
Peña, C. J., Bagot, R. C., Labonté, B., & Nestler, E. J. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.03.016 · Cited by 163 · see citing works
Self-citationDonahue, R. J., Muschamp, J. W., Russo, S. J., Nestler, E. J., & Carlezon, W. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.12.014 · Cited by 161 · see citing works
Self-citationRegulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens
Barrot, M., Wallace, D. L., Bolaños, C. A., Graham, D. L., Perrotti, L. I., Neve, R. L., Chambliss, H., Yin, J. C. P., & Nestler, E. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500587102 · Cited by 161 · see citing works
Self-citationThe Fibroblast Growth Factor Family: Neuromodulation of Affective Behavior
Turner, C. A., Watson, S. J., & Akil, H. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.037 · Cited by 160 · see citing works
Induction of nuclear factor‐κB in nucleus accumbens by chronic cocaine administration
Ang, E. S. B. C., Chen, J., Zagouras, P., Magna, H. A., Holland, J., Schaeffer, E., & Nestler, E. J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00563.x · Cited by 146 · see citing works
Self-citationRole of Nuclear Factor κB in Ovarian Hormone-Mediated Stress Hypersensitivity in Female Mice
LaPlant, Q., Chakravarty, S., Vialou, V., Mukherjee, S., Koo, J. W., Kalahasti, G., Bradbury, K. R., Taylor, S. V., Maze, I., Kumar, A., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.024 · Cited by 136 · see citing works
Self-citationModulation of Anxiety-Like Behavior and Morphine Dependence in CREB-Deficient Mice
Valverde, O., Mantamadiotis, T., Torrecilla, M., Ugedo, L., Pineda, J., Bleckmann, S. C., Gass, P., Kretz, O., Mitchell, J., Schütz, G., et al. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300416 · Cited by 118 · see citing works
Analytical tools and current challenges in the modern era of neuroepigenomics
Maze, I., Shen, L., Zhang, B., Garcia, B. A., Shao, N., Mitchell, A., Sun, H., Akbarian, S., Allis, C. D., & Nestler, E. J. (2014) · Nature Neuroscience · doi:10.1038/nn.3816 · Cited by 100 · see citing works
Self-citationDiNieri, J. A., Nemeth, C. L., Parsegian, A., Carle, T. L., Gurevich, V. V., Gurevich, E. V., Neve, R. L., Nestler, E. J., & Carlezon, W. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5104-08.2009 · Cited by 98 · see citing works
Self-citationSerum Response Factor Promotes Resilience to Chronic Social Stress through the Induction of ΔFosB
Vialou, V., Maze, I., Renthal, W., LaPlant, Q. C., Watts, E. L., Mouzon, E., Ghose, S., Tamminga, C. A., & Nestler, E. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2496-10.2010 · Cited by 91 · see citing works
Self-citationTreatment strategies to improve and sustain remission in major depressive disorder
Trivedi, M. H., & Daly, E. J. (2008) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2008.10.4/mhtrivedi · Cited by 89 · see citing works
Maternal separation is associated with DNA methylation and behavioural changes in adult rats
Anier, K., Malinovskaja, K., Pruus, K., Aonurm‐Helm, A., Zharkovsky, A., & Kalda, A. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.07.012 · Cited by 82 · see citing works
Vialou, V., Feng, J., Robison, A. J., Ku, S. M., Ferguson, D., Scobie, K. N., Mazei‐Robison, M. S., Mouzon, E., & Nestler, E. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1381-12.2012 · Cited by 77 · see citing works
Self-citationCREB Modulates the Functional Output of Nucleus Accumbens Neurons
Huang, Y. H., Lin, Y., Brown, T. E., Han, M., Saal, D. B., Neve, R. L., Zukin, R. S., Sorg, B. A., Nestler, E. J., Malenka, R. C., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706578200 · Cited by 71 · see citing works
Self-citationTreatment strategies to improve and sustain remission in major depressive disorder.
Trivedi, M. H., & Daly, E. (2008) · Europe PMC (PubMed Central) · Cited by 70 · see citing works
Réus, G. Z., Abelaira, H. M., dos Santos, M. A. B., Carlessi, A. S., Tomaz, D. B., Neotti, M. V., Liranço, J. L. G., Gubert, C., Barth, M., Kapczinski, F. P., et al. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.041 · Cited by 66 · see citing works
Muschamp, J. W., Nemeth, C. L., Robison, A. J., Nestler, E. J., & Carlezon, W. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.08.011 · Cited by 46 · see citing works
Self-citationRegulation of Antidepressant Activity by cAMP Response Element Binding Proteins
Conti, A. C., & Blendy, J. A. (2004) · Molecular Neurobiology · doi:10.1385/mn:30:2:143 · Cited by 28 · see citing works
Silbersweig, D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.011 · Cited by 17 · see citing works
Neurobiology and Treatment of Anxiety: Signal Transduction and Neural Plasticity
Duman, C. H., & Duman, R. S. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-28082-0_11 · Cited by 12 · see citing works
A molecular knife to dice depression
Schratt, G. M. (2014) · Nature · doi:10.1038/nature13942 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The menace of obesity to depression and anxiety prevalence
Fulton, S., Décarie-Spain, L., Fioramonti, X., Guiard, B., & Nakajima, S. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2021.10.005 · Cited by 441 · see citing works
“In contrast, increasing brain-derived neurotrophic factor in the nucleus accumbens or ventral tegmental area produces a depressive-like phenotype, whereas animals with selective knockout of brain-derived neurotrophic factor in ventral tegmental area are protected from depressive effects produced by social defeat stres…”
BackgroundNeurobiology of Resilience: Interface Between Mind and Body
Cathomas, F., Murrough, J. W., Nestler, E. J., Han, M.-H., & Russo, S. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.011 · Cited by 296 · see citing works
Self-citationCircuit Mechanisms of Reward, Anhedonia, and Depression
Höflich, A., Michenthaler, P., Kasper, S., & Lanzenberger, R. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy081 · Cited by 253 · see citing works
Goodwill, H. L., Manzano-Nieves, G., Gallo, M. E., Lee, H.-I., Oyerinde, E., Serre, T., & Bath, K. G. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0195-5 · Cited by 233 · see citing works
Bolton, J. L., Molet, J., Regev, L., Chen, Y., Rismanchi, N., Haddad, E., Yang, D. Z., Obenaus, A., & Baram, T. Z. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.023 · Cited by 215 · see citing works
Gui, W.-S., Xiao, W., Mai, C.-L., Murugan, M., Wu, L., Xin, W., Zhou, L., & Liu, X. (2016) · Molecular Pain · doi:10.1177/1744806916646784 · Cited by 198 · see citing works
Deep brain stimulation for depression.
Figee, M., Riva-Posse, P., Choi, K. S., Bederson, L., Mayberg, H. S., & Kopell, B. H. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01270-3 · Cited by 175 · see citing works
Neuropeptide and small transmitter coexistence: Fundamental studies and relevance to mental illness
Hökfelt, T., Barde, S., Xu, Z.-Q. D., Kuteeva, E., Rüegg, J., Le Maitre, E., Risling, M., Kehr, J., Ihnatko, R., Theodorsson, E., et al. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00106 · Cited by 139 · see citing works
From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms
Kabir, Z. D., Martínez-Rivera, A., & Rajadhyaksha, A. M. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0532-0 · Cited by 125 · see citing works
The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder
Abdallah, C. G., Jackowski, A., Salas, R., Gupta, S., Sato, J. R., Mao, X., Coplan, J. D., Shungu, D. C., & Mathew, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.49 · Cited by 123 · see citing works
Persistent Stress-Induced Neuroplastic Changes in the Locus Coeruleus/Norepinephrine System
Borodovitsyna, O., Joshi, N., & Chandler, D. J. (2018) · Neural Plasticity · doi:10.1155/2018/1892570 · Cited by 95 · see citing works
Sun, H.-L., Zhou, Z.-Q., Zhang, G.-F., Yang, C., Wang, X.-M., Shen, J.-C., Hashimoto, K., & Yang, J.-J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.21 · Cited by 84 · see citing works
Liu, D., Tang, Q., Cui, Y., Song, Y., Liu, Y., Yang, J., Liu, H., Zhang, Y., Wu, S., Song, Y., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000001083 · Cited by 79 · see citing works
Sun, N., Hu, H., Wang, F., Li, L., Zhu, W., Shen, Y., Xiu, J., & Xu, Q. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.11.032 · Cited by 75 · see citing works
Depression and substance use disorders: Clinical comorbidity and shared neurobiology
Calarco, C. A., & Lobo, M. K. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.09.004 · Cited by 69 · see citing works
Irisin: A Multifaceted Hormone Bridging Exercise and Disease Pathophysiology
Paoletti, I., & Coccurello, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413480 · Cited by 70 · see citing works
Lee, Y. L., Subramaniapillai, M., Brietzke, E. M., Mansur, R. B., Ho, R., Yim, S. J., & McIntyre, R. S. (2018) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125318791944 · Cited by 65 · see citing works
Rappeneau, V., Blaker, A. L., Petro, J., Yamamoto, B. K., & Shimamoto, A. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00231 · Cited by 60 · see citing works
Miyanishi, H., & Nitta, A. (2021) · Pharmaceuticals · doi:10.3390/ph14090889 · Cited by 57 · see citing works
Update on GPCR-based targets for the development of novel antidepressants
Mantas, I., Saarinen, M., Xu, Q., & Svenningsson, P. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01040-1 · Cited by 59 · see citing works
Chávez-Castillo, M., Núñez, V., Nava, M., Ortega, Á., Rojas, M., Bermúdez, V., & Rojas, J. (2019) · Advances in Pharmacological Sciences · doi:10.1155/2019/7943481 · Cited by 56 · see citing works
Schmidt, M. E., Kezic, I., Popova, V., Melkote, R., van der Ark, P. D., Pemberton, D. J., Mareels, G., Canuso, C. M., D, M. F. M., & Drevets, W. C. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01862-x · Cited by 53 · see citing works
Depression as a Risk Factor for Impulse Control Disorders in Parkinson Disease
Marín‐Lahoz, J., Sampedro, F., Martínez‐Horta, S., Pagonabarraga, J., & Kulisevsky, J. (2019) · Annals of Neurology · doi:10.1002/ana.25581 · Cited by 53 · see citing works
Elman, I., Upadhyay, J., Langleben, D. D., Albanese, M. A., Becerra, L. R., & Borsook, D. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0292-6 · Cited by 52 · see citing works
The Failing Cascade: Comorbid Post Traumatic- and Opioid Use Disorders.
Elman, I., & Borsook, D. (2019) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.023 · Cited by 40 · see citing works
Porcu, A., Vaughan, M. E., Nilsson, A., Arimoto, N., Lamia, K. A., & Welsh, D. K. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000258117 · Cited by 43 · see citing works
Behavioral Animal Models and Neural-Circuit Framework of Depressive Disorder
Tian, X., Russo, S. J., & Li, L. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01270-7 · Cited by 46 · see citing works
Plasticity of synapses and reward circuit function in the genesis and treatment of depression
Thompson, S. M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01422-1 · Cited by 40 · see citing works
Does Anhedonia Presage Increased Risk of Posttraumatic Stress Disorder?
Risbrough, V. B., Glynn, L. M., Davis, E. P., Sandman, C. A., Obenaus, A., Stern, H. S., Keator, D. B., Yassa, M. A., Baram, T. Z., & Baker, D. G. (2018) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_51 · Cited by 37 · see citing works
Reward Network Immediate Early Gene Expression in Mood Disorders
Manning, C., WILLIAMS, E. S., & Robison, A. J. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00077 · Cited by 36 · see citing works
Nucleus accumbens in the pathogenesis of major depressive disorder: A brief review
Yajie, J., Zou, M., Wang, Y., & Wang, Y. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.03.004 · Cited by 37 · see citing works
Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression
Eren‐Koçak, E., & Dalkara, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.777607 · Cited by 39 · see citing works
Glial mechanisms underlying major depressive disorder: Potential therapeutic opportunities
Rahman, S., & Alzarea, S. I. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.06.010 · Cited by 36 · see citing works
Repurposing of Drugs–The Ketamine Story
Das, J. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01193 · Cited by 35 · see citing works
Movassaghi, C. S., Perrotta, K. A., Yang, H., Iyer, R. K., Cheng, X., Dagher, M., Alcañiz-Fillol, M., & Andrews, A. M. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03665-1 · Cited by 35 · see citing works
Ma, K., Zhang, H., Wei, G., Dong, Z., Zhao, H., Han, X., Song, X., Zhang, H., Zong, X., Baloch, Z., et al. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s200264 · Cited by 32 · see citing works
Paden, W., Barko, K., Puralewski, R., Cahill, K. M., Huo, Z., Shelton, M. A., Tseng, G. C., Logan, R. W., & Seney, M. L. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0742-9 · Cited by 30 · see citing works
Chen, K.-T., Wu, C.-H., Tsai, M., Wu, Y.-C., Jou, M., Huang, C., & Wei, I. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.06.004 · Cited by 29 · see citing works
Bieliński, M. K., Jaracz, M., Lesiewska, N., Tomaszewska, M., Sikora, M., Junik, R., Kamińska, A., Tretyn, A., & Borkowska, A. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s138565 · Cited by 29 · see citing works
Kim, K., Shin, J., Myung, W., D, M. F. M., Mischoulon, D., Papakostas, G. I., Choi, K. W., Na, E. J., Seo, S. W., Seong, J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-43882-4 · Cited by 29 · see citing works
Chakraborty, S., Tripathi, S. J., Srikumar, B. N., Raju, T. R., & Rao, B. S. S. (2019) · Brain stimulation · doi:10.1016/j.brs.2019.01.020 · Cited by 26 · see citing works
Winokur, S. B., Lopes, K. L., Moparthi, Y., & Pereira, M. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12766 · Cited by 21 · see citing works
Meng, Y., Li, H., Wang, J., Xu, Y. J., & Wang, B. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.02.001 · Cited by 21 · see citing works
Hicks, E. M., Seah, C., Cote, A. C., Marchese, S., Brennand, K., Nestler, E. J., Girgenti, M. J., & Huckins, L. M. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02412-7 · Cited by 20 · see citing works
Self-citationAbdelkawy, Y. S., Elharoun, M., Sheta, E., Abdel-Raheem, I. T., & Nematalla, H. A. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176525 · Cited by 21 · see citing works
de la Tremblaye, P. B., Linares, N. F. N., Schock, S., & Plamondon, H. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.019 · Cited by 20 · see citing works
Mansur, R. B., Brietzke, E. M., McIntyre, R. S., Cao, B., Lee, Y., Japiassú, L., Chen, K., Lu, R., Lu, W., Li, T., et al. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12822 · Cited by 20 · see citing works
Castro‐Zavala, A., Martín‐Sánchez, A., Luján, M. Á., & Valverde, O. (2020) · Addiction Biology · doi:10.1111/adb.12911 · Cited by 20 · see citing works
Horii, Y., McTaggart, I. P., & Kawaguchi, M. (2018) · Journal of Visualized Experiments · doi:10.3791/56428 · Cited by 19 · see citing works
Zhang, J., Lu, Y., Jia, M., Bai, Y., Sun, L., Dong, Z., Tian, W., Yin, F., Wei, S., & Wang, Y. (2023) · iScience · doi:10.1016/j.isci.2023.107536 · Cited by 19 · see citing works
Deep gray matter substructure volumes and depressive symptoms in a large multiple sclerosis cohort
Hu, C., Dewey, B., Mowry, E., & Fitzgerald, K. C. (2023) · Multiple Sclerosis · doi:10.1177/13524585221148144 · Cited by 19 · see citing works
Peng, S., Zhou, Y., Xiong, L., & Wang, Q. (2023) · Scientific Reports · doi:10.1038/s41598-023-29101-1 · Cited by 15 · see citing works
Huang, C., Tsai, M., Wu, Y.-C., Chen, K.-T., Chuang, H.-W., Chen, Y., Tseng, G.-W., Fu, P.-I., & Wei, I. (2018) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x18500787 · Cited by 17 · see citing works
Sanna, F., Poddighe, L., Serra, M. P., Boi, M., Bratzu, J., Sanna, F., Corda, M. G., Giorgi, O., Melis, M. R., Argiolas, A., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.11.002 · Cited by 17 · see citing works
A link between ghrelin and major depressive disorder: a mini review
Lis, M., Miłuch, T., Majdowski, M., & Zawodny, T. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1367523 · Cited by 16 · see citing works
Zer‐Aviv, T. M., Islami, L., Hamilton, P. J., Parise, E. M., Nestler, E. J., Sbarski, B., & Akirav, I. (2022) · Biomedicines · doi:10.3390/biomedicines10081789 · Cited by 16 · see citing works
Self-citationTaraku, B., Loureiro, J. R., Sahib, A. K., Zavaliangos‐Petropulu, A., Al‐Sharif, N., Leaver, A. M., Wade, B., Joshi, S. H., Woods, R. P., Espinoza, R. T., et al. (2024) · Brain and Behavior · doi:10.1002/brb3.3511 · Cited by 15 · see citing works
Szczurowska, E., Szánti‐Pintér, E., Chetverikov, N., Randáková, A., Kudová, E., & Jakubík, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010507 · Cited by 14 · see citing works
Desai, S., Zundel, C. G., Evanski, J. M., Gowatch, L. C., Bhogal, A., Ely, S. L., Carpenter, C., Shampine, M. M., O’Mara, E., Rabinak, C. A., et al. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.114925 · Cited by 14 · see citing works
Chen, C.-Y., Wang, Y., Lei, L., & Zhang, Y. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111186 · Cited by 14 · see citing works
CRTC1 signaling involvement in depression-like behavior of prenatally stressed offspring rat
Si, Y., Xue, X., Liu, S., Feng, C., Zhang, H., Zhang, S., Ren, Y., Ma, H., Dong, Y., Li, H., et al. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113000 · Cited by 14 · see citing works
Francis, T. C., & Porcu, A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1188184 · Cited by 14 · see citing works
Clinton, S. M., Shupe, E. A., Glover, M. E., Unroe, K. A., McCoy, C. R., Cohen, J. L., & Kerman, I. A. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15158 · Cited by 13 · see citing works
Huang, X., Hu, J., Peng, H., & Cheng, H. W. (2022) · Nutrients · doi:10.3390/nu14030661 · Cited by 12 · see citing works
Chmiel, J., Stępień–Słodkowska, M., & Ramik-Mażewska, I. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14041337 · Cited by 12 · see citing works
Arasappan, D., Eickhoff, S. B., Nemeroff, C. B., Hofmann, H. A., & Jabbi, M. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02195-8 · Cited by 11 · see citing works
Papp, M., Gruca, P., Litwa, E., Łasoń, M., & Willner, P. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110715 · Cited by 11 · see citing works
The Association Between Affective Temperament Traits and Dopamine Genes in Obese Population
Lesiewska, N., Borkowska, A., Junik, R., Kamińska, A., Pulkowska-Ulfig, J., Tretyn, A., & Bieliński, M. K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081847 · Cited by 11 · see citing works
Downregulated NPAS4 in multiple brain regions is associated with major depressive disorder
Selçuk, B., Aksu, T., Dereli, O., & Adebalı, O. (2023) · Scientific Reports · doi:10.1038/s41598-023-48646-9 · Cited by 10 · see citing works
Fetal development of the human amygdala
Mulc, D., Smilović, D., Krsnik, Ž., Junaković, A., Kopić, J., Kostović, I., Šimić, G., & Vukšić, M. (2024) · The Journal of Comparative Neurology · doi:10.1002/cne.25580 · Cited by 10 · see citing works
Liu, L., Rascón, I. A., Lin, D., Ni, Y., Dong, X., Xue, H., Lin, Y., Haegert, A. M., Sar, F., Peacock, J. W., et al. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100916 · Cited by 10 · see citing works
Brown, R. W., Bhide, P. G., Gill, W. D., & Peeters, L. D. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05631-8 · Cited by 10 · see citing works
Optogenetic behavioral studies in depression research: A systematic review
Spreen, A., Alkhoury, D., Walter, H., & Müller, S. (2024) · iScience · doi:10.1016/j.isci.2024.109776 · Cited by 9 · see citing works
Estradiol, via estrogen receptor β signaling, mediates stress-susceptibility in the male brain
Georgiou, P., Postle, A. F., Mou, T.-C. M., Potter, L. E., An, X., Zanos, P., Patton, M. S., Pultorak, K. J., Clark, S. M., Ngyuyen, V., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03027-8 · Cited by 7 · see citing works
Hippocampal Zkscan4 confers resilience to chronic stress–induced depression-like behaviors
Gao, K., Yang, Y., Sun, X., Wang, J., Sun, X., Lu, T., Wang, L., Li, M., Yue, W., Liu, H., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr2291 · Cited by 8 · see citing works
Varastehmoradi, B., Smith, K. L., Müller, H. K., Elfving, B., Sánchez, C., & Wegener, G. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.03.010 · Cited by 8 · see citing works
Deep Brain Stimulation (DBS) in Treatment-Resistant Depression (TRD): Hope and Concern
Asir, B., Boscutti, A., Fenoy, A. J., & Quevedo, J. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-981-97-4402-2_9 · Cited by 6 · see citing works
Miao, Y., Zhao, H., Li, Y.-F., Sun, Y., Bi, R., Li, H., Fang, X., Li, Z.-S., Ma, Y.-H., Lv, L., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2411280122 · Cited by 5 · see citing works
Shi, P., Hu, L., Ren, H., & Dai, Q. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1084367 · Cited by 5 · see citing works
Stress reveals a specific behavioral phenotype for opioid abuse susceptibility
OʼBrien, C., Vemireddy, R., Mohammed, U., & Barker, D. J. (2022) · Journal of the Experimental Analysis of Behavior · doi:10.1002/jeab.738 · Cited by 5 · see citing works
Ryan, K. M., Smyth, P. C., Blackshields, G., Kranaster, L., Sartorius, A., Sheils, O. M., & McLoughlin, D. M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03131-8 · Cited by 5 · see citing works
Rivera-Irizarry, J. K., Hámor, P. U., Rowson, S. A., Asfouri, J. J., Liu, D., Zallar, L. J., Garcia, A. F., Skelly, M. J., & Pleil, K. E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.03.547570 · Cited by 6 · see citing works
Deep brain stimulation improves symptoms across all dimensions in treatment-resistant depression
Runia, N., Mol, G. J. J., Denys, D. A. J. P., Ardon, H., Beute, G. N., Bot, M., de Waardt, D. A., de Knijff, D. W. W., Mocking, R. J. T., Notten, P., et al. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00623 · Cited by 5 · see citing works
Taraku, B., Nomi, J. S., Zavaliangos‐Petropulu, A., Al‐Sharif, N., Pfeiffer, P., Norris, V., Joshi, S. H., Espinoza, R. T., Uddin, L. Q., & Narr, K. L. (2025) · Imaging Neuroscience · doi:10.1162/imag.a.936 · Cited by 3 · see citing works
Adaptive and maladaptive networks using ecological momentary assessment
Hufschmidt, B., Ebert, M., Nemani, A., Kohl, V., Pahlen, L., Müller, S., Hofmann, S. G., & Stangier, U. (2026) · Clinical Psychology in Europe · doi:10.32872/cpe.17891 · Cited by 2 · see citing works
Understanding in vivo modelling of depression
Bannach‐Brown, A. (2019) · ERA · Cited by 1 · see citing works
Ristea, S., Schenker, R. A., Stovicek, P. O., Pîrlog, M. C., & Marinescu, D. (2021) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.62.3.19 · Cited by 1 · see citing works
Nucleus accumbens degeneration in spinocerebellar ataxia type 2: a preliminary study
Nakayama, K., Nemoto, K., & Arai, T. (2024) · Psychogeriatrics · doi:10.1111/psyg.13080 · Cited by 1 · see citing works
Nucleus accumbens neuron subtype translatome signatures in socially stressed females
Kumar, G., Franco, D., Basu, M., Olusakin, J., Campbell, R. R., Ament, S. A., Fox, M. E., & Lobo, M. K. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02414-1 · Cited by 1 · see citing works
Glaubitz, E., Wang, X. H., Xi, K., Feiz, F., Pahlajani, S. S., Maloney, T., Tanzi, E. B., Hojjati, H., Zhou, L., Glodzik, L., et al. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115889 · Cited by 1 · see citing works
Debnath, R., Lenz, E., Tobelander, J., Schweppe, P. C., Renner, V., & Mulert, C. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03942-6 · Cited by 1 · see citing works
MacLean, R. R., & Sofuoglu, M. (2018) · Current Addiction Reports · doi:10.1007/s40429-018-0212-0 · Cited by 1 · see citing works
Involvement of PKMζ in Stress Response and Depression
Liu, J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.907767 · Cited by 1 · see citing works
Taraku, B., Loureiro, J. R., Sahib, A. K., Zavaliangos‐Petropulu, A., Al‐Sharif, N., Leaver, A. M., Wade, B., Joshi, S. H., Woods, R. P., Espinoza, R. T., et al. (2023) · medRxiv · doi:10.1101/2023.12.01.23299282 · Cited by 1 · see citing works
Ma, X., Kim, H., Zhang, L., Chen, P., Wei, J., Cui, Y., Chen, L., Xu, Y., Zhang, J., Dai, Z., et al. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04128-w
Blum, K., Gold, M. S., Modestino, E. J., Elman, I., Baron, D. A., Badgaiyan, R. D., & Bowirrat, A. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-803161-2.00030-8
Arasappan, D., Eickhoff, S. B., Nemeroff, C. B., Hofmann, H. A., & Jabbi, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/864900
The VTA-BLA-NAc circuit for sex reward inhibited by VTA GABAergic neurons under stress in male micePreprint
Sun, L., You, J., Cui, M., Sun, F., Wang, J., Wang, W., Wang, D., Liu, D., Xu, Z., Qiu, C., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.20.427537
Evrensel, A., & Tarhan, N. (2022) · Neuromethods · doi:10.1007/978-1-0716-2083-0_2 · Cited by 1 · see citing works
The Neurobiology of Resilience
Feder, A., Horn, S. R. G.-V., Haglund, M., Southwick, S. M., & Charney, D. S. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190681425.003.0038
- Authors
- Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Nestler, Eric J.
- ORCID
- Nestler, Eric J.
- Venue
- International review of neurobiology
- Publisher
- Elsevier
- Published
- 2015
- Volume
- 124
- Pages
- 151-170
- ISSN
- 0074-7742 (ISSN-L)
- PMC
- PMC4690450
- OpenAlex
- W2410587014
- Cited by
- 108
- References
- 78
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 12 · 2023: 12 · 2022: 10 · 2021: 10 · 2020: 8 · 2019: 13 · 2018: 11 · 2017: 9 · 2016: 5
- FWCI
- 23.77
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International review of neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (P50MH096890, R01MH051399)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- depression, reward systems, nucleus accumbens, anhedonia, stress-related disorders, transcription factors, CREB, ΔFosB, SRF, NF-κB, β-catenin, antidepressant mechanism, animal models of depression, mood disorders
- MeSH terms
- Animals, Brain, Depression, Disease Models, Animal, Gene Expression Regulation, Humans, Neural Pathways, Reward, Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
