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The brain reward circuitry in mood disorders
Open accessAbstract
Mood disorders are common and debilitating conditions characterized in part by profound deficits in reward-related behavioural domains. A recent literature has identified important structural and functional alterations within the brain's reward circuitry--particularly in the ventral tegmental area-nucleus accumbens pathway--that are associated with symptoms such as anhedonia and aberrant reward-associated perception and memory. This Review synthesizes recent data from human and rodent studies from which emerges a circuit-level framework for understanding reward deficits in depression. We also discuss some of the molecular and cellular underpinnings of this framework, ranging from adaptations in glutamatergic synapses and neurotrophic factors to transcriptional and epigenetic mechanisms.
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“For example, dopaminergic projections from the VTA to the nucleus accumbens (NAc), prefrontal cortex (PFC), amygdala and hippocampus that regulate responses to rewarding or aversive stimuli are reportedly dysregulated in people with MDD as well as in rodent models of chronic stress39–42.”
From Central regulation of stress-evoked peripheral immune responses (2023) · cites this paper as [40]
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In the citing paper
“Notably, several of these bone marrow-innervating brain regions have been implicated in stress responses, reward processing and the pathogenesis of depression and anxiety disorders.”
From Central regulation of stress-evoked peripheral immune responses (2023) · cites this paper as [40]
The cited source says what the claim attributes to it.
In the citing paper
“The NAc plays a crucial role in stress responses and mood disorders including MDD28.”
From Social stress induces neurovascular pathology promoting depression (2017) · cites this paper as [28]
In the citing paper
“Susceptible and resilient mice show distinct cellular and circuit alterations between the NAcc and other brain regions within the reward circuitry”
From Social functioning in major depressive disorder (2016) · cites this paper as Russo and Nestler, 2013
In the citing paper
“demonstrating a causal role for plasticity in this circuit in mediating social anhedonia in a mouse model of depression”
From Social functioning in major depressive disorder (2016) · cites this paper as Russo and Nestler, 2013
In the citing paper
“A grossly oversimplified overview of these circuits is that the prefrontal cortices and hippocampus are devoted to detecting and decoding specific features of stimuli and the environment, including the social environment, to guide decision-making and ensure adaptive, flexible, and predictive responses to rewarding stimuli, whereas the lateral hypothalamus-lateral habenula circuits predominantly En”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [51]
In the citing paper
“Prairie voles strongly express OXTR in regions of the MLR, a conserved neural network (75) involved in reward processing and implicated in numerous human psychiatric disorders including depression (76), addiction (77), and schizophrenia (78).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [75]
In the citing paper
“Depressive behavior is mediated in part by increased NAc BDNF signaling (reviewed in ref. [66]).”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [66]
In the citing paper
“The mesolimbic dopamine system, composed of dopamine neurons of the ventral tegmental area (VTA) and their projections to the nucleus accumbens (NAc), is most often associated with the rewarding effects of food and sex and plays an essential role in stress-induced anhedonia and other depression-related behavioral abnormalities [87, 88].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [88]
In the citing paper
“The mesolimbic dopamine system, composed of dopamine neurons of the ventral tegmental area (VTA) and their projections to the nucleus accumbens (NAc), is most often associated with the rewarding effects of food and sex and plays an essential role in stress-induced anhedonia and other depression-related behavioral abnormalities [87, 88].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [88]
In the citing paper
“One of the sources of DA in the hippocampus derives from DAergic neurons in the VTA17.”
From Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease (2017) · cites this paper as [17]
In the citing paper
“VTA DAergic neurons also target the nucleus accumbens (NAc) and cerebral cortex, mediating the control of incentive motivation and reward processing17.”
From Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease (2017) · cites this paper as [17]
In the citing paper
“Frontostriatal circuits subserving reward processes are modulated by the neurotransmitter dopamine (DA) The primary reward circuit includes dopaminergic projections from the ventral tegmental area (VTA) to the nucleus accumbens, which release dopamine in response to reward-related stimuli (Russo and Nestler, 2013).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Russo and Nestler, 2013
In the citing paper
“Molecular changes within specific cell types of the brain's reward regions shape the ways in which adolescents respond to changes in the environment, determining either resilience or susceptibility (Russo and Nestler, 2013).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Russo and Nestler, 2013
In the citing paper
“Vulnerability for depression, risk taking, or other psychopathologies may be determined by molecular changes in cells that occur following stressors (see Russo and Nestler, 2013).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Russo and Nestler, 2013
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Metadata
- Authors
- Russo, S. J., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Russo, Scott J.
- Venue
- Nature Reviews Neuroscience
- Published
- 2013-08-14
- Volume
- 14
- Issue
- 9
- Pages
- 609-625
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3867253
- OpenAlex
- W2071815275
- Cited by
- 1,870
- References
- 164
- Citations by year
- 2026: 129 · 2025: 144 · 2024: 169 · 2023: 156 · 2022: 143 · 2021: 175 · 2020: 160 · 2019: 147 · 2018: 147 · 2017: 159 · 2016: 140 · 2015: 122 · 2014: 74 · 2013: 4
- FWCI
- 11.54
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-08-20)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH090264, P50MH096890, R01 MH-51399, R01MH051399, P50-MH96890)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- brain reward system, mood disorders, depression, anhedonia, ventral tegmental area, nucleus accumbens, glutamatergic synapses, neurotrophic factors, epigenetic mechanisms, transcriptional regulation, animal models of depression
- MeSH terms
- Animals, Brain, Humans, Neural Pathways, Reward, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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