Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors
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Work-related stress is a growing health problem in modern society. The stress response is characterized by numerous neurochemicals, neuroendocrine and immune modifications that involve various neurological systems and circuits, and regulation of the gene expression of the different receptors. In this regard, a lot of research has focused the attention on the role played by the environment in influencing gene expression, which in turn can control the stress response. In particular, genetic factors can moderate the sensitivities of specific types of neural cells or circuits mediating the imprinting of the environment on different biological systems. In this current review, we wish to analyze systematic reviews and recent experimental research on the physio-pathological mechanisms that underline stress-related responses. In particular, we analyze the relationship between genetic and epigenetic factors in the stress response.
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The greater use of antidepressants than drug abuse is probably due to their greater availability and the progressive increase in the incidence of psychiatric pathologies and stress-related disorders.
“probably due to their greater availability and the progressive increase in the incidence of psychiatric pathologies and stress-related disorders [45,46].”
From Toxicological Findings of Self-Poisoning Suicidal Deaths: A Systematic Review by Countries (2022) · cites this paper as [45]
The Introduction reports that financial crises may increase mental health disorders and substance abuse, which supports only the claim’s general link to rising psychiatric problems. It does not compare antidepressant use with drug abuse or attribute greater antidepressant use to availability or a progressive increase in stress-related disorders. The indexed copy provides no page number for the passage. (LLM, conf=0.78)
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Flagged first, then by citations
Research works printed but not linked: 1
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- Authors
- Cannizzaro, E., Ramaci, T., Cirrincione, L., & Plescia, F.
- Affiliations
- University of Palermo (IT)
- Università degli Studi di Enna Kore (IT)
- Corresponding author
- Cannizzaro, Emanuele
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2019-10-21
- Volume
- 16
- Issue
- 20
- Pages
- 4031
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC6843930
- OpenAlex
- W2980639448
- Cited by
- 39
- References
- 113
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 4 · 2020: 8 · 2019: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- occupational stress, stress response, epigenetics, gene-environment interaction, neuroendocrine regulation, neurochemical changes, immunomodulation, gene expression
- MeSH terms
- Occupational Stress, Humans, Epigenesis, Genetic
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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