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Astrocyte barriers to neurotoxic inflammation
Open accessAbstract
Astrocytes form borders (glia limitans) that separate neural from non-neural tissue along perivascular spaces, meninges and tissue lesions in the CNS. Transgenic loss-of-function studies reveal that astrocyte borders and scars serve as functional barriers that restrict the entry of inflammatory cells into CNS parenchyma in health and disease. Astrocytes also have powerful pro-inflammatory potential. Thus, astrocytes are emerging as pivotal regulators of CNS inflammatory responses. This Review discusses evidence that astrocytes have crucial roles in attracting and restricting CNS inflammation, with important implications for diverse CNS disorders.
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“these phenomena mainly occur when there is disruption of the blood–brain barrier (Fig. 1a)7.”
From Reactive astrocyte nomenclature, definitions, and future directions (2021) · cites this paper as [7]
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“Astrocytes can thus exacerbate or attenuate inflammation [412,413].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [412]
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“Finally, a classical gain of beneficial function is the restriction of immune cell infiltration in open injuries by scar-border forming reactive astrocytes7.”
From Reactive astrocyte nomenclature, definitions, and future directions (2021) · cites this paper as [7]
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Astrocytic P2X7 receptor in retrosplenial cortex drives electroacupuncture analgesia
Zhao, W., Liu, S.-L., Lin, S.-S., Zhang, Y., & Yu, C. C. (2024) · Purinergic Signalling · doi:10.1007/s11302-024-10043-w · Cited by 5
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Astrocytes play a crucial role in the formation and evolution of MS lesions – Yes
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‘A picture is worth a thousand words’: The use of microscopy for imaging neuroinflammation
de Fraga, L. S., Tassinari, I. D., Jantsch, J., Guedes, R. P., & Bambini-Júnior, V. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13669 · Cited by 5
The brain after ischemic stroke: a clinical/histological study
Sergeeva, S. P., Савин, A. A., Shishkina, L. V., & Vinogradov, E. V. (2017) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20171173266-70 · Cited by 5
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Metadata
- Authors
- Sofroniew, M. V.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Sofroniew, Michael V.
- Venue
- Nature Reviews Neuroscience
- Published
- 2015-04-20
- Volume
- 16
- Issue
- 5
- Pages
- 249-263
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC5253239
- OpenAlex
- W2018681635
- Cited by
- 1,202
- References
- 140
- Citations by year
- 2026: 76 · 2025: 114 · 2024: 98 · 2023: 120 · 2022: 103 · 2021: 151 · 2020: 137 · 2019: 126 · 2018: 97 · 2017: 79 · 2016: 72 · 2015: 28
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-05-08)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- National Institute of Neurological Disorders and Stroke (NS084030, NS057624, R01NS057624, R01NS084030)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- astrocytes, glia limitans, neuroinflammation, scar formation, meninges, perivascular spaces, pro-inflammatory signaling, central nervous system lesions, neurodegenerative diseases
- MeSH terms
- Animals, Astrocytes, Cell Communication, Central Nervous System Diseases, Humans, Inflammation, Neurons, Inflammation Mediators
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