Cited by 1,202Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function StudiesTraumatic Brain Injury and Neurovascular Disturbances

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Astrocyte barriers to neurotoxic inflammation

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Sofroniew, Michael V.·2015·Nature Reviews Neuroscience

DOI 10.1038/nrn3898PMC PMC5253239

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Abstract

Astrocytes form borders (glia limitans) that separate neural from non-neural tissue along perivascular spaces, meninges and tissue lesions in the CNS. Transgenic loss-of-function studies reveal that astrocyte borders and scars serve as functional barriers that restrict the entry of inflammatory cells into CNS parenchyma in health and disease. Astrocytes also have powerful pro-inflammatory potential. Thus, astrocytes are emerging as pivotal regulators of CNS inflammatory responses. This Review discusses evidence that astrocytes have crucial roles in attracting and restricting CNS inflammation, with important implications for diverse CNS disorders.

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Authors: Sofroniew, M. V.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Sofroniew, Michael V.
ORCID: Sofroniew, Michael V.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2015-04-20
Volume: 16
Issue: 5
Pages: 249-263
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3898
PMC: PMC5253239
OpenAlex: W2018681635
Cited by: 1,202
References: 140
Citations by year: 2026: 76 · 2025: 114 · 2024: 98 · 2023: 120 · 2022: 103 · 2021: 151 · 2020: 137 · 2019: 126 · 2018: 97 · 2017: 79 · 2016: 72 · 2015: 28
FWCI: 7.34
Type: journal article
Language: en
Update notices: erratum (2015-05-08)
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
National Institute of Neurological Disorders and Stroke (NS084030, NS057624, R01NS057624, R01NS084030)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: astrocytes, glia limitans, neuroinflammation, scar formation, meninges, perivascular spaces, pro-inflammatory signaling, central nervous system lesions, neurodegenerative diseases
MeSH terms: Animals, Astrocytes, Cell Communication, Central Nervous System Diseases, Humans, Inflammation, Neurons, Inflammation Mediators

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