Acute lesions that impair affective empathy
Open accessAbstract
Functional imaging studies of healthy participants and previous lesion studies have provided evidence that empathy involves dissociable cognitive functions that rely on at least partially distinct neural networks that can be individually impaired by brain damage. These studies converge in support of the proposal that affective empathy--making inferences about how another person feels--engages at least the following areas: prefrontal cortex, orbitofrontal gyrus, anterior insula, anterior cingulate cortex, temporal pole, amygdala and temporoparietal junction. We hypothesized that right-sided lesions to any one of these structures, except temporoparietal junction, would cause impaired affective empathy (whereas bilateral damage to temporoparietal junction would be required to disrupt empathy). We studied 27 patients with acute right hemisphere ischaemic stroke and 24 neurologically intact inpatients on a test of affective empathy. Acute impairment of affective empathy was associated with infarcts in the hypothesized network, particularly temporal pole and anterior insula. All patients with impaired affective empathy were also impaired in comprehension of affective prosody, but many patients with impairments in prosodic comprehension had spared affective empathy. Patients with impaired affective empathy were older, but showed no difference in performance on tests of hemispatial neglect, volume of infarct or sex distribution compared with patients with intact affective empathy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Emotion recognition and empathic deficits occur after insular cortex lesions.
“emotion recognition and empathic deficits occur after insular cortex lesions3–5”
From Insular cortex mediates approach and avoidance responses to social affective stimuli (2018) · cites this paper as [5]
The amygdala contributes to the emotional component of empathy.
“the amygdala contributing to the emotional component of empathy (Cox et al., 2012; Leigh et al., 2013).”
From Oxytocin Enhancement of Emotional Empathy: Generalization Across Cultures and Effects on Amygdala Activity (2018) · cites this paper as Leigh et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Measuring individual differences in empathy: Evidence for a multidimensional approach.
Davis, M. H. (1983) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.44.1.113 · Cited by 10,272 · see citing works
The reorienting system of the human brain: from environment to theory of mind
Corbetta, M., Patel, G., & Shulman, G. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.017 · Cited by 3,889 · see citing works
The functional architecture of human empathy
Decety, J., & Jackson, P. L. (2004) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582304267187 · Cited by 3,407 · see citing works
People thinking about thinking peopleThe role of the temporo-parietal junction in “theory of mind”
Saxe, R., & Kanwisher, N. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00230-1 · Cited by 2,316 · see citing works
Lamm, C., Decety, J., & Singer, T. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.014 · Cited by 2,016 · see citing works
Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas
Carr, L., Iacoboni, M., Dubeau, M.-C., Mazziotta, J. C., & Lenzi, G. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0935845100 · Cited by 1,978 · see citing works
Shamay-Tsoory, S. G., Aharon-Peretz, J., & Perry, D. (2009) · Brain · doi:10.1093/brain/awn279 · Cited by 1,544 · see citing works
Shamay-Tsoory, S. G. (2011) · The Neuroscientist · doi:10.1177/1073858410379268 · Cited by 1,059 · see citing works
Decety, J., & Lamm, C. (2007) · The Neuroscientist · doi:10.1177/1073858407304654 · Cited by 1,044 · see citing works
Dziobek, I., Rogers, K., Fleck, S., Bahnemann, M., Heekeren, H. R., Wolf, O. T., & Convit, A. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0486-x · Cited by 951 · see citing works
Dissociable prefrontal networks for cognitive and affective theory of mind: A lesion study
Shamay-Tsoory, S. G., & Aharon-Peretz, J. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.05.021 · Cited by 816 · see citing works
Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S., Dziobek, I., Gallinat, J., Wagner, M., Maier, W., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5538-09.2010 · Cited by 771 · see citing works
Understanding Other Minds: Linking Developmental Psychology and Functional Neuroimaging
Saxe, R., Carey, S., & Kanwisher, N. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.142044 · Cited by 726 · see citing works
Bzdok, D., Schilbach, L., Vogeley, K., Schneider, K., Laird, A. R., Langner, R., & Eickhoff, S. B. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0380-y · Cited by 653 · see citing works
Oishi, K., Faria, A. V., Jiang, H., Li, X., Akhter, K., Zhang, J., Hsu, J. T., Miller, M. I., van Zijl, P. C. M., Albert, M., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.002 · Cited by 574 · see citing works
Self-citationLeft temporoparietal junction is necessary for representing someone else's belief
Samson, D., Apperly, I. A., Chiavarino, C., & Humphreys, G. W. (2004) · Nature Neuroscience · doi:10.1038/nn1223 · Cited by 559 · see citing works
Theory of mind—evolution, ontogeny, brain mechanisms and psychopathology
Brüne, M., & Brüne-Cohrs, U. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.08.001 · Cited by 540 · see citing works
Structural anatomy of empathy in neurodegenerative disease
Rankin, K. P., Gorno-Tempini, M. L., Allison, S. C., Stanley, C. M., Glenn, S., Weiner, M. W., & Miller, B. L. (2006) · Brain · doi:10.1093/brain/awl254 · Cited by 504 · see citing works
Thompson-Schill, S. L., Swick, D., Farah, M. J., D’Esposito, M., Kan, I. P., & Knight, R. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15855 · Cited by 488 · see citing works
Shamay‐Tsoory, S., Tomer, R., Berger, B. D., & Aharon‐Peretz, J. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903321593063 · Cited by 476 · see citing works
Neural processing associated with cognitive and affective theory of mind in adolescents and adults
Sebastian, C. L., Fontaine, N. M. G., Bird, G., Blakemore, S.-J., De Brito, S. A., McCrory, E. J. P., & Viding, E. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr023 · Cited by 457 · see citing works
Impaired “Affective Theory of Mind” Is Associated with Right Ventromedial Prefrontal Damage
Shamay-Tsoory, S. G., Tomer, R., Berger, B. D., Goldsher, D., & Aharon-Peretz, J. (2005) · Cognitive and Behavioral Neurology · doi:10.1097/01.wnn.0000152228.90129.99 · Cited by 445 · see citing works
Differential role of the orbital frontal lobe in emotional versus cognitive perspective-taking
Hynes, C. A., Baird, A. A., & Grafton, S. T. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2005.06.011 · Cited by 396 · see citing works
Neurological and Neuropsychological Bases of Empathy
Eslinger, P. J. (1998) · European Neurology · doi:10.1159/000007933 · Cited by 374 · see citing works
Seeing it my way: a case of a selective deficit in inhibiting self-perspective
Samson, D., Apperly, I. A., Kathirgamanathan, U., & Humphreys, G. W. (2005) · Brain · doi:10.1093/brain/awh464 · Cited by 349 · see citing works
Acquired theory of mind impairments in individuals with bilateral amygdala lesions
Stone, V. E., Baron-Cohen, S., Calder, A., Keane, J., & Young, A. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(02)00151-3 · Cited by 348 · see citing works
Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration
Rankin, K. P., Kramer, J. H., & Miller, B. L. (2005) · Cognitive and Behavioral Neurology · doi:10.1097/01.wnn.0000152225.05377.ab · Cited by 343 · see citing works
Cox, C. L., Uddin, L. Q., Di Martino, A., Castellanos, F. X., Milham, M. P., & Kelly, C. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr051 · Cited by 333 · see citing works
Neurology of affective prosody and its functional–anatomic organization in right hemisphere
Ross, E. D., & Monnot, M. (2007) · Brain and Language · doi:10.1016/j.bandl.2007.04.007 · Cited by 316 · see citing works
Explicit and Incidental Facial Expression Processing: An fMRI Study
Gorno‐Tempini, M. L., Pradelli, S., Serafini, M., Pagnoni, G., Baraldi, P., Porro, C. A., Nicoletti, R., Umità, C., & Nichelli, P. (2001) · NeuroImage · doi:10.1006/nimg.2001.0811 · Cited by 313 · see citing works
Ross, E. D., Thompson, R. D., & Yenkosky, J. (1997) · Brain and Language · doi:10.1006/brln.1997.1731 · Cited by 294 · see citing works
Jean Decety, A., & Chaminade, T. (2003) · Consciousness and Cognition · doi:10.1016/s1053-8100(03)00076-x · Cited by 288 · see citing works
McDonald, S., & Flanagan, S. (2004) · Neuropsychology · doi:10.1037/0894-4105.18.3.572 · Cited by 277 · see citing works
de Waal, F. B. M. (2012) · Science · doi:10.1126/science.1220999 · Cited by 245 · see citing works
Anterior insular cortex is necessary for empathetic pain perception
Gu, X., Gao, Z., Wang, X., Liu, X., Knight, R. T., Hof, P. R., & Fan, J. (2012) · Brain · doi:10.1093/brain/aws199 · Cited by 223 · see citing works
Schnell, K., Bluschke, S., Konradt, B., & Walter, H. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.024 · Cited by 217 · see citing works
Dissociation of body-centered and stimulus-centered representations in unilateral neglect
Ota, H., Fujii, T., Suzuki, K., Fukatsu, R., & Yamadori, A. (2001) · Neurology · doi:10.1212/wnl.57.11.2064 · Cited by 185 · see citing works
Eslinger, P. J., Moore, P., Anderson, C., & Grossman, M. (2011) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.23.1.74 · Cited by 184 · see citing works
SHAMAYTSOORY, S., AHARONPERETZ, J., & LEVKOVITZ, Y. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2006.09.020 · Cited by 161 · see citing works
Metacognitive deficits in frontotemporal dementia
Eslinger, P. J. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.053157 · Cited by 151 · see citing works
Schizophrenia patients are impaired in empathic accuracy
Lee, J., Zaki, J., Harvey, P., Ochsner, K. N., & Green, M. F. (2011) · Psychological Medicine · doi:10.1017/s0033291711000614 · Cited by 138 · see citing works
Method Matters: An Empirical Study of Impact in Cognitive Neuroscience
Fellows, L. K., Heberlein, A. S., Morales, D. A., Shivde, G., Waller, S. S., & Wu, D. H. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929054021139 · Cited by 129 · see citing works
The frontal lobes and theory of mind: Developmental concepts from adult focal lesion research
Stuss, D. T., & Anderson, V. A. (2004) · Brain and Cognition · doi:10.1016/s0278-2626(03)00271-9 · Cited by 128 · see citing works
Viskontas, I. V., Possin, K. L., & Miller, B. L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.025 · Cited by 126 · see citing works
Couto, B., Sedeño, L., Sposato, L. A., Sigman, M., Riccio, P. M., Salles, A., López, V., Schröeder, J., Manes, F. F., & Ibáñez, A. M. (2012) · Cortex · doi:10.1016/j.cortex.2012.08.006 · Cited by 116 · see citing works
Damage to the left ventromedial prefrontal cortex impacts affective theory of mind
Leopold, A., Krüeger, F., Monte, O. D., Pardini, M., Pulaski, S. J., Solomon, J. M., & Grafman, J. H. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr071 · Cited by 109 · see citing works
Empathy, self-esteem, and birth order.
Stotland, E., & Dunn, R. E. (1963) · Journal of Abnormal & Social Psychology · doi:10.1037/h0042891 · Cited by 83 · see citing works
Theory of mind in frontotemporal dementia
Kipps, C., & Hodges, J. R. (2006) · Social Neuroscience · doi:10.1080/17470910600989847 · Cited by 77 · see citing works
Samson, D., Apperly, I. A., & Humphreys, G. W. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.03.013 · Cited by 75 · see citing works
Vasopressin modulates neural responses related to emotional stimuli in the right amygdala
Brunnlieb, C., Münte, T. F., Tempelmann, C., & Heldmann, M. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.009 · Cited by 63 · see citing works
Caviness, V. S., Makris, N., Montinaro, E., Sahin, N. T., Bates, J. F., Schwamm, L. H., Caplan, D. N., & Kennedy, D. N. (2002) · Stroke · doi:10.1161/01.str.0000036083.90045.08 · Cited by 60 · see citing works
Affect Recognition, Empathy, and Dysosmia After Traumatic Brain Injury
Neumann, D. M., Zupan, B., Babbage, D. R., Radnovich, A. J., Tomita, M., Hammond, F. M., & Willer, B. S. (2012) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2012.03.009 · Cited by 51 · see citing works
The impact of bilateral cerebellar damage on theory of mind, empathy and decision making
Gerschcovich, E. R., Cerquetti, D., Tenca, E., & Leiguarda, R. C. (2010) · Neurocase · doi:10.1080/13554791003730618 · Cited by 44 · see citing works
Jimura, K., Konishi, S., Asari, T., & Miyashita, Y. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.016 · Cited by 38 · see citing works
Balconi, M., & Bortolotti, A. (2012) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-012-9188-z · Cited by 35 · see citing works
Dara, C., Kirsch‐Darrow, L., Ochfeld, E. N., Slenz, J., Agranovich, A. V., FARIA, A. V., Ross, E. D., Hillis, A. E., & Kortte, K. B. (2012) · Neurocase · doi:10.1080/13554794.2012.701641 · Cited by 31 · see citing works
Self-citationClinical characterization of bvFTD due to FUS neuropathology
Lee, S. E., Seeley, W. W., Poorzand, P., Rademakers, R., Karydas, A., Stanley, C. M., Miller, B. L., & Rankin, K. P. (2011) · Neurocase · doi:10.1080/13554794.2011.604637 · Cited by 27 · see citing works
Of brain and bone: The unusual case of Dr. A
Narvid, J. A., Gorno‐Tempini, M., Slavotinek, A. M., DeArmond, S. J., Cha, Y. H., Miller, B. L., & Rankin, K. (2009) · Neurocase · doi:10.1080/13554790802632967 · Cited by 25 · see citing works
Acute stroke effects on emotions: an interpretation through the mirror system
Bodini, B., Iacoboni, M., & Lenzi, G. L. (2004) · Current Opinion in Neurology · doi:10.1097/00019052-200402000-00010 · Cited by 24 · see citing works
Tománek, A., Hudon, M. E., Sevick, R. J., Simon, J. E., Schebel, M., Frayne, R., Buchan, A. M., & Demchuk, A. M. (2003) · Stroke · Cited by 11 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Finley A, Saver J, Alger J, Pregenzer M, Leary M, Ovbiagele B. Diffusion weighted imaging assessment of insular vulnerability in acute middle cerebral artery infarctions [abstract] Stroke. 2003;34:259. discussion. [Google Scholar]
Cited by
Sorted by citations
Insular cortex mediates approach and avoidance responses to social affective stimuli
Rogers-Carter, M. M., Varela, J. A., Gribbons, K. B., Pierce, A. F., McGoey, M. T., Ritchey, M., & Christianson, J. P. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0071-y · Cited by 277 · see citing works
The role of shared neural activations, mirror neurons, and morality in empathy – A critical comment
Lamm, C., & Majdandžić, J. (2015) · Neuroscience Research · doi:10.1016/j.neures.2014.10.008 · Cited by 252 · see citing works
The temporal pole: From anatomy to function—A literature appraisal
Herlin, B., Navarro, V., & Dupont, S. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.101925 · Cited by 247 · see citing works
Neuropsychiatric sequelae of stroke
Ferro, J. M., Caeiro, L., & Figueira, M. L. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.46 · Cited by 237 · see citing works
Uncovering the role of the insula in non-motor symptoms of Parkinson’s disease
Christopher, L., Koshimori, Y., Lang, A. E., Criaud, M., & Strafella, A. P. (2014) · Brain · doi:10.1093/brain/awu084 · Cited by 168 · see citing works
Inability to empathize: brain lesions that disrupt sharing and understanding another’s emotions.
Hillis, A. E. (2014) · Brain · doi:10.1093/brain/awt317 · Cited by 158 · see citing works
Self-citationSeparable systems for recovery of finger strength and control after stroke
Xu, J., Ejaz, N., Hertler, B., Branscheidt, M., Widmer, M., Faria, A. V., Harran, M. D., Cortés, J. C., Kim, N., Celnik, P. A., et al. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00123.2017 · Cited by 140 · see citing works
Critical role of the right uncinate fasciculus in emotional empathy
Oishi, K., Faria, A. V., Hsu, J., Tippett, D. C., Mori, S., & Hillis, A. E. (2014) · Annals of Neurology · doi:10.1002/ana.24300 · Cited by 134 · see citing works
Self-citationThe structural and functional brain networks that support human social networks
Noonan, M. P., Mars, R. B., Sallet, J., Dunbar, R. I. M., & Fellows, L. K. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.019 · Cited by 131 · see citing works
Empathy in autism Spectrum disorder
Harmsen, I. E. (2019) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-019-04087-w · Cited by 129 · see citing works
Social learning in humans and other animals
Gariépy, J., Watson, K. K., Du, E., Xie, D. L., Erb, J., Amasino, D. R., & Platt, M. L. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00058 · Cited by 119 · see citing works
Zhou, F., Li, J., Zhao, W., Xu, L., Zheng, X., Fu, M., Yao, S., Kendrick, K. M., Wager, T. D., & Becker, B. (2020) · eLife · doi:10.7554/elife.56929 · Cited by 102 · see citing works
Krall, S. C., Volz, L. J., Oberwelland, E., Grefkes, C., Fink, G. R., & Konrad, K. (2015) · Human Brain Mapping · doi:10.1002/hbm.23068 · Cited by 101 · see citing works
Social information processing following resection of the insular cortex
Boucher, O., Rouleau, I., Lassonde, M. C., Leporé, F., Bouthillier, A., & Nguyen, D. K. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.03.008 · Cited by 99 · see citing works
Temporopolar regions of the human brain
Mesulam, M. M. (2022) · Brain · doi:10.1093/brain/awac339 · Cited by 91 · see citing works
Shdo, S. M., Ranasinghe, K. G., Gola, K. A., Mielke, C. J., Sukhanov, P., Miller, B. L., & Rankin, K. P. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.02.010 · Cited by 93 · see citing works
Social neuroscience: undoing the schism between neurology and psychiatry
Ibáñez, A. M., García, A. M., Esteves, S., Yoris, A., Muñoz, É., Reynaldo, L., Pietto, M. L., Adolfi, F., & Manes, F. F. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1245214 · Cited by 85 · see citing works
Geng, Y., Zhao, W., Zhou, F., Ma, X., Yao, S., Hurlemann, R., Becker, B., & Kendrick, K. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00512 · Cited by 78 · see citing works
A meta-analytic review of social cognitive function following stroke
Adams, A. G., Schweitzer, D. R., Molenberghs, P., & Henry, J. D. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.011 · Cited by 69 · see citing works
Maternal sensitivity and the empathic brain: Influences of early life maltreatment
Mielke, E. L., Neukel, C., Bertsch, K., Reck, C., Möhler, E., & Herpertz, S. C. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.02.013 · Cited by 64 · see citing works
Immoral behaviour following brain damage: A review
Roberts, S., Henry, J. D., & Molenberghs, P. (2018) · Journal of Neuropsychology · doi:10.1111/jnp.12155 · Cited by 58 · see citing works
Right Hemisphere Regions Critical for Expression of Emotion Through Prosody
Patel, S. A., Oishi, K., Wright, A. E., Sutherland-Foggio, H., Saxena, S., Sheppard, S. M., & Hillis, A. E. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00224 · Cited by 60 · see citing works
Self-citationThe neural mediators of kindness-based meditation: a theoretical model
Mascaro, J. S., Darcher, A., Negi, L. T., & Raison, C. L. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00109 · Cited by 58 · see citing works
Picturing the Size and Site of Stroke With an Expanded National Institutes of Health Stroke Scale
Agis, D., Goggins, M. B., Oishi, K., Oishi, K., Davis, C. L., Wright, A. E., Kim, E. H., Sebastian, R., Tippett, D. C., Faria, A. V., et al. (2016) · Stroke · doi:10.1161/strokeaha.115.012324 · Cited by 58 · see citing works
Self-citationBretas, R. V., Taoka, M., Suzuki, H., & Iriki, A. (2020) · Experimental Brain Research · doi:10.1007/s00221-020-05727-9 · Cited by 57 · see citing works
Convergent Neural Correlates of Empathy and Anxiety During Socioemotional Processing
Knight, L. K., Stoica, T., Fogleman, N. D., & Depue, B. E. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00094 · Cited by 56 · see citing works
Sun, B., Luo, Z., Zhang, W., Li, W., & Li, X. (2017) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2017.1360835 · Cited by 58 · see citing works
Impaired Recognition of Emotional Faces after Stroke Involving Right Amygdala or Insula
Godin, B., Oishi, K., Oishi, K., Davis, C. L., Gomez, Y., Trupe, L. A., Kim, E. Y., Hillis, A. E., & Tippett, D. C. (2018) · Seminars in Speech and Language · doi:10.1055/s-0037-1608859 · Cited by 54 · see citing works
Self-citationEffects of prefrontal cortex damage on emotion understanding: EEG and behavioural evidence
Perry, A., Saunders, S. N., Stiso, J., Dewar, C. D., Lubell, J., Meling, T. R., Solbakk, A., Endestad, T., & Knight, R. T. (2017) · Brain · doi:10.1093/brain/awx031 · Cited by 50 · see citing works
Pasquini, L., Nana, A. L., Toller, G., Brown, J. A., Deng, J., Staffaroni, A. M., Kim, E. J., Hwang, J., Li, L., Park, Y., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa119 · Cited by 47 · see citing works
Keysers, C., Paracampo, R., & Gazzola, V. (2018) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.04.001 · Cited by 49 · see citing works
Taneja, K., Lu, H., Welch, B. G., Thomas, B. P., Pinho, M. C., Lin, D. D. M., Hillis, A. E., & Liu, P. (2019) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2019.03.003 · Cited by 49 · see citing works
Self-citationMultidimensional assessment of empathic abilities in patients with insular glioma
Chen, P., Wang, G., Ma, R., Jing, F., Zhang, Y., Wang, Y., Zhang, P., Niu, C., & Zhang, X. (2016) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-016-0445-0 · Cited by 46 · see citing works
Li, Y., Zhang, T., Li, W., Zhang, J., Jin, Z., & Li, L. (2019) · Human Brain Mapping · doi:10.1002/hbm.24858 · Cited by 46 · see citing works
Cerebral Lateralization of Pro- and Anti-Social Tendencies
Hecht, D. (2014) · Experimental Neurobiology · doi:10.5607/en.2014.23.1.1 · Cited by 43 · see citing works
Corradi‐Dell’Acqua, C., Ronchi, R., Thomasson, M., Bernati, T., Saj̈, A., & Vuilleumier, P. O. (2020) · Cortex · doi:10.1016/j.cortex.2020.03.019 · Cited by 44 · see citing works
Sebastian, R., Schein, M. G., Davis, C. L., Gomez, Y., Newhart, M., Oishi, K., & Hillis, A. E. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00231 · Cited by 42 · see citing works
Self-citationLeukoaraiosis is independently associated with naming outcome in poststroke aphasia
Wright, A. E., Tippett, D. C., Saxena, S., Sebastian, R., Breining, B. L., Faria, A. V., & Hillis, A. E. (2018) · Neurology · doi:10.1212/wnl.0000000000005945 · Cited by 42 · see citing works
Self-citationMcDonald, S., Dalton, K., Rushby, J., & Landín-Romero, R. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9906-0 · Cited by 41 · see citing works
Ventromedial Prefrontal Cortex Is Critical for Helping Others Who Are Suffering
Beadle, J. N., Paradiso, S., & Tranel, D. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00288 · Cited by 40 · see citing works
Contagious depression: Automatic mimicry and the mirror neuron system - A review
Paz, L. V., Viola, T. W., Milanesi, B. B., Sulzbach, J. H., Mestriner, R. G., Wieck, A., & Xavier, L. L. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.032 · Cited by 47 · see citing works
Distinct neural correlates of emotional and cognitive empathy in older adults
Moore, R. C., Dev, S. I., Jeste, D. V., Dziobek, I., & Eyler, L. T. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.10.016 · Cited by 39 · see citing works
Emotions after stroke: A narrative update
Ferro, J. M., & Santos, A. C. (2019) · International Journal of Stroke · doi:10.1177/1747493019879662 · Cited by 39 · see citing works
Lv, Q., Xu, G., Pan, Y., Liu, T., Liu, X., Miao, L., Chen, X., Jiang, L., Chen, J., He, Y., et al. (2021) · Neural Plasticity · doi:10.1155/2021/8841720 · Cited by 38 · see citing works
Pharmacotherapy for Neuropsychiatric Symptoms in Frontotemporal Dementia
Le, C., & Finger, E. (2021) · CNS Drugs · doi:10.1007/s40263-021-00854-5 · Cited by 26 · see citing works
Sleep quality and its association with the insular cortex in emotional empathy
Guadagni, V., Burles, F., Ferrara, M., & Iaria, G. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14124 · Cited by 34 · see citing works
Xu, X., Dai, J., Liu, C., Chen, Y., Xin, F., Zhou, F., Zhou, X., Huang, Y., Wang, J., Zou, Z., et al. (2019) · Psychotherapy and Psychosomatics · doi:10.1159/000504180 · Cited by 33 · see citing works
Baldo, J. V., Kacinik, N. A., Moncrief, A., Beghin, F., & Dronkers, N. F. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.11.001 · Cited by 31 · see citing works
Patient's Loss of Empathy Is Associated With Caregiver Burden
Pomponi, M., Ricciardi, L., Torre, G. L., Fusco, D., Morabito, B., Ricciardi, D., Gioia, A. D., Bernabei, R., & Bentivoglio, A. R. (2016) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000568 · Cited by 30 · see citing works
Cannabidiol normalizes resting-state functional connectivity in treatment-resistant epilepsy
Nenert, R. E., Allendorfer, J. B., Bebin, E. M., Gaston, T. E., Grayson, L. E., Houston, J. T., & Szaflarski, J. P. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107297 · Cited by 30 · see citing works
Masina, F., Pezzetta, R., Lago, S., Mantini, D., Scarpazza, C., & Arcara, G. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104713 · Cited by 30 · see citing works
Dara, C., Bang, J., Gottesman, R. F., & Hillis, A. E. (2014) · PubMed · Cited by 30 · see citing works
Self-citationVariability in Brain Structure and Function Reflects Lack of Peer Support
Schurz, M., Uddin, L. Q., Kanske, P., Lamm, C., Sallet, J., Bernhardt, B. C., Mars, R. B., & Bzdok, D. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab109 · Cited by 26 · see citing works
Toller, G., Adhimoolam, B., Rankin, K. P., Huppertz, H., Kurthen, M., & Jokeit, H. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.09.010 · Cited by 29 · see citing works
Wu, X., Xu, F., Chen, X., Wang, L., Huang, W., Wan, K., Ji, G., Xiao, G., Xu, S. H., Yu, F., et al. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00446 · Cited by 28 · see citing works
Lesion Mapping the Four-Factor Structure of Emotional Intelligence
Operskalski, J. T., Paul, E. J., Colom, R., Barbey, A. K., & Grafman, J. H. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00649 · Cited by 28 · see citing works
Circles of engagement: Childhood pain and parent brain
Simons, L. E., Goubert, L., Vervoort, T., & Borsook, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.020 · Cited by 28 · see citing works
Right-Hemisphere Pragmatic Disorders
Blake, M. L. (2017) · Perspectives in pragmatics, psychology & philosophy · doi:10.1007/978-3-319-47489-2_10 · Cited by 27 · see citing works
Neural effects of oxytocin and mimicry in frontotemporal dementia: A randomized crossover study
Oliver, L. D., Stewart, C., Coleman, K., Kryklywy, J. H., Bartha, R., Mitchell, D. G. V., & Finger, E. C. (2020) · Neurology · doi:10.1212/wnl.0000000000010933 · Cited by 26 · see citing works
Left Hemisphere Bias of NIH Stroke Scale Is Most Severe for Middle Cerebral Artery Strokes
Vitti, E., Kim, G., Stockbridge, M. D., Hillis, A. E., & Faria, A. V. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.912782 · Cited by 26 · see citing works
Self-citationImpairment of sociocognitive functions in patients with brain tumours
Pertz, M., Okoniewski, A., Schlegel, U. S., & Thoma, P. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.018 · Cited by 25 · see citing works
Long, Y., Zhong, M., Aili, R., Zhang, H., Fang, X., & Lu, C. (2022) · Brain stimulation · doi:10.1016/j.brs.2022.12.009 · Cited by 24 · see citing works
Right mesial temporal lobe epilepsy impairs empathy-related brain responses to dynamic fearful faces
Toller, G., Adhimoolam, B., Grünwald, T., Huppertz, H., Kurthen, M., Rankin, K. P., & Jokeit, H. (2015) · Journal of Neurology · doi:10.1007/s00415-014-7622-2 · Cited by 23 · see citing works
White matter tracts critical for recognition of sarcasm
Davis, C. L., Oishi, K., Faria, A. V., Hsu, J., Gomez, Y., Mori, S., & Hillis, A. E. (2015) · Neurocase · doi:10.1080/13554794.2015.1024137 · Cited by 23 · see citing works
Self-citationRushby, J. A., McDonald, S., Fisher, A. C., Kornfeld, E. J., Blasio, F. M. D., Parks, N., & Piguet, O. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.09.017 · Cited by 23 · see citing works
The Affective Nature of Formulaic Language: A Right-Hemisphere Subcortical Process
Sidtis, D. V. L., & Sidtis, J. J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00573 · Cited by 23 · see citing works
Cognitive and affective theory of mind double dissociation after parietal and temporal lobe tumours
Campanella, F., West, T., Corradi‐Dell’Acqua, C., & Škrap, M. (2021) · Brain · doi:10.1093/brain/awab441 · Cited by 22 · see citing works
The neuropsychology of empathy: evidence from lesion studies
Shamay‐Tsoory, S. (2015) · Revue de neuropsychologie · doi:10.3917/rne.074.0237 · Cited by 22 · see citing works
Social Cognition and White Matter: Connectivity and Cooperation
Filley, C. M. (2020) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000223 · Cited by 21 · see citing works
Developments in treating the nonmotor symptoms of stroke
Hillis, A. E. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1763173 · Cited by 21 · see citing works
Self-citationBehavioral Variant Frontotemporal Dementia and Social and Criminal Transgressions
Mendez, M. F. (2022) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.21080224 · Cited by 21 · see citing works
Deep-learning-enabled brain hemodynamic mapping using resting-state fMRI
Hou, X., Guo, P., Wang, P., Liu, P., Lin, D. D. M., Fan, H., Li, Y., Wei, Z., Lin, Z., Jiang, D., et al. (2023) · npj Digital Medicine · doi:10.1038/s41746-023-00859-y · Cited by 21 · see citing works
Self-citationState and trait characteristics of anterior insula time-varying functional connectivity
Pasquini, L., Toller, G., Staffaroni, A. M., Brown, J. A., Deng, J., Lee, A. J., Kurcyus, K., Shdo, S. M., Allen, I. E., Sturm, V. E., et al. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116425 · Cited by 20 · see citing works
The neuropsychology of empathy: evidence from lesion studies
Shamay‐Tsoory, S. (2016) · Revue de neuropsychologie · doi:10.1684/nrp.2015.0356 · Cited by 19 · see citing works
The Company Prosodic Deficits Keep Following Right Hemisphere Stroke: A Systematic Review
Sheppard, S. M., Stockbridge, M. D., Keator, L. M., Murray, L. L., & Blake, M. L. (2022) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617721001302 · Cited by 19 · see citing works
Johnstone, B., Cohen, D., Bryant, K. R., Glass, B. A., & Christ, S. E. (2014) · Neuropsychology · doi:10.1037/neu0000155 · Cited by 18 · see citing works
Improving Empathy in the Care of Pain Patients
Jackson, P. L., Eugène, F., & Tremblay, M. (2015) · AJOB Neuroscience · doi:10.1080/21507740.2015.1047053 · Cited by 17 · see citing works
Minor Hemisphere Major Syndromes
Carota, A., & Bogousslavsky, J. (2017) · Monographs in clinical neuroscience/Frontiers of neurology and neuroscience/Monographs in neural sciences · doi:10.1159/000475690 · Cited by 17 · see citing works
Li, C., Cheng, T.-H. Z., & Tsai, C. (2019) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2019.04.014 · Cited by 17 · see citing works
Dynamical predictions of insular hubs for social cognition and their application to stroke
Limongi, R., Tomio, A., & Ibáñez, A. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00380 · Cited by 16 · see citing works
Arnett, K., Roach, A. E., Elzy, M. B., & Jelsone-Swain, L. M. (2018) · Social Neuroscience · doi:10.1080/17470919.2018.1441905 · Cited by 15 · see citing works
Emotional processing impairments in patients with insula lesions following stroke
Lotze, M. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120591 · Cited by 15 · see citing works
The relationship between social cognition and participation in the long term after stroke
Stiekema, A. P. M., Nijsse, B., de Kort, P. L. M., Spikman, J. M., Visser‐Meily, J. M. A., & Heugten, C. M. V. (2019) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2019.1692670 · Cited by 15 · see citing works
Brain structural alterations in autism and criminal psychopathy
Noppari, T., Sun, L., Lukkarinen, L., Putkinen, V., Tani, P., Lindberg, N., Saure, E., Lauerma, H., Tiihonen, J., Venetjoki, N., et al. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103116 · Cited by 14 · see citing works
Hengstschläger, A., Sommerlad, A., & Huntley, J. D. (2022) · Brain Sciences · doi:10.3390/brainsci12091136 · Cited by 13 · see citing works
Emotional processing in patients with single brain damage in the right hemisphere
Fernández, S. Á., Andrade‐González, N., Simal, P., Matías‐Guiu, J. A., Gómez-Escalonilla, C., Rodríguez–Jiménez, R., Stiles, B. J., & Lahera, G. (2023) · BMC Psychology · doi:10.1186/s40359-022-01033-x · Cited by 11 · see citing works
Jami, P. Y., Han, H., Thoma, S. J., Mansouri, B., & Houser, R. A. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.689304 · Cited by 11 · see citing works
Expressive Prosody in Patients With Focal Anterior Temporal Neurodegeneration
Geraudie, A., Pressman, P., Pariente, J., Millanski, C., Palser, E. R., Ratnasiri, B. M., Battistella, G., Mandelli, M. L., Miller, Z., Miller, B. L., et al. (2023) · Neurology · doi:10.1212/wnl.0000000000207516 · Cited by 10 · see citing works
Empathy: The genetics-environment-endocrine-brain mechanism
Yang, Y., Yi, T. A. N. G., Peng, W., Lu, X., Hu, L., & Chen, J. (2017) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972017-00832 · Cited by 10 · see citing works
Trieu, M., Foster, A. E., Yaseen, Z. S., Beaubian, C., & Calati, R. (2019) · Springer eBooks · doi:10.1007/978-3-030-29876-0_2 · Cited by 12 · see citing works
Suarez, A., Saxena, S., Oishi, K., Oishi, K., Walker, A., Rorden, C., & Hillis, A. E. (2020) · Cortex · doi:10.1016/j.cortex.2019.12.030 · Cited by 10 · see citing works
Self-citationImpaired Empathy Versus General Hypoemotionality in Frontotemporal Dementia
Mendez, M. F., Carr, A. R., Jimenez, E. E., Riedel, B. C., & Thompson, P. M. (2019) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.18090202 · Cited by 9 · see citing works
Cohen, D., Bhushan, B., Hanks, R. A., Yoon, D. P., Johnstone, B., & Hunt, I. (2020) · Mental Health Religion & Culture · doi:10.1080/13674676.2020.1725454 · Cited by 8 · see citing works
I feel your pain: higher empathy is associated with higher posterior default mode network activity
Oliva, V. N. L. D. S., Riegner, G., Dean, J. G., Khatib, L. A., Allen, A., Barrows, D., Chen, C., Fuentes, R., Jacobson, A., Lopez, C., et al. (2024) · Pain · doi:10.1097/j.pain.0000000000003434 · Cited by 7 · see citing works
Ozzoude, M., Varriano, B. M., Beaton, D., Ramirez, J., Holmes, M. F., Scott, C. J. M., Gao, F., Sunderland, K. M., McLaughlin, P. M., Rabin, J. S., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00539-x · Cited by 7 · see citing works
Braga, M. F. M., Juranek, J. J., Eiden, L. E., Li, Z., Figueiredo, T. H., Furtado, M. D. A., & Marini, A. M. (2022) · Amino Acids · doi:10.1007/s00726-022-03184-y · Cited by 8 · see citing works
Effects of emotional valence and intensity on cognitive and affective empathy after insula lesions
Holtmann, O., Schloßmacher, I., Franz, M., Mönig, C., Tenberge, J., Preul, C., Schwindt, W., Bruchmann, M., Melzer, N., Miltner, W. H. R., et al. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac362 · Cited by 7 · see citing works
Zhou, Y., Dai, A., Feng, S., Zhu, T., Liu, M., Shi, J., & Wang, D. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1297149 · Cited by 7 · see citing works
Social problem solving and trait socioemotional abilities in ambulatory stroke patients
Pertz, M., Braunwarth, J. I., Steinbach, J., Wißing, S., & Thoma, P. (2022) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2022.2101619 · Cited by 6 · see citing works
Location of Hyperintense Vessels on FLAIR Associated with the Location of Perfusion Deficits in PWI
Bunker, L. D., & Hillis, A. E. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041554 · Cited by 6 · see citing works
Self-citation
- Authors
- Leigh, R., Oishi, K., Hsu, J., Lindquist, M., Gottesman, R. F., Jarso, S., Crainiceanu, C., Mori, S., & Hillis, A. E.
- Affiliations
- Johns Hopkins University (US)
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-07-03
- Volume
- 136
- Issue
- 8
- Pages
- 2539-2549
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC3722353
- OpenAlex
- W2170090072
- Cited by
- 148
- References
- 60
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 8 · 2022: 15 · 2021: 12 · 2020: 12 · 2019: 16 · 2018: 18 · 2017: 9 · 2016: 10 · 2015: 13 · 2014: 10 · 2013: 2
- FWCI
- 17.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01 NS47691, R01NS047691)
- National Institute of Biomedical Imaging and Bioengineering (P41EB015909)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD065955)
- Topics
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Health Sciences › Medicine › Psychiatry and Mental health › Empathy and Medical Education
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- affective empathy, acute stroke, right hemisphere infarction, temporal pole, anterior insula, temporoparietal junction, hemispatial neglect
- MeSH terms
- Adult, Aged, Brain, Brain Mapping, Brain Ischemia, Cognition, Emotions, Empathy, Female, Humans, Functional Laterality, Male, Middle Aged, Nerve Net, Social Perception, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
