Ageing of the male germ line

Instability and decay of the primary structure of DNA

Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679 · see citing works

Rate of de novo mutations and the importance of father’s age to disease risk

Kong, A., Frigge, M. L., Masson, G., Besenbacher, S., Sulem, P., Magnusson, G., Gudjonsson, S. A., Sigurdsson, A., Jonasdottir, A., Jonasdottir, A., et al. (2012) · Nature · doi:10.1038/nature11396 · Cited by 2,134 · see citing works

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

Ouelle, D. E., Zindy, F., Ashmun, R. A., & Sherr, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90214-7 · Cited by 1,485 · see citing works

Cell intrinsic alterations underlie hematopoietic stem cell aging

Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · see citing works

Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa

Aitken, R. J., & Clarkson, J. S. (1987) · Reproduction · doi:10.1530/jrf.0.0810459 · Cited by 1,020 · see citing works

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972 · see citing works

The origins, patterns and implications of human spontaneous mutation

Crow, J. F. (2000) · Nature Reviews Genetics · doi:10.1038/35049558 · Cited by 928 · see citing works

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer

Teschendorff, A. E., Menon, U., Gentry-Maharaj, A., Ramus, S. J., Weisenberger, D. J., Shen, H., Campan, M., Noushmehr, H., Bell, C. G., Maxwell, A. P., et al. (2010) · Genome Research · doi:10.1101/gr.103606.109 · Cited by 855 · see citing works

Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all

Gil, J., & Peters, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1987 · Cited by 843 · see citing works

Relative Impact of Oxidative Stress on the Functional Competence and Genomic Integrity of Human Spermatozoa1

Aitken, R. J., Gordon, E., Harkiss, D., Twigg, J., MILNE, P. A., Jennings, Z., & Irvine, D. S. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.5.1037 · Cited by 795 · see citing works

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domainsPreprint

Rakyan, V. K., Down, T. A., Maslau, S., Andrew, T., Yang, T.-P., Beyan, H., Whittaker, P., McCann, O. T., Finer, S., Valdes, A. M., et al. (2010) · Genome Research · doi:10.1101/gr.103101.109 · Cited by 750 · see citing works

Effects of male age on semen quality and fertility: a review of the literature

Kidd, S. A., Eskenazi, B., & Wyrobek, A. J. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01679-4 · Cited by 703 · see citing works

Births: final data for 2009.

Martin, J. A., Hamilton, B. E., Ventura, S. J., Osterman, M. J. K., Kirmeyer, S., Mathews, T. J., & Wilson, E. C. (2011) · PubMed · Cited by 702 · see citing works

The cycle of the seminiferous epithelium in man

Clermont, Y. (1963) · American Journal of Anatomy · doi:10.1002/aja.1001120103 · Cited by 682 · see citing works

Widespread and tissue specific age-related DNA methylation changes in mice

Maegawa, S., Hinkal, G., Kim, H. S., Shen, L., Zhang, L., Zhang, J., Zhang, N., Liang, S., Donehower, L. A., & Issa, J.-P. J. (2010) · Genome Research · doi:10.1101/gr.096826.109 · Cited by 553 · see citing works

Sperm DNA fragmentation: paternal effect on early post-implantation embryo development in ART

Borini, A., Tarozzi, N., Bizzaro, D., Bonu, M. A., Fava, L., Flamigni, C., & Coticchio, G. (2006) · Human Reproduction · doi:10.1093/humrep/del251 · Cited by 462 · see citing works

Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies

Hultman, C. M., Sandin, S., Levine, S. Z., Lichtenstein, P., & Reichenberg, A. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.121 · Cited by 444 · see citing works

Effects of age on DNA double-strand breaks and apoptosis in human sperm

Singh, N. P., MULLER, C. H., & Berger, R. E. (2003) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.04.002 · Cited by 442 · see citing works

Human DNA repair genes, 2005

Wood, R. D., Mitchell, M., & Lindahl, T. L. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.03.007 · Cited by 424 · see citing works

Impact of aging on DNA methylation

Richardson, B. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00010-2 · Cited by 420 · see citing works

Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm

Wyrobek, A. J., Eskenazi, B., Young, S., Arnheim, N., Tiemann‐Boege, I., Jabs, E. W., Glaser, R. L., Pearson, F. S., & Evenson, D. P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506468103 · Cited by 402 · see citing works

Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection

Twigg, J., Irvine, D. S., & Aitken, R. J. (1998) · Human Reproduction · doi:10.1093/humrep/13.7.1864 · Cited by 380 · see citing works

Development of an Image Analysis System to Monitor the Retention of Residual Cytoplasm by Human Spermatozoa: Correlation With Biochemical Markers of the Cytoplasmic Space, Oxidative Stress, and Sperm Function

Gómez, E., Buckingham, D. W., Brindle, J., Lanzafame, F., Irvine, D. S., & Aitken, R. J. (1996) · Journal of Andrology · doi:10.1002/j.1939-4640.1996.tb01783.x · Cited by 375 · see citing works

Long-Term Effects of Mouse Intracytoplasmic Sperm Injection with DNA-Fragmented Sperm on Health and Behavior of Adult Offspring1

Fernández‐González, R., Moreira, P. N., Pérez-Crespo, M., Sánchez‐Martín, M., Ramírez, M. Á., Pericuesta, E., Bilbao, A., Bermejo‐Álvarez, P., Hourcade, J. D. D., de Fonseca, F. R., et al. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.107.065623 · Cited by 366 · see citing works

Paternal Age Effect Mutations and Selfish Spermatogonial Selection: Causes and Consequences for Human Disease

Goriely, A., & Wilkie, A. O. M. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.12.017 · Cited by 365 · see citing works

Rare congenital disorders, imprinted genes, and assisted reproductive technology

Gosden, R. G., Trasler, J. M., Lucifero, D., & Faddy, M. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13592-1 · Cited by 360 · see citing works

PARENTAL AGE AND MUTATION

Penrose, L. S. (1955) · The Lancet · doi:10.1016/s0140-6736(55)92305-9 · Cited by 348 · see citing works

A novel signal transduction cascade in capacitating human spermatozoa characterised by a redox-regulated, cAMP-mediated induction of tyrosine phosphorylation

Aitken, R. J., Harkiss, D., Knox, W., Paterson, M., & Irvine, D. S. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.5.645 · Cited by 331 · see citing works

Effect of male age on fertility: evidence for the decline in male fertility with increasing age

Hassan, M. A. M., & Killick, S. R. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00366-2 · Cited by 311 · see citing works

A positive role for the superoxide anion in triggering hyperactivation and capacitation of human spermatozoa

de Lamirande, E., & Gagnon, C. (1993) · International Journal of Andrology · doi:10.1111/j.1365-2605.1993.tb01148.x · Cited by 307 · see citing works

Antioxidant system in rat testicular cells

Bauché, F., Fouchard, M.-H., & Jégou, B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00709-8 · Cited by 300 · see citing works

Paternal age and schizophrenia: a population based cohort study

Sipos, A., Rasmussen, F. E., Harrison, G. L., Tynelius, P., Lewis, G., Leon, D. A., & Gunnell, D. (2004) · BMJ · doi:10.1136/bmj.38243.672396.55 · Cited by 292 · see citing works

Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm

Kimura, M., Cherkas, L. F., Kato, B. S., Demissie, S., Hjelmborg, J., Brimacombe, M. B., Cupples, L. A., Hunkin, J., Gardner, J. P., Lu, X., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0040037 · Cited by 270 · see citing works

Decline in Self-Renewal Factors Contributes to Aging of the Stem Cell Niche in the Drosophila Testis

Boyle, M., Wong, C., Rocha, M., & Jones, D. L. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.002 · Cited by 268 · see citing works

Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men

Ford, W. C. L. (2000) · Human Reproduction · doi:10.1093/humrep/15.8.1703 · Cited by 267 · see citing works

Effects of Aging and Niche Microenvironment on Spermatogonial Stem Cell Self-Renewal

Ryu, B.-Y., Orwig, K. E., Oatley, J. M., Avarbock, M. R., & Brinster, R. L. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0580 · Cited by 265 · see citing works

Advancing Paternal Age and Bipolar Disorder

Frans, E. M., Sandin, S., Reichenberg, A., Lichtenstein, P., Långström, N., & Hultman, C. M. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.9.1034 · Cited by 249 · see citing works

Male age negatively impacts embryo development and reproductive outcome in donor oocyte assisted reproductive technology cycles

Frattarelli, J. L., Miller, K. A., Miller, B. T., Elkind-Hirsch, K. E., & Scott, R. T. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.06.009 · Cited by 243 · see citing works

The effects of male age on sperm DNA damage in healthy non-smokers

Schmid, T. E., Eskenazi, B., Baumgartner, A., Marchetti, F., Young, S., Weldon, R. H., Anderson, D. C., & Wyrobek, A. J. (2006) · Human Reproduction · doi:10.1093/humrep/del338 · Cited by 236 · see citing works

Parent-of-origin effects in multiple endocrine neoplasia type 2B.

Carlson, K. M., Bracamontes, J. R., Jackson, C. E., Clark, R., Lacroix, A., Wells, S. A., & Goodfellow, P. J. (1994) · PubMed Central · Cited by 229 · see citing works

DNA repair mechanisms and gametogenesis

Baarends, W. M., van der Laan, R., & Grootegoed, J. A. (2001) · Reproduction · doi:10.1530/rep.0.1210031 · Cited by 220 · see citing works

Fathers over 40 and increased failure to conceive: the lessons of in vitro fertilization in France

Rochebrochard, É. D. L., de Mouzon, J., Thépot, F., & Thonneau, P. F. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.11.040 · Cited by 216 · see citing works

Reproductive aging in the male brown-Norway rat: a model for the human

Wang, C., Leung, A., & Sinha‐Hikim, A. P. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243304 · Cited by 212 · see citing works

Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors

Goriely, A., Hansen, R. M. S., Taylor, I. B., Olesen, I. A., Jacobsen, G. K., McGowan, S. J., Pfeifer, S. P., McVean, G. A. T., Meyts, E. R.-D., & Wilkie, A. O. M. (2009) · Nature Genetics · doi:10.1038/ng.470 · Cited by 205 · see citing works

Paternal Origin of FGFR2 Mutations in Sporadic Cases of Crouzon Syndrome and Pfeiffer Syndrome

Glaser, R. L., Jiang, W. G., Boyadjiev, S. A., Tran, A. K., Zachary, A. A., Maldergem, L. V., Johnson, D., Walsh, S., Oldridge, M., Wall, S. A., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/302831 · Cited by 205 · see citing works

Statement on guidance for genetic counseling in advanced paternal age

Toriello, H. V., & Meck, J. M. (2008) · Genetics in Medicine · doi:10.1097/gim.0b013e318176fabb · Cited by 194 · see citing works

Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants

Eisenberg, D. T. A., Hayes, M. G., & Kuzawa, C. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202092109 · Cited by 193 · see citing works

Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats

Oakes, C. C., Smiraglia, D. J., Plass, C., Trasler, J. M., & Robaire, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437971100 · Cited by 184 · see citing works

Spermatogenesis and Aging in the Human

Johnson, L. W. (1986) · Journal of Andrology · doi:10.1002/j.1939-4640.1986.tb00943.x · Cited by 177 · see citing works

Age‐Related Decreased Leydig Cell Testosterone Production in the Brown Norway Rat

CHEN, H., Hardy, M. P., Huhtaniemi, I. T., & Zirkin, B. R. (1994) · Journal of Andrology · doi:10.1002/j.1939-4640.1994.tb00498.x · Cited by 171 · see citing works

Effect of paternal age in achondroplasia, thanatophoric dysplasia, and osteogenesis imperfecta

Orioli, I. M., Castilla, E. E., Scarano, G., & Mastroiacovo, P. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320590218 · Cited by 166 · see citing works

The effect of advancing paternal age on pregnancy and live birth rates in couples undergoing in vitro fertilization or gamete intrafallopian transfer

Klonoff-Cohen, H. S., & Natarajan, L. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.01.035 · Cited by 150 · see citing works

Comparative analysis of the ability of precursor germ cells and epididymal spermatozoa to generate reactive oxygen metabolites

Fisher, H. M., & Aitken, R. J. (1997) · Journal of Experimental Zoology · doi:10.1002/(sici)1097-010x(19970401)277:5 · Cited by 149 · see citing works

Paternal Age and Spontaneous Abortion

Kleinhaus, K., Perrin, M. C., Friedlander, Y., Paltiel, O., Malaspina, D., & Harlap, S. (2006) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000224606.26514.3a · Cited by 147 · see citing works

Association of Paternal Age and Risk for Major Congenital Anomalies From the National Birth Defects Prevention Study, 1997 to 2004

Green, R. F., Devine, O. J., Crider, K. S., Olney, R. S., Archer, N. P., Olshan, A. F., & Shapira, S. K. (2010) · Annals of Epidemiology · doi:10.1016/j.annepidem.2009.10.009 · Cited by 145 · see citing works

Parental Age As a Risk Factor of Childhood Leukemia and Brain Cancer in Offspring

Hemminki, K., Kyyrönen, P., & Vaittinen, P. (1999) · Epidemiology · doi:10.1097/00001648-199905000-00014 · Cited by 143 · see citing works

Ultrastructure of the aging human testis

Paniagua, R., Nistal, M., SÁEZ, F. J., & Fraile, B. (1991) · Journal of Electron Microscopy Technique · doi:10.1002/jemt.1060190209 · Cited by 143 · see citing works

Paternal Age and Schizophrenia: Further Support for an Association

Dalman, C., & Alle­beck, P. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.9.1591 · Cited by 136 · see citing works

Mutation frequency declines during spermatogenesis in young mice but increases in old mice

Walter, C. A., Intano, G. W., McCarrey, J. R., McMahan, C. A., & Walter, R. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10015 · Cited by 135 · see citing works

Spermatozoa Have Decreased Antioxidant Enzymatic Capacity and Increased Reactive Oxygen Species Production During Aging in the Brown Norway Rat

Weir, C., & Robaire, B. (2007) · Journal of Andrology · doi:10.2164/jandrol.106.001362 · Cited by 131 · see citing works

DNA repair in mammalian embryos

Jaroudi, S., & SenGupta, S. B. (2006) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2006.09.002 · Cited by 129 · see citing works

The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population

Brahem, S., Mehdi, M., Elghezal, H., & Saâd, A. (2011) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-011-9537-5 · Cited by 126 · see citing works

Prevalence and parental origin of de novo RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma. Le Groupe d'Etude des Tumeurs a Calcitonine.

Schuffenecker, I., Ginet, N., Goldgar, D., Eng, C., Chambe, B., Boneu, A., Houdent, C., Pallo, D., Schlumberger, M. J., Thivolet, C. H., et al. (1997) · Europe PMC (PubMed Central) · Cited by 117 · see citing works

Effect of sperm DNA damage and sperm protamine deficiency on fertilization and embryo development post-ICSI.

Mohammad, H. N.-E., Mohammad, S., Shahnaz, R., Maryam, A. I., Shahla, R., Fariba, M., & Mohammad, M. (2005) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60959-5 · Cited by 115 · see citing works

Paternal age ≥40 years: An important risk factor for infertility

Rochebrochard, É. D. L., & Thonneau, P. F. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/s0002-9378(03)00753-1 · Cited by 115 · see citing works

Paternal age and the risk of congenital heart defects

Olshan, A. F., Schnitzer, P. G., & Baird, P. A. (1994) · Teratology · doi:10.1002/tera.1420500111 · Cited by 114 · see citing works

Attenuation of DNA polymerase β-dependent base excision repair and increased DMS-induced mutagenicity in aged mice

Cabelof, D. C., Raffoul, J. J., Yanamadala, S., Ganir, C., Guo, Z., & Heydari, A. R. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00003-9 · Cited by 114 · see citing works

Aging of Male Germ Line Stem Cells in Mice1

Zhang, X., Ebata, K. T., Robaire, B., & Nagano, M. C. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.045591 · Cited by 110 · see citing works

Anti‐aging activity of the Ink4/Arf locus

Matheu, A., Maraver, A., Collado, M., Garcı́a-Cao, I., Cañamero, M., Borrás, C., Flores, J. M., Klatt, P., Viña, J., & Serrano, M. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00458.x · Cited by 106 · see citing works

The correlation between male age, sperm quality and sperm DNA fragmentation in 320 men attending a fertility center

Winkle, T., Rosenbusch, B. E., Gagsteiger, F., Paiss, T., & Zoller, N. (2008) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-008-9277-3 · Cited by 98 · see citing works

Parental Age and Risk of Sporadic and Familial Cancer in Offspring

Hemminki, K., & Kyyrönen, P. (1999) · Epidemiology · doi:10.1097/00001648-199911000-00016 · Cited by 94 · see citing works

Developmental Regulation and In Vitro Culture Effects on Expression of DNA Repair and Cell Cycle Checkpoint Control Genes in Rhesus Monkey Oocytes and Embryos1

Zheng, P., Schramm, R. D., & Latham, K. E. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.104.039073 · Cited by 92 · see citing works

Reference values for body proportions and body composition in adult women with Ullrich-Turner syndrome

Gravholt, C. H., & Næraa, R. W. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19971112)72:4 · Cited by 92 · see citing works

The Effect of Aging on the Seminiferous Epithelium of the Brown Norway Rat

Wright, W. W., FIORE, C., & Zirkin, B. R. (1993) · Journal of Andrology · doi:10.1002/j.1939-4640.1993.tb01661.x · Cited by 85 · see citing works

Association of paternal age at birth and the risk of breast cancer in offspring: a case control study

Choi, J., Lee, K.-M., Park, S. K., Noh, D., Ahn, S. H., Yoo, K., & Kang, D. (2005) · BMC Cancer · doi:10.1186/1471-2407-5-143 · Cited by 84 · see citing works

DNA double strand break repair in brain: Reduced NHEJ activity in aging rat neurons

Vyjayanti, V. N., & Rao, K. S. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.053 · Cited by 83 · see citing works

Advancing Paternal Age Is Associated with Deficits in Social and Exploratory Behaviors in the Offspring: A Mouse Model

Smith, R. G., Kember, R. L., Mill, J. S., Fernandes, C., Schalkwyk, L. C., Buxbaum, J. D., & Reichenberg, A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008456 · Cited by 81 · see citing works

Parental age effects on the occurrence of new mutations for the Marfan syndrome

Murdoch, J. L., Walker, B. A., & McKusick, V. A. (1972) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1957.tb01406.x · Cited by 79 · see citing works

Aging Results in Differential Regulation of DNA Repair Pathways in Pachytene Spermatocytes in the Brown Norway Rat1

Paul, C., Nagano, M. C., & Robaire, B. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.111.094219 · Cited by 76 · see citing works

Sperm Structural and Motility Changes During Aging in the Brown Norway Rat

Syntin, P., & Robaire, B. (2001) · Journal of Andrology · doi:10.1002/j.1939-4640.2001.tb02176.x · Cited by 75 · see citing works

Reproductive Aging in the Brown Norway Rat Is Characterized by Accelerated Germ Cell Apoptosis and Is Not Altered by Luteinizing Hormone Replacement

Wang, C., Hikim, A. P. S., Lue, Y., Leung, A., Baravarian, S., & Swerdloff, R. S. (1999) · Journal of Andrology · doi:10.1002/j.1939-4640.1999.tb02550.x · Cited by 71 · see citing works

Paternal Age Over 40 Years: The “Amber Light” in the Reproductive Life of Men?

Rochebrochard, É. D. L., McElreavey, K., & Thonneau, P. F. (2003) · Journal of Andrology · doi:10.1002/j.1939-4640.2003.tb02694.x · Cited by 71 · see citing works

Non‐homologous DNA end joining in the mature rat brain

Ren, K., & de Ortı́z, S. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00776.x · Cited by 70 · see citing works

Age and Sex Effects on Human Mutation Rates: An Old Problem with New Complexities

Crow, J. F. (2006) · Journal of Radiation Research · doi:10.1269/jrr.47.b75 · Cited by 69 · see citing works

Paternal age is a risk factor for Alzheimer disease in the absence of a major gene

Bertram, L., Busch, R., Spiegl, M., Lautenschlager, N. T., Müller, U., & Kurz, A. (1998) · Neurogenetics · doi:10.1007/s100480050041 · Cited by 68 · see citing works

Aneuploidies and micronuclei in the germ cells of male mice of advanced age

Lowe, X. R., Collins, B. W., Allen, J. W., Titenko-Holland, N. V., Breneman, J. W., van Beek, M., Bishop, J. B., & Wyrobek, A. J. (1995) · Mutation Research/DNAging · doi:10.1016/0921-8734(95)00012-u · Cited by 66 · see citing works

Tissue-specific changes of DNA repair protein Ku and mtHSP70 in aging rats and their retardation by caloric restriction

Um, J. H., Kim, S. J., Kim, D. W., Ha, M. Y., Jang, J. H., Kim, D. W., Chung, B., Kang, C., & Kim, S. H. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00169-6 · Cited by 64 · see citing works

Maternal age and paternal age are associated with distinct childhood behavioural outcomes in a general population birth cohort

Saha, S., Barnett, A. G., Buka, S. L., & McGrath, J. J. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.09.012 · Cited by 63 · see citing works

Mutation load and human longevity

Gavrilov, L. A., Gavrilova, N. S., Kroutko, V. N., Николаевна, Е. Г., Semyonova, V. G., Gavrilova, A. L., Lapshin, E. V., Nn, E., & Kushnareva, Y. E. (1997) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00058-4 · Cited by 63 · see citing works

Structure and gametogenic potential of seminiferous tubules in ageing mice

Gosden, R. G., Richardson, D. C., Brown, N. A., & Davidson, D. W. (1982) · Reproduction · doi:10.1530/jrf.0.0640127 · Cited by 61 · see citing works

Paternal age affects fertility and progeny outcome in the Brown Norway rat

Serre, V., & Robaire, B. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00259-3 · Cited by 60 · see citing works

Base Excision Repair Is Limited by Different Proteins in Male Germ Cell Nuclear Extracts Prepared from Young and Old Mice

Intano, G. W., McMahan, C. A., McCarrey, J. R., Walter, R. B., McKenna, A. E., Matsumoto, Y., MacInnes, M. A., Chen, D. J., & Walter, C. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.2410-2418.2002 · Cited by 60 · see citing works

Effects of ageing on spermatozoal chromatin and its sensitivity to in vivo and in vitro oxidative challenge in the Brown Norway rat.

Zubkova, E., & Robaire, B. (2006) · Human Reproduction · doi:10.1093/humrep/del193 · Cited by 60 · see citing works

Semen quality and aging: analysis of 9.168 samples in Cordoba. Argentina.

Molina, R. I., Martini, A. C., Tissera, A. D., Olmedo, J. J., Senestrari, D., de Cúneo, M. F., & Ruiz, R. D. (2010) · PubMed · Cited by 53 · see citing works

Long-Term Effects of Delayed Fatherhood in Mice on Postnatal Development and Behavioral Traits of Offspring1

García-Palomares, S., Pertusa, J. F., Miñarro, J., García‐Pérez, M. Á., Hermenegildo, C., Rausell, F., Cano, A., & Tarín, J. J. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.108.072066 · Cited by 53 · see citing works

Reproductive functions, fertility and genetic risks of ageing men

Rolf, C., & Nieschlag, E. (2001) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2001-14825 · Cited by 52 · see citing works

Frequency of human sperm carrying structural aberrations of chromosome 1 increases with advancing age

Sloter, E. D., Marchetti, F., Eskenazi, B., Weldon, R. H., Nath, J., Cabreros, D., & Wyrobek, A. J. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.08.112 · Cited by 50 · see citing works

Advanced paternal age is associated with alterations in discrete behavioural domains and cortical neuroanatomy of C57BL/6J mice

Foldi, C. J., Eyles, D. W., McGrath, J. J., & Burne, T. H. J. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07074.x · Cited by 48 · see citing works

Late paternity and stillbirth risk

Astolfi, P., Pasquale, A. D., & Zonta, L. A. (2004) · Human Reproduction · doi:10.1093/humrep/deh449 · Cited by 47 · see citing works

Spontaneous Mutation as a Risk Factor

Crow, J. F. (2015) · KARGER eBooks · doi:10.1159/000424865 · Cited by 45 · see citing works

Increased de novo copy number variants in the offspring of older males

Flatscher‐Bader, T., Foldi, C. J., Chong, S., Whitelaw, E., Moser, R. J., Burne, T. H. J., Eyles, D. W., & McGrath, J. J. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.30 · Cited by 44 · see citing works

The effects of male age on semen parameters: analysis of 1364 men attending an andrology center

Maya, W. D. C., Berdugo, J., & Jaramillo, Á. C. (2009) · The Aging Male · doi:10.3109/13685530903322841 · Cited by 42 · see citing works

Deoxyribonucleic acid repair and apoptosis in testicular germ cells of aging fertile men: the role of the poly(adenosine diphosphate-ribosyl)ation pathway

El-Domyati, M. M., Al-Din, A.-B. M., Barakat, M. T., El‐Fakahany, H. M., Xu, J., & Sakkas, D. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.03.027 · Cited by 42 · see citing works

Biological Clock Ticks for Men, Too

Thacker, P. D. (2004) · JAMA · doi:10.1001/jama.291.14.1683 · Cited by 41 · see citing works

Analysis of age-associated changes in mitochondrial free radical generation by rat testis

Vázquez-Memije, M. E., Capín, R., Tolosa, A., & El‐Hafidi, M. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9580-9 · Cited by 41 · see citing works

Exponential Decrease During Aging and Random Lifetime of Mouse Spermatogonial Stem Cells

Suzuki, N., & Withers, H. R. (1978) · Science · doi:10.1126/science.725597 · Cited by 36 · see citing works

DNA Repair Genes

(2007) · Hawley's Condensed Chemical Dictionary · doi:10.1002/9780470114735.hawley06132 · Cited by 27 · see citing works

Aging does not affect spermatogenic recovery after experimentally induced injury in mice

Ehmcke, J., Joshi, B., Hergenrother, S. D., & Schlatt, S. (2007) · Reproduction · doi:10.1530/rep-06-0148 · Cited by 25 · see citing works

Paternal age effect on age of onset in bipolar I disorder is mediated by sex and family history

Grigoroiu‐Serbânescu, M., WICKRAMARATNE, P. J., Mihăilescu, R., Prelipceanu, D., Sima, D., Codreanu, M., Grimberg, M., & Elston, R. C. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32063 · Cited by 23 · see citing works

When Fatherhood Should Stop?

Gavrilov, L. A. (1997) · Science · doi:10.1126/science.277.5322.17b · Cited by 23 · see citing works

Transgenic Mouse Models

Nishino, T., Ni, J., & Devuyst, O. (2007) · Peritoneal Dialysis International · doi:10.1177/089686080702700604 · Cited by 20 · see citing works

Envejecimiento y calidad seminal: un análisis de 9.168 casos en Córdoba, Argentina

Molina, R. I., Martini, A. C., Tissera, A. D., Olmedo, J. J., Senestrari, D., de Cúneo, M. F., & Ruiz, R. D. (2010) · Archivos Españoles de Urología · doi:10.4321/s0004-06142010000300007 · Cited by 19 · see citing works

Arrested germ cell divisions in the ageing human testis

Miething, A. (2005) · Andrologia · doi:10.1111/j.1439-0272.2004.00645.x · Cited by 16 · see citing works

Effects of primary testicular damage on sperm DNA oxidative status and embryonic and foetal development

Dimitriadis, F., Giannakis, D., Pardalidis, N. P., Τσουκανέλης, Κ., Kanakas, N., Saito, M., Watanabe, T., Miyagawa, I., Tsounapi, P., & Sofikitis, N. (2009) · Andrologia · doi:10.1111/j.1439-0272.2009.00929.x · Cited by 11 · see citing works

Spermatid micronucleus analysis of aging effects in hamsters

Allen, J. W., Collins, B. W., & Setzer, R. W. (1996) · Mutation Research/DNAging · doi:10.1016/s0921-8734(96)90008-9 · Cited by 10 · see citing works

All for One, or One for All?

Adamson, P. C., Paradis, C., & Smith, M. L. (2007) · The Hastings Center Report · doi:10.1353/hcr.2007.0049 · Cited by 8 · see citing works

Aging and diethylstilbestrol-induced aneuploidy in male germ cells: a transgenic mouse model

Xiao, Y., Tates, A. D., Boei, J. J. W. A., & Natarajan, A. T. (1998) · Chromosoma · doi:10.1007/s004120050336 · Cited by 6 · see citing works

Inflammation and aging: signaling pathways and intervention therapies

Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works

Oxidative stress and male infertility

Bisht, S., Faiq, M. A., Tolahunase, M., & Dada, R. (2017) · Nature reviews. Urology · doi:10.1038/nrurol.2017.69 · Cited by 958 · see citing works

New insights into the generation and role of de novo mutations in health and disease

Acuña‐Hidalgo, R., Veltman, J. A., & Hoischen, A. (2016) · Genome biology · doi:10.1186/s13059-016-1110-1 · Cited by 451 · see citing works

Age-Associated Sperm DNA Methylation Alterations: Possible Implications in Offspring Disease Susceptibility

Jenkins, T. G., Aston, K. I., Pflueger, C., Cairns, B. R., & Carrell, D. T. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004458 · Cited by 299 · see citing works

Fertility preservation in men with cancer

Tournaye, H. J., Dohle, G. R., & Barratt, C. L. R. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60495-5 · Cited by 146 · see citing works

Aging and the Male Reproductive System.

Kaufman, J., Lapauw, B., Mahmoud, A., T'sjoen, G., & Huhtaniemi, I. (2019) · Endocrine reviews · doi:10.1210/er.2018-00178 · Cited by 97 · see citing works

Reproduction

Almeling, R. (2015) · Annual Review of Sociology · doi:10.1146/annurev-soc-073014-112258 · Cited by 123 · see citing works

Spermatozoa from patients with seminal alterations exhibit a differential micro-ribonucleic acid profile

Salas‐Huetos, A., Blanco, J., Vidal, F., Godo, A., Grossmann, M., Pons, M. C., F-Fernández, S., Garrido, N., & Antón, E. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.06.015 · Cited by 118 · see citing works

The Epididymis

Robaire, B., & Hinton, B. T. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00017-x · Cited by 104 · see citing works

The deteriorating soma and the indispensable germline: gamete senescence and offspring fitness

Monaghan, P., & Metcalfe, N. B. (2019) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.2187 · Cited by 100 · see citing works

Ageing and inflammation – A central role for mitochondria in brain health and disease

Currais, A. J. M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.02.001 · Cited by 95 · see citing works

Orchestrating the antioxidant defenses in the epididymis

O’Flaherty, C. (2019) · Andrology · doi:10.1111/andr.12630 · Cited by 94 · see citing works

Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline

Giannoulatou, E., McVean, G., Taylor, I. B., McGowan, S. J., Maher, G. J., Iqbal, Z., Pfeifer, S. P., Turner, I., Burkitt‐Wright, E., Shorto, J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311381110 · Cited by 86 · see citing works

Fertility in the aging male: a systematic review

Jimbo, M., Kunisaki, J., Ghaed, M., Yu, V., Flores, H. A., & Hotaling, J. M. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.10.035 · Cited by 84 · see citing works

Cellular evidence for selfish spermatogonial selection in aged human testes

Maher, G. J., Goriely, A., & Wilkie, A. O. M. (2013) · Andrology · doi:10.1111/j.2047-2927.2013.00175.x · Cited by 70 · see citing works

De novo mutations, genetic mosaicism and human disease

Mohiuddin, M., Kooy, R. F., & Pearson, C. E. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.983668 · Cited by 66 · see citing works

High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations

Cao, M., Shao, X., Chan, P. T. K., Cheung, W., Kwan, T., Pastinen, T., & Robaire, B. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00988-1 · Cited by 62 · see citing works

Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes

Maher, G. J., McGowan, S. J., Giannoulatou, E., Verrill, C., Goriely, A., & Wilkie, A. O. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521325113 · Cited by 59 · see citing works

Peroxiredoxin 6: The Protector of Male Fertility

O’Flaherty, C. (2018) · Antioxidants · doi:10.3390/antiox7120173 · Cited by 62 · see citing works

The effects of male age on sperm DNA damage: an evaluation of 2,178 semen samples

Comar, V. A., Ricci, J., Dieamant, F., Oliveira, J. B. A., Baruffi, R. L. R., & Franco, J. G., Jr. (2018) · JBRA · doi:10.5935/1518-0557.20180047 · Cited by 57 · see citing works

On the origin of sperm epigenetic heterogeneity

Laurentino, S., Borgmann, J., & Gromoll, J. (2016) · Reproduction · doi:10.1530/rep-15-0436 · Cited by 54 · see citing works

Insights into replicative senescence of human testicular peritubular cells

Schmid, N., Flenkenthaler, F., Stöckl, J. B., Dietrich, K.-G., Köhn, F. M., Schwarzer, J. U., Kunz, L., Luckner, M., Wanner, G., Arnold, G. J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51380-w · Cited by 49 · see citing works

FSH treatment in infertile males candidate to assisted reproduction improved sperm DNA fragmentation and pregnancy rate

Garolla, A., Ghezzi, M., Cosci, I., Sartini, B., Bottacin, A., Engl, B., Nisio, A. D., & Foresta, C. (2016) · Endocrine · doi:10.1007/s12020-016-1037-z · Cited by 46 · see citing works

Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells

Pohl, E., Höffken, V., Schlatt, S., Kliesch, S., Gromoll, J., & Wistuba, J. (2019) · Andrology · doi:10.1111/andr.12665 · Cited by 45 · see citing works

X‐box binding protein 1 (XBP1) function in diseases

Xu, W., Wang, C., & Hua, J. (2020) · Cell Biology International · doi:10.1002/cbin.11533 · Cited by 44 · see citing works

The effects of age on sperm quality: an evaluation of 1,500 semen samples

Oliveira, J. B. A., Petersen, C. G., Mauri, A. L., Vagnini, L. D., Baruffi, R. L. R., & Franco, J. (2014) · JBRA · doi:10.5935/1518-0557.20140002 · Cited by 43 · see citing works

Antioxidant Enzymes and Male Fertility: Lessons from Knockout Models

Scarlata, E., & O’Flaherty, C. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7985 · Cited by 42 · see citing works

Meta gene set enrichment analyses link miR-137-regulated pathways with schizophrenia risk

Wright, C., Calhoun, V. D., Ehrlich, S., Wang, L., Turner, J. A., & Perrone‐Bizzozero, N. I. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00147 · Cited by 40 · see citing works

Reactive Oxygen Species and Male Fertility

O’Flaherty, C. (2020) · Antioxidants · doi:10.3390/antiox9040287 · Cited by 39 · see citing works

Sperm sequencing reveals extensive positive selection in the male germline

Neville, M., Lawson, A., Sanghvi, R., Abascal, F., Pham, M. H., Cagan, A., Nicola, P., Bayzetinova, T., Baez-Ortega, A., Roberts, K., et al. (2024) · Nature · doi:10.1038/s41586-025-09448-3 · Cited by 46 · see citing works

Development of the adverse outcome pathway “alkylation of DNA in male premeiotic germ cells leading to heritable mutations” using the OECD 's users' handbook supplement

Yauk, C. L., Lambert, I. B., Meek, M. E., Douglas, G. R., & Marchetti, F. (2015) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21954 · Cited by 38 · see citing works

Evaluation of candidate spermatogonial markers ID 4 and GPR 125 in testes of adult human cadaveric organ donors

Sachs, C., Robinson, B. D., Martin, L. A., Webster, T. M., Gilbert, M., Lo, H. G., Rafii, S., Ng, C. K., & Seandel, M. (2014) · Andrology · doi:10.1111/j.2047-2927.2014.00226.x · Cited by 38 · see citing works

Telomere Dynamics Throughout Spermatogenesis

Fice, H. E., & Robaire, B. (2019) · Genes · doi:10.3390/genes10070525 · Cited by 37 · see citing works

Advanced Paternal Age and Future Generations

Chan, P. T. K., & Robaire, B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.897101 · Cited by 36 · see citing works

Impaired ketogenesis in Leydig Cells drives testicular aging

Liu, C., Peng, H. Y., Yu, J., Luo, P., Xiong, C., Chen, H., Fan, H., Ma, Y., Ou, W., Zhang, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59591-8 · Cited by 38 · see citing works

Parental mosaicism for apparent de novo genetic variants: Scope, detection, and counseling challenges

Zemet, R., den Veyver, I. B. V., & Stankiewicz, P. (2022) · Prenatal Diagnosis · doi:10.1002/pd.6144 · Cited by 34 · see citing works

Evidence for Paternal Age-Related Alterations in Meiotic Chromosome Dynamics in the Mouse

Vrooman, L. A., Nagaoka, S. I., Hassold, T. J., & Hunt, P. A. (2013) · Genetics · doi:10.1534/genetics.113.158782 · Cited by 34 · see citing works

Age-Dependent De Novo Mutations During Spermatogenesis and Their Consequences

Cioppi, F., Casamonti, E., & Krausz, C. G. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-21664-1_2 · Cited by 35 · see citing works

The dynamic changes of Nrf2 mediated oxidative stress, DNA damage and base excision repair in testis of rats during aging

Zhao, H., Song, L., Ma, N., Liu, C., Dun, Y., Zhou, Z., Yuan, D., & Zhang, C. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111460 · Cited by 30 · see citing works

Oleanolic acid rejuvenates testicular function through attenuating germ cell DNA damage and apoptosis via deactivation of NF-κB, p53 and p38 signalling pathways

Zhao, H., Liu, J., Song, L., Liu, Z., Han, G., Yuan, D., Wang, T., Dun, Y., Zhou, Z., Liu, Z., et al. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12668 · Cited by 29 · see citing works

Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes

Haroon, H., Ma, X.-M., Li, Y., Zhang, H., Liu, Q., Su, X.-H., & Xing, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-64890-9 · Cited by 29 · see citing works

Aging Results in Molecular Changes in an Enriched Population of Undifferentiated Rat Spermatogonia1

Paul, C., Nagano, M. C., & Robaire, B. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.112995 · Cited by 29 · see citing works

Fertility preservation in testicular cancer – predictors of spermatogenesis

Moody, J. A., Ahmed, K., Horsfield, C. J., Pedersen, M. R. V., Yap, T., & Shabbir, M. (2018) · British Journal of Urology · doi:10.1111/bju.14214 · Cited by 27 · see citing works

Sexual rest and post‐meiotic sperm ageing in house mice

Firman, R. C., Young, F., Rowe, D. C., Dương, H. T., & Gasparini, C. (2015) · Journal of Evolutionary Biology · doi:10.1111/jeb.12661 · Cited by 27 · see citing works

Computer Simulation of the Rodent Spermatogonial Stem Cell Niche1

de Rooij, D. G., & van Beek, M. E. A. B. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.108639 · Cited by 26 · see citing works

Decline in testicular function in ageing rats: Changes in the unfolded protein response and mitochondrial apoptotic pathway

Zhao, H., Ma, N., Chen, Q., You, X., Liu, C., Wang, T., Yuan, D., & Zhang, C. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110721 · Cited by 26 · see citing works

Protective effect of Wuzi Yanzong recipe on testicular dysfunction through inhibition of germ cell apoptosis in ageing rats via endoplasmic reticulum stress

Zhao, H., Ma, N., Liu, Z., Wang, T., Yuan, C., He, Y., Dun, Y., Zhou, Z., Yuan, D., & Zhang, C. (2018) · Andrologia · doi:10.1111/and.13181 · Cited by 25 · see citing works

Database on spermatozoa transcriptogram of catagorised Frieswal crossbred (Holstein Friesian X Sahiwal) bulls

Singh, R., Junghare, V., Hazra, S., Singh, U., Sengar, G. S., RAJA, T. V., Kumar, S., Tyagi, S., Das, A. K., Kumar, A., et al. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.01.025 · Cited by 24 · see citing works

Discovery of an unusually high number of de novo mutations in sperm of older men using duplex sequencingPreprint

Salazar, R., Arbeithuber, B., Ivanković, M., Heinzl, M., Moura, S., Hartl, I., Mair, T., Lahnsteiner, A., Ebner, T., Shebl, O., et al. (2022) · Genome Research · doi:10.1101/gr.275695.121 · Cited by 20 · see citing works

Meta-analysis shows no consistent evidence for senescence in ejaculate traits across animals

Sanghvi, K., Vega‐Trejo, R., Nakagawa, S., Gascoigne, S. J. L., Johnson, S. L., Salguero‐Gómez, R., Pizzari, T., & Sepil, I. (2024) · Nature Communications · doi:10.1038/s41467-024-44768-4 · Cited by 25 · see citing works

Age-Related Alterations in the Testicular Proteome of a Non-Human Primate

Stöckl, J. B., Schmid, N., Flenkenthaler, F., Drummer, C., Behr, R., Mayerhofer, A., Arnold, G. J., & Fröhlich, T. (2021) · Cells · doi:10.3390/cells10061306 · Cited by 21 · see citing works

The Effect of Paternal Age on Offspring Intelligence and Personality when Controlling for Parental Trait Levels

Arslan, R. C., Penke, L., Johnson, W., Iacono, W. G., & McGue, M. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090097 · Cited by 20 · see citing works

Timeless or tainted? The effects of male ageing on seminal fluid

Fricke, C., Sanghvi, K., Emery, M., Lindenbaum, I., Wigby, S., Ramm, S. A., & Sepil, I. (2023) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2023.1066022 · Cited by 20 · see citing works

Total flavonoids ofEpimediumreduce ageing-related oxidative DNA damage in testis of rats via p53-dependent pathway

Zhao, H., Li, S., Huang, W., Liu, J., Yuan, D., Wang, Y., & Zhang, C. (2017) · Andrologia · doi:10.1111/and.12756 · Cited by 20 · see citing works

Effects of benzo[a]pyrene on mouse germ cells: heritable DNA mutation, testicular cell hypomethylation and their interaction with nucleotide excision repair

Godschalk, R., Verhofstad, N., Verheijen, M. C. T., Yauk, C. L., Linschooten, J. O., STEEG, H. V., van Oostrom, C. T., van Benthem, J., & van Schooten, F. (2015) · Toxicology Research · doi:10.1039/c4tx00114a · Cited by 19 · see citing works

Low NAD+ Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice

Meyer‐Ficca, M. L., Zwerdling, A. E., Swanson, C. A., Tucker, A. G., Lopez, S. A., Wandersee, M. K., Warner, G. M., Thompson, K. L., Chini, C. C. S., Chen, H., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.896356 · Cited by 18 · see citing works

Hypermaintenance and hypofunction of aged spermatogonia: insight from age-related increase of Plzf expression

Ferder, I. C., & Wang, N. (2015) · Oncotarget · doi:10.18632/oncotarget.4045 · Cited by 17 · see citing works

EMAS position statement: Fertility preservation

Mintziori, G., Lambrinoudaki, I. V., Ceauşu, I., Depypere, H. T., Erel, C. T., Pérez-López, F. R., Schenck-Gustafsson, K. G., van der Schouw, Y. T., Simoncini, T., Trémollières, F., et al. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.10.010 · Cited by 15 · see citing works

High expression of the breast cancer susceptibility gene BRCA1 in long-lived termite kings

Tasaki, E., Mitaka, Y., Nozaki, T., Kobayashi, K., Matsuura, K., & Iuchi, Y. (2018) · Aging · doi:10.18632/aging.101578 · Cited by 14 · see citing works

The Solute Carrier Family 7 Member 11 (SLC7A11) is Regulated by LH/Androgen and Required for Cystine/Glutathione Homeostasis in Mouse Sertoli Cells

Liu, Z., Wang, H., Larsen, M., Gunewardana, S., Cendali, F. I., Reisz, J. A., Akiyama, H., Behringer, R. R., Ma, Q., Hammoud, S. S., et al. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111641 · Cited by 14 · see citing works

Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model

Stöckl, J. B., Schmid, N., Flenkenthaler, F., Drummer, C., Behr, R., Mayerhofer, A., Arnold, G. J., & Fröhlich, T. (2020) · Cells · doi:10.3390/cells9112498 · Cited by 12 · see citing works

EMAS position statement: Late parenthood

Mintziori, G., Lambrinoudaki, I. V., Kolibianakis, E. M., Ceauşu, I., Depypere, H., Erel, C. T., Pérez-López, F. R., Schenck-Gustafsson, K. G., van der Schouw, Y. T., Simoncini, T., et al. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.07.008 · Cited by 12 · see citing works

Evolution of a Higher Intracellular Oxidizing Environment in Caenorhabditis elegans under Relaxed Selection

Joyner‐Matos, J., Hicks, K. A., Cousins, D. J., Keller, M., Denver, D. R., Baer, C. F., & Estes, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065604 · Cited by 11 · see citing works

Increased double-strand breaks in aged mouse male germ cells may result from changed expression of the genes essential for homologous recombination or nonhomologous end joining repair

Talibova, G., Bilmez, Y., & Öztürk, S. (2022) · Histochemistry and Cell Biology · doi:10.1007/s00418-022-02157-2 · Cited by 10 · see citing works

Reappraisal of the Concept of Accelerated Aging in Neurodegeneration and Beyond

Statsenko, Y., Kuznetsov, N. V., Morozova, D., Liaonchyk, K., Simiyu, G., Smetanina, D., Kashapov, A., Meribout, S., Gorkom, K., Hamoudi, R., et al. (2023) · Cells · doi:10.3390/cells12202451 · Cited by 8 · see citing works

Sperm HSP70: may not be an age-dependent gene but is associated with field fertility in Bali bulls (Bos sondaicus)

Fatmila, D. T., Pardede, B. P., Maulana, T., Said, S., Yudi, Y., & Purwantara, B. (2024) · Animal Reproduction · doi:10.1590/1984-3143-ar2023-0048 · Cited by 9 · see citing works

When Testosterone Fades: Leydig Cell Aging Shaped by Environmental Toxicants, Metabolic Dysfunction, and Testicular Niche Crosstalk

Kaltsas, A., Dimitriadis, F., Zachariou, A., Koukos, S., Chrisofos, M., & Sofikitis, N. (2026) · Cells · doi:10.3390/cells15020158 · Cited by 12 · see citing works

Petasites japonicus Stimulates the Proliferation of Mouse Spermatogonial Stem Cells

Kang, H.-R., Lee, Y., Kim, Y.-H., Lee, D. G., Kim, B., Kim, K., Kim, B.-G., Oh, M.-G., Han, C. K., Lee, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133077 · Cited by 9 · see citing works

Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations

Yauk, C. L., Lambert, I. B., Marchetti, F., & Douglas, G. R. (2016) · OECD series on adverse outcome pathways · doi:10.1787/5jlsvvxn1zjc-en · Cited by 9 · see citing works

Responses to genotoxicity in mouse testicular germ cells and epididymal spermatozoa are affected by increased age

Taylor, J. D., Baumgartner, A., Schmid, T. E., & Brinkworth, M. H. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.04.013 · Cited by 8 · see citing works

Spliced X-box binding protein 1 (XBP1s) protects spermatogonial stem cells (SSCs) from lipopolysaccharide (LPS)-induced damage by regulating the testicular microenvironment.

Xu, W., Yang, Y., Li, Y.-X., Yang, D., Wan, S.-C., Li, N., & Hua, J. (2022) · Theriogenology · doi:10.1016/j.theriogenology.2022.07.014 · Cited by 6 · see citing works

Metabolism in Male Reproductive Aging

Meyer, R. G., & Meyer‐Ficca, M. L. (2021) · Advances in Geriatric Medicine and Research · doi:10.20900/agmr20210005 · Cited by 6 · see citing works

Aging affects gene expression in spermatids of Brown Norway rats

Fice, H. E., & Robaire, B. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112086 · Cited by 6 · see citing works

Sialylation status and its relationship with morphofunctional changes in human adult testis during sexually mature life and aging: A narrative review

Manetti, M., Marini, M., Perna, A., Tani, A., & Sgambati, E. (2024) · Acta Histochemica · doi:10.1016/j.acthis.2024.152143 · Cited by 6 · see citing works

Parental age influences developmental stability of the progeny inDrosophila

Colines, B., Rodríguez, N. C., Hasson, E., Carreira, V. P., & Frankel, N. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.2437 · Cited by 6 · see citing works

Selective mutation accumulation: a computational model of the paternal age effect

Whelan, E. C., Nwala, A. C., Osgood, C. J., & Olariu, S. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw528 · Cited by 6 · see citing works

Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Yun, C., Wang, Z., He, P., Guo, C., Chen, G., & Zheng, X. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13111168 · Cited by 6 · see citing works

Behavioural avoidance of sperm ageing depends on genetic similarity of mates in a monogamous seabird

Pineaux, M., Blanchard, P., Danchin, É., Hatch, S. A., Helfenstein, F., Mulard, H., White, J., Leclaire, S., & Wagner, R. H. (2019) · Biological Journal of the Linnean Society · doi:10.1093/biolinnean/blz079 · Cited by 5 · see citing works

Fertile androgenetic mice generated by targeted epigenetic editing of imprinting control regions

Wei, Y., Yue, T., Wang, Y., & Yang, Y. X. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2425307122 · Cited by 4 · see citing works

Phosphorylated mixed lineage kinase domain‐like protein in human seminal plasma: A potential novel biomarker of spermatogenic function

Xie, Y., Lv, L., Yao, J., Zhang, C., Chen, H., Chen, W., Liang, X., Sun, X., Deng, C., & Liu, G. (2019) · Andrologia · doi:10.1111/and.13310 · Cited by 4 · see citing works

Paternally Mediated Developmental Toxicity

Downey, A. M., Robaire, B., & Hales, B. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64213-7 · Cited by 4 · see citing works

No general effects of advancing male age on ejaculates: a meta-analysis across the animal kingdomPreprint

Sanghvi, K., Vega‐Trejo, R., Nakagawa, S., Gascoigne, S. J. L., Johnson, S. L., Salguero‐Gómez, R., Pizzari, T., & Sepil, I. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.14.536443 · Cited by 4 · see citing works

Sperm DNA fragmentation

Franco, J. G., Jr. (2017) · Translational Andrology and Urology · doi:10.21037/tau.2017.05.07 · Cited by 3 · see citing works

The Impact of Modern Medicine on Human Evolution

Zampieri, F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-420190-3.00043-0 · Cited by 3 · see citing works

Fertility preservation 1 Fertility preservation in men with cancer

Tournaye, H. J., Dohle, G. R., & Barratt, C. L. R. (2014) · Cited by 2 · see citing works

A lifespan atlas of the killifish testis defines a pronounced mid-age remodeling shift during testicular aging

Franěk, R., Radek Sindelka, E., Torres-Martínez, A., Štundl, J., Konar, E. S. M., de Siqueira‐Silva, D. H., Sehadová, H., Pšenička, M., & Tichopád, T. (2026) · BMC Biology · doi:10.1186/s12915-026-02689-2 · Cited by 1 · see citing works

The aging spermatogonial stem cell niche

La, H. M., & Hobbs, R. M. (2020) · Advances in stem cells and their niches · doi:10.1016/bs.asn.2020.05.002 · Cited by 1 · see citing works

Paternally Mediated Developmental Toxicity

Robaire, B., & Hales, B. F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00152-2 · Cited by 1 · see citing works

Rejuvenation on the Road to Pluripotency

Sarkar, T. J., & Sebastiano, V. (2016) · InTech eBooks · doi:10.5772/63219 · Cited by 2 · see citing works

The Effect of Endocrine Disruptors and Environmental and Lifestyle Factors on the Sperm Epigenome

Santana, V. P., Salas‐Huetos, A., James, E. R., & Carrell, D. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108762571.004 · Cited by 1 · see citing works

Ageing in Evolutionary Perspective

Cordella, M., & Poiani, A. (2021) · International perspectives on aging · doi:10.1007/978-3-030-60071-6_9 · Cited by 1 · see citing works

Male Reproductive Senescence

Noblanc, A., & Robaire, B. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64610-x · Cited by 1 · see citing works

Discovery of an unusual high number of de novo mutations in sperm of older men using duplex sequencingPreprint

Salazar, R., Arbeithuber, B., Ivanković, M., Heinzl, M., Moura, S., Hartl, I., Mair, T., Lahnsteiner, A., Ebner, T., Shebl, O., et al. (2021) · bioRxiv · doi:10.1101/2021.04.26.441422 · Cited by 1 · see citing works

The role of miR-137 in schizophrenia

Wright, C. L. (2014) · UNM’s Digital Repository (University of New Mexico)

Session 18: Lifestyle dangers for men's fertility

Pedros, D. C. C., Oliveira, J. B. A., Petersen, C. G., Mauri, A. L., Nascimento, A. M., Vagnini, L. D., Nicoletti, A., Massaro, F. C., Cavagna, M., Martins, A., et al. (2013) · Human Reproduction · doi:10.1093/humrep/det145

The Spermatogonial Stem Cell and the Environment

Horan, T. S. A., Sartain, C. V., & Hunt, P. A. (2017) · Springer eBooks · doi:10.1007/978-1-4939-7505-1_9

Epigenetic landscape of infertility

Bisht, S., Chaurasia, P., Goswami, A., Khan, S., & Dada, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814259-2.00013-3

Aging of male and female gametes

James, E. R., Salas‐Huetos, A., Gostick, A. R., Carrell, D. T., Aston, K. I., & Jenkins, T. G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819753-0.00013-1

Activating mutations in FGFR3 are associated with clonal expansion events and high de novo rates in the male germlinePreprint

Moura, S., Hartl, I., Yasari, A., Brumovská, V., Striedner, Y., Bishara, M., Mair, T., Ebner, T., Schütz, G., Sevcsik, E., et al. (2022) · bioRxiv · doi:10.1101/2022.07.31.502216

Male Reproductive Senescence

Fice, H. E., & Robaire, B. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21477-6.00395-3

Paternal age, de novo mutations, and offspring health? New directions for an ageing problem

Aitken, R. J. (2024) · Human Reproduction · doi:10.1093/humrep/deae230 · Cited by 26 · see citing works

L26/O-258 Reproductive aging in men: new findings

Hallak, J. (2026) · Human Reproduction · doi:10.1093/humrep/deag083.256

Male age and progeny

AUROUX, M. R. (1998) · The Aging Male · doi:10.3109/13685539809146105 · Cited by 5 · see citing works

Reproductive functions of the ageing male

Nieschlag, E. (2004)

Male reproductive ageing: a radical road to ruin

Aitken, R. J. (2023) · Human Reproduction · doi:10.1093/humrep/dead157 · Cited by 59 · see citing works