The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
DNA resection in eukaryotes: deciding how to fix the break
Open accessAbstract
DNA double-strand breaks are repaired by different mechanisms, including homologous recombination and nonhomologous end-joining. DNA-end resection, the first step in recombination, is a key step that contributes to the choice of DSB repair. Resection, an evolutionarily conserved process that generates single-stranded DNA, is linked to checkpoint activation and is critical for survival. Failure to regulate and execute this process results in defective recombination and can contribute to human disease. Here I review recent findings on the mechanisms of resection in eukaryotes, from yeast to vertebrates, provide insights into the regulatory strategies that control it, and highlight the consequences of both its impairment and its deregulation.
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Cites
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Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
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Recombination Proteins in Yeast
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Cited by
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
Polo, S. E., & Jackson, S. P. (2011) · Genes & Development · doi:10.1101/gad.2021311 · Cited by 1,092
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
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Chromatin Remodeling at DNA Double-Strand Breaks
Price, B. D., & D’Andrea, A. D. (2013) · Cell · doi:10.1016/j.cell.2013.02.011 · Cited by 588
Chiolo, I., Minoda, A., Colmenares, S. U., Polyzos, A., Costes, S. V., & Karpen, G. H. (2011) · Cell · doi:10.1016/j.cell.2011.02.012 · Cited by 527
The MRN complex in double‐strand break repair and telomere maintenance
Lamarche, B. J., Orazio, N. I., & Weitzman, M. D. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.07.029 · Cited by 446
Metadata
- Authors
- Huertas, P.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2010-01
- Volume
- 17
- Issue
- 1
- Pages
- 11-16
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W1981816841
- Cited by
- 403
- References
- 75
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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