Cited by 446DNA Repair MechanismsTelomeres, Telomerase, and SenescenceDNA and Nucleic Acid Chemistry

The MRN complex in double‐strand break repair and telomere maintenance

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Lamarche, Brandon J., Orazio, Nicole I., Weitzman, Matthew D.·2010·FEBS Letters

Abstract

Genomes are subject to constant threat by damaging agents that generate DNA double‐strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA damage recognition and end‐joining, and this is achieved through protein–DNA complexes known as telomeres. The Mre11–Rad50–Nbs1 (MRN) complex plays important roles in detection and signaling of DSBs, as well as the repair pathways of homologous recombination (HR) and non‐homologous end‐joining (NHEJ). In addition, MRN associates with telomeres and contributes to their maintenance. Here, we provide an overview of MRN functions at DSBs, and examine its roles in telomere maintenance and dysfunction.

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Authors
Lamarche, B. J., Orazio, N. I., & Weitzman, M. D.
Affiliations
Salk Institute for Biological Studies (US)
Corresponding author
Weitzman, Matthew D.
Venue
FEBS Letters
Publisher
Wiley
Published
2010-07-22
Volume
584
Issue
17
Pages
3682-3695
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2028921845
Cited by
446
References
177
Citations by year
2026: 11 · 2025: 22 · 2024: 23 · 2023: 17 · 2022: 40 · 2021: 51 · 2020: 35 · 2019: 33 · 2018: 34 · 2017: 34 · 2016: 32 · 2015: 22 · 2014: 28 · 2013: 16 · 2012: 16
FWCI
1.79
Type
journal article
Language
en
Open access
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (AI067952, CA097093, AI051686)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords
MRN complex, Mre11-Rad50-Nbs1, DNA double-strand break repair, telomere maintenance, homologous recombination, non-homologous end joining, telomere dysfunction, DNA damage response
MeSH terms
Animals, DNA Damage, DNA Repair, Humans, Mutation, Signal Transduction, Telomere, Genome, Sequence Deletion, Models, Animal, Nijmegen Breakage Syndrome, Mice, DNA Breaks, Double-Stranded

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